The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Control of Food Intake in Older Men
Abstract
OBJECTIVE: To investigate the effects of aging on mechanisms of body energy regulation and thereby determine the causes of unexplained weight loss in older persons, a factor predisposing to premature death and disability. DESIGN: Dietary intervention study. SETTING: Metabolic ward and outpatient. PARTICIPANTS: The subjects were 35 healthy younger and older men of normal body weight consuming a diet of typical composition and performing usual activities. MAIN OUTCOME MEASURES: Subjects were either overfed by a mean (+/- SD) of 4.09 (+/- 0.26) MJ/d (n = 17) or underfed by 3.17 (+/- 0.68) MJ/d (n = 18) for 21 days. Measurements were made of changes in body weight, body composition, and energy expenditure during overfeeding or underfeeding, and of subsequent voluntary nutrient intakes and changes in body weight. RESULTS: There was no significant effect of aging on changes in body composition, body weight, or energy expenditure with overfeeding or underfeeding. However, following overfeeding, younger men exhibited spontaneous hypophagia, whereas the older men did not (mean [+/- SD] changes in energy intake relative to control values were -2.11 [+/- 2.18] and 1.55 [+/- 2.11] MJ/d, respectively; P = .006). As a result, the younger men lost the excess body weight gained during overfeeding but the older men did not. Similarly, following underfeeding, the younger men exhibited hyperphagia while the older men did not (mean [+/- SD] changes in energy intake relative to control values were 1.88 [+/- 2.31] and -0.52 [+/- 1.54] MJ/d, respectively; P = .02), and as a result the older men failed to regain the weight lost during underfeeding. CONCLUSIONS: These results in 35 men suggest that aging may be associated with a significant impairment in the ability to control food intake following overeating or undereating. Since overeating and undereating occur routinely as part of the normal pattern of energy regulation, the findings reported herein may help to explain the vulnerability of older persons to unexplained weight gain and weight loss.
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Cites
Food intake and energy expenditure of army recruits
Edholm, O. G., Adam, J. M., Healy, M. J. R., Wolff, H. S., Goldsmith, R., & Best, T. W. (1970) · British Journal of Nutrition · doi:10.1079/bjn19700112 · Cited by 185
Cited by
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
Haslam, D. W., & James, W. P. T. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67483-1 · Cited by 3,757
Godbout, J. P., Chen, J., Abraham, J., Richwine, A. F., Berg, B. M., Kelley, K. W., & Johnson, R. W. (2005) · The FASEB Journal · doi:10.1096/fj.05-3776fje · Cited by 813
Weight Change in Old Age and its Association with Mortality
Newman, A. B., Yanez, D., Harris, T., Duxbury, A., Enright, P. L., Fried, L. P., & for the Cardiovascular Study Research Group (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.49258.x · Cited by 566
Newman, A. B., Lee, J. S., Visser, M., Goodpaster, B. H., Kritchevsky, S. B., Tylavsky, F. A., Nevitt, M., & Harris, T. B. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.4.872 · Cited by 445
Metadata
- Authors
- Roberts, S. B.
- Venue
- JAMA: The Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1994-11-23
- Volume
- 272
- Issue
- 20
- Pages
- 1601
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W1987089805
- Cited by
- 419
- References
- 1
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- closed
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