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Linking Clinical Variables With Health-Related Quality of Life: A Conceptual Model of Patient Outcomes
Abstract
HEALTH-related quality of life (HRQL) is increasingly used as an outcome in clinical trials, effectiveness research, and research on quality of care. Factors that have facilitated this increased usage include the accumulating evidence that measures of HRQL are valid and "reliable,"1the publication of several large clinical trials showing that these outcome measures are responsive to important clinical changes,2-5and the successful development and testing of shorter instruments that are easier to understand and administer.6-13Because these measures describe or characterize what the patient has experienced as the result of medical care, they are useful and important supplements to traditional physiological or biological measures of health status. Given this improved ability to assess patients' health status, how can physicians and health care systems intervene to improve HRQL? Implicit in the use of measures of HRQL in clinical trials and in effectiveness research is the concept that clinical
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“Symptoms and side effects are the most proximally and least confounded clinical variables associated with disease and treatment; however, as one moves further away from the direct effects of disease and treatment, towards the broader construct of quality of life, many other confounding patient and environmental factors influence a quality of life score.”
In the citing paper
“The model suggests that to be very precise and valid, distinctly different PROs should be assessed separately to maximize information and decrease overlap between constructs.”
In the citing paper
“Per Wilson and Cleary, HRQOL is a broad, multi-faceted construct affected by many confounding variables [16].”
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Does endoscopy have a positive impact on quality of life in dyspepsia?
Wiklund, I. E., Glise, H., Jerndal, P., Carlsson, J., & Talley, N. J. (1998) · Gastrointestinal Endoscopy · doi:10.1016/s0016-5107(98)70243-3 · Cited by 104
Cognitive Deficits and Health-Related Quality of Life in Chronic Heart Failure
Pressler, S. J., Subramanian, U., Kareken, D. A., Perkins, S. M., Gradus‐Pizlo, I., Sauvé, M. J., Ding, Y., Kim, J., Sloan, R. S., Jaynes, H. A., et al. (2010) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0b013e3181ca36fe · Cited by 100
“Health-related quality of life is a multidimensional concept that includes biological variables, symptom status, functional status, health perceptions, and overall well-being.(5) In previous studies, better physical symptom status, older age, and fewer depressive symptoms were associated with better HRQL.”
BackgroundOldridge, N., Gottlieb, M. S., Guyatt, G. H., Jones, N. L., Streiner, D. L., & Feeny, D. H. (1998) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-199803000-00002 · Cited by 102
Determinants of Health-Related Quality of Life in Long-Term Survivors of Hodgkin's Lymphoma
Wettergren, L., Björkholm, M., Axdorph, U., & Langius‐Eklöf, A. (2004) · Quality of Life Research · doi:10.1023/b:qure.0000040790.43372.69 · Cited by 102
“One way to increase clarification is to link results of HRQL research to a conceptual model [13, 24, 25] exemplified by Wilson and Cleary’s model (Figure 1) [26].”
Pasipanodya, J. G., Miller, T. L., Vecino, M., Munguia, G., Bae, S., Drewyer, G., & Weis, S. E. (2007) · CHEST Journal · doi:10.1378/chest.07-0755 · Cited by 103
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Patient‐based outcomes and quality of life
Graziani, F., & Tsakos, G. (2020) · Periodontology 2000 · doi:10.1111/prd.12305 · Cited by 101
Kehyayan, V., Hirdes, J. P., Tyas, S. L., & Stolee, P. (2015) · Journal of Aging and Health · doi:10.1177/0898264315594138 · Cited by 99
“The remaining sample size of 847 was more than adequate for statistical power in bivariate and regression analyses (Altman, 1991; Wilson & Cleary, 1995).”
BackgroundUsing the SF-12 Health Status Measure to Improve Predictions of Medical Expenditures
Fleishman, J. A., Cohen, J. W., Manning, W. G., & Kosinski, M. R. (2006) · Medical Care · doi:10.1097/01.mlr.0000208141.02083.86 · Cited by 101
“In the model developed by Wilson and Cleary, for example, clinical conditions can be seen as precursors to measures of health status.(32) Expenditures prior to completing the SF-12 can be viewed as reflecting aspects of health status.”
MethodClark, J. H., Yeagle, J. D., Arbaje, A. I., Lin, F. R., Niparko, J. K., & Francis, H. W. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2012.04150.x · Cited by 100
Application of Structural Equation Modeling to Health Outcomes Research
Hays, R. D., Revicki, D. A., & Coyne, K. S. (2005) · Evaluation & the Health Professions · doi:10.1177/0163278705278277 · Cited by 100
“One model developed by Wilson and Cleary (1995) specifies a series of relationships between several patient outcome assessments that extends from cellular and biological processes to NOTE: Estimated correlations for English and Spanish respondents, respectively, were as follows: physical and mental…”
Impact of liver transplantation on health-related quality of life
Younossi, Z. M., McCormick, M., Price, L. L., Boparai, N., Farquhar, L., Henderson, J. M., & Guyatt, G. (2000) · Liver Transplantation · doi:10.1053/jlts.2000.18499 · Cited by 98
Validation of the Sign and Symptom Check‐List for Persons with HIV Disease (SSC‐HIV)
Holzemer, W. L., Henry, S. B., Nokes, K. M., Corless, I. B., Brown, M., Powell‐Cope, G. M., Turner, J. G., & Inouye, J. (1999) · Journal of Advanced Nursing · doi:10.1046/j.1365-2648.1999.01204.x · Cited by 101
Quality of Life in Adult Home Parenteral Nutrition Patients
Winkler, M. F. (2005) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607105029003162 · Cited by 100
Measurement of Health-Related Quality of Life in Multiple Sclerosis Patients
Brunei, D. G., Hopman, W. M., Singer, M. A., Edgar, C. M., & MacKenzie, T. A. (1996) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100038798 · Cited by 97
“as well as mental health and general health perceptions.(3) HRQOL is to be distinguished from quality of life (QOL) because the former is based on health domains which can be measured and quantitated.”
BackgroundŠabanović, S., Chang, W.-L., Bennett, C. C., Piatt, J. A., & Hakken, D. (2015) · Lecture Notes in Computer Science · doi:10.1007/978-3-319-20892-3_11 · Cited by 100
Health-related quality of life in individuals with chronic obstructive pulmonary disease
Hu, J., & Meek, P. (2005) · Heart & Lung · doi:10.1016/j.hrtlng.2005.03.008 · Cited by 103
DuBeau, C. E., Levy, B. R., Mangione, C. M., et al. (1998) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1998.tb03801.x · Cited by 99
Khanna, D., Yan, X., Tashkin, D. P., Furst, D. E., Elashoff, R. M., Roth, M. D., Silver, R. M., Strange, C., Bolster, M. B., Seibold, J. R., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22580 · Cited by 98
Bauer, M., Leavens, A., & Schwartzman, K. (2012) · Quality of Life Research · doi:10.1007/s11136-012-0329-x · Cited by 98
“Terms included in the search strategy related to the concepts of the operational definition of HRQOL as described by Wilson and Cleary [55].”
MethodThe impact of stomatological disease on oral health‐related quality of life
Llewellyn, C. D., & Warnakulasuriya, S. (2003) · European Journal Of Oral Sciences · doi:10.1034/j.1600-0722.2003.00057.x · Cited by 98
Enhancing Oral Health via Sense of Coherence
Nammontri, O., Robinson, P. G., & Baker, S. R. (2012) · Journal of Dental Research · doi:10.1177/0022034512459757 · Cited by 98
“A secondary aim was to Enhancing Oral Health via sense of coherence: A clusterrandomized trial examine the direct and indirect (mediating) determinants of OHRQoL in children, with the Wilson and Cleary (1995) model as an a priori theoretical framework.”
BackgroundMethodEvaluating the Psychometric Properties of the Eating Assessment Tool (EAT-10) Using Rasch Analysis
Cordier, R., Joosten, A. V., Clavé, P., Schindler, A., Bülow, M., Demır, N., Arslan, S. S., & Speyer, R. (2016) · Dysphagia · doi:10.1007/s00455-016-9754-2 · Cited by 95
“FHS is concerned with the influence of a given disease on particular functional aspects of a patient’s health, such as the ability to perform tasks in multiple domains [14, 15].”
BackgroundDepression and appearance-related distress in functioning with lipedema
Dudek, J. E., Białaszek, W., Ostaszewski, P., & Smidt, T. (2018) · Psychology Health & Medicine · doi:10.1080/13548506.2018.1459750 · Cited by 97
“In accordance with Wilson and Cleary’s model of quality of life in chronic diseases (Wilson & Cleary, 1995), we look at the overall quality of life not only as a resultant of biological abnormalities, but also perceived symptoms and physical and psychological functioning with the disease.”
MethodTurner, J. G., Page, K. A., Chin, D. P., Osmond, D. H., Mossar, M., Markstein, L., Huitsing, J., Barnes, S., Clemente, V., & Chesney, M. A. (2001) · AIDS Patient Care and STDs · doi:10.1089/108729101753354617 · Cited by 97
Self-Management Improves Outcomes in Persons With Limb Loss
Wegener, S. T., MacKenzie, E. J., Ephraim, P. L., Ehde, D. M., & Williams, R. M. (2009) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2008.08.222 · Cited by 97
Quality of Life and the Concept of “Living Well” With HIV/AIDS in Sub‐Saharan Africa
Phaladze, N., Human, S. P., Dlamini, S., et al. (2005) · Journal of Nursing Scholarship · doi:10.1111/j.1547-5069.2005.00023.x · Cited by 97
Association of Gingivitis With Child Oral Health–Related Quality of Life
Tomazoni, F., Zanatta, F. B., Tuchtenhagen, S., et al. (2014) · Journal of Periodontology · doi:10.1902/jop.2014.140026 · Cited by 96
Patient‐reported outcomes in cirrhosis: A scoping review of the literature
Tapper, E. B., Kanwal, F., Asrani, S. K., et al. (2017) · Hepatology · doi:10.1002/hep.29756 · Cited by 96
“status, function, satisfaction with care or adherence to medication.(18) Furthermore, in contrast to the development of psychometric indices, for the purpose of Quality Improvement it is”
BackgroundStrength Training Following Hematopoietic Stem Cell Transplantation
Hacker, E. D., Larson, J. L., Kujath, A. S., Peace, D. J., Rondelli, D., & Gaston, L. (2010) · Cancer Nursing · doi:10.1097/ncc.0b013e3181fb3686 · Cited by 96
Quality of life after pulmonary embolism as assessed with SF-36 and PEmb-QoL
van Es, J., den Exter, P. L., Kaptein, A. A., et al. (2013) · Thrombosis Research · doi:10.1016/j.thromres.2013.06.016 · Cited by 96
Chandra, P. S., Gandhi, C., Satishchandra, P., Kamat, A., Desai, A. S., Ravi, V., Ownby, R. L., Subbakrishna, D. K., & Kumar, M. (2006) · Quality of Life Research · doi:10.1007/s11136-006-9001-7 · Cited by 96
“Studies of both generic and disease-specific quality of life (QOL) measures in HIV infected populations have revealed consistently that QOL appears to be associated with treatment [1, 2], physical symptoms [3–6], adverse event occurrences and markers of disease severity [4–6].”
BackgroundGuedes, R. S., Piovesan, C., Antunes, J. L. F., Mendes, F. M., & Ardenghi, T. M. (2014) · Quality of Life Research · doi:10.1007/s11136-014-0690-z · Cited by 95
Health-related quality of life and associated factors in people with HIV: an Irish cohort study
George, S., Bergin, C. J., Clarke, S., Courtney, G., & Codd, M. (2016) · Health and Quality of Life Outcomes · doi:10.1186/s12955-016-0517-4 · Cited by 95
“The conceptual framework underpinning this study is based on the Wilson and Cleary’s model of assessing health outcomes in terms of biological and physiological variables, symptom status, functional status, general health perception and overall QoL and the causal relationship between these variables [43].”
MethodTsakos, G., Steele, J. G., Marcenes, W., et al. (2006) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.2006.00398.x · Cited by 95
Årestedt, K., Saveman, B., Johansson, P., & Blomqvist, K. (2012) · European Journal of Cardiovascular Nursing · doi:10.1177/1474515111432997 · Cited by 95
Osborne, T. R., Ramsenthaler, C., de Wolf‐Linder, S., Schey, S., Siegert, R. J., Edmonds, P. M., & Higginson, I. J. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-496 · Cited by 92
“A recent systematic review found Wilson and Cleary’s model to be the most widely used in the literature [12].”
MethodInfluentialvan der Wees, P. J., Verkerk, E. W., Verbiest, M. E. A., Zuidgeest, M., Bakker, C., Braspenning, J. C. C., de Boer, D., Terwee, C. B., Vajda, I., Beurskens, A. J. H. M., et al. (2019) · Journal of Patient-Reported Outcomes · doi:10.1186/s41687-019-0171-9 · Cited by 101
Gullick, J. G., & Stainton, M. C. (2008) · Journal of Advanced Nursing · doi:10.1111/j.1365-2648.2008.04823.x · Cited by 94
Patient-Reported Outcomes in Orthopaedics
MOTION Group (2018) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.17.00608 · Cited by 97
Ramasubbu, S. K., Pasricha, R., Nath, U., Rawat, V., & Das, B. (2020) · Cancer Reports · doi:10.1002/cnr2.1312 · Cited by 88
Cruz, L., Fleck, M. P. D. A., Oliveira, M. R., Camey, S., Hoffmann, J. F., Bagattini, Â., & Polanczyk, C. (2013) · Ciência & Saúde Coletiva · doi:10.1590/s1413-81232013000700006 · Cited by 87
Determinants of Disability after Lower Extremity Fracture
Mock, C., MacKenzie, E. J., JURKOVICH, G. J., et al. (2000) · doi:10.1097/00005373-200012000-00005 · Cited by 93
O'Donnell, M. L., Creamer, M. C., Elliott, P., Atkin, C., & Kossmann, T. (2005) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000197621.94561.4e · Cited by 92
Poley, M. J. (2004) · Archives of Disease in Childhood · doi:10.1136/adc.2002.016543 · Cited by 93
Finch, A. P., Brazier, J. E., Mukuria, C., & Bjørner, J. B. (2017) · Value in Health · doi:10.1016/j.jval.2017.06.002 · Cited by 93
Oral health‐related quality of life of children with oligodontia
Locker, D., Jokovic, A., Prakash, P., & Tompson, B. D. (2009) · International Journal of Paediatric Dentistry · doi:10.1111/j.1365-263x.2009.01001.x · Cited by 92
Issues in Cross‐cultural Quality‐of‐Life Research
Corless, I. B., Nicholas, P. K., & Nokes, K. M. (2001) · Journal of Nursing Scholarship · doi:10.1111/j.1547-5069.2001.00015.x · Cited by 92
Shikako‐Thomas, K., Dahan‐Oliel, N., Shevell, M. I., et al. (2012) · International Journal of Pediatrics · doi:10.1155/2012/387280 · Cited by 92
“Diversity and intensity of participation accounted for 32% (P = 0.002) of the variance for physical well-being and 48% (P 0.001) when age and gross motor functioning were added.”
BackgroundInfluentialVetsch, J., Wakefield, C. E., Robertson, E. G., Trahair, T. N., Mateos, M. K., Grootenhuis, M. A., Marshall, G. M., Cohn, R. J., & Fardell, J. E. (2018) · Quality of Life Research · doi:10.1007/s11136-018-1788-5 · Cited by 93
“Having a positive outlook, living a healthy lifestyle, and seeking support and companionship from others were reported as strategies to enhance HRQL during survivorship [67], consistent with the framework of disease adaptation [12] and models of HRQL [10, 11].”
BackgroundMethodShah, N., Cader, M., Andrews, W. P., Wijesekera, D., & Stewart-Brown, S. L. (2018) · Health and Quality of Life Outcomes · doi:10.1186/s12955-018-1060-2 · Cited by 92
“Mental wellbeing is now also beginning to be recognised as an outcome of importance in mental health services [6] where valid outcome measures, usually based on patient self-report, are required by commissioners to monitor the effectiveness of service provision [7].”
BackgroundQuality of life in osteogenesis imperfecta: A mixed‐methods systematic review
Dahan‐Oliel, N., Oliel, S., Tsimicalis, A., Montpetit, K., Rauch, F., & Dogba, M. J. (2015) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.37377 · Cited by 89
Functional status, life-space mobility, and quality of life: a longitudinal mediation analysis
Bentley, J. P., Brown, C. J., McGwin, G., Sawyer, P., Allman, R. M., & Roth, D. L. (2012) · Quality of Life Research · doi:10.1007/s11136-012-0315-3 · Cited by 92
“Wilson and Cleary [5] developed a theoretical framework to link the biomedical model of health with a quality of life model.”
BackgroundTesting a Conceptual Model of Oral Health: a Structural Equation Modeling Approach
Baker, S. R. (2007) · Journal of Dental Research · doi:10.1177/154405910708600804 · Cited by 91
“One model is that by Wilson and Cleary (1995) , which has been used extensively in health-related quality-of-life research outside of dentistry, and has recently been applied to oral health (Baker et al., 2007).”
MethodSystemic and global toxicities of head and neck treatment
Murphy, B. A., Gilbert, J., & Ridner, S. H. (2007) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.7.7.1043 · Cited by 94
Caregivers' oral health literacy and their young children's oral health-related quality-of-life
Divaris, K., Lee, J. Y., Baker, A. D., & Vann, W. F. (2011) · Acta Odontologica Scandinavica · doi:10.3109/00016357.2011.629627 · Cited by 92
“This is consistent with Wilson and Cleary’s [59] modified conceptual model of patient outcomes on which Wandera et al. [51] based their examination of the relationship of psychosocial factors with C-OHRQoL.”
Arkela-Kautiainen, M., Haapasaari, J., Kautiainen, H., et al. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2004.026591 · Cited by 91
Herrmann, S., McKinnon, E., Hyland, N., Lalanne, C., Mallal, S. A., Nolan, D. A., Chassany, O., & Duracinský, M. (2013) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-11-56 · Cited by 90
“The results from the survey, supported by the interview material, demonstrate that HIV influences HRQL across the spectrum of biological, social and psychological domains that comprise the complex continuum of measures of health [28].”
ResultAtkinson, M. J., Allen, R. P., DuChane, J., Murray, C. B., Kushida, C. A., & Roth, T. G. (2004) · Quality of Life Research · doi:10.1023/b:qure.0000021322.22011.d0 · Cited by 91
“Under most circumstances, a HRQL measure should be affected by the clinical severity of an illness [34] and thus a validity criterion of the RLSQLI is demonstration of a clear association with the IRLS severity measure.”
BackgroundRapkin, B. D., & Schwartz, C. E. (2019) · Quality of Life Research · doi:10.1007/s11136-019-02248-z · Cited by 90
Buldur, B., & Güvendi, Ö. N. (2019) · International Journal of Paediatric Dentistry · doi:10.1111/ipd.12583 · Cited by 91
Dong, S., Costa, D. S. J., Butow, P. N., Lovell, M. R., Agar, M. R., Velikova, G., Teckle, P., Tong, A., Tebbutt, N. C., Clarke, S. J., et al. (2015) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2015.07.013 · Cited by 93
Effects of Graves’ ophthalmopathy on quality of life
Wiersinga, W. M., Prummel, M. F., & Terwee, C. B. (2004) · Journal of Endocrinological Investigation · doi:10.1007/bf03345275 · Cited by 90
Measuring a Dimension of Spirituality for Health Research
Frey, B. B., Daaleman, T. P., & Peyton, V. (2005) · Research on Aging · doi:10.1177/0164027505277847 · Cited by 94
Construct Validity of Locker’s Global Oral Health Item
Thomson, W. M., Mejía, G. C., Broadbent, J. M., et al. (2012) · Journal of Dental Research · doi:10.1177/0022034512460676 · Cited by 90
“…indeed provide an adequate summary of how people view their oral health (at least among those older than 34 yrs), and that it unified their subjective perceptions and objective observations in a coherent way which is consistent with contemporary models and understanding (Wilson and Cleary, 1995).”
ResultSchönberger, M., Ponsford, J. L., Gould, K. R., & Johnston, L. (2011) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617711000701 · Cited by 90
“It has also been argued that the relationship between psychiatric disorders and functional status is bi-directional (Wilson & Cleary, 1995).”
BackgroundQuality of life among advanced breast cancer patients with and without distant metastasis
Wyatt, G. K., Sikorskii, A. E., Tamkus, D. M., & You, M. (2012) · European Journal of Cancer Care · doi:10.1111/ecc.12028 · Cited by 89
“For this work, HRQOL is conceptualised by the theoretical framework proposed by Wilson and Cleary (1995) and further developed by Ferrans et al. (2005).”
MethodA quality-of-life measure for adults with primary ciliary dyskinesia: QOL–PCD
Lucas, J. S., Behan, L., DunnGalvin, A., Alpern, A. N., Morris, A. M., Carroll, M. P., Knowles, M. R., Leigh, M. W., & Quittner, A. L. (2015) · European Respiratory Journal · doi:10.1183/09031936.00216214 · Cited by 90
Health-related quality of life and pain beliefs among people suffering from chronic pain
Dysvik, E., Lindstrøm, T. C., Eikeland, O., & Natvig, G. K. (2004) · Pain Management Nursing · doi:10.1016/j.pmn.2003.11.003 · Cited by 89
Mathews, W. C., & May, S. J. (2007) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-5-5 · Cited by 89
Ware, J. E., Gandek, B., Guyer, R., & Deng, N. (2016) · Health and Quality of Life Outcomes · doi:10.1186/s12955-016-0483-x · Cited by 95
“Background Disease-specific measures of quality of life (QOL) have the advantage of frequently being more responsive and clinically useful than generic QOL measures which do not focus on any specific condition [1–3], while generic measures have the advantage of enabling comparisons of QOL burden and treatment benefit…”
BackgroundHack, M. (1999) · PEDIATRICS · doi:10.1542/peds.103.se1.319 · Cited by 89
Quality-of-Life Measurements Versus Disease Activity in Systemic Lupus Erythematosus
Kiani, A. N., & Petri, M. (2010) · Current Rheumatology Reports · doi:10.1007/s11926-010-0114-1 · Cited by 85
“It has deleterious effects on quality of life [10, 33, 34 ].”
BackgroundMwesigire, D. M., Katamba, A., Martin, F., Seeley, J., & Wu, A. W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126810 · Cited by 88
“Wilson and Cleary [18] proposed that behavioral factors determine QoL and these include alcohol use, which has also been associated with risky sexual behavior among Ugandan PLHIV on ART [19].”
BackgroundHalvorsrud, L., & Kalfoss, M. H. (2007) · European Journal of Ageing · doi:10.1007/s10433-007-0063-3 · Cited by 89
“QoL measurements and domains Wilson and Cleary (1995) have developed a conceptual model for HRQoL outcomes that has increased in popularity (Ferrans et al. 2005; Patrick and Chiang 2000).”
BackgroundHealth-Related Quality of Life (HR-QOL) and Regulatory Issues
Apolone, G., Carli, G. D., Brunetti, M., & Garattini, S. K. (2001) · PharmacoEconomics · doi:10.2165/00019053-200119020-00005 · Cited by 86
“Thus, a causal relationship pathway can be expected and then empirically tested.[16] Several examples of the empirical utilisation of HR-QOL instruments in clinical studies (observational or experimental) can be found in the literature,[17,18] with an impressive increase in their use from 1985 to 1994 (0.”
BackgroundAssessment of Patient-Reported Clinical Outcome in Pancreatic and Other Hepatobiliary Cancers
Yount, S., Cella, D. F., Webster, K., Heffernan, N., Chang, C., Odom, L., & van Gool, R. (2002) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(02)00422-0 · Cited by 88
An Exploration of Quality of Life and the Experience of Living With Home Parenteral Nutrition
Winkler, M. F., Hagan, E., Wetle, T., et al. (2010) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607110362582 · Cited by 88
Symonds, T. L., Berzon, R. A., Marquis, P., & Rummans, T. A. (2002) · Mayo Clinic Proceedings · doi:10.4065/77.6.572 · Cited by 88
Factors That Contribute to Positive Perceived Health in an Older Population
Bryant, L. L., Beck, A. L., & Fairclough, D. L. (2000) · Journal of Aging and Health · doi:10.1177/089826430001200202 · Cited by 88
“…the theorized incremental effects of progressively less individual and more social-behavioral and social-delivery-of-care factors, as suggested by Wilson and Cleary (1995), sequential or hierarchical entry of categories began with sociodemographics, followed by chronic conditions, physical…”
BackgroundInfluentialHedrich, U. B. S., Lauxmann, S., Wolff, M., Synofzik, M., Bast, T., Binelli, A., Serratosa, J. M., Martínez-Ulloa, P., Allen, N. M., King, M. D., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz4957 · Cited by 87
Mollon, L. E., & Bhattacharjee, S. (2017) · Health and Quality of Life Outcomes · doi:10.1186/s12955-017-0809-3 · Cited by 87
“An important aspect to understanding this linkage is general health perception, which has been shown to be an independent predictor of use of medical or mental health services and mortality [25].”
BackgroundMethodVettore, M. V., Ahmad, S. F. H., Machuca, C., & Fontanini, H. (2019) · European Journal Of Oral Sciences · doi:10.1111/eos.12605 · Cited by 87
Quality of life outcomes in women with endometriosis are highly influenced by recruitment strategies
de Graaff, A. A., Dirksen, C. D., Simoens, S., Bie, B. D., Hummelshøj, L., D’Hooghe, T. M., & Dunselman, G. A. J. (2015) · Human Reproduction · doi:10.1093/humrep/dev084 · Cited by 85
Smith, T. J., Radler, D. R., Denmark, R., Haley, T. F., & Touger-Decker, R. E. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512004138 · Cited by 86
“The Wilson & Cleary((13)) HRQL conceptual model provides a framework for indirectly assessing the impact of probiotics on HRQL during URI episodes.”
BackgroundResultInfluentialCook, K. F., Victorson, D. E., Cella, D. F., Schalet, B. D., & Miller, D. M. (2014) · Quality of Life Research · doi:10.1007/s11136-014-0790-9 · Cited by 88
Health‐related quality of life in patients with chronic hepatitis B
Bondini, S., Kallman, J. B., Dan, A. A., Younoszai, Z., Ramsey, L., Nader, F., & Younossi, Z. M. (2007) · Liver International · doi:10.1111/j.1478-3231.2007.01558.x · Cited by 85
Cross-sectional validation of the PROMIS-Preference scoring system
Hanmer, J., Dewitt, B., Yu, L., Tsevat, J., Roberts, M. S., Revicki, D. A., Pilkonis, P. A., Hess, R., Hays, R. D., Fischhoff, B., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201093 · Cited by 84
“Patient reports about functioning and well-being, or health-related quality of life (HRQoL), are important outcomes of health care and policy [1,2].”
BackgroundDifferences in What Quality-of-Life Instruments Measure
Ferrans, C. E. (2007) · JNCI Monographs · doi:10.1093/jncimonographs/lgm008 · Cited by 86
Bruscolini, A., Sacchetti, M., Cava, M. L., Nebbioso, M., Iannitelli, A., Quartini, A., Lambìase, A., Ralli, M., VIRGILIO, A. D., & Greco, A. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.12.012 · Cited by 85
Carrière, M. E., Mokkink, L. B., Tyack, Z. F., Westerman, M. J., Pijpe, A., Pleat, J., van de Kar, A. L., Brown, J. N., de Vet, H. C. W., & van Zuijlen, P. P. M. (2022) · Quality of Life Research · doi:10.1007/s11136-022-03244-6 · Cited by 91
Measuring postoperative recovery: What are clinically meaningful differences?
Antonescu, I., Scott, S. C., Tran, T. T., Mayo, N. E., & Feldman, L. S. (2014) · Surgery · doi:10.1016/j.surg.2014.03.005 · Cited by 85
La Medida de la Calidad de Vida Relacionada con la Salud en la Investigación y la Práctica Clínica
Alonso, J. (2000) · Gaceta Sanitaria · doi:10.1016/s0213-9111(00)71450-6 · Cited by 84
Transitions of Elders Between Long-Term Care and Hospitals
Naylor, M. D., Kurtzman, E. T., & Pauly, M. V. (2009) · Policy Politics & Nursing Practice · doi:10.1177/1527154409355710 · Cited by 86
“rates also are poorly understood.[1, 39-41 ] These data are essential to inform measure development.”
BackgroundBiopsychosocial Predictors of Health-Related Quality of Life in Patients With Chronic Hepatitis C
Häuser, W., Zimmer, C., Schiedermaier, P., & Grandt, D. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000145824.82125.a8 · Cited by 85
“Not only physicians and psychologists but also pharmaceutical companies are engaged in the development of HRQOL questionnaires, because the American Food and Drug Administration requires proof of HRQOL benefits for the license of a drug (4).”
BackgroundThe Impact of Laryngopharyngeal Reflux on Patient‐Reported Quality of Life
Carrau, R. L., Khidr, A., Crawley, J. A., et al. (2004) · The Laryngoscope · doi:10.1097/00005537-200404000-00014 · Cited by 85
Maziarz, R. T., Waller, E. K., Jaeger, U., Fleury, I., McGuirk, J. P., Holte, H., Jaglowski, S. M., Schuster, S. J., Bishop, M. R., Westin, J. R., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2019001026 · Cited by 83
Validation of a Core Patient-Reported Outcome Measure for Fatigue in Patients Receiving Hemodialysis
Ju, A., Teixeira-Pinto, A. M., Tong, A., Smith, A. C., Unruh, M. L., Davison, S. N., Dapueto, J. J., Dew, M. A., Fluck, R., Germain, M. J., et al. (2020) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.05880420 · Cited by 84
“Undergraduate/postgraduate 23 (8) 26 (25) 34 (32) 83 (17) Missing 1 (0) 3 (3) 0 (0) 4 (1) Years on dialysis, n (%) ,1 226 (75) 34 (32) 10 (13) 270 (56) 1–5 44 (15) 43 (41) 48 (63) 135 (28) 6–10 18 (6) 18 (17) 9 (12) 45 (10) 111 14 (5) 11 (10) 9 (12) 34 (7) Missing 1 (0) 0 (0) 0 (0) 1 (0) CJASN 15: 1614–1621, November,…”
Kimmel, P. L. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.07419.x · Cited by 83
Validation of a Quality-of-Life Instrument for Laryngopharyngeal Reflux
Carrau, R. L., Khidr, A., Gold, K. F., Crawley, J. A., Hillson, E., Koufman, J. A., & Pashos, C. L. (2005) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.131.4.315 · Cited by 83
“Health-related quality of life (HRQL) has been studied in depth for many diseases, including gastrointestinal disorders.(11-14) A variety of generic and disease-specific instruments have been used to measure the impact on HRQL of GERD,(15-26) and other instruments have been used to evaluate the impact of voice disorde…”
Metadata
- Authors
- Wilson, I. B.
- Corresponding author
- Wilson, Ira B.
- ORCID
- Wilson, Ira B.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1995-01-04
- Volume
- 273
- Issue
- 1
- Pages
- 59
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W4292024189
- Cited by
- 3,027
- References
- 0
- Citations by year
- 2026: 151 · 2025: 168 · 2024: 134 · 2023: 141 · 2022: 176 · 2021: 183 · 2020: 197 · 2019: 137 · 2018: 138 · 2017: 130 · 2016: 145 · 2015: 131 · 2014: 128 · 2013: 123 · 2012: 106
- FWCI
- 96.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- Funders
- Agency for Healthcare Research and Quality (1-R01-HS06239)
- Topics
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Keywords
- health-related quality of life, clinical factors, patient-reported outcomes, outcome measures, quality of care, effectiveness research, health assessment
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