Prognostic Utility of Novel Biomarkers of Cardiovascular Stress: The Framingham Heart Study
Open accessAbstract
BACKGROUND: Biomarkers for predicting cardiovascular events in community-based populations have not consistently added information to standard risk factors. A limitation of many previously studied biomarkers is their lack of cardiovascular specificity. METHODS AND RESULTS: To determine the prognostic value of 3 novel biomarkers induced by cardiovascular stress, we measured soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I in 3428 participants (mean age, 59 years; 53% women) in the Framingham Heart Study. We performed multivariable-adjusted proportional hazards models to assess the individual and combined ability of the biomarkers to predict adverse outcomes. We also constructed a "multimarker" score composed of the 3 biomarkers in addition to B-type natriuretic peptide and high-sensitivity C-reactive protein. During a mean follow-up of 11.3 years, there were 488 deaths, 336 major cardiovascular events, 162 heart failure events, and 142 coronary events. In multivariable-adjusted models, the 3 new biomarkers were associated with each end point (P<0.001) except coronary events. Individuals with multimarker scores in the highest quartile had a 3-fold risk of death (adjusted hazard ratio, 3.2; 95% confidence interval, 2.2-4.7; P<0.001), 6-fold risk of heart failure (6.2; 95% confidence interval, 2.6-14.8; P<0.001), and 2-fold risk of cardiovascular events (1.9; 95% confidence interval, 1.3-2.7; P=0.001). Addition of the multimarker score to clinical variables led to significant increases in the c statistic (P=0.005 or lower) and net reclassification improvement (P=0.001 or lower). CONCLUSION: Multiple biomarkers of cardiovascular stress are detectable in ambulatory individuals and add prognostic value to standard risk factors for predicting death, overall cardiovascular events, and heart failure.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Elevated serum GDF15 levels have been found in patients with heart failure.
“Elevated serum GDF15 level have also been found in patients with heart failure”
From Regulation of erythropoiesis by hypoxia-inducible factors (2013) · cites this paper as [221]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793 · see citing works
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297 · see citing works
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works
Pencina, M. J., D' Agostino, R. B., D' Agostino, R. B., & Vasan, R. S. (2008) · Statistics in Medicine · doi:10.1002/sim.2929 · Cited by 6,493 · see citing works
Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers
Pencina, M. J., D’Agostino, R. B., & Steyerberg, E. W. (2010) · Statistics in Medicine · doi:10.1002/sim.4085 · Cited by 2,478 · see citing works
WRITING COMMITTEE MEMBERS, Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M., Konstam, M. A., Mancini, D. M., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.167586 · Cited by 2,251 · see citing works
2010 ACCF/AHA Guideline for Assessment of Cardiovascular Risk in Asymptomatic Adults
Greenland, P., Alpert, J. S., Beller, G. A., Benjamin, E. J., Budoff, M. J., Fayad, Z. A., Foster, E., Hlatky, M. A., Hodgson, J. M., Kushner, F. G., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3182051b4c · Cited by 1,968 · see citing works
AN INVESTIGATION OF CORONARY HEART DISEASE IN FAMILIES
Kannel, W. B., Feinleib, M., McNAMARA, P. M., Garrison, R. J., & Castelli, W. P. (1979) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112813 · Cited by 1,635 · see citing works
Plasma Natriuretic Peptide Levels and the Risk of Cardiovascular Events and Death
Wang, T. J., Larson, M. G., Levy, D. A., Benjamin, E. J., Leip, E. P., Omland, T., Wolf, P. A., & Vasan, R. S. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031994 · Cited by 1,527 · see citing works
Prevalence of Conventional Risk Factors in Patients With Coronary Heart Disease
Khot, U. N. (2003) · JAMA · doi:10.1001/jama.290.7.898 · Cited by 1,494 · see citing works
Pencina, M. J., & D’Agostino, R. B. (2004) · Statistics in Medicine · doi:10.1002/sim.1802 · Cited by 1,446 · see citing works
Multiple Biomarkers for the Prediction of First Major Cardiovascular Events and Death
Wang, T. J., Gona, P. N., Larson, M. G., Tofler, G. H., Levy, D. A., Newton‐Cheh, C., Jacques, P. F., Rifai, N., Selhub, J., Robins, S. J., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055373 · Cited by 1,342 · see citing works
Criteria for Evaluation of Novel Markers of Cardiovascular Risk
Hlatky, M., Greenland, P., Arnett, D., Ballantyne, C., Criqui, M., Elkind, M., Go, A., Harrell, F. E. J., Hong, Y.-L., Howard, B., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.192278 · Cited by 1,153 · see citing works
de Lemos, J. A., Drazner, M. H., Omland, T., Ayers, C. R., Khera, A., Rohatgi, A. K., Hashim, I. A., Berry, J. D., Das, S. R., Morrow, D. A., et al. (2010) · JAMA · doi:10.1001/jama.2010.1768 · Cited by 1,105 · see citing works
Ridker, P. M., Paynter, N. P., Rifai, N., Gaziano, J. M., & Cook, N. R. (2008) · Circulation · doi:10.1161/circulationaha.108.814251 · Cited by 841 · see citing works
Saunders, J. T., Nambi, V., de Lemos, J. A., Chambless, L. E., Virani, S. S., Boerwinkle, E., Hoogeveen, R. C., Liu, X., Astor, B. C., Mosley, T. H., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.005264 · Cited by 756 · see citing works
Cardiac Troponin and Outcome in Acute Heart Failure
Peacock, W. F., Marco, T. D., Fonarow, G. C., Diercks, D. B., Wynne, J., Apple, F. S., & Wu, A. H. B. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706824 · Cited by 731 · see citing works
deFilippi, C. R., de Lemos, J. A., Christenson, R. H., Gottdiener, J. S., Kop, W. J., Zhan, M., & Seliger, S. L. (2010) · JAMA · doi:10.1001/jama.2010.1708 · Cited by 716 · see citing works
Latini, R., Masson, S., Anand, I. S., Missov, E. D., Carlson, M., Vago, T., Angelici, L., Barlera, S., Parrinello, G., Maggioni, A. P., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.655076 · Cited by 705 · see citing works
The Polymorphonuclear Leukocyte and the Abdominal Aortic Aneurysm
Tilson, M. D. (2005) · Circulation · doi:10.1161/circulationaha.105.553370 · Cited by 654 · see citing works
Kempf, T., Eden, M., Strelau, J., Naguib, M., Willenbockel, C., Tongers, J., Heineke, J., Kotlarz, D., Xu, J., Molkentin, J. D., et al. (2006) · Circulation Research · doi:10.1161/01.res.0000202805.73038.48 · Cited by 651 · see citing works
Self-citationWeinberg, E. O., Shimpo, M., Keulenaer, G. W. D., MacGillivray, C., Tominaga, S., Solomon, S. D., Rouleau, J. L., & Lee, R. T. (2002) · Circulation · doi:10.1161/01.cir.0000038705.69871.d9 · Cited by 645 · see citing works
IL-33 reduces the development of atherosclerosis
Miller, A. M., Xu, D., Asquith, D. L., Denby, L., Li, Y., Sattar, N. A., Baker, A. H., McInnes, I. B., & Liew, F. Y. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071868 · Cited by 642 · see citing works
Novel and Conventional Biomarkers for Prediction of Incident Cardiovascular Events in the Community
Melander, O. (2009) · JAMA · doi:10.1001/jama.2009.943 · Cited by 552 · see citing works
Measurement of the Interleukin Family Member ST2 in Patients With Acute Dyspnea
Januzzi, J. L., Peacock, W. F., Maisel, A. S., Chae, C. U., Jesse, R. L., Baggish, A. L., O’Donoghue, M. L., Sakhuja, R., Chen‐Tournoux, A., van Kimmenade, R. R. J., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.05.014 · Cited by 523 · see citing works
Kempf, T., Zarbock, A., Widera, C., Butz, S., Stadtmann, A., Rossaint, J., Bolomini-Vittori, M., Korf-Klingebiel, M., Napp, L. C., Hansen, B., et al. (2011) · Nature Medicine · doi:10.1038/nm.2354 · Cited by 518 · see citing works
Xu, J., Kimball, T. R., Lorenz, J. N., Brown, D. A., Bauskin, A. R., Klevitsky, R., Hewett, T. E., Breit, S. N., & Molkentin, J. D. (2006) · Circulation Research · doi:10.1161/01.res.0000202804.84885.d0 · Cited by 507 · see citing works
Identification of Serum Soluble ST2 Receptor as a Novel Heart Failure Biomarker
Weinberg, E. O., Shimpo, M., Hurwitz, S., Tominaga, S., Rouleau, J. L., & Lee, R. T. (2003) · Circulation · doi:10.1161/01.cir.0000047274.66749.fe · Cited by 504 · see citing works
Profile for Estimating Risk of Heart Failure
Kannel, W. B., D’Agostino, R. B., Silbershatz, H., Belanger, A. J., Wilson, P. W. F., & Levy, D. A. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.11.1197 · Cited by 422 · see citing works
Shimpo, M., Morrow, D. A., Weinberg, E. O., Sabatine, M. S., Murphy, S. A., Antman, E. M., & Lee, R. T. (2004) · Circulation · doi:10.1161/01.cir.0000127958.21003.5a · Cited by 410 · see citing works
Characteristics of the Novel Interleukin Family Biomarker ST2 in Patients With Acute Heart Failure
Rehman, S., Mueller, T., & Januzzi, J. L. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.07.042 · Cited by 388 · see citing works
Wollert, K. C., Kempf, T., Peter, T., Olofsson, S., James, S. K., Johnston, N., Lindahl, B., Horn-Wichmann, R., Brabant, G. E., Simoons, M. L., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.650846 · Cited by 379 · see citing works
High-Sensitivity ST2 for Prediction of Adverse Outcomes in Chronic Heart Failure
Ky, B., French, B. C., McCloskey, K., Rame, J. E., McIntosh, E. E., Shahi, P., Dries, D. L., Tang, W. H. W., Wu, A. H. B., Fang, J. C.-T., et al. (2010) · Circulation Heart Failure · doi:10.1161/circheartfailure.110.958223 · Cited by 376 · see citing works
Contribution of 30 Biomarkers to 10-Year Cardiovascular Risk Estimation in 2 Population Cohorts
Blankenberg, S., Zeller, T., Saarela, O., Havulinna, A. S., Kee, F., Tunstall‐Pedoe, H., Kuulasmaa, K., Yarnell, J., Schnabel, R. B., Wild, P. S., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.901413 · Cited by 366 · see citing works
Seki, K., Sanada, S., Kudinova, A. Y., Steinhauser, M. L., Handa, V., Gannon, J., & Lee, R. T. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.873240 · Cited by 364 · see citing works
The search for new cardiovascular biomarkers
Gerszten, R. E., & Wang, T. J. (2008) · Nature · doi:10.1038/nature06802 · Cited by 358 · see citing works
Serial Measurement of Growth-Differentiation Factor-15 in Heart Failure
Anand, I. S., Kempf, T., Rector, T. S., Tapken, H., Allhoff, T., Jantzen, F., Kuskowski, M. A., Cohn, J. N., Drexler, H., & Wollert, K. C. (2010) · Circulation · doi:10.1161/circulationaha.109.928846 · Cited by 321 · see citing works
Sabatine, M. S., Morrow, D. A., Higgins, L., MacGillivray, C., Guo, W., Bode, C., Rifai, N., Cannon, C. P., Gerszten, R. E., & Lee, R. T. (2008) · Circulation · doi:10.1161/circulationaha.107.728022 · Cited by 315 · see citing works
Assessing the Role of Circulating, Genetic, and Imaging Biomarkers in Cardiovascular Risk Prediction
Wang, T. J. (2011) · Circulation · doi:10.1161/circulationaha.109.912568 · Cited by 295 · see citing works
Ultrasensitive Flow-based Immunoassays Using Single-Molecule Counting
Todd, J., Freese, B., Lu, A., Held, D., Morey, J., Livingston, R., & Goix, P. J. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2007.091181 · Cited by 289 · see citing works
Kempf, T., Horn-Wichmann, R., Brabant, G. E., Peter, T., Allhoff, T., Klein, G. G., Drexler, H., Johnston, N., Wallentin, L. C., & Wollert, K. C. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2006.076828 · Cited by 286 · see citing works
Brown, D. A., Breit, S. N., Buring, J. E., Fairlie, W. D., Bauskin, A. R., Liu, T., & Ridker, P. M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09093-1 · Cited by 258 · see citing works
Daniels, L. B., Clopton, P., Laughlin, G. A., Maisel, A. S., & Barrett-Connor, E. L. (2011) · Circulation · doi:10.1161/circulationaha.110.979740 · Cited by 248 · see citing works
Lind, L., Wallentin, L. C., Kempf, T., Tapken, H., Quint, A., Lindahl, B., Olofsson, S., Venge, P., Larsson, A. O., Hulthe, J., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp261 · Cited by 244 · see citing works
Dieplinger, B., Januzzi, J. L., Steinmair, M., Gabriel, C., Poelz, W., Haltmayer, M., & Mueller, T. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.08.010 · Cited by 240 · see citing works
Kempf, T., Björklund, E., Olofsson, S., Lindahl, B., Allhoff, T., Peter, T., Tongers, J., Wollert, K. C., & Wallentin, L. C. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm465 · Cited by 227 · see citing works
Schlittenhardt, D., Schober, A., Strelau, J., Bonaterra, G. A., Schmiedt, W., Unsicker, K., Metz, J., & Kinscherf, R. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0986-3 · Cited by 224 · see citing works
de Jager, S. C. A., Bermúdez, B., Bot, I., Koenen, R. R., Bot, M., Kavelaars, A., de Waard, V., Heijnen, C. J., Muriana, F. J. G., Weber, C., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20100370 · Cited by 222 · see citing works
Serial Sampling of ST2 Predicts 90-Day Mortality Following Destabilized Heart Failure
Boisot, S., Beede, J., Isakson, S. R., Chiu, A., Clopton, P., Januzzi, J. L., Maisel, A. S., & Fitzgerald, R. L. (2008) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2008.06.415 · Cited by 210 · see citing works
Ding, Q., Mráček, T., González‐Muniesa, P., Kos, K., Wilding, J. P. H., Trayhurn, P., & Chen, B. (2008) · Endocrinology · doi:10.1210/en.2008-0952 · Cited by 193 · see citing works
IL-33 Reduces Macrophage Foam Cell Formation
McLaren, J. E., Michael, D. R., Salter, R. C., Ashlin, T. G., Calder, C. J., Miller, A. M., Liew, F. Y., & Ramji, D. P. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000520 · Cited by 184 · see citing works
Gene Expression Pattern in Biomechanically Stretched Cardiomyocytes
Frank, D., Kühn, C., Brors, B., Hanselmann, C., Lüdde, M., Katus, H. A., & Frey, N. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.098046 · Cited by 181 · see citing works
U.S. Preventive Services Task Force* (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-7-200910060-00008 · Cited by 180 · see citing works
Release of cardiac troponin in acute coronary syndromes: ischemia or necrosis?
Wu, A. H. B., & Ford, L. (1999) · Clinica Chimica Acta · doi:10.1016/s0009-8981(99)00078-9 · Cited by 165 · see citing works
Novel biomarkers in cardiovascular disease: Update 2010
Hochholzer, W., Morrow, D. A., & Giugliano, R. P. (2010) · American Heart Journal · doi:10.1016/j.ahj.2010.06.010 · Cited by 155 · see citing works
Multimarker Approach for the Prediction of Heart Failure Incidence in the Community
Velagaleti, R. S., Gona, P. N., Larson, M. G., Wang, T. J., Levy, D. A., Benjamin, E. J., Selhub, J., Jacques, P. F., Meigs, J. B., Tofler, G. H., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.929661 · Cited by 147 · see citing works
Wu, A. H. B., Fukushima, N. H., Puskas, R., Todd, J., & Goix, P. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2006.073163 · Cited by 141 · see citing works
Kempf, T., Sinning, J., Guba‐Quint, A., Bickel, C., Sinning, C., Wild, P. S., Schnabel, R. B., Lubos, E., Rupprecht, H. J., Münzel, T. F., et al. (2009) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.108.824870 · Cited by 131 · see citing works
Antiangiogenic Activity of the MDM2 Antagonist Nutlin-3
Secchiero, P., Corallini, F., Gonelli, A., Dell’Eva, R., Vitale, M., Capitani, S., Albini, A., & Zauli, G. (2006) · Circulation Research · doi:10.1161/01.res.0000253975.76198.ff · Cited by 125 · see citing works
Multimarker Prediction of Coronary Heart Disease Risk
Kim, H. C., Greenland, P., Rossouw, J. E., Manson, J. E., Cochrane, B. B., Lasser, N. L., Limacher, M. C., Lloyd‐Jones, D. M., Margolis, K. L., & Robinson, J. G. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.12.047 · Cited by 112 · see citing works
Bermúdez, B., López, S., Pacheco, Y. M., Villar, J. R., Muriana, F. J. G., Hoheisel, J. D., Bauer, A. S., & Abia, R. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn082 · Cited by 84 · see citing works
Apple, F. S., Simpson, P. A., & Murakami, M. M. (2010) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2010.05.014 · Cited by 75 · see citing works
Sakhuja, R., Green, S., Oestreicher, E. M., Sluss, P. M., Lee-Lewandrowski, E., Lewandrowski, K. B., & Januzzi, J. L. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.074047 · Cited by 40 · see citing works
Significance of Circulating Troponins in Heart Failure
Wang, T. J. (2007) · Circulation · doi:10.1161/circulationaha.107.721845 · Cited by 36 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [29]Ky B French B McCloskey K Rame JE McIntosh E Shahi P Dries DL Tang WH Wu AH Fang JC Boxer R Sweitzer NK Levy WC Goldberg LR Jessup M Cappola TP High-sensitivity st2 for prediction of adverse outcomes in chronic heart failure Circ Heart Fail 2012 4 180 187 21178018 PMC3163169
Cited by
Sorted by citations
2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M. L., Bozkurt, B., Butler, J., Casey, D. E., Colvin, M. M., Drazner, M. H., Filippatos, G. S., Fonarow, G. C., Givertz, M. M., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.04.025 · Cited by 3,476 · see citing works
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Colvin, M. M., Drazner, M. H., Filippatos, G. S., Fonarow, G. C., Givertz, M. M., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000509 · Cited by 3,109 · see citing works
Regulation of erythropoiesis by hypoxia-inducible factors
Haase, V. H. (2013) · Blood Reviews · doi:10.1016/j.blre.2012.12.003 · Cited by 787 · see citing works
2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M. L., Bozkurt, B., Butler, J., Casey, D. E., Colvin, M. M., Drazner, M. H., Filippatos, G. S., Fonarow, G. C., Givertz, M. M., et al. (2017) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2017.04.014 · Cited by 769 · see citing works
Chow, S. L., Maisel, A. S., Anand, I. S., Bozkurt, B., de Boer, R. A., Felker, G. M., Fonarow, G. C., Greenberg, B., Januzzi, J. L., Kiernan, M. S., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000490 · Cited by 617 · see citing works
Growth Differentiation Factor 15 as a Biomarker in Cardiovascular Disease
Wollert, K. C., Kempf, T., & Wallentin, L. C. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2016.255174 · Cited by 569 · see citing works
Biomarkers and diagnostics in heart failure
Gaggin, H. K., & Januzzi, J. L. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.12.014 · Cited by 423 · see citing works
Emerging Risk Biomarkers in Cardiovascular Diseases and Disorders
Upadhyay, R. K. (2015) · Journal of Lipids · doi:10.1155/2015/971453 · Cited by 362 · see citing works
Willeit, P., Welsh, P. I., Evans, J. D. W., Tschiderer, L., Boachie, C., Jukema, J. W., Ford, I., Trompet, S., Stott, D. J., Kearney, P. M., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.05.062 · Cited by 298 · see citing works
Xanthakis, V., Enserro, D. M., Murabito, J. M., Polak, J. F., Wollert, K. C., Januzzi, J. L., Wang, T. J., Tofler, G., & Vasan, R. S. (2014) · Circulation · doi:10.1161/circulationaha.114.009273 · Cited by 287 · see citing works
Protein Biomarkers of Cardiovascular Disease and Mortality in the Community
Ho, J. E., Lyass, A., Courchesne, P. L., Chen, G., Liu, C., Yin, X., Hwang, S., Massaro, J. M., Larson, M. G., & Levy, D. A. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.008108 · Cited by 270 · see citing works
de Boer, R. A., Nayor, M. G., deFilippi, C. R., Enserro, D. M., Bhambhani, V., Kizer, J. R., Blaha, M. J., Brouwers, F. P. J., Cushman, M., Lima, J. A. C., et al. (2018) · JAMA Cardiology · doi:10.1001/jamacardio.2017.4987 · Cited by 264 · see citing works
GDF15: a hormone conveying somatic distress to the brain
Lockhart, S. M., Saudek, V., & O’Rahilly, S. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa007 · Cited by 256 · see citing works
Evaluating the Atrial Myopathy Underlying Atrial Fibrillation
Goldberger, J. J., Arora, R., Green, D., Greenland, P., Lee, D. C., Lloyd‐Jones, D. M., Markl, M., Ng, J., & Shah, S. J. (2015) · Circulation · doi:10.1161/circulationaha.115.016795 · Cited by 244 · see citing works
Cardiac troponin level elevations not related to acute coronary syndromes
Giannitsis, E., & Katus, H. A. (2013) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2013.129 · Cited by 243 · see citing works
A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging
Linders, A. N., Dias, I. B., López‐Fernández, T., Tocchetti, C. G., Bömer, N., & van der Meer, P. (2024) · npj Aging · doi:10.1038/s41514-024-00135-7 · Cited by 257 · see citing works
Gaggin, H. K., Szymonifka, J. D., Bhardwaj, A., Belcher, A. M., Berardinis, B. D., Motiwala, S. R., Wang, T. J., & Januzzi, J. L. (2014) · JACC Heart Failure · doi:10.1016/j.jchf.2013.10.005 · Cited by 234 · see citing works
Smith, J. G., & Gerszten, R. E. (2017) · Circulation · doi:10.1161/circulationaha.116.025446 · Cited by 209 · see citing works
Clinical and Prognostic Significance of sST2 in Heart Failure
Aimo, A., Januzzi, J. L., Bayés‐Genís, A., Vergaro, G., Sciarrone, P., Passino, C., & Emdin, M. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.08.1039 · Cited by 208 · see citing works
Coglianese, E. E., Larson, M. G., Vasan, R. S., Ho, J. E., Ghorbani, A., McCabe, E. L., Cheng, S. C., Fradley, M. G., Kretschman, D. M., Gao, W. D., et al. (2012) · Clinical Chemistry · doi:10.1373/clinchem.2012.192153 · Cited by 203 · see citing works
State of the Art: Newer Biomarkers in Heart Failure
de Boer, R. A., Daniels, L. B., Maisel, A. S., & Januzzi, J. L. (2015) · European Journal of Heart Failure · doi:10.1002/ejhf.273 · Cited by 189 · see citing works
Meijers, W. C., Bayés‐Genís, A., Mebazaa, A., Bauersachs, J. K., Cleland, J. G. F., Coats, A. J. S., Januzzi, J. L., Maisel, A. S., McDonald, K., Mueller, T., et al. (2021) · European Journal of Heart Failure · doi:10.1002/ejhf.2346 · Cited by 194 · see citing works
Cardiovascular Risk Factors Are Associated With Future Cancer
Lau, E. S., Paniagua, S. M., Liu, E. E., Jovani, M., Li, S. X., Takvorian, K. S., Suthahar, N., Cheng, S. C., Splansky, G. L., Januzzi, J. L., et al. (2021) · JACC CardioOncology · doi:10.1016/j.jaccao.2020.12.003 · Cited by 185 · see citing works
A Sensitive Aβ Oligomer Assay Discriminates Alzheimer's and Aged Control Cerebrospinal Fluid
Savage, M. J., Kalinina, J., Wolfe, A. L., Tugusheva, K., Korn, R., Cash-Mason, T., Maxwell, J. W., Hatcher, N. G., Haugabook, S. J., Wu, G., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1675-13.2014 · Cited by 183 · see citing works
Increasingly Sensitive Assays for Cardiac Troponins
de Lemos, J. A. (2013) · JAMA · doi:10.1001/jama.2013.5809 · Cited by 175 · see citing works
Temporal shifts in clinical presentation and underlying mechanisms of atherosclerotic disease
Pasterkamp, G., den Ruijter, H. M., & Libby, P. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.166 · Cited by 168 · see citing works
Emmerson, P. J., Duffin, K. L., Chintharlapalli, S. R., & Wu, X. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01712 · Cited by 168 · see citing works
Plasma proteomic profiles predict individual future health risk
You, J., Guo, Y., Zhang, Y., Kang, J., Wang, L., Feng, J., Cheng, W., & Yu, J. (2023) · Nature Communications · doi:10.1038/s41467-023-43575-7 · Cited by 157 · see citing works
Novel Risk Markers and Risk Assessments for Cardiovascular Disease
Thomas, M. R., & Lip, G. Y. H. (2017) · Circulation Research · doi:10.1161/circresaha.116.309955 · Cited by 154 · see citing works
Dieplinger, B., & Mueller, T. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.09.021 · Cited by 152 · see citing works
GDF15 and Cardiac Cells: Current Concepts and New Insights
Rochette, L., Dogon, G., Zeller, M., Cottin, Y., & Vergely, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168889 · Cited by 154 · see citing works
Novel biomarkers of cardiovascular disease: Applications in clinical practice
Lyngbakken, M. N., Myhre, P. L., Røsjø, H. R., & Omland, T. (2018) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2018.1525335 · Cited by 143 · see citing works
McEvoy, J. W., Chen, Y., Ndumele, C. E., Solomon, S. D., Nambi, V., Ballantyne, C. M., Blumenthal, R. S., Coresh, J., & Selvin, E. (2016) · JAMA Cardiology · doi:10.1001/jamacardio.2016.0765 · Cited by 139 · see citing works
Prevalence, Neurohormonal Correlates, and Prognosis of Heart Failure Stages in the Community
Xanthakis, V., Enserro, D. M., Larson, M. G., Wollert, K. C., Januzzi, J. L., Levy, D. A., Aragam, J. R., Benjamin, E. J., Cheng, S. C., Wang, T. J., et al. (2016) · JACC Heart Failure · doi:10.1016/j.jchf.2016.05.001 · Cited by 135 · see citing works
GDF-15 for Prognostication of Cardiovascular and Cancer Morbidity and Mortality in Men
Wallentin, L. C., Zethelius, B., Berglund, L., Eggers, K. M., Lind, L., Lindahl, B., Wollert, K. C., & Siegbahn, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078797 · Cited by 132 · see citing works
Antibody‐based proteomics and biomarker research—Current status and limitations
Solier, C., & Langen, H. (2014) · PROTEOMICS · doi:10.1002/pmic.201300334 · Cited by 131 · see citing works
Everett, B. M., Zeller, T., Glynn, R. J., Ridker, P. M., & Blankenberg, S. (2015) · Circulation · doi:10.1161/circulationaha.114.014522 · Cited by 131 · see citing works
Biomarkers for heart failure: small molecules with high clinical relevance
Magnussen, C., & Blankenberg, S. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12756 · Cited by 130 · see citing works
Growth Differentiation Factor 15 in Heart Failure: An Update
Wollert, K. C., & Kempf, T. (2012) · Current Heart Failure Reports · doi:10.1007/s11897-012-0113-9 · Cited by 128 · see citing works
GDF-15, Galectin 3, Soluble ST2, and Risk of Mortality and Cardiovascular Events in CKD
Tuegel, C., Katz, R., Alam, M., Bhat, Z. Y., Bellovich, K. A., de Boer, I. H., Brosius, F. C., Gadegbeku, C. A., Gipson, D. S., Hawkins, J. J., et al. (2018) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2018.03.025 · Cited by 128 · see citing works
Biomarkers in heart failure: the past, current and future
Michael, S., Wang, Y., Wei, J., Huang, Y., Li, M., Li, L., Acheampong, E., Zhou, Z., Xiaoyan, Q., Xu, Y., et al. (2019) · Heart Failure Reviews · doi:10.1007/s10741-019-09807-z · Cited by 128 · see citing works
Circulating Proteins as Predictors of Incident Heart Failure in the Elderly
Stenemo, M., Nowak, C., Byberg, L., Sundström, J., Giedraitis, V., Lind, L., Ingelsson, E., Fall, T., & Ärnlöv, J. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.980 · Cited by 127 · see citing works
Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling
Ho, J. E., Chen, W., Chen, M., Larson, M. G., McCabe, E. L., Cheng, S. C., Ghorbani, A., Coglianese, E. E., Emilsson, V., Johnson, A. D., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67119 · Cited by 124 · see citing works
Segar, M. W., Jaeger, B. C., Patel, K. V., Nambi, V., Ndumele, C. E., Correa, A., Butler, J., Chandra, A., Ayers, C. R., Rao, S. G., et al. (2021) · Circulation · doi:10.1161/circulationaha.120.053134 · Cited by 124 · see citing works
Dieplinger, B., Egger, M., Haltmayer, M., Kleber, M. E., Scharnagl, H., Silbernagel, G., de Boer, R. A., Maerz, W., & Mueller, T. (2014) · Clinical Chemistry · doi:10.1373/clinchem.2013.209858 · Cited by 117 · see citing works
Biomarkers of Cardiovascular Stress and Incident Chronic Kidney Disease
Ho, J. E., Hwang, S., Wollert, K. C., Larson, M. G., Cheng, S. C., Kempf, T., Vasan, R. S., Januzzi, J. L., Wang, T. J., & Fox, C. S. (2013) · Clinical Chemistry · doi:10.1373/clinchem.2013.205716 · Cited by 113 · see citing works
Lindman, B. R., Breyley, J. G., Schilling, J. D., Vatterott, A. M., Zajarias, A., Maniar, H. S., Damiano, R. J., Moon, M. R., Lawton, J. S., Gage, B. F., et al. (2015) · Heart · doi:10.1136/heartjnl-2015-307742 · Cited by 114 · see citing works
Eggers, K. M., Kempf, T., Wallentin, L. C., Wollert, K. C., & Lind, L. (2013) · Clinical Chemistry · doi:10.1373/clinchem.2012.201210 · Cited by 113 · see citing works
Cardiac Biomarkers: What Is and What Can Be
Jacob, R. T., & Khan, M. (2018) · Indian Journal of Cardiovascular Disease in Women · doi:10.1055/s-0039-1679104 · Cited by 113 · see citing works
Charting a Roadmap for Heart Failure Biomarker Studies
Ahmad, T., Fiuzat, M., Pencina, M. J., Geller, N. L., Zannad, F. M., Cleland, J. G. F., Snider, J., Blankenberg, S., Adams, K. F., Redberg, R. F., et al. (2014) · JACC Heart Failure · doi:10.1016/j.jchf.2014.02.005 · Cited by 110 · see citing works
GDF 15 - A Novel Biomarker in the Offing for Heart Failure
George, M., Jena, A., Srivatsan, V., Rajaram, M., & Dhandapani, V. E. (2016) · Current Cardiology Reviews · doi:10.2174/1573403x12666160111125304 · Cited by 109 · see citing works
Omland, T., de Lemos, J. A., Holmen, O. L., Dalen, H., Benth, J. Š., Nygård, S., Hveem, K., & Røsjø, H. R. (2015) · Clinical Chemistry · doi:10.1373/clinchem.2014.234369 · Cited by 111 · see citing works
Lax, A., Sánchez‐Más, J., Lopez, M., Palacio, M. J. F., Caballero, L., Garrido, I. P., Pastor‐Pérez, F. J., Januzzi, J. L., & Pascual-Figal, D. A. (2014) · JACC Heart Failure · doi:10.1016/j.jchf.2014.07.015 · Cited by 107 · see citing works
Multimodality Strategy for Cardiovascular Risk Assessment
de Lemos, J. A., Ayers, C. R., Levine, B. D., deFilippi, C. R., Wang, T. J., Hundley, W. G., Berry, J. D., Seliger, S. L., McGuire, D. K., Ouyang, P., et al. (2017) · Circulation · doi:10.1161/circulationaha.117.027272 · Cited by 105 · see citing works
Up-Date on Diabetic Nephropathy
Pelle, M. C., Provenzano, M., Busutti, M., Porcu, C. V., Zaffina, I., Stanga, L., & Arturi, F. (2022) · Life · doi:10.3390/life12081202 · Cited by 110 · see citing works
Growth differentiation factor 15: A novel biomarker with high clinical potential
Desmedt, S., Desmedt, V., Vos, L. D., Delanghe, J., Speeckaert, R., & Speeckaert, M. M. (2019) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2019.1615034 · Cited by 104 · see citing works
Mechanistic Biomarkers Informative of Both Cancer and Cardiovascular Disease
Narayan, V., Thompson, E. W., Demissei, B. G., Ho, J. E., Januzzi, J. L., & Ky, B. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.03.067 · Cited by 104 · see citing works
Soluble ST2—Analytical Considerations
Mueller, T., & Jaffe, A. S. (2015) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2015.01.035 · Cited by 103 · see citing works
Fernández‐Ortíz, A., Jiménez‐Borreguero, L. J., Peñalvo, J. L., Ordovás, J. M., Mocoroa, A., Fernández‐Friera, L., Laclaustra, M., García, L., Molina, J., Mendiguren, J. M., et al. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.08.024 · Cited by 102 · see citing works
Rienstra, M., Yin, X., Larson, M. G., Fontes, J. D., Magnani, J. W., McManus, D. D., McCabe, E. L., Coglianese, E. E., Amponsah, M., Ho, J. E., et al. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.10.003 · Cited by 101 · see citing works
Sex-Related Differences in Contemporary Biomarkers for Heart Failure: A Review
Suthahar, N., Meems, L. M. G., Ho, J. E., & de Boer, R. A. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1771 · Cited by 99 · see citing works
Hara, A., Niwa, M., Kanayama, T., Noguchi, K., Niwa, A., Matsuo, M., Kuroda, T., Hatano, Y., Okada, H., & Tomita, H. (2020) · Biomolecules · doi:10.3390/biom10091277 · Cited by 99 · see citing works
Lok, D. J. A., Klip, I. T., Lok, S. I., de la Porte, P. W. B., Badings, E., van Wijngaarden, J., Voors, A. A., de Boer, R. A., van Veldhuisen, D. J., & van der Meer, P. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.05.013 · Cited by 98 · see citing works
Demyanets, S., Speidl, W. S., Tentzeris, I., Járai, R., Katsaros, K. M., Farhan, S., Krychtiuk, K. A., Wonnerth, A., Weiss, T. W., Huber, K., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095055 · Cited by 96 · see citing works
Population Risk Prediction Models for Incident Heart Failure
Echouffo-Tcheugui, J. B., Greene, S. J., Papadimitriou, L., Zannad, F. M., Yancy, C. W., Gheorghiade, M., & Butler, J. (2015) · Circulation Heart Failure · doi:10.1161/circheartfailure.114.001896 · Cited by 96 · see citing works
Parikh, R. H., Seliger, S. L., Christenson, R. H., Gottdiener, J. S., Psaty, B. M., & deFilippi, C. R. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.003188 · Cited by 95 · see citing works
Proteomic Bioprofiles and Mechanistic Pathways of Progression to Heart Failure
Ferreira, J. P., Verdonschot, J. A. J., Collier, T. J., Wang, P., Pizard, A., Bär, C., Björkman, J., Boccanelli, A., Butler, J., Clark, A. L., et al. (2019) · Circulation Heart Failure · doi:10.1161/circheartfailure.118.005897 · Cited by 93 · see citing works
Sze, J., Mooney, J. F., Barzi, F., Hillis, G. S., & Chow, C. K. (2015) · Heart Lung and Circulation · doi:10.1016/j.hlc.2015.09.001 · Cited by 92 · see citing works
Clerico, A., Zaninotto, M., Ripoli, A., Masotti, S., Prontera, C., Passino, C., & Plebani, M. (2017) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2016-0933 · Cited by 91 · see citing works
ST2 as a Cardiovascular Risk Biomarker: From the Bench to the Bedside
Januzzi, J. L. (2013) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-013-9459-y · Cited by 91 · see citing works
Gahlot, S., Dappozze, F., Mishra, S., & Guillard, C. (2021) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2021.105587 · Cited by 89 · see citing works
The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality
Sanders, J. L., Putman, R. K., Dupuis, J., Xu, H., Murabito, J. M., Araki, T., Nishino, M., Benjamin, E. J., Levy, D., Ramachandran, V. S., et al. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202007-2993oc · Cited by 84 · see citing works
Profiling of the plasma proteome across different stages of human heart failure
Egerstedt, A., Berntsson, J., Smith, M. L., Gidlöf, O., Nilsson, R., Benson, M. D., Wells, Q. S., Celik, S., Lejonberg, C., Farrell, L. A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13306-y · Cited by 88 · see citing works
He, H., Li, R., Choi, S., Zhou, L., Pavel, A. B., Estrada, Y. D., Krueger, J. G., & Guttman‐Yassky, E. (2019) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2019.10.013 · Cited by 87 · see citing works
van der Linden, N., Klinkenberg, L. J. J., Bekers, O., van Loon, L. J. C., van Dieijen‐Visser, M. P., Zeegers, M. P., & Meex, S. J. R. (2016) · Medicine · doi:10.1097/md.0000000000005703 · Cited by 86 · see citing works
Holmgren, G., Synnergren, J., Bogestål, Y. R., Améen, C., Åkesson, K., Holmgren, S., Lindahl, A. H., & Sartipy, P. (2014) · Toxicology · doi:10.1016/j.tox.2014.12.018 · Cited by 86 · see citing works
Zeisbrich, M., Becker, N., Benner, A., Radujkovic, A., Schmitt, K., Beimler, J., Ho, A. D., Zeier, M., Dreger, P., & Luft, T. (2017) · Bone Marrow Transplantation · doi:10.1038/bmt.2017.119 · Cited by 85 · see citing works
Discovery of New Risk Markers for Ischemic Stroke Using a Novel Targeted Proteomics Chip
Lind, L., Siegbahn, A., Lindahl, B., Stenemo, M., Sundström, J., & Ärnlöv, J. (2015) · Stroke · doi:10.1161/strokeaha.115.010829 · Cited by 84 · see citing works
Biomarkers of aging in frailty and age-associated disorders: State of the art and future perspective
Salvioli, S., Basile, M. S., Bencivenga, L., Carrino, S., Conte, M., Damanti, S., LORENZO, R. D., Fiorenzato, E., Gialluisi, A., Ingannato, A., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102044 · Cited by 85 · see citing works
Bansal, N., Zelnick, L. R., Go, A. S., Anderson, A. H., Christenson, R. H., Deo, R., deFilippi, C. R., Lash, J. P., He, J., Ky, B., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012336 · Cited by 80 · see citing works
Secemsky, E. A., Scherzer, R., Nitta, E. M., Wu, A. H. B., Lange, D. C., Deeks, S. G., Martin, J. N., Snider, J., Ganz, P., & Hsue, P. Y. (2015) · JACC Heart Failure · doi:10.1016/j.jchf.2015.03.007 · Cited by 80 · see citing works
Positioning of Inflammatory Biomarkers in the Heart Failure Landscape
Hartupee, J. C., & Mann, D. L. (2013) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-013-9467-y · Cited by 80 · see citing works
di Candia, A. M., de Avila, D. X., Moreira, G. R., Villacorta, H., & Maisel, A. S. (2021) · American Heart Journal Plus: Cardiology Research and Practice · doi:10.1016/j.ahjo.2021.100046 · Cited by 79 · see citing works
Andersson, C., Preis, S. R., Beiser, A., DeCarli, C. S., Wollert, K. C., Wang, T. J., Januzzi, J. L., Vasan, R. S., & Seshadri, S. S. (2015) · Stroke · doi:10.1161/strokeaha.115.009026 · Cited by 78 · see citing works
High-Sensitivity Cardiac Troponin and New-Onset Heart Failure
Evans, J. D. W., Dobbin, S. J. H., Pettit, S., Angelantonio, E. D., & Willeit, P. (2018) · JACC Heart Failure · doi:10.1016/j.jchf.2017.11.003 · Cited by 79 · see citing works
Shah, A. M., Myhre, P. L., Arthur, V., Dorbala, P., Rasheed, H., Buckley, L. F., Claggett, B. L., Liu, G., Ma, J., Nguyen, N. Q., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44680-3 · Cited by 81 · see citing works
Sahle, B. W., Owen, A. J., Chin, K. L., & Reid, C. M. (2017) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2017.03.005 · Cited by 77 · see citing works
Andersson, C., Enserro, D. M., SULLIVAN, L. M., Wang, T. J., Januzzi, J. L., Benjamin, E. J., Vita, J. A., Hamburg, N. M., Larson, M. G., Mitchell, G. F., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.02.013 · Cited by 75 · see citing works
Xanthakis, V., Larson, M. G., Wollert, K. C., Aragam, J. R., Cheng, S. C., Ho, J. E., Coglianese, E. E., Levy, D. A., Colucci, W. S., Felker, G. M., et al. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000399 · Cited by 75 · see citing works
Using ST2 in Cardiovascular Patients: A Review
Daniels, L. B., & Bayés‐Genís, A. (2014) · Future Cardiology · doi:10.2217/fca.14.36 · Cited by 74 · see citing works
Soluble ST2 and Galectin-3 and Progression of CKD
Alam, M., Katz, R., Bellovich, K. A., Bhat, Z. Y., Brosius, F. C., de Boer, I. H., Gadegbeku, C. A., Gipson, D. S., Hawkins, J. J., Himmelfarb, J., et al. (2018) · Kidney International Reports · doi:10.1016/j.ekir.2018.09.013 · Cited by 73 · see citing works
Neumann, F., Havulinna, A. S., Zeller, T., Appelbaum, S., Kunnas, T. A., Nikkari, S. T., Jousilahti, P., Blankenberg, S., Sydow, K., & Salomaa, V. V. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090063 · Cited by 72 · see citing works
Zile, M. R., & Baicu, C. F. (2013) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-013-9472-1 · Cited by 71 · see citing works
Cardiac and Kidney Markers for Cardiovascular Prediction in Individuals With Chronic Kidney Disease
Matsushita, K., Sang, Y., Ballew, S. H., Astor, B. C., Hoogeveen, R. C., Solomon, S. D., Ballantyne, C. M., Woodward, M., & Coresh, J. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303465 · Cited by 71 · see citing works
Carlsson, A. C., Nowak, C., Lind, L., Östgren, C. J., Nyström, F. H., Sundström, J., Carrero, J. J., Risérus, U., Ingelsson, E., Fall, T., et al. (2019) · Upsala Journal of Medical Sciences · doi:10.1080/03009734.2019.1696430 · Cited by 70 · see citing works
Constituents of fine particulate matter and asthma in 6 low- and middle-income countries
Wang, X., Guo, Y., Cai, M., Qian, Z. M., Zhang, S., Zhang, Z., Yang, Y., Vaughn, M. G., Aaron, H. E., Wu, F., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.12.779 · Cited by 70 · see citing works
Welsh, P. I., Kimenai, D. M., Marioni, R. E., Hayward, C., Campbell, A. I., Porteous, D. J., Mills, N. L., O’Rahilly, S., & Sattar, N. A. (2022) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2022-0135 · Cited by 68 · see citing works
Alcázar, J., Frandsen, U., Prokhorova, T. A., Kamper, R. S., Haddock, B., Aagaard, P., & Suetta, C. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12823 · Cited by 67 · see citing works
The clinical impact of growth differentiation factor-15 in heart disease: A 2019 update
Arkoumani, M., Papadopoulou-Marketou, N., Nicolaides, N. C., Kanaka-Gantenbein, C., Tentolouris, N., & Papassotiriou, I. (2020) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2019.1678565 · Cited by 64 · see citing works
Clerico, A., Zaninotto, M., Padoan, A., Masotti, S., Musetti, V., Prontera, C., Ndreu, R., Zucchelli, G., Passino, C., Migliardi, M., et al. (2019) · Advances in clinical chemistry · doi:10.1016/bs.acc.2019.07.005 · Cited by 64 · see citing works
- Authors
- Wang, T. J., Wollert, K. C., Larson, M. G., Coglianese, E., McCabe, E. L., Cheng, S., Ho, J. E., Fradley, M. G., Ghorbani, A., Xanthakis, V., Kempf, T., Benjamin, E. J., Levy, D., Vasan, R. S., & Januzzi, J. L.
- Affiliations
- Boston University (US)
- ORCID
- Venue
- Circulation
- Published
- 2012-09-25
- Volume
- 126
- Issue
- 13
- Pages
- 1596-1604
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC3656719
- OpenAlex
- W2163917890
- Cited by
- 482
- References
- 65
- Citations by year
- 2026: 16 · 2025: 16 · 2024: 29 · 2023: 33 · 2022: 25 · 2021: 32 · 2020: 40 · 2019: 42 · 2018: 31 · 2017: 42 · 2016: 45 · 2015: 38 · 2014: 44 · 2013: 43 · 2012: 6
- FWCI
- 32.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1)
- National Heart, Lung, and Blood Institute (R01HL086875, N01‐HC25195, K99HL107642, R01-HL-08675, N01-HC-025195)
- Topics
- Health Sciences › Medicine › Rheumatology › GDF15 and Related Biomarkers
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- soluble ST2, growth differentiation factor 15, high-sensitivity troponin I, cardiovascular mortality, heart failure, major cardiovascular events, brain natriuretic peptide, C-reactive protein, prognostic value, Framingham Heart Study
- MeSH terms
- Interleukin-1 Receptor-Like 1 Protein, Aged, C-Reactive Protein, Cardiovascular Diseases, Follow-Up Studies, Heart Failure, Humans, Male, Middle Aged, Prognosis, Receptors, Cell Surface, Retrospective Studies, Risk Factors, Biomarkers, Proportional Hazards Models, Troponin I, Natriuretic Peptide, Brain, Growth Differentiation Factor 15
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
