Cited by 431Substance Abuse Treatment and OutcomesAlcohol Consumption and Health EffectsAlcoholism and Thiamine Deficiency

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Disulfiram Treatment of Alcoholism: A Veterans Administration Cooperative Study

Fuller, Richard K.·1986·JAMA

DOI 10.1001/jama.1986.03380110055026

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Abstract

We conducted a controlled, blinded, multicenter study of disulfiram treatment of alcoholism in 605 men randomly assigned to 250 mg of disulfiram (202 men); 1 mg of disulfiram (204 men), a control for the threat of the disulfiram-ethanol reaction; or no disulfiram (199 men), a control for the counseling that all received. Bimonthly treatment assessments were done for one year. Relative/ friend interviews and blood and urine ethanol analyses were used to corroborate patients' reports. There were no significant differences among the groups in total abstinence, time to first drink, employment, or social stability. Among the patients who drank and had a complete set of assessment interviews, those in the 250-mg disulfiram group reported significantly fewer drinking days (49.0 ±8.4) than those in the 1-mg (75.4±11.9) or the no-disulfiram (86.5 ± 13.6) groups. There was a significant relationship between adherence to drug regimen and complete abstinence in all groups. We conclude that disulfiram may help reduce drinking frequency after relapse, but does not enhance counseling in aiding alcoholic patients to sustain continuous abstinence or delay the resumption of drinking. (JAMA1986;256:1449-1455)

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Sousa, A. D. (2019) · Springer eBooks · doi:10.1007/978-981-32-9876-7_2 · Cited by 6
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Oppong‐Damoah, A., Gannon, B. M., & Murnane, K. S. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210211115007 · Cited by 6
Pharmacological Intervention for Preventing Violence Among the Mentally Ill with Secondary Alcohol-And Drug-Use Disorders
Tiihonen, J., & Swartz, M. (2000) · Springer eBooks · doi:10.1007/978-94-011-4130-7_10 · Cited by 8
Alcoholism
Blondell, R. D., Frierson, R. L., & Lippmann, S. (1996) · Postgraduate Medicine · doi:10.3810/pgm.1996.07.8 · Cited by 6
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Ritson, B. (1992) · Journal of the Royal Society of Medicine · doi:10.1177/014107689208500816 · Cited by 6
Issues in the Formulation of Drugs for Oral Use in Children
Pawar, S., & Kumar, A. (2002) · Pediatric Drugs · doi:10.2165/00148581-200204060-00004 · Cited by 5
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Huang, D., Yao, Y., Lou, Y., Kou, L., Yao, Q., & Chen, R. (2024) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2024.100307 · Cited by 7
A case of marked ST depression and myocardial injury as a result of disulfiram–ethanol reaction
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“Disulfiram is an irreversible inhibitor of aldehyde dehydrogenase (ALDH) recommended in the treatment of alcohol dependency disorders to prevent drinking [1—3].”
Background
Non-physiological mechanisms influencing disulfiram treatment of alcohol use disorder: A grounded theory study
Newton‐Howes, G., Levack, W., McBride, S., Gilmor, M., & Tester, R. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.05.027 · Cited by 6
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Authors: Fuller, R. K.
Corresponding author: Fuller, Richard K.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 1986-09-19
Volume: 256
Issue: 11
Pages: 1449
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.1986.03380110055026
OpenAlex: W3027683458
Cited by: 431
References: 0
Citations by year: 2026: 6 · 2025: 6 · 2024: 13 · 2023: 10 · 2022: 10 · 2021: 14 · 2020: 11 · 2019: 11 · 2018: 6 · 2017: 12 · 2016: 15 · 2015: 7 · 2014: 17 · 2013: 17 · 2012: 8
FWCI: 7.22
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
Keywords: disulfiram, alcoholism, alcoholism treatment, disulfiram-ethanol reaction, abstinence, drinking frequency, relapse, medication adherence, counseling

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Disulfiram Treatment of Alcoholism: A Veterans Administration Cooperative Study

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