Cited by 2,582Sepsis Diagnosis and TreatmentIntensive Care Unit Cognitive DisordersDementia and Cognitive Impairment Research

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Long-term cognitive impairment and functional disability among survivors of severe sepsis.

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Iwashyna, Theodore J., Ely, E. Wesley, Smith, Dylan M., Langa, Kenneth M.·2010·JAMA

DOI 10.1001/jama.2010.1553PMC PMC3345288

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Abstract

CONTEXT: Cognitive impairment and functional disability are major determinants of caregiving needs and societal health care costs. Although the incidence of severe sepsis is high and increasing, the magnitude of patients' long-term cognitive and functional limitations after sepsis is unknown. OBJECTIVE: To determine the change in cognitive impairment and physical functioning among patients who survive severe sepsis, controlling for their presepsis functioning. DESIGN, SETTING, AND PATIENTS: A prospective cohort involving 1194 patients with 1520 hospitalizations for severe sepsis drawn from the Health and Retirement Study, a nationally representative survey of US residents (1998-2006). A total of 9223 respondents had a baseline cognitive and functional assessment and had linked Medicare claims; 516 survived severe sepsis and 4517 survived a nonsepsis hospitalization to at least 1 follow-up survey and are included in the analysis. MAIN OUTCOME MEASURES: Personal interviews were conducted with respondents or proxies using validated surveys to assess the presence of cognitive impairment and to determine the number of activities of daily living (ADLs) and instrumental ADLs (IADLs) for which patients needed assistance. RESULTS: Survivors' mean age at hospitalization was 76.9 years. The prevalence of moderate to severe cognitive impairment increased 10.6 percentage points among patients who survived severe sepsis, an odds ratio (OR) of 3.34 (95% confidence interval [CI], 1.53-7.25) in multivariable regression. Likewise, a high rate of new functional limitations was seen following sepsis: in those with no limits before sepsis, a mean 1.57 new limitations (95% CI, 0.99-2.15); and for those with mild to moderate limitations before sepsis, a mean of 1.50 new limitations (95% CI, 0.87-2.12). In contrast, nonsepsis general hospitalizations were associated with no change in moderate to severe cognitive impairment (OR, 1.15; 95% CI, 0.80-1.67; P for difference vs sepsis = .01) and with the development of fewer new limitations (mean among those with no limits before hospitalization, 0.48; 95% CI, 0.39-0.57; P for difference vs sepsis <.001 and mean among those with mild to moderate limits, 0.43; 95% CI, 0.23-0.63; P for difference = .001). The declines in cognitive and physical function persisted for at least 8 years. CONCLUSIONS: Severe sepsis in this older population was independently associated with substantial and persistent new cognitive impairment and functional disability among survivors. The magnitude of these new deficits was large, likely resulting in a pivotal downturn in patients' ability to live independently.

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Show all 56 references

Research works printed but not linked: 1

[27]Banaszak-Holl J Fendrick AM Foster NL Cognitive function and chronic medical conditions as predictors of nursing home admission in a nationally representative sample of older Americans Alzheimer's Disease and Associated Disorders 2004 18 2 83 89 15249852

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Data that drive: Closing the loop in the learning hospital system
Liu, V. X., Morehouse, J. W., Baker, J. M., Greene, J., Kipnis, P., & Escobar, G. J. (2016) · Journal of Hospital Medicine · doi:10.1002/jhm.2651 · Cited by 34
Nonhuman primate species as models of human bacterial sepsis
Chen, L., Welty‐Wolf, K. E., & Kraft, B. D. (2019) · Lab Animal · doi:10.1038/s41684-018-0217-2 · Cited by 33
The needs of patients with post–intensive care syndrome: A prospective, observational study
Heydon, E., Wibrow, B. A., Jacques, A., Sonawane, R., & Anstey, M. (2019) · Australian Critical Care · doi:10.1016/j.aucc.2019.04.002 · Cited by 41
Preoperative Chronic and Acute Pain Affects Postoperative Cognitive Function Mediated by Neurotransmitters
Ding, X., Gao, X., Wang, Z., Jiang, X., Lu, S., Xu, J., Qin, G., Gu, Z., & Huang, D. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01673-x · Cited by 33
Cytotoxic tau released from lung microvascular endothelial cells upon infection with Pseudomonas aeruginosa promotes neuronal tauopathy
Choi, C., Gwin, M. S., Voth, S. B., Kolb, C., Zhou, C., Nelson, A. R., Deweever, A., Koloteva, A., Annamdevula, N. S., Murphy, J. M., et al. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101482 · Cited by 33
Lung function and quality of life in survivors of the acute respiratory distress syndrome (ARDS)
Wilcox, M. E., & Herridge, M. S. (2011) · La Presse Médicale · doi:10.1016/j.lpm.2011.04.024 · Cited by 33
Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis
Zolfaghari, P., Carré, J. E., Parker, N., Curtin, N. A., Duchen, M. R., & Singer, M. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00562.2014 · Cited by 34
Alzheimer’s Disease (AD) Therapeutics—2: Beyond Amyloid—Re-Defining AD and Its Causality to Discover Effective Therapeutics
Mullane, K., & Williams, M. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.09.027 · Cited by 32
Return to work after hospitalization for sepsis: a nationwide, registry-based cohort study
Skei, N. V., Moe, K., Nilsen, T. I. L., Aasdahl, L., Prescott, H. C., Damås, J. K., & Gustad, L. T. (2023) · Critical Care · doi:10.1186/s13054-023-04737-7 · Cited by 31
Mobile Critical Care Recovery Program for Survivors of Acute Respiratory Failure
Khan, B. A., Perkins, A. J., Khan, S., Unverzagt, F. W., Lasiter, S., Gao, S., Wang, S., Zarzaur, B. L., Rahman, O., Eltarras, A. M. A. A., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.53158 · Cited by 37
Targeted rescue of synaptic plasticity improves cognitive decline in sepsis-associated encephalopathy
Grünewald, B., Wickel, J., Hahn, N., Rahmati, V., Rupp, H., Chung, H., Haselmann, H., Strauß, A., Schmidl, L., Hempel, N., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.05.001 · Cited by 32
The role of trained immunity in sepsis
Wang, W., Ma, L., Liu, B., & Ouyang, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1449986 · Cited by 36
Muscle weakness after critical illness: unravelling biological mechanisms and clinical hurdles
Pierre, A., Favory, R., Bourel, C., Howsam, M., Romien, R., Lancel, S., & Préau, S. (2025) · Critical Care · doi:10.1186/s13054-025-05462-z · Cited by 39
Critical Care Evidence—New Directions
Marini, J. J., Vincent, J., & Annane, D. (2015) · JAMA · doi:10.1001/jama.2014.18484 · Cited by 32
Restorative Mechanisms Regulating Protein Balance in Skeletal Muscle During Recovery From Sepsis
Crowell, K. T., Soybel, D. I., & Lang, C. H. (2016) · Shock · doi:10.1097/shk.0000000000000762 · Cited by 32
Management of Sepsis and Septic Shock for the Obstetrician–Gynecologist
Plante, L. A. (2016) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2016.07.010 · Cited by 33
Healthcare trajectories before and after critical illness: population-based insight on diverse patients clusters
Jouan, Y., Grammatico‐Guillon, L., Teixera, N., Hassen‐Khodja, C., Gaborit, C., Salmon-Gandonnière, C., Guillon, A., & Ehrmann, S. (2019) · Annals of Intensive Care · doi:10.1186/s13613-019-0599-3 · Cited by 34
Inhibition of the prostaglandin EP2 receptor prevents long-term cognitive impairment in a model of systemic inflammation
Jiang, C., Caskurlu, A., Ganesh, T., & Dingledine, R. J. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100132 · Cited by 33
Associations between carotid atherosclerotic plaque characteristics determined by magnetic resonance imaging and improvement of cognition in patients undergoing carotid endarterectomy
Huo, R., Liu, Y., Xu, H., Li, J., Xin, R., Xing, Z., Deng, S., Wang, T., Yuan, H., & Zhao, X. (2022) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-21-981 · Cited by 32
Functional dependence following intensive care unit-treated sepsis: three-year follow-up results from the prospective Mid-German Sepsis Cohort (MSC)
Fleischmann-Struzek, C., Born, S., Kesselmeier, M., Ely, E. W., Töpfer, K., Romeike, H., Bauer, M. W., Bercker, S., Bodechtel, U., Fiedler, S., et al. (2024) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2024.101066 · Cited by 34
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Artificial Intelligence in the Management of Infectious Diseases in Older Adults: Diagnostic, Prognostic, and Therapeutic Applications
Pinto, A., Pennisi, F., Odelli, S., Ponti, E. D., Veronese, N., Signorelli, C., Baldo, V., & Gianfredi, V. (2025) · Biomedicines · doi:10.3390/biomedicines13102525 · Cited by 36
A Practical, Global Perspective on Using Administrative Data to Conduct Intensive Care Unit Research.
Garland, A., Gershengorn, H., Marrie, R., Reider, N., & Wilcox, M. E. (2015) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201503-136fr · Cited by 29
Sepsis survivors monitoring and coordination in outpatient health care (SMOOTH): study protocol for a randomized controlled trial
Smooth Study Group, Schmidt, K. F. R., Thiel, P., Mueller, F., Schmücker, K., Worrack, S., Mehlhorn, J., Engel, C., Brenk-Franz, K., Kausche, S., et al. (2014) · Trials · doi:10.1186/1745-6215-15-283 · Cited by 31
Intensivist-reported Facilitators and Barriers to Discussing Post-Discharge Outcomes with Intensive Care Unit Surrogates. A Qualitative Study
Turnbull, A. E., Davis, W. E., Needham, D. M., White, D. B., & Eakin, M. N. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201603-212oc · Cited by 33
Predictive Validity of Sepsis-3 Definitions and Sepsis Outcomes in Critically Ill Patients: A Cohort Study in 49 ICUs in Argentina
Estenssoro, E., Edul, V. S. K., Loudet, C., Osatnik, J., Ríos, F. G., Vázquez, D. N., Pozo, M. O., Lattanzio, B., Pálizas, F., Klein, F., et al. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003208 · Cited by 31
RETRACTED: MicroRNA-30e promotes hepatocyte proliferation and inhibits apoptosis in cecal ligation and puncture-induced sepsis through the JAK/STAT signaling pathway by binding to FOSL2
Ling, L., Zhang, S., Zhi, L.-D., Li, H., Wen, Q.-K., Li, G., & Zhang, W. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.042 · Cited by 31
Retracted
Fish oil–rich lipid emulsion modulates neuroinflammation and prevents long-term cognitive dysfunction after sepsis
Giustina, A. D., Goldim, M. P. D. S., Danielski, L. G., Florentino, D., Garbossa, L., Joaquim, L. D. S., de Oliveira, A. N., Mathias, K., Fileti, M. E., Zarbato, G. F., et al. (2018) · Nutrition · doi:10.1016/j.nut.2018.12.003 · Cited by 31
Association Between Critical Care Admissions and Cognitive Trajectories in Older Adults*
Schulte, P. J., Warner, D. O., Martin, D. P., Deljou, A., Mielke, M. M., Knopman, D. S., Petersen, R. C., Weingarten, T. N., Warner, M. A., Rabinstein, A. A., et al. (2019) · Critical Care Medicine · doi:10.1097/ccm.0000000000003829 · Cited by 33
Glycemic control with insulin attenuates sepsis-associated encephalopathy by inhibiting glial activation via the suppression of the nuclear factor kappa B and mitogen-activated protein kinase signaling pathways in septic rats
Huang, C., Lue, J., Cheng, T.-H., & Tsai, Y. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146822 · Cited by 32
PPARα contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression
Bai, Y., Han, Q., Dong, B., Lin, H., Jiang, Y., Zhang, X., Chen, H., & Yu, Y. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.03.015 · Cited by 31
A multicentre evaluation exploring the impact of an integrated health and social care intervention for the caregivers of ICU survivors
McPeake, J. M., Henderson, P., MacTavish, P., Devine, H., Daniel, M., Lucie, P., Bollan, L., Hogg, L., MacMahon, M., Mulhern, S., et al. (2022) · Critical Care · doi:10.1186/s13054-022-04014-z · Cited by 31
Self-citation
The potential role of nano- and micro-technology in the management of critical illnesses
Sadikot, R. T. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.07.004 · Cited by 31
Incidence, prevalence, and occurrence rate of infection among adults hospitalized after traumatic brain injury: study protocol for a systematic review and meta-analysis
Scott, B. N. V., Roberts, D. J., Robertson, H. L., Kramer, A. H., Laupland, K. B., Ousman, S. S., Kubes, P., & Zygun, D. A. (2013) · Systematic Reviews · doi:10.1186/2046-4053-2-68 · Cited by 32
Systemic inflammation induces a profound long term brain cell injury in rats
Fan, L., Wang, T., Chang, L., Song, Y., Wu, Y., & Ma, D. (2014) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2014-1995 · Cited by 31
Outcomes of Older Adults With Sepsis at Admission to an Intensive Care Unit
Rowe, T. A., Araujo, K. L. B., Ness, P. H. V., Pisani, M. A., & Juthani‐Mehta, M. (2016) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofw010 · Cited by 31
Mild Cognitive Impairment and Risk of Critical Illness*
Teeters, D., Moua, T., Li, G., Kashyap, R., Biehl, M., Kaur, R., Gajic, O., Boeve, B. F., Louis, E. K. S., Petersen, R. C., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001842 · Cited by 32
Hypotension in ICU Patients Receiving Vasopressor Therapy
Yapps, B., Shin, S., Bighamian, R., Thorsen, J. E., Arsenault, C., Quraishi, S. A., Hahn, J., & Reisner, A. T. (2017) · Scientific Reports · doi:10.1038/s41598-017-08137-0 · Cited by 31

Authors: Iwashyna, T. J., Ely, E. W., Smith, D. M., & Langa, K. M.
Affiliations: University of Michigan (US)
Vanderbilt University (US)
Stony Brook University Hospital (US)
ORCID: Iwashyna, Theodore J.
Ely, E. Wesley
Smith, Dylan M.
Langa, Kenneth M.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2010-10-27
Volume: 304
Issue: 16
Pages: 1787
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2010.1553
PMC: PMC3345288
OpenAlex: W2098572294
Cited by: 2,582
References: 56
Citations by year: 2026: 162 · 2025: 172 · 2024: 205 · 2023: 190 · 2022: 212 · 2021: 260 · 2020: 223 · 2019: 200 · 2018: 163 · 2017: 151 · 2016: 140 · 2015: 159 · 2014: 116 · 2013: 110 · 2012: 71
FWCI: 52.52
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs (U01 AG09740)
National Institutes of Health
Michigan Institute for Clinical and Health Research (UL 1RR024986)
Geriatric Research Education and Clinical Center
National Institute on Aging (U01 AG 09740, R01AG030155, K23AG001023, AG027472, R01AG027472, U01AG009740, R01AG027010)
National Heart, Lung, and Blood Institute (K08HL091249)
National Institute of Diabetes and Digestive and Kidney Diseases (P60DK020572, P60 DK 20572)
National Center for Research Resources (UL1RR024986)
NIH Clinical Center
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: severe sepsis, cognitive impairment, functional disability, activities of daily living, instrumental activities of daily living, long-term outcomes, older adults, hospitalization, Health and Retirement Study, Medicare claims data, health care costs
MeSH terms: Activities of Daily Living, Aged, Aged, 80 and over, Cognition Disorders, Female, Persons with Disabilities, Disabled Persons, Health Status, Hospitalization, Humans, Male, Prospective Studies, Severity of Illness Index, United States, Case-Control Studies, Survivors, Sepsis

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Long-term cognitive impairment and functional disability among survivors of severe sepsis.

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