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Long-term cognitive impairment and functional disability among survivors of severe sepsis.
Open accessAbstract
CONTEXT: Cognitive impairment and functional disability are major determinants of caregiving needs and societal health care costs. Although the incidence of severe sepsis is high and increasing, the magnitude of patients' long-term cognitive and functional limitations after sepsis is unknown. OBJECTIVE: To determine the change in cognitive impairment and physical functioning among patients who survive severe sepsis, controlling for their presepsis functioning. DESIGN, SETTING, AND PATIENTS: A prospective cohort involving 1194 patients with 1520 hospitalizations for severe sepsis drawn from the Health and Retirement Study, a nationally representative survey of US residents (1998-2006). A total of 9223 respondents had a baseline cognitive and functional assessment and had linked Medicare claims; 516 survived severe sepsis and 4517 survived a nonsepsis hospitalization to at least 1 follow-up survey and are included in the analysis. MAIN OUTCOME MEASURES: Personal interviews were conducted with respondents or proxies using validated surveys to assess the presence of cognitive impairment and to determine the number of activities of daily living (ADLs) and instrumental ADLs (IADLs) for which patients needed assistance. RESULTS: Survivors' mean age at hospitalization was 76.9 years. The prevalence of moderate to severe cognitive impairment increased 10.6 percentage points among patients who survived severe sepsis, an odds ratio (OR) of 3.34 (95% confidence interval [CI], 1.53-7.25) in multivariable regression. Likewise, a high rate of new functional limitations was seen following sepsis: in those with no limits before sepsis, a mean 1.57 new limitations (95% CI, 0.99-2.15); and for those with mild to moderate limitations before sepsis, a mean of 1.50 new limitations (95% CI, 0.87-2.12). In contrast, nonsepsis general hospitalizations were associated with no change in moderate to severe cognitive impairment (OR, 1.15; 95% CI, 0.80-1.67; P for difference vs sepsis = .01) and with the development of fewer new limitations (mean among those with no limits before hospitalization, 0.48; 95% CI, 0.39-0.57; P for difference vs sepsis <.001 and mean among those with mild to moderate limits, 0.43; 95% CI, 0.23-0.63; P for difference = .001). The declines in cognitive and physical function persisted for at least 8 years. CONCLUSIONS: Severe sepsis in this older population was independently associated with substantial and persistent new cognitive impairment and functional disability among survivors. The magnitude of these new deficits was large, likely resulting in a pivotal downturn in patients' ability to live independently.
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In the citing paper
“Key information from hospitalization is often missing on hospital discharge documentation (615-618).”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [617]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“The early administration of enteral nutrition in patients with sepsis and septic shock has potential physiologic advantages related to the maintenance of gut integrity and prevention of intestinal permeability, dampening of the inflammatory response, and modulation of metabolic responses that may reduce insulin resistance (529,530).”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [529]
Experimental — accuracy not yet measuredIn the citing paper
“Many sepsis survivors experience short and/or long-term sequela such as cognitive and/or physical disability, with ongoing recovery persisting for months to years [620].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [620]
In the citing paper
“Sepsis is associated with newly acquired cognitive impairment and functional disability amongst survivors [620].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [620]
In the citing paper
“Some studies have reported inflammatory challenges as an associated risk factor for the development of dementia-related symptoms, as they show increased pro-inflammatory cytokines levels [147, 148].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [147]
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Citations
Cites
Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data
Quan, H., Sundararajan, V., Halfon, P., Fong, A., Burnand, B., Luthi, J.-C., Saunders, L. D., Beck, C. A., Feasby, T. E., & Ghali, W. A. (2005) · Medical Care · doi:10.1097/01.mlr.0000182534.19832.83 · Cited by 10,669
Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503
The epidemiology of sepsis in the United States from 1979 through 2000
Martin, G. S., Mannino, D. M., Eaton, S., & Moss, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022139 · Cited by 5,841
Fixed Effects Regression Models
Allison, P. (2009) · doi:10.4135/9781412993869 · Cited by 3,999
Schweickert, W. D., Pohlman, M. C., Pohlman, A. S., Nigos, C., Pawlik, A. J., Esbrook, C. L., Spears, L., Miller, M., Franczyk, M., Deprizio, D., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60658-9 · Cited by 3,339
Delirium as a Predictor of Mortality in Mechanically Ventilated Patients in the Intensive Care Unit
Ely, E. W. (2004) · JAMA · doi:10.1001/jama.291.14.1753 · Cited by 3,073
Self-citationOne-Year Outcomes in Survivors of the Acute Respiratory Distress Syndrome
Herridge, M. S., Cheung, A. M., Tansey, C. M., Matte-Martyn, A., Diaz-Granados, N., Al-Saidi, F., Cooper, A. B., Guest, C. B., Mazer, C. D., Mehta, S., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022450 · Cited by 2,334
Prevalence of Dementia in the United States: The Aging, Demographics, and Memory Study
Plassman, B. L., Langa, K. M., Fisher, G. G., Heeringa, S. G., Weir, D. R., Ofstedal, M. B., Burke, J. R., Hurd, M. D., Potter, G. G., Rodgers, W. L., et al. (2007) · Neuroepidemiology · doi:10.1159/000109998 · Cited by 1,932
Self-citationCovinsky, K. E., Palmer, R. M., Fortinsky, R. H., Counsell, S. R., Stewart, A. L., Kresevic, D., Burant, C. J., & Landefeld, C. S. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51152.x · Cited by 1,670
Understanding the treatment preferences of seriously ill patients.
Fried, T., Bradley, E. H., Towle, V., & Allore, H. (2002) · New England Journal of Medicine · doi:10.1056/nejmsa012528 · Cited by 1,426
Research works printed but not linked: 1
- [27]Banaszak-Holl J Fendrick AM Foster NL Cognitive function and chronic medical conditions as predictors of nursing home admission in a nationally representative sample of older Americans Alzheimer's Disease and Associated Disorders 2004 18 2 83 89 15249852
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Aligning use of intensive care with patient values in the USA: past, present, and future
Turnbull, A. E., Bosslet, G. T., & Kross, E. K. (2019) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(19)30087-6 · Cited by 31
Fan, T. H., Premraj, L., Roberts, J. S., Lydston, M., Robba, C., Hager, D. N., Suárez, J. I., Battaglini, D., & Cho, S. (2023) · Critical Care Medicine · doi:10.1097/ccm.0000000000006096 · Cited by 31
Fuentes-Aspe, R., Gutiérrez-Arias, R. E., González-Seguel, F., Marzuca-Nassr, G. N., Torres‐Castro, R., Najum, J., & Pamela Serón, S. (2024) · Journal of Intensive Care · doi:10.1186/s40560-024-00744-0 · Cited by 34
Han, Y., Xie, X., Qiu, J., Tang, Y., Song, Z., Li, W., & Wu, X. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1545979 · Cited by 34
Convergence of sepsis-associated encephalopathy pathogenesis onto microglia
Xiao, D., Wang, X., Liang, W., Yang, Y., Du, Y., Liu, C., Xu, F., Yang, Y., Wei, M., & Yang, G. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06635-8 · Cited by 33
Wang, H. E., Moore, J. X., Donnelly, J. P., Levitan, E. B., & Safford, M. M. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix248 · Cited by 30
Khoury, J., Arow, M., Elias, A., Makhoul, B. F., Berger, G., Kaplan, M., Mashiach, T., Ismael-Badarneh, R., Aronson, D., & Azzam, Z. S. (2017) · Journal of Critical Care · doi:10.1016/j.jcrc.2017.07.009 · Cited by 30
Contou, D., Canouï‐Poitrine, F., Coudroy, R., Préau, S., Cour, M., Barbier, F., Terzi, N., Schnell, G., Galbois, A., Zafrani, L., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy901 · Cited by 30
Fluid Management in Acute Respiratory Distress Syndrome
Casey, J. D., Semler, M. W., & Rice, T. W. (2019) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0039-1685206 · Cited by 31
Xie, X., Li, M.-Z., Yao, E., Gong, S., Xie, J., Gao, W., Xie, Z., Li, Z., Bai, X., Liu, L., et al. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.03.019 · Cited by 32
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Catalão, C. H. R., Santos-Júnior, N. N., da Costa, L. H. A., Souza, A. D. O., Cárnio, E. C., Sebollela, A. S., Alberici, L. C., & Rocha, M. J. A. (2020) · Neurotoxicity Research · doi:10.1007/s12640-020-00222-z · Cited by 32
Apitzsch, S., Larsson, L., Larsson, A., & Linder, A. (2021) · Archives of Public Health · doi:10.1186/s13690-021-00585-5 · Cited by 55
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Pandolfi, F., Guillemot, D., Watier, L., & Brun‐Buisson, C. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-058205 · Cited by 30
Liu, Y., Yu, Y., Liu, J., Liu, W., Cao, Y., Yan, R., & Yao, Y. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.892480 · Cited by 32
Gao, H., Ren, Y., & Liu, C. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/9697887 · Cited by 30
High Mobility Group Box 1 (HMGB1): Potential Target in Sepsis-Associated Encephalopathy
DeWulf, B., Minsart, L., Verdonk, F., Kruys, V., Piagnerelli, M., Maze, M., & Saxena, S. (2023) · Cells · doi:10.3390/cells12071088 · Cited by 30
Gao, R., Tang, Y.-H., Tong, J.-H., Yang, J., Ji, M., & Zhu, S. (2015) · Inflammation · doi:10.1007/s10753-015-0175-4 · Cited by 30
Zuliani, G., Bonetti, F., Magon, S., Prandini, S., Sioulis, F., D’Amato, M., Zampi, E., Gasperini, B., & Cherubini, A. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt021 · Cited by 29
Platelets in infectious disease
Middleton, E. A., & Rondina, M. T. (2016) · Hematology · doi:10.1182/asheducation-2016.1.256 · Cited by 30
On behalf of Atrium Health ACORN Investigators, Kowalkowski, M., Chou, S.-H., McWilliams, A., Lashley, C., Murphy, S., Rossman, W., Papali, A., Heffner, A., Russo, M., et al. (2019) · Trials · doi:10.1186/s13063-019-3792-7 · Cited by 29
Paratz, J. D., Kenardy, J., Mitchell, G., Comans, T., Coyer, F., Thomas, P., Singh, S., Luparia, L., & Boots, R. J. (2014) · BMJ Open · doi:10.1136/bmjopen-2014-004966 · Cited by 29
“Patients with sepsis syndromes have signi fi cantly worse outcomes with lower health-related quality of life (HRQoL), 13 – 16 particularly in the physical domain, 17 18 chronic pain 5 19 and cognitive domain 20 compared with non-septic ICU survivors.”
Park, C., Lei, Z., Li, Y., Ren, B., He, J., Huang, H., Chen, F., Li, H., Brunner, K., Zhu, J., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03250-0 · Cited by 32
Wolters, A. E., Peelen, L. M., Veldhuijzen, D. S., Zaal, I. J., de Lange, D. W., Pasma, W., van Dijk, D., Cremer, O. L., & Slooter, A. J. C. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14660 · Cited by 32
de Queiroz, R. S., Saquetto, M. B., Martinez, B. P., Andrade, E. A., da Silva, P. A. M. P., & Neto, M. G. (2018) · Heart & Lung · doi:10.1016/j.hrtlng.2018.03.003 · Cited by 29
Infection‐induced endothelial amyloids impair memory
Balczon, R., Pittet, J., Wagener, B. M., Moser, S. A., Voth, S. B., Vorhees, C. V., Williams, M. T., Bridges, J. P., Alvarez, D. F., Koloteva, A., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900322r · Cited by 28
Association Between Sepsis and Microvascular Brain Injury*
Ehlenbach, W. J., Sonnen, J. A., Montine, T. J., & Larson, E. B. (2019) · Critical Care Medicine · doi:10.1097/ccm.0000000000003924 · Cited by 31
Turnbull, A. E., Hurley, M. S., Oppenheim, I. M., Hosey, M. M., & Parker, A. M. (2020) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201910-772ip · Cited by 31
Mayer, K. P., Dhar, S., Cassity, E. P., Denham, A., England, J., Morris, P. E., & Dupont‐Versteegden, E. E. (2020) · Physical Therapy · doi:10.1093/ptj/pzaa068 · Cited by 33
Sepsis in the critically ill patient: current and emerging management strategies
Heming, N., Azabou, É., Cazaumayou, X., Moine, P., & Annane, D. (2020) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2021.1846522 · Cited by 32
Lymphatic Flow: A Potential Target in Sepsis-Associated Acute Lung Injury
Wu, C., Li, H., Zhang, P., Tian, C., Luo, J., Zhang, W., Bhandari, S., Jin, S., & Yu, H. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s284090 · Cited by 29
Time course of dementia following sepsis in German health claims data
Fritze, T., Doblhammer, G., Widmann, C. N., & Heneka, M. T. (2020) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000911 · Cited by 29
NOVOCHADLO, M. M., Goldim, M. P. D. S., Bonfante, S., Joaquim, L. D. S., Mathias, K., Metzker, K. L. L., Machado, R. S., Lanzzarin, E., Bernades, G. C., Bagio, É., et al. (2021) · Microvascular Research · doi:10.1016/j.mvr.2021.104193 · Cited by 29
Bottom-Tanzer, S. F., Poyant, J., Louzada, M. T., Ahmed, S. E., Boudouvas, A., Poon, E., Hojman, H. M., Bugaev, N., Johnson, B. P., Kirk, A. L. V., et al. (2021) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000003231 · Cited by 30
Musculoskeletal complications following critical illness: A scoping review
Gustafson, O. D., Williams, M. A., McKechnie, S., Dawes, H., & Rowland, M. J. (2021) · Journal of Critical Care · doi:10.1016/j.jcrc.2021.08.002 · Cited by 29
Limited recovery from post-acute sequelae of SARS-CoV-2 at 8 months in a prospective cohort
Darley, D. R., Dore, G. J., Byrne, A., Plit, M., Brew, B. J., Kelleher, A. D., & Matthews, G. V. T. (2021) · ERJ Open Research · doi:10.1183/23120541.00384-2021 · Cited by 26
Dementia Risk among Coronavirus Disease Survivors: A Nationwide Cohort Study in South Korea
Park, H.-Y., Song, I., & Oh, T.-K. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11101015 · Cited by 31
Hodgson, C. L., Higgins, A. M., Bailey, M., Barrett, J., Bellomo, R., Cooper, D. J., Gabbe, B. J., Iwashyna, T. J., Linke, N. J., Myles, P. S., et al. (2022) · Critical Care · doi:10.1186/s13054-022-04041-w · Cited by 29
Self-citationLong-term recovery after critical illness in older adults
Kaushik, R., & Ferrante, L. E. (2022) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000981 · Cited by 31
Ge, C., Chen, W., Zhang, L., Ai, Y., Zou, Y., & Peng, Q. (2023) · Theranostics · doi:10.7150/thno.82889 · Cited by 29
Measuring and predicting long-term outcomes in older survivors of critical illness.
Baldwin, M. R. (2015) · PubMed · Cited by 29
Davydow, D. S., Levine, D. A., Zivin, K., Katon, W. J., & Langa, K. M. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000136 · Cited by 29
Self-citationHuerta, P. T., Robbiati, S. F., Huerta, T. S., Sabharwal, A., Berlin, R., Frankfurt, M., & Volpe, B. T. (2016) · Molecular Medicine · doi:10.2119/molmed.2015.00201 · Cited by 30
Long-Term Outcomes After Extracorporeal Life Support for Acute Respiratory Failure
McDonald, M. D., Sandsmark, D. K., Palakshappa, J. A., Mikkelsen, M. E., Anderson, B. J., & Gutsche, J. T. (2018) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2018.05.023 · Cited by 29
Qi, B., Song, Y., Chen, C., Zhao, L., Ma, W., Meng, S., Zhuang, X., Lin, H., Liang, J., Cui, Y., et al. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109603 · Cited by 28
Alves, V. S., da Silva, J. P., Rodrigues, F. C., Araújo, S. M. B., Gouvêa, A. L., Leite-Aguiar, R., Santos, S. A. C. S., da Silva, M. S. P., Ferreira, F. S., Marques, E. P., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1179723 · Cited by 29
Sepsis subphenotypes: bridging the gaps in sepsis treatment strategies
Zhang, X., Zhang, W., Zhang, H., & Liao, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1546474 · Cited by 30
S3-Leitlinie Sepsis – Prävention, Diagnose, Therapie und Nachsorge – Update 2025
Brunkhorst, F. M., Adamzik, M., Axer, H., Bauer, M. W., Bode, C., Bone, H.-G., Brenner, T., Bucher, M., David, S., Dietrich, M., et al. (2025) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-025-01317-1 · Cited by 35
Quality of Life of Severe Sepsis Survivors After Hospital Discharge
Contrin, L. M., Paschoal, V. D., Beccária, L. M., Cesarino, C. B., & Lobo, S. M. (2013) · Revista Latino-Americana de Enfermagem · doi:10.1590/s0104-11692013000300020 · Cited by 28
Wang, H., Li, Z., Yin, M., Chen, X., Ding, S., Li, C., Zhai, Q., Li, Y., Liu, H., & Wu, D. (2014) · Journal of Critical Care · doi:10.1016/j.jcrc.2014.11.013 · Cited by 28
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Zang, Q. S. (2014) · Aging and Disease · doi:10.14336/ad.2014.0500137 · Cited by 28
César, C. C., Mambrini, J. V. D. M., Ferreira, F. R., & Lima‐Costa, M. F. (2015) · Cadernos de Saúde Pública · doi:10.1590/0102-311x00093214 · Cited by 28
The additive effect of aging on sepsis-induced cognitive impairment and neuroinflammation
Olivieri, R., Michels, M., Pescador, B., Ávila, P. R. M., Abatti, M. R., Cucker, L., Burger, H., Dominguini, D., Quevedo, J., & Dal‐Pizzol, F. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.11.014 · Cited by 29
Kawakami, M., Hattori, M., Ohashi, W., Fujimori, T., Hattori, K., Takebe, M., Tomita, K., Yokoo, H., Matsuda, N., Yamazaki, M., et al. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14329 · Cited by 28
Chen, G., Gao, Y., Jiang, Y., Yang, F., Li, S., Tan, D., & Ma, Q. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00743 · Cited by 28
Kim, J., Arnaout, L., & Remick, D. G. (2019) · Shock · doi:10.1097/shk.0000000000001385 · Cited by 28
The Role of Adipokines as Circulating Biomarkers in Critical Illness and Sepsis
Loosen, S. H., Koch, A. H., Tacke, F., Roderburg, C., & Luedde, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194820 · Cited by 27
Xu, R., Shao, Z., & Cao, Q. (2021) · Immunology Letters · doi:10.1016/j.imlet.2020.12.015 · Cited by 28
Peach, B. C., Valenti, M., & Sole, M. L. (2021) · World Medical & Health Policy · doi:10.1002/wmh3.401 · Cited by 28
Postmortem Evidence of Brain Inflammatory Markers and Injury in Septic Patients: A Systematic Review
Barichello, T., Generoso, J. S., Dominguini, D., Córneo, E. D. S., Giridharan, V. V., Sahrapour, T. A., Simões, L. R., da Rosa, M. I., Petronilho, F. C., Ritter, C., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005307 · Cited by 30
AMP deamination is sufficient to replicate an atrophy-like metabolic phenotype in skeletal muscle
Miller, S. G., Hafen, P. S., Law, A. S., Springer, C. B., Logsdon, D. L., O’Connell, T. M., Witczak, C. A., & Brault, J. J. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154864 · Cited by 31
Optimal timing of introducing mobilization therapy for ICU patients with sepsis
Liu, K., Shibata, J., Fukuchi, K., Takahashi, K., Sonoo, T., Ogura, T., & Goto, T. (2022) · Journal of Intensive Care · doi:10.1186/s40560-022-00613-8 · Cited by 28
Duindam, H. B., Kessels, R. P. C., van den Borst, B., Pickkers, P., & Abdo, W. F. (2022) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100513 · Cited by 31
Sepsis and the brain: a review for acute and general physicians
Carter, B. L., & Underwood, J. (2022) · Clinical Medicine · doi:10.7861/clinmed.2022-0346 · Cited by 28
Autoantibodies are highly prevalent in non–SARS-CoV-2 respiratory infections and critical illness
Feng, A., Yang, E., Moore, A. R., Dhingra, S., Chang, S. E., Yin, X., Pi, R., Mack, E., Völkel, S., Gessner, R. V., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.163150 · Cited by 38
Late brain alterations in sepsis‐survivor rats
Steckert, A. V., Comim, C. M., Mina, F., Mendonça, B. P., Dominguini, D., Ferreira, G. K., Carvalho‐Silva, M., Vieira, J. S., STRECK, E. L., Quevedo, J., et al. (2013) · Synapse · doi:10.1002/syn.21686 · Cited by 28
Biomarcadores na encefalopatia séptica: revisão sistemática dos estudos clínicos
Zenaide, P., & Gusmao-Flores, D. (2013) · Revista Brasileira de Terapia Intensiva · doi:10.1590/s0103-507x2013000100011 · Cited by 28
Eccentric Exercise and the Critically Ill Patient
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McDaniel, M., Keller, J. M., White, S., & Baird, A. J. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01321 · Cited by 28
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Denver, P., & Cunningham, C. M. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110285 · Cited by 33
Ouellette, D. R., Moscoso, E. E., Corrales, J. P., & Peters, M. A. (2015) · Annals of Intensive Care · doi:10.1186/s13613-015-0049-9 · Cited by 27
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Long, D., Capan, M., Mascioli, S., Weldon, D. L. M., Arnold, R. C., & Miller, K. (2018) · Critical Care Nurse · doi:10.4037/ccn2018352 · Cited by 26
Loots, F. J., Smits, M., van Steensel, C., Giesen, P. H. J., Hopstaken, R., & van Zanten, A. R. H. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-022832 · Cited by 27
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Baysan, M., Baroni, G. D., van Boekel, A. M., Steyerberg, E. W., Arbous, M. S., & van der Bom, J. G. (2020) · Critical Care Explorations · doi:10.1097/cce.0000000000000087 · Cited by 28
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Ge, C., Chen, W., Zhang, L., Ai, Y., Zou, Y., & Peng, Q. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14013 · Cited by 28
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Götz, T., Günther, A., Witte, O. W., Brunkhorst, F. M., Seidel, G., & Hamzei, F. (2014) · BMC Neurology · doi:10.1186/1471-2377-14-145 · Cited by 27
Ramsay, P., Salisbury, L., Merriweather, J. L., Huby, G. Ø., Rattray, J. E., Hull, A. M., Brett, S. J., MacKenzie, S. J., Murray, G. D., Forbes, J., et al. (2014) · Trials · doi:10.1186/1745-6215-15-38 · Cited by 28
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Tian, J., Tai, Y., Shi, M., Zhao, C., Xu, W., Ge, X., & Zhu, G. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00750-z · Cited by 27
Dong, H., Dai, X., Zhou, Y., Shi, C., Bhuiyan, P., Sun, Z., Li, N., & Jin, W. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03028-4 · Cited by 27
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Chalitsios, C. V., Baskaran, V., Harwood, R., Lim, W. S., & McKeever, T. M. (2022) · ERJ Open Research · doi:10.1183/23120541.00328-2022 · Cited by 26
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Schembari, G., Santonocito, C., Messina, S., Caruso, A., Cardia, L., Rubulotta, F. M., Noto, A., Bignami, E. G., & Sanfilippo, F. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13195881 · Cited by 40
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Rubenfeld, G. D. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201408-1574cp · Cited by 26
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Sidhu, N., Joffe, A. R., Doughty, P., Vatanpour, S., Dinu, I. A., Alton, G. Y., Acton, B. V., Robertson, C. M. T., & Program, F. T. W. C. C. P. T. F. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.001954 · Cited by 27
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Hughes, C. G., & Pandharipande, P. P. (2011) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318215366d · Cited by 26
Zhang, J., Ma, Y., Wei, X.-Y., Liu, K.-Y., Wang, H., Han, H., Cui, Y., Zhang, M., & Qin, W. (2019) · Mediators of Inflammation · doi:10.1155/2019/3013716 · Cited by 26
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Thurston, L. M., Milnes, S. L., Hodgson, C. L., Berkovic, D. E., Ayton, D., Iwashyna, T. J., & Orford, N. R. (2020) · Journal of Critical Care · doi:10.1016/j.jcrc.2020.01.028 · Cited by 28
Self-citationMcPeake, J. M., Iwashyna, T. J., Henderson, P., Leyland, A. H., Mackay, D., Quasim, T., Walters, J., Harhay, M. O., & Shaw, M. (2021) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2021.100121 · Cited by 26
Self-citation
Metadata
- Authors
- Iwashyna, T. J., Ely, E. W., Smith, D. M., & Langa, K. M.
- Affiliations
- University of Michigan (US)
- Vanderbilt University (US)
- Stony Brook University Hospital (US)
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2010-10-27
- Volume
- 304
- Issue
- 16
- Pages
- 1787
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC3345288
- OpenAlex
- W2098572294
- Cited by
- 2,582
- References
- 56
- Citations by year
- 2026: 162 · 2025: 172 · 2024: 205 · 2023: 190 · 2022: 212 · 2021: 260 · 2020: 223 · 2019: 200 · 2018: 163 · 2017: 151 · 2016: 140 · 2015: 159 · 2014: 116 · 2013: 110 · 2012: 71
- FWCI
- 52.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (U01 AG09740)
- National Institutes of Health
- Michigan Institute for Clinical and Health Research (UL 1RR024986)
- Geriatric Research Education and Clinical Center
- National Institute on Aging (U01 AG 09740, R01AG030155, K23AG001023, AG027472, R01AG027472, U01AG009740, R01AG027010)
- National Heart, Lung, and Blood Institute (K08HL091249)
- National Institute of Diabetes and Digestive and Kidney Diseases (P60DK020572, P60 DK 20572)
- National Center for Research Resources (UL1RR024986)
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- severe sepsis, cognitive impairment, functional disability, activities of daily living, instrumental activities of daily living, long-term outcomes, older adults, hospitalization, Health and Retirement Study, Medicare claims data, health care costs
- MeSH terms
- Activities of Daily Living, Aged, Aged, 80 and over, Cognition Disorders, Female, Persons with Disabilities, Disabled Persons, Health Status, Hospitalization, Humans, Male, Prospective Studies, Severity of Illness Index, United States, Case-Control Studies, Survivors, Sepsis
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