The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Sarcoidosis: Clinical Presentation, Immunopathogenesis, and Therapeutics
Abstract
Sarcoidosis is a multisystem granulomatous disorder that most often affects the lungs and may cause significant morbidity. Sarcoidosis can manifest as neurological disease, uveitis, blindness, end-stage pulmonary fibrosis, pulmonary hypertension, dysrhythmias, cardiomyopathy, hypercalcemia, and renal failure. Sarcoidosis persists as chronic disease in approximately one-third of those affected. Clinical pitfalls and misconceptions about the course of disease place this population at risk for delayed or inadequate care. While noncaseating granulomas are the histopathological hallmark of sarcoidosis, they also are nonspecific. No pathognomonic diagnostic test exists for sarcoidosis, so the diagnosis remains one of exclusion. While the etiology of sarcoidosis is still unknown, recent insights into its immunopathogenesis have moved investigators closer to finding more effective treatments. Corticosteroids remain the standard of care when treatment is indicated, despite their adverse effect profile. Clinical investigations of novel drugs and biological agents targeting mechanisms involving CD4 type 1 helper T cells may provide more effective, better tolerated therapies.
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Citations
Cites
sarcoidosis, S. O. (1999) · American Journal of Respiratory and Critical Care Medicine · Cited by 1,953
Clinical Characteristics of Patients in a Case Control Study of Sarcoidosis
BAUGHMAN, R. P., TEIRSTEIN, A. S., JUDSON, M. A., ROSSMAN, M. D., YEAGER, H., BRESNITZ, E. A., DePALO, L., HUNNINGHAKE, G., IANNUZZI, M. C., JOHNS, C. J., et al. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.10.2104046 · Cited by 1,808
Self-citationStatins as a newly recognized type of immunomodulator.
Kwak, B., Mulhaupt, F., Myit, S., & Mach, F. (2000) · Nature Medicine · doi:10.1038/82219 · Cited by 1,383
Conti, M., & Beavo, J. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060305.150444 · Cited by 1,183
Racial Differences in Sarcoidosis Incidence: A 5-Year Study in a Health Maintenance Organization
Rybicki, B. A., Major, M., Popovich, J., Maliank, M. J., & lannuzzi, M. C. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009096 · Cited by 1,011
Anti-Inflammatory Effects of Statins: Clinical Evidence and Basic Mechanisms
Jain, M. K., & Ridker, P. M. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1901 · Cited by 915
A Case Control Etiologic Study of Sarcoidosis: Environmental and Occupational Risk Factors
Newman, L. S., Rose, C. S., Bresnitz, E. A., Rossman, M. D., Barnard, J., Frederick, M., Terrin, M. L., Weinberger, S. E., Moller, D. R., McLennan, G., et al. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200402-249oc · Cited by 801
Self-citationDetection of Myocardial Damage in Patients With Sarcoidosis
Patel, M. R., Cawley, P. J., Heitner, J. F., Klem, I., Parker, M. A., Jaroudi, W. A., Meine, T. J., White, J. B., Elliott, M. D., Kim, H. W., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.851352 · Cited by 719
Infliximab Therapy in Patients with Chronic Sarcoidosis and Pulmonary Involvement
Baughman, R. P., Drent, M., Kavuru, M., Judson, M. A., Costabel, U., du Bois, R., Albera, C., Brutsche, M., Davis, G., Donohue, J. F., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200603-402oc · Cited by 714
Sarcoidosis is associated with a truncating splice site mutation in BTNL2
Valentonyte, R., Hampe, J., Huse, K., Rosenstiel, P., Albrecht, M., Stenzel, A., Nagy, M., Gaede, K. I., Franke, A., Haesler, R., et al. (2005) · Nature Genetics · doi:10.1038/ng1519 · Cited by 491
Cited by
Valeyre, D., Prasse, A., Nunes, H., Uzunhan, Y., Brillet, P.-Y., & Müller-Quernheim, J. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60680-7 · Cited by 1,087
Osborne, M. T., Hulten, E. A., Singh, A., Waller, A. H., Bittencourt, M. S., Stewart, G. C., Hainer, J., Murthy, V. L., Skali, H., Dorbala, S., et al. (2014) · Journal of Nuclear Cardiology · doi:10.1007/s12350-013-9828-6 · Cited by 298
Linke, M., Pham, H. T. T., Katholnig, K., Schnöller, T., Miller, A., Demel, F., Schütz, B., Rosner, M., Kovacic, B., Sukhbaatar, N., et al. (2017) · Nature Immunology · doi:10.1038/ni.3655 · Cited by 286
Sarcoidosis-associated fatigue
Drent, M., Lower, E. E., & De Vries, J. (2012) · European Respiratory Journal · doi:10.1183/09031936.00002512 · Cited by 285
An mTORC1‐Dependent Mouse Model for Cardiac Sarcoidosis
Bueno‐Beti, C., Lim, C. X., Protonotarios, A., Szabo, P. L., Westaby, J., Mazic, M., Sheppard, M. N., Behr, E., Hamza, O., Kiss, A., et al. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.123.030478 · Cited by 34
Metadata
- Authors
- Iannuzzi, M. C.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2011-01-26
- Volume
- 305
- Issue
- 4
- Pages
- 391
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W1965053951
- Cited by
- 338
- References
- 39
- FWCI
- 20.22
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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