The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index; none of the 19 sources its claims cite is checked for support yet.
Telomere Length and Risk of Incident Cancer and Cancer Mortality
Open accessAbstract
CONTEXT: Telomeres are essential to preserve the integrity of the genome. Critically short telomeres lead to replicative cell senescence and chromosomal instability and may thereby increase cancer risk. OBJECTIVE: To determine the association between baseline telomere length and incident cancer and cancer mortality. DESIGN, SETTING, AND PARTICIPANTS: Leukocyte telomere length was measured by quantitative polymerase chain reaction in 787 participants free of cancer at baseline in 1995 from the prospective, population-based Bruneck Study in Italy. MAIN OUTCOME MEASURES: Incident cancer and cancer mortality over a follow-up period of 10 years (1995-2005 with a follow-up rate of 100%). RESULTS: A total of 92 of 787 participants (11.7%) developed cancer (incidence rate, 13.3 per 1000 person-years). Short telomere length at baseline was associated with incident cancer independently of standard cancer risk factors (multivariable hazard ratio [HR] per 1-SD decrease in log(e)-transformed telomere length, 1.60; 95% confidence interval [CI], 1.30-1.98; P < .001). Compared with participants in the longest telomere length group, the multivariable HR for incident cancer was 2.15 (95% CI, 1.12-4.14) in the middle length group and 3.11 (95% CI, 1.65-5.84) in the shortest length group (P < .001). Incidence rates were 5.1 (95% CI, 2.9-8.7) per 1000 person-years in the longest telomere length group, 14.2 (95% CI, 10.0-20.1) per 1000 person-years in the middle length group, and 22.5 (95% CI, 16.9-29.9) per 1000 person-years in the shortest length group. The association equally applied to men and women and emerged as robust under a variety of circumstances. Furthermore, short telomere length was associated with cancer mortality (multivariable HR per 1-SD decrease in log(e)-transformed telomere length, 2.13; 95% CI, 1.58-2.86; P < .001) and individual cancer subtypes with a high fatality rate. CONCLUSION: In this study population, there was a statistically significant inverse relationship between telomere length and both cancer incidence and mortality.
Overview
AI snapshot
Written from the paper’s full text.
TL;DR
In the prospective, population-based Bruneck Study, shorter baseline leukocyte telomere length was associated with higher incident cancer and cancer mortality over 10 years. The association was independent of standard cancer risk factors and appeared stronger for fatal cancers.
Key findings
- Among 787 cancer-free participants at baseline, 92 (11.7%) developed cancer over 10 years (incidence rate, 13.3 per 1000 person-years); 44 cancer deaths occurred (mortality rate, 6.2 per 1000 person-years).
- Each 1-SD decrease in log e-transformed telomere length was associated with incident cancer (multivariable HR, 1.60; 95% CI, 1.30-1.98; P<.001) and cancer mortality (multivariable HR, 2.13; 95% CI, 1.58-2.86; P<.001).
- Compared with the longest telomere length tertile, incident cancer HRs were 2.15 (95% CI, 1.12-4.14) in the middle tertile and 3.11 (95% CI, 1.65-5.84) in the shortest tertile; cancer mortality HRs were 5.63 (95% CI, 1.27-24.98) and 11.11 (95% CI, 2.61-47.36), respectively.
- Incidence rates were 5.1, 14.2, and 22.5 per 1000 person-years across longest, middle, and shortest telomere tertiles; cancer mortality rates were 0.8, 6.0, and 12.9 per 1000 person-years, respectively.
Methods
- Prospective, population-based cohort: the Bruneck Study in Italy; 787 participants free of cancer at the 1995 baseline, followed for 10 years (1995-2005) with 100% follow-up.
- Leukocyte telomere length was measured by quantitative polymerase chain reaction and expressed as relative T/S ratio; analyses used log e-transformed T/S ratios and tertile groups.
- Cox proportional hazard models estimated associations with incident cancer and cancer mortality, adjusted for age, sex, social class, smoking, alcohol, diabetes, physical activity, BMI, high-sensitivity C-reactive protein, vitamin D, LDL cholesterol, and in a second model interleukin 6 and chronic infection.
Limitations
- The paper states the study population was entirely white, so findings cannot necessarily be extrapolated to other races and ethnicities.
- The paper states the number of cases was limited to 92 incident cancers and 44 cancer deaths, and the sample was too small to precisely assess associations for each specific cancer type.
- The paper states telomere length was measured in circulating blood leukocytes rather than distinct tissues, and fatal/nonfatal tumor classification was based on data through 2005 and subject to further refinement; the observational design also cannot by itself establish causality.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
0 of 19 cited sources checked · 0 supported · 0 flagged
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Furthermore, short telomere length was associated with cancer mortality (multivariable HR per 1-SD decrease in log e -transformed telomere length, 2.13; 95% CI, 1.58-2.86;PϽ.001)”
- Also stated in: § RESULTS · plain
“An association was seen between baseline telomere length and cancer mortality (multivariable HR per 1-SD decrease in log e -transformed telomere length, 2.13 [95% CI, 1.58-2.86];P Ͻ .001)”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > Abstract
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Also stated in: § RESULTS · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Compared with participants with the longest telomere lengths, the multivariable HR for cancer mortality was 5.63 (95% CI, 1.27-24.98) in the middle length group and 11.11 (95% CI, 2.61-47.36) in the shortest length group (PϽ.001).”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > RESULTS
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Compared with participants in the longest telomere length group, the multivariable HR for incident cancer was 2.15 (95% CI, 1.12-4.14) in the middle length group and 3.11 (95% CI, 1.65-5.84) in the shortest length group (PϽ.001).”
- Also stated in: § RESULTS · plain
“Compared with participants in the longest telomere length group, the multivariable HR for incident cancer was 2.15 (95% CI, 1.12-4.14) in the middle length group and 3.11 (95% CI, 1.65-5.84) in the shortest length group (P Ͻ.001).”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > Abstract
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Also stated in: § RESULTS · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“that surpassed the associations obtained for cardiovascular mortality (HR, 1.41 [95% CI, 1.01-1.96];P = .05)and mortality from other causes (HR, 1.57 [95% CI, 1.17-2.10];P = .003).”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > RESULTS
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Compared with participants with the longest telomere lengths, the multivariable HR for cancer mortality was 5.63 (95% CI, 1.27-24.98) in the middle length group and 11.11 (95% CI, 2.61-47.36) in the shortest length group (PϽ.001).”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > RESULTS
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Short telomere length at baseline was associated with incident cancer independently of standard cancer risk factors (multivariable hazard ratio [HR] per 1-SD decrease in log e -transformed telomere length, 1.60; 95% confidence interval [CI], 1.30-1.98;PϽ.001).”
- Also stated in: § RESULTS · plain
“The HR per 1-SD decrease in log etransformed telomere length for incident cancer was 1.60 (95% CI, 1.30-1.98;multivariable model, P Ͻ .001)”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > Abstract
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Also stated in: § RESULTS · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“that surpassed the associations obtained for cardiovascular mortality (HR, 1.41 [95% CI, 1.01-1.96];P = .05)and mortality from other causes (HR, 1.57 [95% CI, 1.17-2.10];P = .003).”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > RESULTS
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Incidence rates were 5.1 per 1000 person-years in the longest telomere length group, 14.2 per 1000 person-years in the middle length group, and 22.5 per 1000 personyears in shortest length group.”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > RESULTS
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Of note, telomere length was preferentially associated with individual cancers characterized by a high fatality rate such as gastric, lung, and ovarian cancer, but less so with tumors linked to better prognosis (see eFigure 4 at http://www .jama.com).”
- Also stated in: § COMMENT · hedged
“There was evidence of heterogeneous effects according to cancer type, whereby (1) tumors with a high fatality rate tended to exhibit more prominent relationships with telomere length (see eFigure 4 at http://www.jama.com)and ( 2) tumors with a more favorable prognosis showed modest or no associations.”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > RESULTS
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Also stated in: § COMMENT · hedged
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Baseline telomere length was substantially shorter in participants with incident cancer (mean telomere length, 1.12; 95% CI, 1.01-1.23)than in those who remained free of cancer (mean telomere length, 1.53 [95% CI, 1.47-1.59];P Ͻ .001).”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > RESULTS
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes
- It may state two separate claims as one. 15
- The quote only partly states this claim. 1
- Probably not a substantial claim. 9
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“A total of 92 of 787 participants (11.7%) developed cancer (incidence rate, 13.3 per 1000 person-years).”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > Abstract
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one. The quote only partly states this claim.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“in 44 of whom it was fatal (mortality rate, 6.2 per 1000 person-years; 95% CI, 4.6-8.3).”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > RESULTS
Strength:plain· not yet calibratedn = 92Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In absolute terms 2, 14, and 28 of individuals in the longest, middle, and short-est telomere length groups, respectively, died of cancer, corresponding to mortality rates of 0.8, 6.0, and 12.9 per 1000 person-years, respectively.”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > RESULTS
Strength:plain· not yet calibratedn = 28Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Furthermore, an analysis revealed telomere length to have a similar predictive value for cancer in both men and women and in various age groups (FIGURE 3).”
- Also stated in: § Abstract · boosted
“The association equally applied to men and women and emerged as robust under a variety of circumstances.”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > RESULTS
Strength:boosted· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Abstract · boosted
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the overall number of cases is limited to 92 and 44, respectively”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > COMMENT
Strength:plain· not yet calibratedn = 92Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Sensitivity analyses excluding participants with prior cancer or extending the list of covariates yielded similar results (Figure 1).”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > RESULTS
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“ConclusionIn this study population, there was a statistically significant inverse relationship between telomere length and both cancer incidence and mortality.”
- Also stated in: § COMMENT · boosted
“We demonstrated significant inverse correlations between baseline leukocyte telomerelengthandbothcancerincidenceand mortality,whichemergedasindependent of standard cancer risk factors (Figure 1).”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > Abstract
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Also stated in: § COMMENT · boosted
None of the sources cited for this claim have been checked yet.
In the paper
“In fibroblast cultures, accruing senescent cells were shown to produce and release high amounts of growth factors, 27 causing an overwhelming proliferation of the surrounding tissue, and to secrete metalloproteinase, diminishing intercellular adhesions and potentially favoring metastatic spread of tumors.28”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > COMMENT
What the sources say
- Not checked yetcites [27]
- Not checked yetcites [28]
Strength:hedged· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“Current evidence mainly derives from case-control studies and is inconsistent for various specific types of cancer.[7][8][9][10][11][12][13][14][15]”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > ELOMERES ARE NUCLEOPROTEIN
What the sources say
- Not checked yetcites [7][8][9][10][11][12][13][14][15]
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Inamousemodel,deficiencyofthetelom-eraseRNAcomponent(theRNAtemplate fortelomereprolongation)causedamarkedlyenhancedfrequencyofchromosomal abnormalities and sporadic cancer, 2 particularly in the case of simultaneous inactivation of the tumor suppressor gene p53. 1”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > COMMENT
What the sources say
- Not checked yetcites [2]
- Not checked yetcites [1]
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Dyskeratosis congenita, a rare disorder of telomere maintenance, was associated with visceral malignancies and squamous cell carcinoma of the skin. 32”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > COMMENT
What the sources say
- Not checked yetcites [32]
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Moreover, a significantly higher productionofvascularendothelialgrowthfactor in senescent cells 29,30 may stimulate tumorgrowthanddisseminationbypromoting neovascularization.”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > COMMENT
What the sources say
- Not checked yetcites [29]
- Not checked yetcites [30]
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“there are several lines of evidence from experimental animals, basic research, genome-wide association studies, and rare disorders of telomere maintenance [1][2][3][4][5] suggesting that short telomeres and concurrent chromosomal instability contribute to malignant cell transformation.3,6”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > ELOMERES ARE NUCLEOPROTEIN
What the sources say
- Not checked yetcites [1][2][3][4][5]
- Not checked yetcites [3]
- Not checked yetcites [6]
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In conclusion, our study shows that short telomeres are associated with an enhanced risk of cancer and fatal cancer in particular.”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > COMMENT
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Complete follow-up data on clinical end points occurring between 1995 and 2005 were available for the remaining 787 participants.”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > METHODS
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
In the paper
“Rafnar et al 5 demonstrated that polymorphisms in the gene encoding TERT, the catalytic subunit of telomerase, were associated with an increased risk for cancer of the lung, urinary bladder, prostate, and cervix.”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > COMMENT
What the sources say
- Not checked yetcites Rafnar et al 5
Strength:boosted· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Population characteristics are comparable with those of other Western communities, but transferability of our findings to geographical regions with a prominently distinct genetic background remains to be established.”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > COMMENT
Strength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Our results corroborate well with previous evaluations demonstrating a link between short telomere length and bladder cancer, 7,8,22 renal cell carcinoma, 8,9 non-Hodgkin lymphoma, 10 lung cancer, 11 and head and neck tumors, 8 but failed to obtain significant correlations between short telomere length and colorectal and breast cancer.[12][13][14]23”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > COMMENT
What the sources say
- Not checked yetcites [7]
- Not checked yetcites [8]
- Not checked yetcites [22]
- Not checked yetcites [9]
- Not checked yetcites [10]
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“As shown previously, 21 telomere length measurement by quantitative PCR was highly reproducible and correlated with Southern Blot-based mean telomere length restriction fragments.”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > METHODS
What the sources say
- Not checked yetcites [21]
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Telomere length measurement was performed in quadruplicate, showed a high level of reproducibility, and was corrected for quantitative PCR efficiency.”
§ Telomere Length and Risk of Incident Cancer and Cancer Mortality > COMMENT
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
The authors state this as an assumption.
This is the first prospective, population-based study to estimate the impact of telomere length on overall cancer manifestation and mortality.
“Toourknowledge,thisisthefirstprospective, population-based study to estimate the impact of telomere length on overall cancer manifestation and mortality.”
The paper relies on this without support.
There is a considerable paucity of data regarding cancer mortality.
“Moreover, there is a considerable paucity of data regarding cancer mortality.”
The paper relies on this without support.
Few evaluations have been prospective in design and measured telomere length well in advance of cancer manifestation; all studies to date were conducted in selected patient groups or healthy volunteers recruited among health professionals.
“Few evaluations have been prospective in design and have measured telomere length well in advance of cancer manifestation; all of the studies, to date, were conducted in selected patient groups or healthy volunteers re-cruited among health professionals.”
The paper relies on this without support.
A variety of experimental and genetic studies support the hypothesis that telomere attrition contributes to the manifestation and dissemination of malignancies.
“A variety of experimental and genetic studies support the hypothesis that telomere attrition contributes to the manifestation and dissemination of malignancies.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In several studies, not only did baseline LTL correlate with medical illnesses cross-sectionally but predicted the subsequent development of cancers, CVD, diabetes or mortality (Cawthon et al., 2003; Willeit et al 2010; Zhao et al., 2014).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Willeit et al 2010
In the citing paper
“Short telomeres have been linked to numerous diseases of aging and in many but not all cases, to all-cause and disease-specific mortality (12–17).”
From Determinants of telomere attrition over 1 year in healthy older women: stress and health behaviors matter (2015) · cites this paper as [14]
Citations
Cites
Telomere measurement by quantitative PCR
Cawthon, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e47 · Cited by 3,538
Krtolica, A., Parrinello, S., Lockett, S., Desprez, P.-Y., & Campisi, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211053698 · Cited by 1,730
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
Rudolph, K. L., Chang, S., Lee, H.-W., Blasco, M., Gottlieb, G. J., Greider, C., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80580-2 · Cited by 1,349
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
Artandi, S. E., Chang, S., Lee, S.-L., Alson, S., Gottlieb, G. J., Chin, L., & DePinho, R. A. (2000) · Nature · doi:10.1038/35020592 · Cited by 1,085
Toll-like Receptor 4 Polymorphisms and Atherogenesis
Kiechl, S. J., Lorenz, E., Reindl, M., Wiedermann, C. J., Oberhollenzer, F., Bonora, E., Willeit, J., & Schwartz, D. A. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012673 · Cited by 1,022
Self-citationCalado, R. T., & Young, N. S. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0903373 · Cited by 814
Telomerase activity in normal and malignant hematopoietic cells.
Broccoli, D., Young, J. W., & de Lange, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9082 · Cited by 754
Brouilette, S., Moore, J. S., McMahon, A. D., Thompson, J. R., Ford, I., Shepherd, J., Packard, C. J., & Samani, N. J. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60071-3 · Cited by 747
Sequence variants at the TERT-CLPTM1L locus associate with many cancer types
Rafnar, Þ., Sulem, P., Stacey, S., Geller, F., Guðmundsson, J., Sigurðsson, Á., Jakobsdottir, M., Helgadottir, H. T., Thorlacius, S., Aben, K. K. H., et al. (2009) · Nature Genetics · doi:10.1038/ng.296 · Cited by 609
Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence
Coppé, J.-P., Kauser, K., Campisi, J., & Beauséjour, C. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603307200 · Cited by 604
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 478
Ye, S., Shaffer, J. A., Kang, M. S., Harlapur, M., Muntner, P., Epel, E. S., Guernsey, D. L., Schwartz, J. E., Davidson, K. W., Kirkland, S., et al. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.12.017 · Cited by 33
Gao, X., Zhang, Y., Mons, U., & Brenner, H. (2018) · Epigenetics · doi:10.1080/15592294.2018.1514853 · Cited by 34
Telomere length as a risk factor for hereditary prostate cancer
Hurwitz, L. M., Heaphy, C. M., Joshu, C. E., Isaacs, W. B., Konishi, Y., Marzo, A. M. D., Isaacs, S. D., Wiley, K. E., Platz, E. A., & Meeker, A. K. (2013) · The Prostate · doi:10.1002/pros.22755 · Cited by 33
Delgado, D. A., Zhang, C., Gleason, K. J., Demanelis, K., Chen, L., Gao, J., Roy, S., Shinkle, J., Sabarinathan, M., Argos, M., et al. (2018) · Human Genetics · doi:10.1007/s00439-018-1964-2 · Cited by 32
Frailty Index as a clinical measure of biological age in psychiatry
Bersani, F. S., Canevelli, M., Cesari, M., Maggioni, E., Pasquini, M., Wolkowitz, O. M., Ferracuti, S., Biondi, M., & Bruno, G. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.03.015 · Cited by 33
Use of Telomere Length as a Biomarker for Aging and Age-Related Disease
Fossel, M. (2012) · Current Translational Geriatrics and Experimental Gerontology Reports · doi:10.1007/s13670-012-0013-6 · Cited by 33
Jung, S. W., Park, N. H., Shin, J. W., Park, B. R., Kim, C. J., Lee, J.-E., Shin, E., Kim, J., & Chung, Y. (2013) · Hepatology · doi:10.1002/hep.26655 · Cited by 31
Raschenberger, J., Kollerits, B., Hammerer‐Lercher, A., Rantner, B., Stadler, M., Haun, M., Klein-Weigel, P. F., Fraedrich, G., & Kronenberg, F. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.05.027 · Cited by 31
Self-citationTelomere length and risk of glioma
Walcott, F. L., Rajaraman, P., Gadalla, S. M., Inskip, P. D., Purdue, M. P., Albanes, D., Orr, E. H., Vivo, I. D., & Savage, S. A. (2013) · Cancer Epidemiology · doi:10.1016/j.canep.2013.10.002 · Cited by 30
Ning, X., Zhang, N., Li, T., Wu, P., Wang, X., Li, X., Peng, S., Wang, J., Chen, J.-C., & Gong, K. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0024 · Cited by 30
The acceleration of ageing in older patients with cancer
Muhandiramge, J., Orchard, S. G., Haydon, A. M., & Zalcberg, J. R. (2020) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2020.09.010 · Cited by 31
Needham, B. L., Roux, A. V. D., Bird, C. E., Bradley, R. D., Fitzpatrick, A. L., Jacobs, D. R., Ouyang, P., Seeman, T. E., Thurston, R. C., Vaidya, D. M., et al. (2014) · Biodemography and Social Biology · doi:10.1080/19485565.2014.947471 · Cited by 30
Soluble CD163 Is Associated With Shortened Telomere Length in HIV-Infected Patients
Srinivasa, S., Fitch, K. V., Petrow, E., Burdo, T. H., Williams, K. C., Lo, J., Côté, H. C. F., & Grinspoon, S. K. (2014) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000329 · Cited by 30
Bone marrow failure and the new telomere diseases: practice and research
Young, N. S. (2012) · Hematology · doi:10.1179/102453312x13336169155132 · Cited by 30
The Long and Short of Telomeres and Cancer Association Studies
Savage, S. A., Gadalla, S. M., & Chanock, S. J. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt041 · Cited by 30
TERT Polymorphism rs2853669 Influences on Lung Cancer Risk in the Korean Population
Yoo, S. S., Do, S. K., Choi, J. E., Lee, S. Y., Lee, J., Ick, S., Kim, C. H., & Park, J. Y. (2015) · Journal of Korean Medical Science · doi:10.3346/jkms.2015.30.10.1423 · Cited by 29
Xu, X., Qu, K., Pang, Q., Wang, Z., Zhou, Y., & Liu, C. (2016) · Frontiers of Medicine · doi:10.1007/s11684-016-0450-2 · Cited by 29
Woody, A., Hamilton, K. R., Livitz, I. E., Figueroa, W. S., & Zoccola, P. M. (2017) · Stress · doi:10.1080/10253890.2017.1328494 · Cited by 29
Alpha- and Gamma-Tocopherol and Telomere Length in 5768 US Men and Women: A NHANES Study
Tucker, L. A. (2017) · Nutrients · doi:10.3390/nu9060601 · Cited by 29
Leukocyte telomere length and diet in the apparently healthy, middle-aged Asklepios population
Meyer, T. D., Bekaert, S., Buyzere, M. D., Bacquer, D. D., Langlois, M. R., Shivappa, N., Hébert, J. R., Gillebert, T. C., Rietzschel, E. R., & Huybrechts, I. (2018) · Scientific Reports · doi:10.1038/s41598-018-24649-9 · Cited by 29
Protsenko, E., Rehkopf, D. H., Prather, A. A., Epel, E. S., & Lin, J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0240185 · Cited by 29
The TERT rs2736100 polymorphism increases cancer risk: A meta-analysis
Li, H., Xu, Y., Mei, H., Liang, P., Li, X., & Tang, J. (2017) · Oncotarget · doi:10.18632/oncotarget.16309 · Cited by 29
Lu, L., Johnman, C., McGlynn, L. M., Mackay, D., Shiels, P. G., & Pell, J. P. (2017) · International Journal of Epidemiology · doi:10.1093/ije/dyx212 · Cited by 29
Telomere Length Calibration from qPCR Measurement: Limitations of Current Method
Wang, Y., Savage, S. A., Alsaggaf, R., Aubert, G., Dagnall, C. L., Spellman, S. R., Lee, S. J., Hicks, B. D., Jones, K. M., Katki, H. A., et al. (2018) · Cells · doi:10.3390/cells7110183 · Cited by 29
Yin, Z., Wang, Q., Li, Y., Hong Kui, W. E. I., Shi, J., & Li, A. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0309-0 · Cited by 29
Rosa, E. C. C. C., dos Santos, R. R. C., Fernandes, L. F. A., Neves, F. D. A. R., Coelho, M. S., & Amato, A. A. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.10.020 · Cited by 28
Shi, J., Sun, F. Y., Peng, L. J., Li, B., Liu, L., Zhou, C., Han, J., Zhang, L., Zhou, L., Zhang, X., et al. (2012) · International Journal of Cancer · doi:10.1002/ijc.27959 · Cited by 28
Eisenberg, D. T. A., Borja, J. B., Hayes, M. G., & Kuzawa, C. W. (2017) · American Journal of Human Biology · doi:10.1002/ajhb.22962 · Cited by 29
A study of telomere length, arsenic exposure, and arsenic toxicity in a Bangladeshi cohort
Zhang, C., Kibriya, M. G., Jasmine, F., Roy, S., Gao, J., Sabarinathan, M., Shinkle, J., Delgado, D. A., Ahmed, A., Islam, T., et al. (2018) · Environmental Research · doi:10.1016/j.envres.2018.03.005 · Cited by 28
Chen, L., Shivappa, N., Dong, X., Ming, J., Zhao, Q., Xu, H., Liang, P., Cheng, M., Liu, J., Sun, P., et al. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.11.031 · Cited by 28
Telomerase and telomere biology in hematological diseases: A new therapeutic target
Allegra, A., Innao, V., Penna, G., Gerace, D. G., Allegra, A. G., & Musolino, C. (2017) · Leukemia Research · doi:10.1016/j.leukres.2017.02.002 · Cited by 31
Shortened telomeres in families with a propensity to autism
Nelson, C. A., Varcin, K. J., Coman, N. K., DeVivo, I., & Tager-Flusberg, H. (2015) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2015.04.006 · Cited by 27
Giaccherini, M., Gentiluomo, M., Fornili, M., Lucenteforte, E., Baglietto, L., & Campa, D. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103510 · Cited by 27
Verma, A. K., Singh, P., Al‐Saeed, F. A., Ahmed, A. E., Kumar, S., Kumar, A., Dev, K., & Dohare, R. (2022) · Tissue and Cell · doi:10.1016/j.tice.2022.101925 · Cited by 29
van Ockenburg, S. L., de Jonge, P., van der Harst, P., Ormel, J., & Rosmalen, J. G. M. (2013) · Psychological Medicine · doi:10.1017/s0033291713001657 · Cited by 28
Lincoln, K. D., Lloyd, D. A., & Nguyen, A. W. (2017) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbx049 · Cited by 27
Telomere length, arsenic exposure and risk of basal cell carcinoma of skin
Srinivas, N., Rachakonda, P. S., Hielscher, T., Calderazzo, S., Rudnai, P., Gurzau, E. S., Koppová, K., Fletcher, T., & Kumar, R. (2019) · Carcinogenesis · doi:10.1093/carcin/bgz059 · Cited by 27
Walking the Walk from Genes through Telomere Maintenance to Cancer Risk
Blackburn, E. H. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0066 · Cited by 26
Zhang, C., Lauderdale, D. S., & Pierce, B. L. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kww102 · Cited by 26
Liang, X., Aouizerat, B. E., So‐Armah, K., Cohen, M. H., Marconi, V. C., Xu, K., & Justice, A. C. (2024) · Aging Cell · doi:10.1111/acel.14174 · Cited by 26
Li, Y., Sundquist, K., Wang, X., Zhang, N., Hedelius, A., Sundquist, J., & Memon, A. A. (2021) · Cancers · doi:10.3390/cancers13153842 · Cited by 26
Do, S. K., Yoo, S. S., Choi, Y. Y., Choi, J. E., Jeon, H., Lee, W. K., Lee, S. Y., Lee, J., Ick, S., Kim, C. H., et al. (2015) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2015.30.5.719 · Cited by 25
Jeon, H., Choi, Y. Y., Choi, J. E., Lee, W. K., Lee, E., Yoo, S. S., Lee, S. Y., Lee, J., Ick, S., Kim, C. H., et al. (2012) · Molecular Carcinogenesis · doi:10.1002/mc.21972 · Cited by 25
Telomeres in Molecular Epidemiology Studies
Bodelón, C., Savage, S. A., & Gadalla, S. M. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-397898-1.00005-0 · Cited by 25
Leukocyte telomere length in paediatric critical illness: effect of early parenteral nutrition
Verstraete, S., Vanhorebeek, I., van Puffelen, E., Derese, I., Ingels, C., Verbruggen, S. C. A. T., Wouters, P. J., Joosten, K., Hanot, J., Guerra, G. G., et al. (2018) · Critical Care · doi:10.1186/s13054-018-1972-6 · Cited by 25
Loss of Notch1 predisposes oro-esophageal epithelium to tumorigenesis
Sawangarun, W., Mandasari, M., Aida, J., Morita, K.-I., Kayamori, K., Ikeda, T., & Sakamoto, K. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.09.019 · Cited by 25
Weng, X., Zhang, H., Kan, M., Ye, J., Liu, F., Wang, T., Deng, J., Tan, Y., He, L., & Liu, Y. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.06.004 · Cited by 25
Relationship Between Leukocyte Telomere Length and Personality Traits in Healthy Subjects
Sadahiro, R., Suzuki, A., Enokido, M., Matsumoto, Y., Shibuya, N., Kamata, M., Goto, K., & Otani, K. (2014) · European Psychiatry · doi:10.1016/j.eurpsy.2014.03.003 · Cited by 23
Delay discounting, genetic sensitivity, and leukocyte telomere length
Yim, O. S., Zhang, X., Shalev, I., Monakhov, M. V., Zhong, S., Hsu, M., Chew, S. H., Lai, P. S., & Ebstein, R. P. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514351113 · Cited by 24
Friedenreich, C. M., Wang, Q., Ting, N. S. Y., Brenner, D. R., Conroy, S. M., McIntyre, J. B., Mickle, A. T., Courneya, K. S., & Beattie, T. L. (2018) · Cancer Epidemiology · doi:10.1016/j.canep.2018.07.012 · Cited by 23
What telomeres teach us about MS
Miner, A. E., & Graves, J. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.103084 · Cited by 23
Ndumbi, P., Gilbert, L., & Tsoukas, C. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117039 · Cited by 22
Genomic Instability in Newborn with Short Telomeres
Moreno-Palomo, J., Creus, A., Marcos, R., & Hernández, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091753 · Cited by 22
Kim, E. S., Ye, Y., Vaporciyan, A. A., Xing, J., Huang, M., Gu, J. H., Roth, J. A., Lippman, S. M., & Wu, X. (2014) · Journal of Thoracic Oncology · doi:10.1097/jto.0000000000000398 · Cited by 22
Hardikar, S. S., Song, X., Risques, R. A., Montine, T. J., Duggan, C. R., Blount, P. L., Reid, B. J., Anderson, G. L., Kratz, M., White, E., et al. (2015) · BMC Obesity · doi:10.1186/s40608-015-0063-3 · Cited by 21
Aging and energetics’ ‘Top 40’ future research opportunities 2010-2013
Allison, D. B., Antoine, L. H., Ballinger, S. W., Bamman, M. M., Biga, P. R., Darley-Usmar, V. M., Fisher, G., Gohlke, J. M., Halade, G. V., Hartman, J. L., et al. (2014) · F1000Research · doi:10.12688/f1000research.5212.1 · Cited by 21
Du, M., Prescott, J., Cornelis, M. C., Hankinson, S. E., Giovannucci, E. L., Kraft, P. L., & Vivo, I. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0052240 · Cited by 23
Riegert‐Johnson, D. L., Boardman, L. A., Crook, J. E., Thomas, C. S., Johnson, R., & Roberts, M. E. (2012) · The International Journal of Biological Markers · doi:10.5301/jbm.2012.9347 · Cited by 20
Genetic Variants in Telomere-Maintenance Genes and Bladder Cancer Risk
Chang, J., Dinney, C. P., Huang, M., Wu, X., & Gu, J. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030665 · Cited by 20
Early ageing after cytotoxic treatment for testicular cancer and cellular senescence: Time to act
Lubberts, S., Meijer, C., Demaria, M., & Gietema, J. A. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.102963 · Cited by 19
Ramírez, J. A., Elmofty, M., Castillo, E., DeRouen, M. C., Shariff‐Marco, S., Allen, L., Gomez, S. L., Nápoles, A. M., & Márquez-Magaña, L. M. (2017) · Journal of Community Genetics · doi:10.1007/s12687-016-0288-y · Cited by 21
Pavanello, S., Carta, A., Mastrangelo, G., Campisi, M., Arici, C., & Porru, S. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15010005 · Cited by 19
Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population
Chang, X., Gurung, R. L., Wang, L., Jin, A., Li, Z., Wang, R., Beckman, K. B., Adams‐Haduch, J. M., Meah, W. Y., Sim, K. S., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02056-7 · Cited by 19
Rolles, B., Tometten, M., Meyer, R., Kirschner, M., Beier, F., & Brümmendorf, T. H. (2024) · Transfusion Medicine and Hemotherapy · doi:10.1159/000540109 · Cited by 18
Role of Telomere Dysfunction in Genetic Intratumor Diversity
Genescà, A., Pampalona, J., Frías-López, C., Domínguez, D., & Tusell, L. (2011) · Advances in cancer research · doi:10.1016/b978-0-12-387688-1.00002-8 · Cited by 19
Predicting Response to Chemotherapy With Early-Stage Lung Cancer
Rosell, R., Tarón, M., Massutí, B., Mederos, N., Magrí, I., Santarpía, M., & Sánchez, J. M. (2011) · The Cancer Journal · doi:10.1097/ppo.0b013e3182091fa3 · Cited by 18
Telomere Dysfunction and Hematologic Disorders
Paiva, R. M. A., & Calado, R. T. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-397898-1.00006-2 · Cited by 18
Telomere length, telomerase activity, stress, and aging
Im, S., Mikhelson, V. M., & Spivak, D. L. (2016) · Advances in Gerontology · doi:10.1134/s2079057016010136 · Cited by 18
George, A., Venkatesan, S., Ashok, N., Saraswathy, R., & Hande, M. P. (2018) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2018.06.015 · Cited by 18
Social determinants of health, personalized medicine, and child maltreatment
Lane, W. G., & Dubowitz, H. (2020) · Pediatric Research · doi:10.1038/s41390-020-01290-9 · Cited by 18
Pal, D., Sharma, U., Khajuria, R., Singh, S. K., Kakkar, N., & Prasad, R. (2015) · Gene · doi:10.1016/j.gene.2015.02.079 · Cited by 20
MicroRNA-centered theranostics for pulmoprotection in critical COVID-19
Perez‐Pons, M., Molinero, M., Benitez, I. D., García‐Hidalgo, M. C., Chatterjee, S., Bär, C., González, J., Torres, A., Barbé, F., & de Gonzalo‐Calvo, D. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102118 · Cited by 17
Targets of Immune Regeneration in Rheumatoid Arthritis
Hohensinner, P. J., Goronzy, J. J., & Weyand, C. M. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.01.020 · Cited by 17
Association between genetic risk score for telomere length and risk of breast cancer
Luu, H. N., Long, J., Wen, W., Zheng, Y., Cai, Q., Gao, Y., Zheng, W., & Shu, X. (2016) · Cancer Causes & Control · doi:10.1007/s10552-016-0800-z · Cited by 17
Are Short Telomeres Hallmarks of Cancer Recurrence?
Shay, J. W. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-3198 · Cited by 17
Mechanobiological Implications of Cancer Progression in Space
Kim, H., Shin, Y. J., & Kim, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.740009 · Cited by 19
Fat metabolism is associated with telomere length in six population-based studies
van der Spek, A., Karamujić‐Čomić, H., Pool, R., Bot, M., Beekman, M., Garmaeva, S., Arp, P., Henkelman, S., Liu, J., Alves, A. C., et al. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab281 · Cited by 16
Prognostic value of telomere attrition in patients with aplastic anemia
Scheinberg, P. (2013) · International Journal of Hematology · doi:10.1007/s12185-013-1332-x · Cited by 16
Biological Age in Congenital Heart Disease—Exploring the Ticking Clock
Tournoy, T. K., Moons, P., Daelman, B., & Backer, J. F. A. D. (2023) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd10120492 · Cited by 15
Wolinsky, H. (2011) · EMBO Reports · doi:10.1038/embor.2011.166 · Cited by 15
Leucocyte telomere length is no molecular marker of physical frailty in late-life depression
Arts, M. H. L., Collard, R. M., Comijs, H. C., de Jonge, L., Penninx, B. W. J. H., Naarding, P., Kok, R., & Voshaar, R. C. O. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.07.016 · Cited by 15
Incident hand OA is strongly associated with reduced peripheral blood leukocyte telomere length
McAlindon, T. E., Roberts, M. B., Driban, J. B., Schaefer, L. F., Haugen, I. K., Smith, S. E., Duryea, J., Cunha, D., Blanco, F. J., Fernández-García, J., et al. (2018) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2018.08.010 · Cited by 15
Telomere length and cancer mortality in American Indians: the Strong Heart Study
Subedi, P., Nembrini, S., An, Q., Zhu, Y., Peng, H. Y., Yeh, F., Cole, S. A., Rhoades, D. A., Lee, E. T., & Zhao, J. (2019) · GeroScience · doi:10.1007/s11357-019-00080-4 · Cited by 15
Yeap, B. B., Hui, J., Knuiman, M. W., Flicker, L. A., Divitini, M., Arscott, G. M., Twigg, S. M., Almeida, O. P., Hankey, G. J., Golledge, J., et al. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa190 · Cited by 15
Yang, X., Benny, P. A., Cervera-Marzal, E., Wu, B., Lassiter, C. B., Astern, J., & Garmire, L. X. (2022) · Aging · doi:10.18632/aging.204445 · Cited by 16
Social support and telomere length: a meta-analysis
Montoya, M., & Uchino, B. N. (2023) · Journal of Behavioral Medicine · doi:10.1007/s10865-022-00389-0 · Cited by 17
Zhao, Q., Zhu, Y., Yeh, F., Lin, J., Lee, E. T., Cole, S. A., Calhoun, D., & Zhao, J. (2016) · Aging · doi:10.18632/aging.101104 · Cited by 15
Huang, Y.-X., Wu, J., Zhao, Y., Sui, W., Tian, T., Han, W., & Ni, J. (2024) · Preventive Medicine · doi:10.1016/j.ypmed.2024.108147 · Cited by 14
Epigenetics of Primary Biliary Cholangitis
Li, Y., Tang, R., & Ma, X. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-3449-2_10 · Cited by 14
Lincoln, K. D., & Nguyen, A. W. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab003 · Cited by 14
Family home visiting and fathers: A scoping review
Burcher, S. A., Corey, L. A., Mentzer, K. M., Davis, L., McNamee, H., Horning, M. L., Brown, S. J., & Shlafer, R. J. (2021) · Children and Youth Services Review · doi:10.1016/j.childyouth.2021.106132 · Cited by 14
Zhang, R., Zhao, J., Xu, J., & Liu, F. (2016) · Oncotarget · doi:10.18632/oncotarget.9536 · Cited by 15
Telomere Length Is Predictive of Breast Cancer Risk inBRCA2Mutation Carriers
Þorvaldsdóttir, B., Aradóttir, M., Stefánsson, Ó. A., Böðvarsdóttir, S. K., & Eyfjord, J. E. (2017) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-16-0946 · Cited by 14
Chang, S., Crous‐Bou, M., Prescott, J., ROSNER, B. A., Simon, N. M., Wang, W., Vivo, I. D., & Okereke, O. I. (2018) · Depression and Anxiety · doi:10.1002/da.22732 · Cited by 14
Promoter Methylation of PGC1A and PGC1B Predicts Cancer Incidence in a Veteran Cohort
Kresovich, J. K., Joyce, B. T., Gao, T., Zheng, Y., Zhang, Z., Achenbach, C. J., Murphy, R. L., Just, A. C., Shen, J., Yang, H., et al. (2018) · Epigenomics · doi:10.2217/epi-2017-0141 · Cited by 15
Shen, G., Huang, J., Huang, Y., & Feng, Y. (2019) · The journal of nutrition health & aging · doi:10.1007/s12603-019-1265-z · Cited by 14
Telomeres and stress: Promising avenues for research in psycho-oncology
Law, E., Girgis, A., Sylvie, L., Levesque, J. V., & Pickett, H. A. (2016) · Asia-Pacific Journal of Oncology Nursing · doi:10.4103/2347-5625.182931 · Cited by 14
Fabiani, R., Chiavarini, M., Rosignoli, P., & Giacchetta, I. (2024) · Cancers · doi:10.3390/cancers16183218 · Cited by 15
Telomere Length and Telomerase Activity as Potential Biomarkers for Gastrointestinal Cancer
Loukopoulou, C., Νikolouzakis, Τ. Κ., Koliarakis, I., Vakonaki, E., & Tsiaoussis, J. (2024) · Cancers · doi:10.3390/cancers16193370 · Cited by 15
Biological monitoring of carcinogens: current status and perspectives
Pavanello, S., & Lotti, M. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0793-z · Cited by 13
Metadata
- Authors
- Willeit, P., Willeit, J., Mayr, A., Weger, S., Oberhollenzer, F., Brandstätter, A., Kronenberg, F., & Kiechl, S.
- Affiliations
- Innsbruck Medical University (AT)
- Corresponding author
- Kiechl, Stefan
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2010-07-07
- Volume
- 304
- Issue
- 1
- Pages
- 69
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2035720189
- Cited by
- 484
- References
- 37
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 31 · 2023: 10 · 2022: 13 · 2021: 26 · 2020: 36 · 2019: 26 · 2018: 42 · 2017: 37 · 2016: 33 · 2015: 38 · 2014: 56 · 2013: 32 · 2012: 49
- FWCI
- 25.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- telomere length, leukocyte telomeres, cancer incidence, cancer mortality, short telomeres, chromosomal instability, Bruneck Study, cancer risk biomarkers, aging and cancer risk, sex differences in cancer risk, genetic susceptibility to cancer, cancer risk factors, cancer screening, early cancer detection
- MeSH terms
- Adult, Aged, Female, Humans, Italy, Leukocytes, Male, Middle Aged, Neoplasms, Prospective Studies, Risk, Polymerase Chain Reaction, Telomere
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-10, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-10 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
