Cited by 222Acute Myocardial Infarction ResearchCardiac Imaging and DiagnosticsBiomarkers in Disease Mechanisms

High-sensitivity assays for troponin in patients with cardiac disease

Westermann, Dirk, Neumann, Johannes Tobias, Sörensen, Nils Arne, Blankenberg, Stefan·2017·Nature Reviews Cardiology

Abstract

Troponin is a widely used biomarker in patients with cardiac disease. The use of troponin is well established in patients with suspected acute myocardial infarction (AMI), but troponin measurement is also used in other acute and nonacute settings. In patients with suspected AMI, early decision-making is crucial to allow rapid treatment and further diagnostic evaluation. Current guidelines recommend serial measurements of troponin with a cut-off concentration at the 99th percentile to triage patients in the emergency department. Newer, high-sensitivity assays for troponin enable the detection of distinctly lower concentrations. Using these assays and very low cut-off concentrations, several rapid diagnostic strategies have been reported to improve diagnosis in acute cardiac care. Furthermore, noncoronary and nonacute applications of troponin assays - for example as a biomarker in patients with heart failure, pulmonary embolism, or stable coronary artery disease - are on the horizon and might improve individual risk stratification. In this Review, we provide an overview on the development of high-sensitivity assays for troponin, and their application in patients with cardiac disease.

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Crossref · 10.1038/nrcardio.2017.48

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Authors
Westermann, D., Neumann, J. T., Sörensen, N. A., & Blankenberg, S.
Affiliations
Universität Hamburg (DE)
Corresponding author
Westermann, Dirk
Venue
Nature Reviews Cardiology
Published
2017-04-06
Volume
14
Issue
8
Pages
472-483
ISSN
  • 1759-5002 (ISSN-L)
  • 1759-5010
OpenAlex
W2605091795
Cited by
222
References
155
Citations by year
2026: 16 · 2025: 24 · 2024: 31 · 2023: 30 · 2022: 18 · 2021: 18 · 2020: 35 · 2019: 18 · 2018: 18 · 2017: 13
FWCI
3.26
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
  • Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Keywords
high-sensitivity troponin assays, troponin, cardiac biomarkers, acute myocardial infarction diagnosis, myocardial injury, serial troponin measurement, emergency department triage, heart failure, pulmonary embolism, stable coronary artery disease, risk stratification
MeSH terms
Blood Chemical Analysis, Heart Diseases, Humans, Myocardial Infarction, Sensitivity and Specificity, Troponin, Biomarkers

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