Cholesterol levels in small LDL particles predict the risk of coronary heart disease in the EPIC-Norfolk prospective population study
Abstract
AIMS: To evaluate the association of low-density lipoprotein cholesterol (LDL-C) levels in small and large LDL particles with risk of incident coronary heart disease (CHD). METHODS AND RESULTS: We performed a prospective case-control study nested in the EPIC-Norfolk cohort. Cases were apparently healthy men and women aged 45-79 years who developed fatal or non-fatal CHD (n = 1035), and who were matched by age, gender, and enrollment time to 1920 controls who remained free of CHD. Electrophoretic characteristics of LDL particles were measured using 2-16% polyacrylamide gradient gel electrophoresis. Concentrations of LDL-C(<255 A) were higher in cases than controls in men (1.34 +/- 0.88 vs. 1.15 +/- 0.80 mmol/L, P < 0.001) as well as in women (1.12 +/- 0.84 vs. 0.94 +/- 0.74 mmol/L, P < 0.001). The unadjusted odds ratio (OR) for future CHD in men of the top tertile of LDL-C(<255 A) was 1.68 (95% CI, 1.33-2.13; P < 0.001) whereas in women the unadjusted OR was 1.53 (95% CI, 1.13-2.07; P < 0.001). However, after further adjustments for confounding variables, the association between LDL-C(<255 A) and CHD was no longer significant in men and in women. CONCLUSION: Cholesterol concentrations in different LDL subclasses show different relationships with CHD risk in this European cohort.
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A high small dense LDL level is a risk factor for ASCVD.
“A high small dense LDL level is a risk factor for ASCVD. (Evidence level: E-1a)”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [252]
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Self-citation
- Authors
- Arsenault, B. J., Lemieux, I., Despres, J.-P., Wareham, N. J., Luben, R., Kastelein, J. J. P., Khaw, K.-T., & Boekholdt, S. M.
- Affiliations
- Université Laval (CA)
- MRC Epidemiology Unit (GB)
- University of Cambridge (GB)
- Amsterdam UMC Location University of Amsterdam (NL)
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-10-17
- Volume
- 28
- Issue
- 22
- Pages
- 2770-2777
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W1986470054
- Cited by
- 63
- References
- 53
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 3
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- Sanofi
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- small dense LDL, coronary heart disease risk, LDL particle size, polyacrylamide gradient gel electrophoresis, EPIC-Norfolk cohort, sex differences in cardiovascular risk, confounding adjustment
- MeSH terms
- Aged, Cholesterol, Coronary Disease, Female, Humans, Cholesterol, LDL, Male, Middle Aged, Particle Size, Prospective Studies, Risk Factors, Case-Control Studies, Risk Assessment
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