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Linking Clinical Variables With Health-Related Quality of Life: A Conceptual Model of Patient Outcomes
Abstract
HEALTH-related quality of life (HRQL) is increasingly used as an outcome in clinical trials, effectiveness research, and research on quality of care. Factors that have facilitated this increased usage include the accumulating evidence that measures of HRQL are valid and "reliable,"1the publication of several large clinical trials showing that these outcome measures are responsive to important clinical changes,2-5and the successful development and testing of shorter instruments that are easier to understand and administer.6-13Because these measures describe or characterize what the patient has experienced as the result of medical care, they are useful and important supplements to traditional physiological or biological measures of health status. Given this improved ability to assess patients' health status, how can physicians and health care systems intervene to improve HRQL? Implicit in the use of measures of HRQL in clinical trials and in effectiveness research is the concept that clinical
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“Symptoms and side effects are the most proximally and least confounded clinical variables associated with disease and treatment; however, as one moves further away from the direct effects of disease and treatment, towards the broader construct of quality of life, many other confounding patient and environmental factors influence a quality of life score.”
In the citing paper
“The model suggests that to be very precise and valid, distinctly different PROs should be assessed separately to maximize information and decrease overlap between constructs.”
In the citing paper
“Per Wilson and Cleary, HRQOL is a broad, multi-faceted construct affected by many confounding variables [16].”
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Hsu, N., Tsao, H.-M., Chen, H., & Chou, P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107609 · Cited by 44
Teli, M., Thato, R., & Rias, Y. A. (2023) · SAGE Open Nursing · doi:10.1177/23779608231185921 · Cited by 41
“HRQoL is a subjective evaluation based on an individual ’ s unique perspective, experiences, and goals (Wilson & Clearly, 1995).”
The Dentine Hypersensitivity Experience Questionnaire: a longitudinal validation study
Baker, S. R., Gibson, B. J., Sufi, F., et al. (2013) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12181 · Cited by 41
Maatouk, I., Wild, B., Herzog, W., Wesche, D., Schellberg, D., Schöttker, B., Müller, H., Rothenbacher, D., Stegmaier, C., & Brenner, H. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e328353d81b · Cited by 41
“In their interesting model of relationships between traditional clinical variables and health-status measures, Wilson and Cleary [19] recommend an investigation of the link of biological factors that are applied to more complex measures, such as HRQOL, in routine clinical practice.”
BackgroundTakeshita, H., Ikebe, K., Kagawa, R., Okada, T., Gondo, Y., Nakagawa, T., Ishioka, Y., Inomata, C., Tada, S., Matsuda, K.-I., et al. (2014) · Journal of Dentistry · doi:10.1016/j.jdent.2014.12.011 · Cited by 41
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Berg, K., Kjellgren, K. I., Unosson, M., et al. (2012) · BMC Nursing · doi:10.1186/1472-6955-11-24 · Cited by 41
“No uniform definition of HRQoL exists, but it is considered a composite of biological function, symptoms, functional status, subjective health and wellbeing [18].”
BackgroundSteca, P., D’Αddario, M., Magrin, M. E., Miglioretti, M., Monzani, D., Pancani, L., Sarini, M., Scrignaro, M., Vecchio, L. P., Fattirolli, F., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161840 · Cited by 45
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Ziemssen, T., Tolley, C., Bennett, B., Kilgariff, S., Jones, E., Pike, J., Tomic, D., Piani-Meier, D., & Lahoz, R. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.101861 · Cited by 39
Adriaanse, M. C., Dekker, J., Spijkerman, A. M. W., et al. (2004) · Diabetic Medicine · doi:10.1111/j.1464-5491.2004.01277.x · Cited by 41
Jung, S.-H., Ryu, J., Tsakos, G., et al. (2008) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-6-17 · Cited by 41
“Such clinical indicators frequently overestimate oral health needs [3].”
Buhl, R., Kardos, P., Richter, K., et al. (2004) · Current Medical Research and Opinion · doi:10.1185/030079903125004303 · Cited by 41
van der Waal, J. M., Terwee, C. B., van der Windt, D., Bouter, L. M., & Dekker, J. (2005) · Quality of Life Research · doi:10.1007/s11136-004-0801-3 · Cited by 40
“This model was based on the disablement process described by Verbrugge and Jette [11] and on a HRQL model of patient outcomes, introduced by Wilson and Cleary [12].”
A simple method to enable patient-tailored treatment and to motivate the patient to change behaviour
Vercoulen, J. H. (2012) · Chronic Respiratory Disease · doi:10.1177/1479972312459974 · Cited by 41
“General theories define health status as an overall concept covering physiological functioning, symptoms, functional impairment, social functioning, and quality of life as main domains.(14,15) These main domains were found to be subdivided into many more concrete subdomains.”
BackgroundRisk Factors Associated With Incorrect Surgical Counts
Rowlands, A. (2012) · AORN Journal · doi:10.1016/j.aorn.2012.06.012 · Cited by 40
Loo, D. W. Y., Jiang, Y., Koh, K. W. L., Lim, F. P., & Wang, W. (2016) · Applied Nursing Research · doi:10.1016/j.apnr.2016.07.007 · Cited by 40
“Wilson and Cleary (1995) model of HRQoL framework guided the development and execution of the study in consolidating current literature to understand the impact of CHF on HRQoL among outpatients in Singapore.”
InfluentialFatigue as a Driver of Overall Quality of Life in Cancer Patients
McCabe, R. M., Grutsch, J. F., Braun, D. P., & Nutakki, S. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130023 · Cited by 40
Manning, V., Gomez, B., Song, G., Low, Y. D., Koh, P. K., & Wong, K. E. (2011) · International Journal of Mental Health and Addiction · doi:10.1007/s11469-011-9349-y · Cited by 39
“Often, health-related QoL measures form the basis of outcome research with the notion that interventions can affect parameters such as physical, social and mental health (Wilson and Cleary 1995).”
BackgroundShyu, Y. L., Liang, J., Wu, C., Cheng, H., & Chen, M.-C. (2010) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-11-225 · Cited by 40
“Similar to our findings, quality of life has previously been found to improve as a result of intervention programs for hip-fractured elders [14,15].”
ResultBuseh, A. G., Kelber, S. T., Hewitt, J. B., Stevens, P. E., & Park, C. G. (2006) · International Journal of Men s Health · doi:10.3149/jmh.0501.35 · Cited by 40
The Measurement of Health-Related Quality of Life in Patients with Coronary Heart Disease
Thompson, D. R., & Roebuck, A. (2001) · The Journal of Cardiovascular Nursing · doi:10.1097/00005082-200110000-00005 · Cited by 40
“A 48-item questionnaire was then formatted using a Likert scale of never (0), occasionally (1), sometimes (2), often (3), always (4).”
Andela, C. D., Lobatto, D. J., Pereira, A. M., van Furth, W. R., & Biermasz, N. R. (2018) · Pituitary · doi:10.1007/s11102-017-0860-4 · Cited by 40
“Symptom status is defined by Wilson and Cleary as a patient’s perception of an abnormal physical, emotional, or cognitive state [9].”
BackgroundMethodSeroprevalence of Toxoplasma gondii infection in goats and sheep in Zimbabwe
Hove, T., Lind, P., & Mukaratirwa, S. (2005) · Onderstepoort Journal of Veterinary Research · doi:10.4102/ojvr.v72i4.175 · Cited by 55
Measures of health-related quality of life for adults with acute sinusitis
Linder, J. A., Singer, D. E., van den Ancker, M., & Atlas, S. J. (2003) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2003.20744.x · Cited by 40
Testing the Psychometric Properties of 9 Bolt-Ons for the EQ-5D-5L in a General Population Sample
Rencz, F., & Janssen, M. F. (2024) · Value in Health · doi:10.1016/j.jval.2024.03.2195 · Cited by 45
Relations Between Health-Related Quality of Life and Well-Being: The Gerontologist's New Clothes?
Spiro, A., & Bossé, R. (2000) · The International Journal of Aging and Human Development · doi:10.2190/49xw-dc4u-yt00-kdb7 · Cited by 39
“…of measures of HQL, as well as their association with more objective medical outcomes such as laboratory tests and health care utilization or mortality, have been well-established (e.g., Kazis, 1990; McHorney, 1996; Stewart & Ware, 1992; Ware, 1995; Ware et al., 1996; Wilson & Cleary, 1995).”
BackgroundArnfinn, R., Kvan, E., Pettersen Kjell, I., et al. (2008) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.1186/1471-2261-8-28 · Cited by 39
“An understanding of the way LVEF may influence HRQoL can be provided from a conceptual model outlined by Wilson and Cleary [33].”
BackgroundInfluentialde Paula, J. S., Sarracini, K. L. M., Meneghim, M. C., et al. (2015) · European Journal Of Oral Sciences · doi:10.1111/eos.12188 · Cited by 39
Machado, D. R., Kimura, M., Duarte, Y. A. O., & Lebrão, M. L. (2020) · Ciência & Saúde Coletiva · doi:10.1590/1413-81232020253.19232018 · Cited by 41
Grove, T. B., Tso, I. F., Chun, J., Mueller, S. A., Taylor, S. F., Ellingrod, V. L., McInnis, M. G., & Deldin, P. J. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.06.031 · Cited by 39
“This suggests that negative affect may be a critical determinant of socioemotional functioning and supports previous work emphasizing the relationship between negative affect and outcomes across psychiatric and non-psychiatric populations (Pilkonis et al., 2013; Wilson and Cleary, 1995).”
ResultTelemonitoring of Type 2 Diabetes Mellitus in Italy
Dario, C., Toffanin, R., Calcaterra, F., Saccavini, C., Stafylas, P. C., Mancin, S., & Vio, E. (2016) · Telemedicine Journal and e-Health · doi:10.1089/tmj.2015.0224 · Cited by 39
Mayo, N. E., Aburub, A. S., Brouillette, M., et al. (2016) · Quality of Life Research · doi:10.1007/s11136-016-1480-6 · Cited by 39
LeBlanc, M. R., Hirschey, R., Bryant, A. L., LeBlanc, T. W., & Smith, S. K. (2019) · Quality of Life Research · doi:10.1007/s11136-019-02392-6 · Cited by 38
Reliability and validity of the Multiple Sclerosis Quality of Life Inventory in older individuals
DiLorenzo, T. A., Halper, J., & Picone, M. A. (2003) · Disability and Rehabilitation · doi:10.1080/0963828031000122195 · Cited by 38
Mathisen, L., Andersen, M. H., Veenstra, M., et al. (2007) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-5-27 · Cited by 39
Health-related quality of life of irritable bowel syndrome patients in different cultural settings
Faresjö, Å., Anastasiou, F., Lionis, C. D., Johansson, S., Wallander, M.-A. A., & Faresjö, T. (2006) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-4-21 · Cited by 39
A Race- and Gender-Specific Replication of Five Dimensions of Functional Limitation and Disability
Clark, D. O., Stump, T. E., & Wolinsky, F. D. (1997) · Journal of Aging and Health · doi:10.1177/089826439700900102 · Cited by 39
Beaton, D., Cole, D. C., Manno, M., Bombardier, C., Hogg‐Johnson, S., & Shannon, H. S. (2000) · Journal of Occupational Rehabilitation · doi:10.1023/a:1009489712094 · Cited by 39
“Although not clearly identified as unique in either the Wilson and Cleary (15) or the Verbrugge (16) model, we felt it important to identify separately in our study because it separates those behaviours that reflect the burden that are more observable by workplace markers.”
BackgroundMethodInfluentialWiklund, I. E., & Butler-Wheelhouse, P. (1996) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529609094759 · Cited by 38
Feng, X., Mosimah, C. I., Sizemore, G., Goyat, R., & Dwibedi, N. (2019) · Journal of Human Behavior in the Social Environment · doi:10.1080/10911359.2018.1470953 · Cited by 42
“The Health Related Quality of Life theoretical framework model described byWilson and Cleary was used in this study (Wilson & Cleary, 1995).”
MethodBarakou, I., Hackett, K. L., Finch, T. L., & Hettinga, F. J. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2270688 · Cited by 49
da Costa, A. C., Rodrigues, F. S., da Fonte, P. P., et al. (2017) · BMC Oral Health · doi:10.1186/s12903-017-0405-2 · Cited by 38
“the Wilson-Cleary model [19] Costa et al.”
BackgroundMethodResultInfluentialYoung, C. A., Ealing, J., McDermott, C. J., Williams, T. L., Al‐Chalabi, A., Majeed, T., Burke, G., Pinto, A. A., Dick, D. J., Talbot, K., et al. (2019) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2019.1615951 · Cited by 38
“These variables were intended to provide a relevant disease-specific interpretation of the Wilson and Cleary model of health related quality of life, as outlined in Figure 1 (8).”
InfluentialDreyer, R. P., van Zitteren, M., Beltrame, J. F., Fitridge, R., Denollet, J., Vriens, P. W. H. E., Spertus, J. A., & Smolderen, K. G. E. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.000863 · Cited by 37
“Depressive symptoms or “mood states” as well as a greater degree of bodily pain may be associated with substantially compromised functional status(48) as well as a poorer prognosis,(49) which ultimately has adverse effects on patients’ health status.(50,51) When we adjusted for depression scores, after including other…”
Kepka, S., Baumann, C., Anota, A., et al. (2013) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-11-134 · Cited by 38
“On the basis of Wilson ’ s [9] and Ferrans models [10], the objective of this study is to clarify the relationships between trait anxiety, optimism and HRQOL.”
Rintell, D. J., Heath, D., Menendez, F. B., Cross, E., Cross, T., Knobel, V., Gagnon, B., Turtle, C. J., Cohen, A., Kalmykov, E. A., et al. (2021) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-021-01706-7 · Cited by 38
de Vries, C. E. E., Terwee, C. B., Nawas, M. A., van Wagensveld, B. A., Janssen, I. M. C., Liem, R. S. L., Nienhuijs, S. W., COHEN, R. V., van Rossum, E. F. C., Brown, W. A., et al. (2022) · Obesity Reviews · doi:10.1111/obr.13452 · Cited by 40
“21 This model distinguishes between biological and physiological factors, symptom status, functional status, general health perceptions, and overall quality of life and shows how these outcomes may interrelate.”
Jiang, H., Lyu, J., Mou, W., Jiang, Q., & Du, J. (2022) · Asia-Pacific Journal of Clinical Oncology · doi:10.1111/ajco.13901 · Cited by 41
Houston, M. N., Bay, R. C., & McLeod, T. C. V. (2016) · Brain Injury · doi:10.3109/02699052.2016.1146960 · Cited by 37
“Although symptoms represent a patient’s physical, emotional, cognitive or psychosomatic state, HRQoL characterizes the impact of a disease or injury on a patient’s daily function[11].”
BackgroundRiezzo, G., Orlando, A., D’Attoma, B., Linsalata, M., Martulli, M., & Russo, F. (2017) · Beneficial Microbes · doi:10.3920/bm2017.0049 · Cited by 37
“The value of assessing QoL has become increasingly evident in clinical research (Bergner, 1989; Testa and Simonson, 1996; Wilson and Cleary, 1995).”
Campolong, K., Jenkins, S. M., Clark, M. M., Borowski, K. S., Nelson, N., Moore, K. M., & Bobo, W. V. (2017) · Archives of Women s Mental Health · doi:10.1007/s00737-017-0783-0 · Cited by 39
Validation and Psychometric Properties of the German Version of the SWAL-QOL
Kraus, E.-M., Rommel, N., Stoll, L. H., Oettinger, A., Vogel, A. P., & Synofzik, M. (2018) · Dysphagia · doi:10.1007/s00455-017-9872-5 · Cited by 34
“This lack of correlation can be explained by the fact that these more symptom-specific subscales of the G-SWALQOL test different constructs than the generic global health-related QOL measures of the SF-36 [32], supporting the discriminant validity of the G-SWAL-QOL.”
ResultRamerman, L., Hoekstra, P. J., & de Kuijper, G. D. (2018) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2018.02.011 · Cited by 34
Factors affecting the health‐related quality of life in community‐dwelling elderly people
Kim, G. M., Hong, M. S., & Noh, W. (2018) · Public Health Nursing · doi:10.1111/phn.12530 · Cited by 38
TONiC Study Group, Pomeroy, I. M., Tennant, A., Mills, R. J., & Young, C. A. (2020) · Quality of Life Research · doi:10.1007/s11136-020-02463-z · Cited by 36
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Quality of Life and Psychosocial Factors in Renal Transplant Recipients
Shah, V. S., Ananth, A., Sohal, G., et al. (2006) · Transplantation Proceedings · doi:10.1016/j.transproceed.2006.03.027 · Cited by 37
A Middle Range Theory for Generative Quality of Life for the Elderly
Register, M. E., & Herman, J. (2006) · Advances in Nursing Science · doi:10.1097/00012272-200610000-00007 · Cited by 37
Factors Associated With Health-Related Quality of Life in Elderly Korean Patients With Heart Failure
Son, Y., Song, Y., Nam, S., Shin, W., Lee, S., & Jin, D. (2012) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0b013e31823fa38a · Cited by 38
LI, L. C., Davis, A. M., Lineker, S. C., Coyte, P. C., & Bombardier, C. (2006) · Arthritis Care & Research · doi:10.1002/art.21692 · Cited by 37
“We used a modified version of Wilson and Cleary’s health-related quality of life model (16) (Appendix A) to guide the selection of outcome measures.”
MethodLiang, Y., Wang, H.-W., & Tao, X. (2015) · International Journal for Equity in Health · doi:10.1186/s12939-015-0199-2 · Cited by 37
“The self-rated evaluation of respondents is sensitive to health changes; as such, the selfrated evaluation is considered as an efficient supplement in traditional, physiological, or biological measures; this tool is also helpful in the self-management of health [43].”
Method3. Uses of Evidence in Disability Outcomes and Effectiveness Research
Jette, A. M., & Keysor, J. J. (2002) · Milbank Quarterly · doi:10.1111/1468-0009.t01-1-00006 · Cited by 37
Antihypertensive Medication and Quality of Life—Silent Treatment of a Silent Killer?
Bremner, A. D. (2002) · Cardiovascular Drugs and Therapy · doi:10.1023/a:1021790112182 · Cited by 37
Molecular biology of prostatic intraepithelial neoplasia
Bostwick, D. G., Pacelli, A., & Antonio Lopez-beltran, B. (1996) · The Prostate · doi:10.1002/(sici)1097-0045(199608)29:2 · Cited by 211
Li, J., Li, Y., Lv, R., Kuang, J., Zhou, K., & Xu, M. (2022) · Quality of Life Research · doi:10.1007/s11136-022-03225-9 · Cited by 40
Saris, L. M. H., Vlooswijk, C. C. P., Kaal, S. E. J., Nuver, J., Bijlsma, R. M., van der Hulle, T., Kouwenhoven, M. C. M., Tromp, J. M., Lalisang, R. I., Bos, M. E. M. M., et al. (2022) · Cancers · doi:10.3390/cancers14215243 · Cited by 36
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The patient’s perspective on the symptom and everyday life impact of AL amyloidosis
Lin, H. M., Seldin, D. C., Hui, A., et al. (2015) · Amyloid · doi:10.3109/13506129.2015.1102131 · Cited by 36
“It is based upon the disease model developed by Wilson and Cleary [18], which shows how the proximal impacts of disease influence patient functioning and”
MethodMatare, C. R., Mbuya, M. N. N., Pelto, G. H., Dickin, K. L., & Stoltzfus, R. J. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ851 · Cited by 41
“be healthy despite suffering from a disease, and alternately, others will perceive themselves to have poor health when there is no objective indication of disease [23].”
BackgroundRitchie, C. S., Zhao, F., Patel, K., et al. (2017) · Cancer · doi:10.1002/cncr.30801 · Cited by 36
Focus on disability-free life expectancy: implications for health-related quality of life
Galvin, A., Friedman, D. B., & Hébert, J. R. (2021) · Quality of Life Research · doi:10.1007/s11136-021-02809-1 · Cited by 37
Development and Validation of the Oral Health Values Scale
Edwards, C. B., Randall, C. L., & McNeil, D. W. (2021) · Community Dentistry And Oral Epidemiology · doi:10.1111/cdoe.12621 · Cited by 38
Mukuria, C., Connell, J., Carlton, J., Peasgood, T., Scope, A., Clowes, M., Rand, S. E., Jones, K., & Brazier, J. E. (2022) · Value in Health · doi:10.1016/j.jval.2021.11.1371 · Cited by 38
Resting and ADL-induced dynamic hyperinflation explain physical inactivity in COPD better than FEV1
Lahaije, A., van Helvoort, H. A. C., Dekhuijzen, P. N. R., Vercoulen, J. H. M. M., & Heijdra, Y. F. (2013) · Respiratory Medicine · doi:10.1016/j.rmed.2013.02.017 · Cited by 36
Eton, D. T., Shevrin, D. H., Beaumont, J. L., Victorson, D. E., & Cella, D. F. (2010) · Value in Health · doi:10.1111/j.1524-4733.2010.00702.x · Cited by 36
Regulatory Issues for Health-Related Quality of Life— PhRMA Health Outcomes Committee Workshop, 1999
Santanello, N. C., Baker, D., Cappelleri, J. C., et al. (2002) · Value in Health · doi:10.1046/j.1524-4733.2002.51047.x · Cited by 36
Bezner, J. R., & Hunter, D. L. (2001) · Archives of Physical Medicine and Rehabilitation · doi:10.1053/apmr.2001.23269 · Cited by 36
Prospective Study of Quality of Life of Patients Receiving Treatment for Prostate Cancer
Eller, L. S., Lev, E. L., Gejerman, G., Colella, J., Esposito, M., Lanteri, V. J., Scheuch, J., Munver, R., Lane, P., Junchaya, C., et al. (2006) · Nursing Research · doi:10.1097/00006199-200603001-00006 · Cited by 35
“…on the conceptual model for the study, hierarchical regression models were built to assess the degree to which independent variables predicted each of the five factors measured by the FACT-P, as these factors were conceptualized as dimensions of QOL (Frosch et al., 2001; Wilson & Cleary, 1995).”
MethodPerceived dental treatment need among older Tanzanian adults – a cross-sectional study
Åstrøm, A. N., & Kida, I. A. (2007) · BMC Oral Health · doi:10.1186/1472-6831-7-9 · Cited by 36
Quality of life among older stroke patients in Taiwan during the first year after discharge
Shyu, Y. L., Maa, S., Chen, S., & Chen, M. (2008) · Journal of Clinical Nursing · doi:10.1111/j.1365-2702.2008.02458.x · Cited by 37
“Traditional indicators of the impact of interventions on patients’ health status, such as mortality and objective clinical parameters, have been increasingly supplemented by selfrated health-related quality of life (HRQoL) (Greenfield & Nelson 1992, Wilson & Cleary 1995).”
BackgroundSimchen, E., Galai, N., Braun, D., et al. (2001) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1067/mtc.2001.112830 · Cited by 36
Simon, J. E., & Docherty, C. L. (2016) · Journal of Athletic Training · doi:10.4085/1062-6050-51.4.05 · Cited by 40
“Health-related quality of life is a broad construct that includes both subjective and objective indicators that affect physical and mental health.(9,10)”
BackgroundCoyne, K. S., Lundergan, C. F., Boyle, D., et al. (2000) · Circulation · doi:10.1161/01.cir.102.11.1245 · Cited by 36
Health-Related Quality of Life in Older Adults with Colorectal Cancer
Lapinsky, E., Man, L. C., & MacKenzie, A. R. (2019) · Current Oncology Reports · doi:10.1007/s11912-019-0830-2 · Cited by 35
Conijn, A. P., Jonkers, W., Rouwet, E. V., et al. (2015) · CardioVascular and Interventional Radiology · doi:10.1007/s00270-015-1060-0 · Cited by 35
Zandifar, A., Masjedi, S. S., Haghdoost, F., Asgari, F., Manouchehri, N., Banihashemi, M., Najafi, M. R., Ghorbani, A., Zolfaghari, B., Gholamrezaei, A., et al. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/950245 · Cited by 35
“This can be attributed to the fact that severity of migraine symptoms is not highly related to quality of life [28].”
BackgroundFactors affecting quality of life in patients with coronary heart disease
Durmaz, T., Özdemir, Ö., ÖZDEMİR, B. A., et al. (2009) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-0901-26 · Cited by 35
Evaluation of self-management interventions for chronic obstructive pulmonary disease
Bentsen, S. B., Langeland, E., & Holm, A. L. (2012) · Journal of Nursing Management · doi:10.1111/j.1365-2834.2012.01469.x · Cited by 35
“Another strength of the study is that the benefits of the self-management interventions were evaluated in this review in terms of the broadly defined concept of QOL (Wilson & Cleary 1995).”
BackgroundInfluentialSelf-perceived health status following aneurysmal subarachnoid haemorrhage: a cohort study
Quinn, A., Bhargava, D., Al-Tamimi, Y., et al. (2014) · BMJ Open · doi:10.1136/bmjopen-2013-003932 · Cited by 35
“adds the potential impact of mediators (such as personal factors) and moderators (such as environmental factors) to the equation.(20) 21 Thus, it is important to understand that the current study does not accept the health-related quality of life (HRQoL) position that, for example, the”
BackgroundRebelo, M. A. B., de Castro, P. H. D. F., Vieira, J. M. R., Robinson, P. G., & Vettore, M. V. (2016) · Journal of Periodontology · doi:10.1902/jop.2016.160204 · Cited by 35
Social support, depression, and quality of life among people living with HIV in Guangxi, China
Xiao, Z., Li, X., Qiao, S., Zhou, Y., & Shen, Z. (2016) · AIDS Care · doi:10.1080/09540121.2016.1224298 · Cited by 34
“QOL includes various dimensions such as global health perspectives, symptom status, functional status, biological and physical variables, individual and environmental characteristics, and general health perceptions (Wilson & Cleary, 1995).”
Backgroundvan Zon, S. K. R., Bültmann, U., Reijneveld, S. A., & de Leon, C. F. M. (2016) · Social Science & Medicine · doi:10.1016/j.socscimed.2016.10.002 · Cited by 35
Cordier, R., Speyer, R., Schindler, A., Michou, E., Heijnen, B. J., Baijens, L. W. J., Karaduman, A. A., Swan, K., Clavé, P., & Joosten, A. V. (2018) · Dysphagia · doi:10.1007/s00455-017-9873-4 · Cited by 38
“In order for clinicians to effectively manage OD it is important to consider a patient’s functional health status (FHS), and evaluate the impact of OD on the functional aspects of patient health, such as the ability to perform various eating and swallowing tasks [7, 8].”
BackgroundAdam, S., Feller, A., Rohrmann, S., & Arndt, V. (2018) · Health and Quality of Life Outcomes · doi:10.1186/s12955-017-0836-0 · Cited by 36
“Additionally, global HRQoL (or overall health perceptions) must be added to this multidimensional concept, as it has proven to be an important predictor of individuals’ health [14].”
BackgroundScrimin, S., Osler, G., Pozzoli, T., & Moscardino, U. M. M. (2018) · Child Care Health and Development · doi:10.1111/cch.12596 · Cited by 35
van Andel, E. M., Koopmann, B. D. M., Crouwel, F., Noomen, C. G., de Boer, N. K. H., van Asseldonk, D. P., & Mokkink, L. B. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaa057 · Cited by 36
Firouzbakht, M., Hajian‐Tilaki, K., & Moslemi, D. (2019) · International Health · doi:10.1093/inthealth/ihz108 · Cited by 39
Tennigkeit, J., Feige, T., Haak, M., Hellqvist, C., Seven, Ü. S., Kalbe, E., Schwarz, J., Warnecke, T., Tönges, L., Eggers, C., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092787 · Cited by 36
“Reported primary or secondary outcomes and employed measurement instruments fell into all domains of health-related outcomes [45], ranging from physiological/biological variables”
Background
Metadata
- Authors
- Wilson, I. B.
- Corresponding author
- Wilson, Ira B.
- ORCID
- Wilson, Ira B.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1995-01-04
- Volume
- 273
- Issue
- 1
- Pages
- 59
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W4292024189
- Cited by
- 3,027
- References
- 0
- Citations by year
- 2026: 151 · 2025: 168 · 2024: 134 · 2023: 141 · 2022: 176 · 2021: 183 · 2020: 197 · 2019: 137 · 2018: 138 · 2017: 130 · 2016: 145 · 2015: 131 · 2014: 128 · 2013: 123 · 2012: 106
- FWCI
- 96.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- Funders
- Agency for Healthcare Research and Quality (1-R01-HS06239)
- Topics
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Keywords
- health-related quality of life, clinical factors, patient-reported outcomes, outcome measures, quality of care, effectiveness research, health assessment
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