The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Increasingly Sensitive Assays for Cardiac Troponins: A Review
Abstract
Cardiac troponins are the preferred biomarkers for diagnosis of myocardial infarction because of their high sensitivity and specificity for myocardial injury. However, acute and chronic conditions distinct from acute coronary syndromes (ACS) commonly lead to small elevations in troponin levels, with few data available regarding management of care for patients with such conditions. Recently developed highly sensitive troponin assays will likely lead to a substantial increase in the proportion of detectable troponin levels attributable to non-ACS conditions. Novel algorithms with highly sensitive assays, incorporating baseline troponin values and changes in values over 1 to 2 hours, may allow rapid exclusion of myocardial infarction and help to address specificity concerns but must be validated in appropriate target populations. Enhanced detection of very low troponin levels with highly sensitive assays has made feasible several potential new indications for troponin testing, including in the ambulatory setting, where assessment for low-level chronic myocardial injury may enhance risk stratification for heart failure and cardiac death.
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Cites
Prognostic Utility of Novel Biomarkers of Cardiovascular Stress: The Framingham Heart Study
Wang, T. J., Wollert, K. C., Larson, M. G., Coglianese, E., McCabe, E. L., Cheng, S., Ho, J. E., Fradley, M. G., Ghorbani, A., Xanthakis, V., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.129437 · Cited by 482
Cited by
2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Colvin, M. M., Drazner, M. H., Filippatos, G. S., Fonarow, G. C., Givertz, M. M., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.04.025 · Cited by 3,418
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Colvin, M. M., Drazner, M. H., Filippatos, G. S., Fonarow, G. C., Givertz, M. M., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000509 · Cited by 3,109
High-sensitivity assays for troponin in patients with cardiac disease
Westermann, D., Neumann, J. T., Sörensen, N. A., & Blankenberg, S. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.48 · Cited by 222
Engler, R. J. M., Nelson, M. R., Collins Jr., L. C., Spooner, C., Hemann, B. A., Gibbs, B. T., Atwood, J. E., Howard, R. S., Chang, A. S., Cruser, D. L., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0118283 · Cited by 169
Supraja, P., Sudarshan, V., Tripathy, S., Agrawal, A., & Singh, S. G. (2019) · Analytical Methods · doi:10.1039/c8ay02617c · Cited by 45
Metadata
- Authors
- de Lemos, J. A.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2013-06-05
- Volume
- 309
- Issue
- 21
- Pages
- 2262
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2080899999
- Cited by
- 174
- References
- 1
- FWCI
- 18.22
- Type
- journal article
- Language
- en
- Open access
- closed
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