Cited by 431Substance Abuse Treatment and OutcomesAlcohol Consumption and Health EffectsAlcoholism and Thiamine Deficiency

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Disulfiram Treatment of Alcoholism: A Veterans Administration Cooperative Study

Fuller, Richard K.·1986·JAMA

DOI 10.1001/jama.1986.03380110055026

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Abstract

We conducted a controlled, blinded, multicenter study of disulfiram treatment of alcoholism in 605 men randomly assigned to 250 mg of disulfiram (202 men); 1 mg of disulfiram (204 men), a control for the threat of the disulfiram-ethanol reaction; or no disulfiram (199 men), a control for the counseling that all received. Bimonthly treatment assessments were done for one year. Relative/ friend interviews and blood and urine ethanol analyses were used to corroborate patients' reports. There were no significant differences among the groups in total abstinence, time to first drink, employment, or social stability. Among the patients who drank and had a complete set of assessment interviews, those in the 250-mg disulfiram group reported significantly fewer drinking days (49.0 ±8.4) than those in the 1-mg (75.4±11.9) or the no-disulfiram (86.5 ± 13.6) groups. There was a significant relationship between adherence to drug regimen and complete abstinence in all groups. We conclude that disulfiram may help reduce drinking frequency after relapse, but does not enhance counseling in aiding alcoholic patients to sustain continuous abstinence or delay the resumption of drinking. (JAMA1986;256:1449-1455)

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Dinis‐Oliveira, R. J., Magalhães, T., Moreira, R. F., Proença, J. B., Pontes, H., Santos, A., Duarte, J. A., & Carvalho, F. D. (2013) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2013.869782 · Cited by 23
“Blocking ALDH2 results in the accumulation of acetaldehyde, which is toxic, and leads to a series of aversive symptoms that deter ethanol consumption (Fuller et al., 1986).”
BackgroundInfluential
The Zebrafish, a Novel Model Organism for Screening Compounds Affecting Acute and Chronic Ethanol-Induced Effects
Tran, S., Facciol, A., & Gerlai, R. T. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.02.016 · Cited by 23
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Evaluation of the accumulation of disulfiram and its copper complex in A549 cells using mass spectrometry
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Exploring the diversity of dual diagnosis: Utility of cluster analysis for program planning
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Safety and Efficacy of L‐tryptophan and Behavioral Incentives for Treatment of Cocaine Dependence: A Randomized Clinical Trial
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Screening, Assessment and Intervention for Substance use Disorders in General Health Care Settings
Fleming, M. F. (2002) · Substance Abuse · doi:10.1080/08897070209511507 · Cited by 22
“While the efficacy of this medication is variable, it is used throughout the world in tablet and implant form.(86)'(87) If patients who are alcohol-dependent take disulfiram daily, it can be an effective deterrent.”
Background
Learning the Language of Abstinence in Addiction Treatment: Some Similarities between Relapse–Prevention with Disulfiram, Naltrexone, and Other Pharmacological Antagonists and Intensive “Immersion” Methods of Foreign Language Teaching
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Pharmacological means of reducing human drug dependence: a selective and narrative review of the clinical literature
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Posttreatment Effects of Topiramate Treatment for Heavy Drinking
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Acamprosate in the treatment of alcohol dependence: clinical and economic considerations
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“Typically, disulfiram is not recommended as a first-line medication for the treatment of newly diagnosed alcohol-dependent patients but is reserved for treating patients who have previously failed 1 or more courses of psychosocial treatment(3) and who are motivated to achieve complete abstinence.(11) Patients taking d…”
Background
Pharmacologic Interventions for Alcohol‐ and Cocaine‐Abusing Individuals
Carroll, K. M., Ziedonis, D. M., O’Malley, S. S., et al. (1993) · American Journal on Addictions · doi:10.1111/j.1521-0391.1993.tb00372.x · Cited by 22

Authors: Fuller, R. K.
Corresponding author: Fuller, Richard K.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 1986-09-19
Volume: 256
Issue: 11
Pages: 1449
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.1986.03380110055026
OpenAlex: W3027683458
Cited by: 431
References: 0
Citations by year: 2026: 6 · 2025: 6 · 2024: 13 · 2023: 10 · 2022: 10 · 2021: 14 · 2020: 11 · 2019: 11 · 2018: 6 · 2017: 12 · 2016: 15 · 2015: 7 · 2014: 17 · 2013: 17 · 2012: 8
FWCI: 7.22
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
Keywords: disulfiram, alcoholism, alcoholism treatment, disulfiram-ethanol reaction, abstinence, drinking frequency, relapse, medication adherence, counseling

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Disulfiram Treatment of Alcoholism: A Veterans Administration Cooperative Study

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