Lessons from recent research about the placebo effect—from art to science

Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome

Kaptchuk, T. J., Kelley, J. M., Conboy, L. A., Davis, R. B., Kerr, C. E., Jacobson, E. E., Kirsch, I., Schyner, R. N., Nam, B. H., Nguyen, L. T., et al. (2008) · BMJ · doi:10.1136/bmj.39524.439618.25 · Cited by 1,196 · see citing works

Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel Syndrome

Kaptchuk, T. J., Friedlander, E., Kelley, J. M., Sanchez, M. N., Kokkotou, E., Singer, J. P., Kowalczykowski, M., Miller, F. G., Kirsch, I., & Lembo, A. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015591 · Cited by 900 · see citing works

Overt versus covert treatment for pain, anxiety, and Parkinson's disease

Colloca, L., Lopiano, L., Lanotte, M., & Benedetti, F. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00908-1 · Cited by 551 · see citing works

Prescribing "placebo treatments": results of national survey of US internists and rheumatologists

Tilburt, J. C., Emanuel, E. J., Kaptchuk, T. J., Curlin, F. A., & Miller, F. G. (2008) · BMJ · doi:10.1136/bmj.a1938 · Cited by 265 · see citing works

The Placebo Effect: Illness and Interpersonal Healing

Miller, F. G., Colloca, L., & Kaptchuk, T. J. (2009) · Perspectives in biology and medicine · doi:10.1353/pbm.0.0115 · Cited by 254 · see citing works

The placebo response. Recent research and implications for family medicine.

Brody, H. A. (2000) · PubMed · Cited by 184 · see citing works

The Legitimacy of Placebo Treatments in Clinical Practice: Evidence and Ethics

Miller, F. G., & Colloca, L. (2009) · The American Journal of Bioethics · doi:10.1080/15265160903316263 · Cited by 156 · see citing works

Family physicians believe the placebo effect is therapeutic but often use real drugs as placebos.

Kermen, R., Hickner, J. M., Brody, H. A., & Hasham, I. (2010) · PubMed · Cited by 74 · see citing works

Placebo Effects: Biological, Clinical and Ethical Advances

Finniss, D., Kaptchuk, T., Miller, F. G., & Benedetti, F. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61706-2 · Cited by 5 · see citing works

Nocebo effects, patient–clinician communication, and therapeutic outcomes

Colloca, L., & Finniss, D. (2012) · JAMA · doi:10.1001/jama.2012.115 · Cited by 326 · see citing works

Are open‐Label Placebos Ethical? Informed Consent and Ethical Equivocations

Blease, C. R., Colloca, L., & Kaptchuk, T. J. (2016) · Bioethics · doi:10.1111/bioe.12245 · Cited by 129 · see citing works

Distinct neural representations of placebo and nocebo effects

Freeman, S., Yu, R., Egorova, N., Chen, X., Kirsch, I., Claggett, B., Kaptchuk, T. J., Gollub, R. L., & Kong, J. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.03.015 · Cited by 116 · see citing works

Are All Placebo Effects Equal? Placebo Pills, Sham Acupuncture, Cue Conditioning and Their Association

Kong, J., Spaeth, R. B., Cook, A., Kirsch, I., Claggett, B. L., Vangel, M. G., Gollub, R. L., Smoller, J. W., & Kaptchuk, T. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067485 · Cited by 98 · see citing works

Specifying the effects of physician's communication on patients’ outcomes: A randomised controlled trial

van Osch, M., van Dulmen, S., van Vliet, L., & Bensing, J. M. (2017) · Patient Education and Counseling · doi:10.1016/j.pec.2017.03.009 · Cited by 98 · see citing works

Infant Colic—What works: A Systematic Review of Interventions for Breast‐fed Infants

Harb, T., Matsuyama, M., David, M., & Hill, R. J. (2016) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001075 · Cited by 92 · see citing works

Efficacy of mirabegron in patients with and without prior antimuscarinic therapy for overactive bladder: a post hoc analysis of a randomized European-Australian Phase 3 trial

Khullar, V., Cambronero, J., Angulo, J. C., Wooning, M., Blauwet, M. B., Dorrepaal, C. A., & Martin, N. (2013) · BMC Urology · doi:10.1186/1471-2490-13-45 · Cited by 70 · see citing works

Ginkgo biloba extract for essential hypertension: A systemic review

Xiong, X., Liu, W., Yang, X., Feng, B., Zhang, Y. Q., Li, S. J., Li, X. K., & Wang, J. (2014) · Phytomedicine · doi:10.1016/j.phymed.2014.04.024 · Cited by 68 · see citing works

Mechanisms and therapeutic implications of the placebo effect in neurological and psychiatric conditions

Murray, D., & Stoessl, A. J. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.07.009 · Cited by 65 · see citing works

Reevaluating the Placebo Effect in Medical Practice

Colloca, L., Jonas, W. B., Killen, J., Miller, F. G., & Shurtleff, D. (2014) · Zeitschrift für Psychologie · doi:10.1027/2151-2604/a000177 · Cited by 46 · see citing works

The Placebo Phenomenon: Implications for the Ethics of Shared Decision-Making

Brody, H. A., Colloca, L., & Miller, F. G. (2012) · Journal of General Internal Medicine · doi:10.1007/s11606-011-1977-1 · Cited by 45 · see citing works

A window into the evolution of trauma-focused psychotherapies for posttraumatic stress disorder

Hoge, C. W., & Chard, K. M. (2018) · JAMA · doi:10.1001/jama.2017.21880 · Cited by 43 · see citing works

Abstinence-related expectancies predict smoking withdrawal effects: implications for possible causal mechanisms

Hendricks, P. S., & Leventhal, A. M. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3169-7 · Cited by 42 · see citing works

Tianma Gouteng Yin as Adjunctive Treatment for Essential Hypertension: A Systematic Review of Randomized Controlled Trials

Wang, J., Feng, B., Yang, X., Liu, W., Liu, Y., Zhang, Y., Gui, Y., Li, S., Zhang, Y., & Xiong, X. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/706125 · Cited by 36 · see citing works

Medicine's inconvenient truth: the placebo and nocebo effect

Arnold, M. H., Finniss, D. G., & Kerridge, I. (2014) · Internal Medicine Journal · doi:10.1111/imj.12380 · Cited by 36 · see citing works

The Placebo Effect in Asthma

Dutile, S., Kaptchuk, T. J., & Wechsler, M. E. (2014) · Current Allergy and Asthma Reports · doi:10.1007/s11882-014-0456-2 · Cited by 33 · see citing works

Can a Brief Relaxation Exercise Modulate Placebo or Nocebo Effects in a Visceral Pain Model?

Elsenbruch, S., Roderigo, T., Enck, P., & Benson, S. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00144 · Cited by 32 · see citing works

Can a brief psychological expectancy intervention improve postoperative pain? A randomized, controlled trial in patients with breast cancer

Benson, S., Hagen, S., Hoffmann, O., Pasler, A., Bingel, U., Schedlowski, M., Peters, J., Elsenbruch, S., & Frey, U. H. (2019) · Pain · doi:10.1097/j.pain.0000000000001546 · Cited by 31 · see citing works

The Medical Alliance

Verhulst, J., Kramer, D. A., Swann, A. C., Hale-Richlen, B., & Beahrs, J. O. (2013) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0b013e31829829e1 · Cited by 29 · see citing works

Caregiver Expectations: Predictors of a Worse Than Expected Caregiving Experience at the End of Life.

Burns, E., Quinn, S., Abernethy, A., & Currow, D. (2015) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2015.04.017 · Cited by 18 · see citing works

Reinterpreting homoeopathy in the light of placebo effects to manage patients who seek homoeopathic care: A systematic review

Antonelli, M., & Donelli, D. (2018) · Health & Social Care in the Community · doi:10.1111/hsc.12681 · Cited by 22 · see citing works

Understanding placebo effects: Implications for nursing practice

Miller, L. R., & Miller, F. G. (2015) · Nursing Outlook · doi:10.1016/j.outlook.2015.03.002 · Cited by 18 · see citing works

Harnessing Placebo Effects in Primary Care: Using the Person-Based Approach to Develop an Online Intervention to Enhance Practitioners' Communication of Clinical Empathy and Realistic Optimism During Consultations

Smith, K. A., Vennik, J. L., Morrison, L. G., Hughes, S. F., Steele, M., Tiwari, R., Bostock, J., Howick, J., Mallen, C. D., Little, P. S., et al. (2021) · Frontiers in Pain Research · doi:10.3389/fpain.2021.721222 · Cited by 15 · see citing works

“Let’s see what happens:”—Women’s experiences of open-label placebo treatment for menopausal hot flushes in a randomized controlled trial

Pan, Y., Frank, M. L., Kaptchuk, T. J., & Nestoriuc, Y. (2022) · PLoS ONE · doi:10.1371/journal.pone.0276499 · Cited by 14 · see citing works

Role of Physician Gender in Drug Therapy

Gouni‐Berthold, I., & Berthold, H. K. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-30726-3_10 · Cited by 14 · see citing works

Making Sense of Studies That Claim Benefits of Frenotomy in the Absence of Classic Tongue-Tie

Douglas, P. (2017) · Journal of Human Lactation · doi:10.1177/0890334417706694 · Cited by 13 · see citing works

HAPPY – Humanity Assurance Protocol in interventional radiotheraPY (brachytherapy) – an AIRO Interventional Radiotherapy Study Group project

Lancellotta, V., Sanctis, V. D., Cornacchione, P., Barbera, F., Fusco, V., Vidali, C., Scalise, S., Panza, G., Tenore, A., Colloca, G. A., et al. (2019) · Journal of Contemporary Brachytherapy · doi:10.5114/jcb.2019.91222 · Cited by 13 · see citing works

Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression

Severus, E., Seemüller, F., Berger, M., Dittmann, S., Obermeier, M., Pfennig, A., Riedel, M. J., Frangou, S., Möller, H., & Bauer, M. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-67 · Cited by 12 · see citing works

Meaning and Affect in the Placebo Effect

Chiffi, D., Pietarinen, A., & Grecucci, A. (2021) · The Journal of Medicine and Philosophy A Forum for Bioethics and Philosophy of Medicine · doi:10.1093/jmp/jhab002 · Cited by 11 · see citing works

Chlorpromazine bioavailability from a topical gel formulation in volunteers

Weiland, A., Protus, B. M., Kimbrel, J. M., Grauer, P. A., & Hirsh, J. (2013) · The Journal of Supportive Oncology · doi:10.12788/j.suponc.0010 · Cited by 11 · see citing works

Causal diagrams, the placebo effect, and the expectation effect

Shahar, E., & Shahar, D. J. (2013) · International Journal of General Medicine · doi:10.2147/ijgm.s52209 · Cited by 11 · see citing works

To Heal and Restore Broken Bodies

Hultman, C. S., Saou, M. A., Roach, S. T., Hultman, S. C., Cairns, B. A., Massey, S., & Koenig, H. G. (2014) · Annals of Plastic Surgery · doi:10.1097/sap.0000000000000087 · Cited by 11 · see citing works

Homage to Henry Beecher (1904-1976)

Miller, F. G. (2012) · Perspectives in biology and medicine · doi:10.1353/pbm.2012.0013 · Cited by 8 · see citing works

Statistical Issues and Lessons Learned From COVID-19 Clinical Trials With Lopinavir-Ritonavir and Remdesivir

Yin, G., Zhang, C., & Jin, H. (2020) · JMIR Public Health and Surveillance · doi:10.2196/19538 · Cited by 8 · see citing works

The Short-Term Placebo Response in Children With Attention-Deficit Hyperactivity Disorder (ADHD)

Cohen, A., Plonsky-Toder, M., & Tirosh, E. (2018) · Journal of Child Neurology · doi:10.1177/0883073818756403 · Cited by 7 · see citing works

Placebo hypoalgesic effects in pain: Potential applications in dental and orofacial pain management

Blasini, M., Movsas, S., & Colloca, L. (2018) · Seminars in Orthodontics · doi:10.1053/j.sodo.2018.04.001 · Cited by 6 · see citing works

Using the Placebo Effect to Treat Cold Symptoms in Children

Taylor, J. A., & Opel, D. J. (2014) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2014.2355 · Cited by 6 · see citing works

On Talking and Touching in Medicine

Brody, H. A. (2012) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.3109/15360288.2012.676619 · Cited by 4 · see citing works

Evaluating final-year medical students' communication skills using an observational rating scale in Shiraz medical school

Bahraminia, S., & Amini, M. (2018) · Biomedical Research - India · doi:10.4066/biomedicalresearch.29-17-3449 · Cited by 4 · see citing works

The Integrated Nurse

Quinn, J. F. (2014) · doi:10.1093/med/9780199860739.003.0003 · Cited by 2 · see citing works

Homeopathic medicine should have a role in managed care.

Wertheimer, A. I., & Brentson, F. A. (2014) · PubMed · Cited by 1 · see citing works

Kidney Failure Treatment: The Freedom to Choose

Gabbay, E., & Meyer, K. B. (2012) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2012.04.005 · Cited by 1 · see citing works

Religion and superstition through a cognitive perspective: examining the relationship of religious and superstitious beliefs to cognitive processes

Rios, J. M. D. C. (2015) · Figshare · Cited by 1 · see citing works

Nutritional modulation of hepatic lipid metabolism in health and disease

Johnston, R. D. (2012) · Nottingham ePrints (University of Nottingham)

This issue: Frontiers in Placebo Effects

Nayak, D. (2014) · Psychiatric Annals · doi:10.3928/00485713-20140205-03

Integration: Medicine, Health, and Empowerment

Hanser, S. B. (2016) · Palgrave Macmillan UK eBooks · doi:10.1057/978-1-137-38477-5_3

Frontiers in Placebo Effects

Nayak, D. (2014)

Peabody’s “Care of the Patient” and the Nature of Medical Science

Brody, H. A. (2014) · Perspectives in biology and medicine · doi:10.1353/pbm.2014.0030

The Role of Communicating the Beliefs of the Clinician – Using the Placebo Effect in Clinical Practice

Harris, P. (2020) · Springer eBooks · doi:10.1007/978-3-030-36822-7_8

Current Status on Treatments and Clinical Trials for COVID-19 (Preprint)Preprint

Yin, G., Zhang, C., & Jin, H. (2020) · doi:10.2196/preprints.22701

Hope

Rosenfeld, R. M. (2013) · Otolaryngology · doi:10.1177/0194599813511935

Healing Hands: The Art and Science of Physiotherapy

Singh, A. H. A. (2023) · Journal of Propulsion Technology · doi:10.52783/tjjpt.v44.i2.1314

Recherche sur le dynamique de construction et d'interprétation des règles applicables à l'expérimentation clinique des médicaments : entre progrès de la connaissance, mise sur le marché et protection des personnes

Demarez, J.-P. (2019) · doi:10.70675/dbb5b0eez2cbez4f67z8a20zf54aa2b186de

The placebo effect

Baughan, D. M. (1985) · JAMA · doi:10.1001/jama.253.17.2493b

Letter: The placebo effect

Fligor, L. W. (1975) · JAMA · doi:10.1001/jama.234.8.808b

The importance of placebo effects

Cleophas, T. J. (1995) · JAMA · doi:10.1001/jama.273.4.283b · Cited by 6 · see citing works

Placebo effects on mind and body

Lavin, M. R. (1991) · JAMA · doi:10.1001/jama.265.13.1753 · Cited by 19 · see citing works

An Experimental Analysis of the Placebo Effect

Pihl, R. O., & Altman, J. L. (1971) · The Journal of Clinical Pharmacology · doi:10.1177/009127007101100203 · Cited by 50 · see citing works