Cited by 847Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsCholesterol and Lipid Metabolism

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Association of Small Low-Density Lipoprotein Particles With the Incidence of Coronary Artery Disease in Men and Women

Gardner, Christopher D.·1996·JAMA: The Journal of the American Medical Association

DOI 10.1001/jama.1996.03540110029028

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Abstract

OBJECTIVE: To investigate the prospective association of low-density lipoprotein (LDL) particle diameter with the incidence of fatal and nonfatal coronary artery disease (CAD). DESIGN: A nested case-control study. SETTING: Cases and controls were identified from a population-based sample of men and women combining all of the 5 cross-sectional surveys conducted from 1979 to 1990 of the Stanford Five-City Project (FCP). PARTICIPANTS: Incident CAD cases were identified through FCP surveillance between 1979 and 1992. Controls were matched by sex, 5-year age groups, survey time point, ethnicity, and FCP treatment condition. The sample included 124 matched pairs: 90 pairs of men and 34 pairs of women. MAIN OUTCOME MEASURES: LDL peak particle diameter (LDL size) was determined by gradient gel electrophoresis on plasma samples collected during the cross-sectional surveys (stored at 70 degrees C for 5-15 years). Established CAD risk-factor data were available from FCP baseline measurements. RESULTS: LDL size was smaller among CAD cases than controls (mean +/- SD) (26.17 +/- 1.00 nm vs 26.68 +/- 0.90 nm; P<.001). The association was graded across control quintiles of LDL size. The significant case-control difference in LDL size was independent of levels of high-density lipoprotein cholesterol (HDL-C), non-HDL cholesterol (non-HDL-C), triglyceride, smoking, systolic blood pressure, and body mass index, but was not significant after adjusting for the ratio of total cholesterol (TC) to HDL-C (TC:HDL-C). Among all the physiological risk factors, LDL size was the best differentiator of CAD status in conditional logistic regression. However, when added to the physiological parameters above, the TC:HDL-C ratio was found to be a stronger independent predictor of CAD status. CONCLUSION: LDL size was significantly smaller in CAD cases than in controls in a prospective, population-based study. These findings support other evidence of a role for small, dense LDL particles in the etiology of atherosclerosis.

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Austin, M. A., King, M. C., Vranizan, K. M., & Krauss, R. M. (1990) · Circulation · doi:10.1161/01.cir.82.2.495 · Cited by 1,411
Regular physical exercise and low-fat diet. Effects on progression of coronary artery disease.
Schuler, G. C., Hambrecht, R., Schlierf, G., Niebauer, J., Hauer, K. A., Neumann, J., Hoberg, E., Drinkmann, A., Bacher, F., & Grunze, M. F. (1992) · Circulation · doi:10.1161/01.cir.86.1.1 · Cited by 1,339
Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state
Patsch, J. R., Miesenböck, G., Hopferwieser, T., Mühlberger, V, Knapp, E., Dunn, J. K., Gotto, A. M., & Patsch, W. (1992) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.12.11.1336 · Cited by 1,122
Identification of multiple subclasses of plasma low density lipoproteins in normal humans.
Krauss, R. M., & Burke, D. J. (1982) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38178-5 · Cited by 992
Role of Insulin Resistance in Human Disease (Syndrome X): An Expanded Definition
Reaven, G. M. (1993) · Annual Review of Medicine · doi:10.1146/annurev.me.44.020193.001005 · Cited by 908
NHLBI funding policies. Enhancing stability, predictability, and cost control.
Lenfant, C. L. (1994) · Circulation · doi:10.1161/01.cir.90.1.1 · Cited by 763
Enhanced susceptibility to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects.
Graaf, J. D., Hak-Lemmers, H. L. M., Hectors, M. P. C., Demacker, P. N. M., Hendriks, J. C. M., & Stalenhoef, A. F. H. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.2.298 · Cited by 714
Insulin resistance and hyperinsulinemia in individuals with small, dense low density lipoprotein particles.
Reaven, G. M., Chen, Y. I., Jeppesen, J., Maheux, P., & Krauss, R. M. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116541 · Cited by 687
Susceptibility of small, dense, low-density lipoproteins to oxidative modification in subjects with the atherogenic lipoprotein phenotype, pattern B
Chait, A., Brazg, R., Tribble, D. L., & Krauss, R. M. (1993) · The American Journal of Medicine · doi:10.1016/0002-9343(93)90144-e · Cited by 554

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Balcı, B. (2012) · Current Cardiology Reviews · doi:10.2174/157340311799960690 · Cited by 59
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Ohmura, H., Mokuno, H., Sawano, M., Hatsumi, C., Mitsugi, Y., Watanabe, Y., Daida, H., & Yamaguchi, H. (2002) · Metabolism · doi:10.1053/meta.2002.34695 · Cited by 58
Visceral obesity and the risk of ischaemic heart disease: insights from the Québec Cardiovascular Study
Lamarche, B., Lemieux, S., Dagenais, G. R., & Després, J. (1998) · Growth Hormone & IGF Research · doi:10.1016/s1096-6374(98)80018-x · Cited by 59
Alterations in low-density lipoprotein and high-density lipoprotein subclasses among hispanic women with polycystic ovary syndrome: influence of insulin and genetic factors
Legro, R. S., Blanche, P. J., Krauss, R. M., & Løbo, R. A. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00401-x · Cited by 57
The ratio of apoB/apoAI, apoB and lipoprotein(a) are the best predictors of stable coronary artery disease
Rasouli, M., Kiasari, A. M., & Mokhberi, V. (2006) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2006.163 · Cited by 57
Long-term effects on lipids and lipoproteins of pioglitazone versus gliclazide addition to metformin and pioglitazone versus metformin addition to sulphonylurea in the treatment of type 2 diabetes
Betteridge, D. J., & Vergès, B. L. (2005) · Diabetologia · doi:10.1007/s00125-005-0034-1 · Cited by 57
“Small, dense LDL particles may be more atherogenic than large, more buoyant ones [3].”
Background
Lipoprotein-associated phospholipase A2: a new biomarker for cardiovascular risk assessment and potential therapeutic target
Carlquist, J. F., Muhlestein, J. B., & Anderson, J. L. (2007) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.7.5.511 · Cited by 57
Rapid Separation of LDL Subclasses by Iodixanol Gradient Ultracentrifugation
Davies, I. G., Graham, J. M., & Griffin, B. A. (2003) · Clinical Chemistry · doi:10.1373/clinchem.2003.023366 · Cited by 57
Assessment of Between-Instrument Variations in a HPLC Method for Serum Lipoproteins and Its Traceability to Reference Methods for Total Cholesterol and HDL-Cholesterol
Usui, S., Nakamura, M., Jitsukata, K., Nara, M., Hosaki, S., & Okazaki, M. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.1.63 · Cited by 57
“Small dense LDL, one of the subclasses of LDL, has an important clinical significance as well (4, 5).”
Background
Low density lipoprotein particle diameter in young, nonobese, normolipidemic Japanese men
Kazumi, T., Kawaguchi, A. T., Hozumi, T., Nagao, M., Iwahashi, M., Hayakawa, M., 石原, 健., & Yoshino, G. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(98)00201-9 · Cited by 57
Efficacy and safety of the coadministration of ezetimibe/simvastatin with fenofibrate in patients with mixed hyperlipidemia
Farnier, M., Roth, E., Gil-Extremera, B., Mendez, G. F., Macdonell, G., Hamlin, C., Perevozskaya, I., Davies, M. J., Kush, D., & Mitchel, Y. B. (2007) · American Heart Journal · doi:10.1016/j.ahj.2006.10.031 · Cited by 83
Abnormal HDL subclasses distribution in overweight children with insulin resistance or type 2 diabetes mellitus
Pérez-Méndez, O. A., Torres‐Tamayo, M., Posadas‐Romero, C., Garcés, V. V., Carreón‐Torres, E., Mendoza-Peŕez, E., Urrutia, A. X. M., Huesca‐Gómez, C., Zamora‐González, J., & Aguilar-Herrera, B. E. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2006.07.003 · Cited by 56
Measurement of low-density lipoprotein particle size by high-performance gel-filtration chromatography
Scheffer, P. G., Bakker, S. J. L., Heine, R. J., & Teerlink, T. (1997) · Clinical Chemistry · doi:10.1093/clinchem/43.10.1904 · Cited by 56
Effect of fluvastatin on low-density lipoprotein peak particle diameter
Superko, H. R., Krauss, R. M., & DiRicco, C. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00288-9 · Cited by 56
A Solid Dietary Fat Containing Fish Oil Redistributes Lipoprotein Subclasses without Increasing Oxidative Stress in Men
Tholstrup, T., Hellgren, L. I., Petersen, M., Basu, S., Straarup, E. M., Schnohr, P., & Sandström, B. (2004) · Journal of Nutrition · doi:10.1093/jn/134.5.1051 · Cited by 55
Absence of association between genetic variation in the promoter of the microsomal triglyceride transfer protein gene and plasma lipoproteins in the Framingham Offspring Study
Couture, P., Otvos, J. D., Cupples, L. A., Wilson, P. W. F., Schaefer, E. J., & Ordovás, J. M. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00281-6 · Cited by 55
“There is also a growing body of evidence to support the role of LDL particle heterogeneity and, in particular, small, dense LDL in the risk of cardiovascular diseases [2–6].”
Background
Lipoprotein subclasses and atherosclerosis.
Superko, R. (2001) · Frontiers in Bioscience · doi:10.2741/superko · Cited by 52
Effect of Fluvastatin Slow-Release on Low Density Lipoprotein (LDL) Subfractions in Patients with Type 2 Diabetes Mellitus: Baseline LDL Profile Determines Specific Mode of Action
Winkler, K., Abletshauser, C., Hoffmann, M. M., Friedrich, I., Baumstark, M. W., Wieland, H., & März, W. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020370 · Cited by 55
Effects of omega-3 fatty acid supplementation and exercise on low-density lipoprotein and high-density lipoprotein subfractions
Thomas, T. R., SMITH, B. K., Donahue, O. M., Altena, T. S., James-Kracke, M., & Sun, G. Y. (2004) · Metabolism · doi:10.1016/j.metabol.2003.12.019 · Cited by 55
Approach to identifying and managing atherogenic dyslipidemia: a metabolic consequence of obesity and diabetes.
Bosomworth, N. J. (2013) · Europe PMC (PubMed Central) · Cited by 54
Low-Density Lipoprotein Particle Size Decreases During Normal Pregnancy in Association With Triglyceride Increases
Hubel, C. A., Shakir, Y., Gallaher, M. J., McLaughlin, M. K., & Roberts, J. M. (1998) · Journal of the Society for Gynecologic Investigation · doi:10.1177/107155769800500504 · Cited by 54
A disparity between conventional lipid and insulin resistance markers at body mass index levels greater than 34 kg/m2
Dixon, J., & O’Brien, P. E. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801624 · Cited by 54
Lipoprotein and apolipoprotein abnormalities in familial combined hyperlipidemia: a 20-year prospective study
McNeely, M. J., Edwards, K. L., Marcovina, S. M., Brunzell, J. D., Motulsky, A. G., & Austin, M. A. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(01)00528-7 · Cited by 54
Evacetrapib alone or in combination with statins lowers lipoprotein(a) and total and small LDL particle concentrations in mildly hypercholesterolemic patients
Nicholls, S. J., Ruotolo, G., Brewer, H. B., Wang, M.-D., Liu, L., Willey, M. B., Deeg, M. A., Krueger, K. A., & Nissen, S. E. (2015) · Journal of clinical lipidology · doi:10.1016/j.jacl.2015.11.014 · Cited by 53
Low-Density Lipoprotein Particle Size Is Inversely Related to Plasminogen Activator Inhibitor-1 Levels
Festa, A., Agostino, R. B. D., Mykkänen, L. M., Tracy, R. P., Howard, B. V., & Haffner, S. M. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.3.605 · Cited by 53
Soy Protein Favorably Affects LDL Size Independently of Isoflavones in Hypercholesterolemic Men and Women
Desroches, S., Mauger, J., Lamarche, B., Ausman, L. M., & Lichtenstein, A. H. (2004) · Journal of Nutrition · doi:10.1093/jn/134.3.574 · Cited by 52
“Also, recent evidence from the large Quebec Cardiovascular Study indicated that an increased proportion of cholesterol within small LDL particles increases the risk of CVD even in the presence of relatively normal LDL-C concentrations (15).”
BackgroundInfluential
A Genomewide Search Using an Original Pairwise Sampling Approach for Large Genealogies Identifies a New Locus for Total and Low-Density Lipoprotein Cholesterol in Two Genetically Differentiated Isolates of Sardinia
Falchi, M., Forabosco, P., Mocci, E., Borlino, C. C., Picciau, A., Virdis, E., Persico, I., Parracciani, D., Angius, A., & Pirastu, M. (2004) · The American Journal of Human Genetics · doi:10.1086/426155 · Cited by 53
“0002-9297/2004/7506-0008$15.00 Breslow 1988; Manninen et al. 1988; Criqui et al. 1993; Gardner et al. 1996; Hokanson and Austin 1996; Stampfer et al. 1996; Murray and Lopez 1997; Lamarche et al. 1998), the leading cause of morbidity and mortality in industrialized countries.”
BackgroundInfluential
Ten-year incidence of diabetic retinopathy and macular edema. Risk factors in a sample of people with type 1 diabetes
Romero‐Aroca, P., Baget‐Bernaldiz, M., Fernandez-Ballart, J. D., Plana, N., Soler-Lluís, N., Méndez-Marín, I., & Bautista-Pérez, Á. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2011.07.004 · Cited by 52
“For example, a preponderance of small LDL-cholesterol has been associated with nephropathy and atherosclerosis [23].”
BackgroundInfluential
Cardiovascular Events With Increased Lipoprotein-Associated Phospholipase A 2 and Low High-Density Lipoprotein-Cholesterol
Robins, S. J., Collins, D. E., Nelson, J. J., Bloomfield, H. E., & Asztalos, B. F. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.160739 · Cited by 52
Current Awareness
Roth, J. (2000) · Diabetes/Metabolism Research and Reviews · doi:10.1002/1520-7560(200007/08)16:4
Insulin Resistance, Impaired Postprandial Lipid Metabolism and Abdominal Obesity
Frayn, K. N. (2002) · Medical Principles and Practice · doi:10.1159/000066414 · Cited by 49
Patient-Level Discordance in Population Percentiles of the Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio in Comparison With Low-Density Lipoprotein Cholesterol and Non–High-Density Lipoprotein Cholesterol
Elshazly, M. B., Quispe, R., Michos, E. D., Sniderman, A. D., Toth, P. P., Banach, M., Kulkarni, K. R., Coresh, J., Blumenthal, R. S., Jones, S. R., et al. (2015) · Circulation · doi:10.1161/circulationaha.115.016163 · Cited by 50
“In another study, the significant difference in LDL size between patients with coronary artery disease and controls became nonsignificant after adjusting for TC/HDL-C.(32) Although more study is needed, this initial evidence indicates that TC/HDL-C may carry information related to particle concentration and size.”
BackgroundInfluential
Lipoproteins and Cardiovascular Disease: An Update on the Clinical Significance of Atherogenic Small, Dense LDL and New Therapeutical Options
Rizvi, A. A., Stoian, A. P., Janež, A., & Rizzo, M. (2021) · Biomedicines · doi:10.3390/biomedicines9111579 · Cited by 51
“Prospective studies of the relation of LDL size with the development of coronary artery disease have been carried out, including the first pioneer nested case-control analysis in the Physician′s Health Study [17], the population-based Stanford Five Cities Project [18], and the Quebec Cardiovascular Study [19].”
Background
Fluvastatin Lowers Atherogenic Dense Low-Density Lipoproteins in Postmenopausal Women With the Atherogenic Lipoprotein Phenotype
März, W., Scharnagl, H., Abletshauser, C., Hoffmann, M. M., Berg, A., Keul, J., Wieland, H., & Baumstark, M. W. (2001) · Circulation · doi:10.1161/01.cir.103.15.1942 · Cited by 50
Small, Dense Low-Density Lipoprotein Particles and Coronary Heart Disease Risk
Coresh, J. (1996) · JAMA · doi:10.1001/jama.1996.03540110068034 · Cited by 49
Did grandma give you heart disease? The new battle against coronary artery disease
Superko, H. R. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00771-1 · Cited by 49
Racial differences in coronary artery calcification are not attributed to differences in lipoprotein particle sizes: The Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) Study
Aiyer, A., Kip, K. E., Marroquin, O. C., Mulukutla, S. R., Edmundowicz, D., & Reís, S. E. (2007) · American Heart Journal · doi:10.1016/j.ahj.2006.11.002 · Cited by 48
Can Measurement of Serum Apolipoprotein B Replace the Lipid Profile Monitoring of Patients with Lipoprotein Disorders?
Miremadi, S., Sniderman, A. D., & Frohlich, J. J. (2002) · Clinical Chemistry · doi:10.1093/clinchem/48.3.484 · Cited by 48
Lipoprotein correlates of LDL particle size
Rainwater, D. L. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00216-6 · Cited by 48
“Prospective studies have reported the small LDL phenotype to be a significant predictor of subsequent CVD [2–4].”
Background
Significance of Small Dense Low-Density Lipoprotein as a Risk Factor for Coronary Artery Disease and Acute Coronary Syndrome
Kwon, S. W., Yoon, S., Kang, T. S., Kwon, H. M., Kim, J., Rhee, J., Lee, S.-J., Park, J., Lim, J. Y., Yoon, Y. W., et al. (2006) · Yonsei Medical Journal · doi:10.3349/ymj.2006.47.3.405 · Cited by 47
α1-Antitrypsin Combines with Plasma Fatty Acids and Induces Angiopoietin-like Protein 4 Expression
Frenzel, E., Wrenger, S., Brügger, B., Salipalli, S., Immenschuh, S., Aggarwal, N., Lichtinghagen, R., Mahadeva, R., Marcondes, A. M., Dinarello, C. A., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500740 · Cited by 47
“Depending on purification methods, therapeutic plasma protein products can contain variable amounts of FAs and lipids (45).”
Background

Authors: Gardner, C. D.
Affiliations: Stanford Medicine (US)
Corresponding author: Gardner, Christopher D.
ORCID: Gardner, Christopher D.
Venue: JAMA: The Journal of the American Medical Association
Publisher: American Medical Association (AMA)
Published: 1996-09-18
Volume: 276
Issue: 11
Pages: 875
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.1996.03540110029028
OpenAlex: W2050758709
Cited by: 843
References: 53
Citations by year: 2026: 3 · 2025: 4 · 2024: 5 · 2023: 10 · 2022: 10 · 2021: 16 · 2020: 23 · 2019: 14 · 2018: 7 · 2017: 16 · 2016: 10 · 2015: 23 · 2014: 14 · 2013: 33 · 2012: 22
FWCI: 37.88
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01hl018574-26, 5r01hl021906-19)
National Heart, Lung, and Blood Institute (T32HL007034, HL21906, HL-18574, 5 T32 HL07034)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: small dense LDL, LDL particle size, coronary artery disease, atherosclerosis, cardiovascular risk factors, TC/HDL-C ratio, HDL cholesterol, non-HDL cholesterol, triglycerides, sex differences
MeSH terms: Adult, Aged, Coronary Disease, Cross-Sectional Studies, Electrophoresis, Polyacrylamide Gel, Female, Humans, Lipids, Lipoproteins, LDL, Male, Middle Aged, Prospective Studies, Risk Factors, Body Mass Index, Incidence, Linear Models, Logistic Models, Case-Control Studies

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Association of Small Low-Density Lipoprotein Particles With the Incidence of Coronary Artery Disease in Men and Women

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