Cited by 1,018Atrial Fibrillation Management and OutcomesCardiovascular and Diving-Related ComplicationsAcute Ischemic Stroke Management

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Percutaneous Left Atrial Appendage Closure vs Warfarin for Atrial Fibrillation: A Randomized Clinical Trial

Reddy, Vivek Y., Sievert, Horst, Halperin, Jonathan, Doshi, Shephal K., Buchbinder, Maurice, Neuzil, Petr, Huber, Kenneth, Whisenant, Brian, Kar, Saibal, Swarup, Vijay, Gordon, Nicole, Holmes, David·2014·JAMA

DOI 10.1001/jama.2014.15192

Open this paper in CoChat — free account

Abstract

IMPORTANCE: While effective in preventing stroke in patients with atrial fibrillation (AF), warfarin is limited by a narrow therapeutic profile, a need for lifelong coagulation monitoring, and multiple drug and diet interactions. OBJECTIVE: To determine whether a local strategy of mechanical left atrial appendage (LAA) closure was noninferior to warfarin. DESIGN, SETTING, AND PARTICIPANTS: PROTECT AF was a multicenter, randomized (2:1), unblinded, Bayesian-designed study conducted at 59 hospitals of 707 patients with nonvalvular AF and at least 1 additional stroke risk factor (CHADS2 score ≥1). Enrollment occurred between February 2005 and June 2008 and included 4-year follow-up through October 2012. Noninferiority required a posterior probability greater than 97.5% and superiority a probability of 95% or greater; the noninferiority margin was a rate ratio of 2.0 comparing event rates between treatment groups. INTERVENTIONS: Left atrial appendage closure with the device (n = 463) or warfarin (n = 244; target international normalized ratio, 2-3). MAIN OUTCOMES AND MEASURES: A composite efficacy end point including stroke, systemic embolism, and cardiovascular/unexplained death, analyzed by intention-to-treat. RESULTS: At a mean (SD) follow-up of 3.8 (1.7) years (2621 patient-years), there were 39 events among 463 patients (8.4%) in the device group for a primary event rate of 2.3 events per 100 patient-years, compared with 34 events among 244 patients (13.9%) for a primary event rate of 3.8 events per 100 patient-years with warfarin (rate ratio, 0.60; 95% credible interval, 0.41-1.05), meeting prespecified criteria for both noninferiority (posterior probability, >99.9%) and superiority (posterior probability, 96.0%). Patients in the device group demonstrated lower rates of both cardiovascular mortality (1.0 events per 100 patient-years for the device group [17/463 patients, 3.7%] vs 2.4 events per 100 patient-years with warfarin [22/244 patients, 9.0%]; hazard ratio [HR], 0.40; 95% CI, 0.21-0.75; P = .005) and all-cause mortality (3.2 events per 100 patient-years for the device group [57/466 patients, 12.3%] vs 4.8 events per 100 patient-years with warfarin [44/244 patients, 18.0%]; HR, 0.66; 95% CI, 0.45-0.98; P = .04). CONCLUSIONS AND RELEVANCE: After 3.8 years of follow-up among patients with nonvalvular AF at elevated risk for stroke, percutaneous LAA closure met criteria for both noninferiority and superiority, compared with warfarin, for preventing the combined outcome of stroke, systemic embolism, and cardiovascular death, as well as superiority for cardiovascular and all-cause mortality. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00129545.

Integrity signals

Registry

Crossref · 10.1001/jama.2014.15192

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Bayesian Data Analysis
Gelman, A., Carlin, J. B., Stern, H. S., & Rubin, D. B. (2003) · doi:10.1201/9780429258480 · Cited by 27,276
Dabigatran versus warfarin in patients with atrial fibrillation
Connolly, S. J., Ezekowitz, M. D., Yusuf, S., Eikelboom, J., Oldgren, J., Parekh, A., Pogue, J., Reilly, P. A., Themeles, E., Varrone, J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0905561 · Cited by 11,215
Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
Patel, M. R., Mahaffey, K. W., Garg, J., Pan, G., Singer, D. E., Hacke, W., Breithardt, G., Halperin, J. L., Hankey, G. J., Piccini, J. P., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1009638 · Cited by 9,430
Self-citation
Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation
Hart, R. G., Pearce, L. A., & Aguilar, M. I. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-12-200706190-00007 · Cited by 4,793 · cited 2×
“Carl Jacobs (Piedmont Hospital, Atlanta [2]); Rajesh Dave (Harrisburg Hospital, Harrisburg, Pennsylvania [1]); John Young (Lindner Clinical Trial Center, Cincinnati, Ohio [1]); David Lasorda (Allegheny General Hospital, Pittsburgh [1]).”
Background
Apixaban in patients with atrial fibrillation
Connolly, S. J., Eikelboom, J., Joyner, C., Diener, H.-C., Hart, R., Golitsyn, S., Flaker, G., Avezum, A., Hohnloser, S. H., Diaz, R., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1007432 · Cited by 2,483
Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial
Holmes, D. R., Reddy, V. Y., Turi, Z. G., Doshi, S. K., Sievert, H., Buchbinder, M., Mullin, C. M., & Sick, P. B. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61343-x · Cited by 2,242
Self-citation
Effect of clopidogrel added to aspirin in patients with atrial fibrillation
The ACTIVE Investigators (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0901301 · Cited by 2,102
A Method to Determine the Optimal Intensity of Oral Anticoagulant Therapy
Rosendaal, F. R., Cannegieter, S. C., van der Meer, F. J. M., & Briët, E. (1993) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1651587 · Cited by 2,070
HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Personnel, Policy, Procedures and Follow-Up
Calkins, H. G., Brugada, J., Packer, D. L., Cappato, R., Chen, S., Crijns, H. J. G. M., Damiano, R. J., Davies, D. W., Haines, D. E., Haı̈ssaguerre, M., et al. (2007) · Heart Rhythm · doi:10.1016/j.hrthm.2007.04.005 · Cited by 1,690
Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation
Blackshear, J. L., & Odell, J. A. (1996) · The Annals of Thoracic Surgery · doi:10.1016/0003-4975(95)00887-x · Cited by 1,686 · cited 3×
“Turi (Cooper Hospital, Camden, New Jersey [4]); Bryan Raybuck (INOVA Research Center, Falls Church, Virginia [3]); Ron Waksman, Horst Sievert (Washington Hospital Center, Washington, DC [4]); Steven Kalbfleisch (Ohio State University, Columbus [3]); Michael Mooney (Abbott Northwestern Hospital, Minneapolis [3]); Willi…”
Background

Flagged first, then by citations

Show all 25 references

Sorted by citations

Items 201–300 of 1,000

Anticoagulation in Heart Failure: a Review.
Zeitler, E. P., & Eapen, Z. J. (2015) · Europe PMC (PubMed Central) · doi:10.4022/jafib.1250 · Cited by 28
Thromboembolism in the Absence of Atrial Fibrillation
Smietana, J. J., Plitt, A., & Halperin, J. L. (2019) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2019.04.027 · Cited by 26
Self-citation
Atrial fibrillation and chronic kidney disease conundrum: an update
Tapoi, L. C., Ureche, C., Sascău, R. A., Bădărau, S., & Covic, A. C. (2019) · Journal of Nephrology · doi:10.1007/s40620-019-00630-1 · Cited by 29
Left atrial enlargement and clinical considerations in patients with or without a residual interatrial shunt after closure of the left atrial appendage with the WATCHMAN™-device
Luani, B., Groscheck, T., Genz, C., Tanev, I., Rauwolf, T., Herold, J., Medunjanin, S., Schmeißer, A., & Braun-Dullaeus, R. C. (2017) · BMC Cardiovascular Disorders · doi:10.1186/s12872-017-0728-6 · Cited by 26
Percutaneous Left Atrial Appendage Occlusion for the Prevention of Stroke in Patients with Atrial Fibrillation: Review and Critical Appraisal
Schellinger, P. D., Tsivgoulis, G. K., Steiner, T., & Köhrmann, M. (2018) · Journal of Stroke · doi:10.5853/jos.2018.02537 · Cited by 26
Device-Sizing and Associated Complications With Left Atrial Appendage Occlusion: Findings From the NCDR LAAO Registry
Sandhu, A., Varosy, P. D., Du, C., Aleong, R. G., Tumolo, A. Z., West, J. J., Tzou, W. S., Curtis, J. P., Freeman, J. V., Friedman, D. J., et al. (2022) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.122.012183 · Cited by 26
Cost-Effectiveness of Left Atrial Appendage Closure for Stroke Prevention in Atrial Fibrillation Patients With Contraindications to Anticoagulation
Saw, J., Bennell, M. C., Singh, S. M., & Wijeysundera, H. C. (2016) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.02.056 · Cited by 26
Extending percutaneous left atrial appendage closure indications using the AMPLATZER™ Cardiac Plug device in patients with persistent left atrial appendage thrombus: The thrombus trapping technique
Jalal, Z., Iriart, X., Dinet, M., Selly, J., Tafer, N., Renou, P., Sibon, I., & Thambo, J. (2016) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2016.02.012 · Cited by 26
Left atrial appendage closure for prevention of death, stroke, and bleeding in patients with nonvalvular atrial fibrillation
Gloekler, S., Saw, J., Koskinas, K. C., Kleinecke, C., Jung, W., Nietlispach, F., & Meier, B. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.08.049 · Cited by 26
Percutaneous Left Atrial Appendage Closure Is a Reasonable Option for Patients With Atrial Fibrillation at High Risk for Cerebrovascular Events
Teíger, E., Thambo, J., Defaye, P., Hermida, J., Abbey, S., Klug, D., Juliard, J., Pasquié, J., Rioufol, G., Lepillier, A., et al. (2018) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.117.005841 · Cited by 26
Watchman device migration and embolization: A report from the NCDR LAAO Registry
Friedman, D. J., Freeman, J. V., Zimmerman, S. L., Tan, Z. W., Pereira, L., Faridi, K. F., & Curtis, J. P. (2023) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15909 · Cited by 25
Anticoagulation Alone vs Anticoagulation Plus Aspirin or DAPT Following Left Atrial Appendage Occlusion
Reinhardt, S. W., Gibson, D. N., Hsu, J. C., Kapadia, S. R., Yeh, R. W., Price, M. J., Piccini, J. P., Nair, D. G., Christen, T., Allocco, D. J., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.05.067 · Cited by 25
The under-representation of women in cardiovascular clinical trials: State-of-the-art review and ethical considerations
Burgess, S. N., Zaman, S. J., Towns, C. R., Coylewright, M. J., & Cader, F. A. (2024) · American Heart Journal · doi:10.1016/j.ahj.2024.12.011 · Cited by 34
Cerebrovascular events, bleeding complications and device related thrombi in atrial fibrillation patients with chronic kidney disease and left atrial appendage closure with the WATCHMAN™ device
Luani, B., Genz, C., Herold, J., Mitrasch, A., Mitusch, J., Wiemer, M., Schmeißer, A., Braun-Dullaeus, R. C., & Rauwolf, T. (2019) · BMC Cardiovascular Disorders · doi:10.1186/s12872-019-1097-0 · Cited by 26
Cost-effectiveness of warfarin care bundles and novel oral anticoagulants for stroke prevention in patients with atrial fibrillation in Thailand
Ng, S. S., Nathisuwan, S., Phrommintikul, A., & Chaiyakunapruk, N. (2019) · Thrombosis Research · doi:10.1016/j.thromres.2019.11.012 · Cited by 25
One-stop strategy for treatment of atrial fibrillation: feasibility and safety of combining catheter ablation and left atrial appendage closure in a single procedure
Chen, M., Wang, Z., Wang, Q., Sun, J., Zhang, P., Feng, X., Li, W., Yu, Y., Liu, B., Mo, B., et al. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000855 · Cited by 25
Clinical outcomes of patients undergoing percutaneous left atrial appendage occlusion in general anaesthesia or conscious sedation: data from the prospective global Amplatzer Amulet Occluder Observational Study
Piayda, K., Hellhammer, K., Nielsen‐Kudsk, J. E., Schmidt, B., Mazzone, P., Berti, S. L., Fischer, S., Lund, J., Montorfano, M., Bella, P. E. D., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-040455 · Cited by 25
Clinical Implications of CT-detected Hypoattenuation Thickening on Left Atrial Appendage Occlusion Devices
Iriart, X., Blanc, G., Bouteiller, X. P., Legghe, B., Bouyer, B., Sridi, S., Bustin, A., Vasile, C. M., Thambo, J., Elbaz, M., et al. (2023) · Radiology · doi:10.1148/radiol.230462 · Cited by 25
Left Atrial Appendage Occlusion for Stroke Prevention
Alli, O. O., & Holmes, D. R. (2015) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2015.06.005 · Cited by 25
Self-citation
Successful closure of residual leak following lariat procedure in a patient with high risk of stroke and hemorrhage
Yeow, W., Matsumoto, T., & Kar, S. (2013) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.25219 · Cited by 24
Self-citation
Screening and management of atrial fibrillation in primary care
Ponamgi, S., Siontis, K. C., Rushlow, D. R., Graff‐Radford, J., Montori, V. M., & Noseworthy, P. A. (2021) · BMJ · doi:10.1136/bmj.n379 · Cited by 27
Left atrial appendage closure – Current status and future directions
Alfadhel, M., Nestelberger, T., Samuel, R., McAlister, C., & Saw, J. (2021) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2021.11.013 · Cited by 24
The contribution of competing mechanisms in stroke despite anticoagulation in patients with atrial fibrillation
Herlekar, R., Roy, A. S., Hajiev, S., Induruwa, I., Agarwal, S., Evans, N. R., Khadjooi, K., Markus, H. S., O’Brien, E., Warburton, E. A., et al. (2023) · European Stroke Journal · doi:10.1177/23969873231168367 · Cited by 24
The Left Atrial Appendage and Atrial Fibrillation—A Contemporary Review
Sulague, R. M., Whitham, T., Danganan, L. M. L., Effiom, V. B., Candelario, K., Latif, N., & Hameed, I. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12216909 · Cited by 23
Ischemic stroke prevention in patients with atrial fibrillation and a recent ischemic stroke, TIA, or intracranial hemorrhage: A World Stroke Organization (WSO) scientific statement
Sposato, L. A., Cameron, A. C., Johansen, M. C., Mira, K., Murthy, S. B., Schachter, M., Sur, N. B., Yaghi, S. R., Aspberg, S., Caso, V., et al. (2024) · International Journal of Stroke · doi:10.1177/17474930241312649 · Cited by 23
Intracardiac echocardiography versus transesophageal echocardiography for left atrial appendage closure: an updated meta-analysis and systematic review.
Jhand, A., Thandra, A., Gwon, Y., Turagam, M. K., Ashwath, M. L., Yadav, P., Alenezi, F. A. M., Garg, J., Abbott, J. D., Lakkireddy, D., et al. (2020) · Europe PMC (PubMed Central) · Cited by 23
Feasibility and Safety of Intracardiac Echocardiography Use in Transcatheter Left Atrial Appendage Closure Procedures
Zahid, S., Gowda, S. N., Hashem, A. M., Khan, M. Z., Ullah, W., Kaur, G., Nasir, U., Rai, D., Faza, N. N., Little, S. H., et al. (2022) · Journal of the Society for Cardiovascular Angiography & Interventions · doi:10.1016/j.jscai.2022.100510 · Cited by 23
Percutaneous left atrial appendage occlusion: Device thrombosis in clopidogrel non-responders
Ketterer, U., D’Ancona, G., Siegel, I., Ortak, J., Ince, H., & Kische, S. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.11.160 · Cited by 23
Percutaneous left atrial appendage occlusion: Effect of device positioning on outcome
Wolfrum, M., Attinger‐Toller, A., Shakir, S., Gloekler, S., Seifert, B., Moschovitis, A., Khattab, A. A., Maisano, F., Meier, B., & Nietlispach, F. (2016) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.26646 · Cited by 23
Left Atrial Appendage Closure With the New Occlutech® Device: First in Man Experience and Neurological Outcome
Bellmann, B., Schnupp, S., Kühnlein, P., JAVERNIK, C., Kleinecke, C., Rillig, A., Landmesser, U., Brachmann, J., & Park, J. (2016) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13141 · Cited by 23
Resumption of Anticoagulation After Intracranial Hemorrhage
da Silva, I. R. F., & Frontera, J. A. (2017) · Current Treatment Options in Neurology · doi:10.1007/s11940-017-0477-y · Cited by 24
Systematic review on left atrial appendage closure with the LAmbre device in patients with non-valvular atrial fibrillation
Ali, M., Rigopoulos, A. G., Mammadov, M., Torky, A.-R. W., Auer, A., Matiakis, M., Abate, E., Bakogiannis, C., Tzikas, S., Bigalke, B., et al. (2020) · BMC Cardiovascular Disorders · doi:10.1186/s12872-020-01349-9 · Cited by 23
CT assessment of the left atrial appendage post-transcatheter occlusion – A systematic review and meta analysis
Banga, S., Osman, M., Sengupta, P. P., Benjamin, M. M., Shrestha, S., Challa, A., Zeb, I., Kadiyala, M., Mills, J., Balla, S., et al. (2020) · Journal of cardiovascular computed tomography · doi:10.1016/j.jcct.2020.12.003 · Cited by 23
Optimizing antithrombotic therapy in patients with coexisting cardiovascular and gastrointestinal disease
Talasaz, A. H., Sadeghipour, P., Ortega‐Paz, L., Kakavand, H., Aghakouchakzadeh, M., Beavers, C. J., Fanikos, J. R., Eikelboom, J. W., Siegal, D. M., Monréal, M., et al. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01003-3 · Cited by 22
Impact of left atrial appendage occlusion on left atrial function—The LAFIT Watchman study
Murtaza, G., Vuddanda, V. L. K., Akella, K., Rocca, D. G. D., Sharma, S. P., Li, L., Kutty, S., Turagam, M. K., Kar, S., Holmes, D. R., et al. (2019) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-019-00674-0 · Cited by 22
Self-citation
Combination of ablation and left atrial appendage closure as “One‐stop” procedure in the treatment of atrial fibrillation: Current status and future perspective
He, B., Jiang, L., Hao, Z., Wang, H., & Miao, Y. (2021) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.14201 · Cited by 21
Epicardial left atrial appendage clip occlusion in patients with atrial fibrillation during minimally invasive cardiac surgery
Rhee, Y., Park, S. J., & Lee, J. W. (2021) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2021.10.032 · Cited by 22
Percutaneous left atrial appendage occlusion in atrial fibrillation patients with a contraindication to oral anticoagulation: a focused review
Nishimura, M., Sab, S., Reeves, R. R., & Hsu, J. C. (2017) · EP Europace · doi:10.1093/europace/eux313 · Cited by 22
Cost-Effectiveness of Percutaneous Closure of the Left Atrial Appendage in Atrial Fibrillation Based on Results From PROTECT AF Versus PREVAIL
Freeman, J. V., Hutton, D. W., Barnes, G. D., Zhu, R. P., Owens, D. K., Garber, A. M., Go, A. S., Hlatky, M. A., Heidenreich, P. A., Wang, P. J., et al. (2016) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.115.003407 · Cited by 23
The WATCHMAN left atrial appendage closure device for patients with atrial fibrillation: current status and future perspectives
Wintgens, L. I. S., Maarse, M., Swaans, M. J., Rensing, B. J. W. M., van Dijk, V. F., & Boersma, L. V. A. (2020) · Expert Review of Medical Devices · doi:10.1080/17434440.2020.1781615 · Cited by 21
In‐hospital outcomes of transesophageal versus intracardiac echocardiography guided left atrial appendage closure
Morcos, R., Megaly, M. S., Saad, M. S., Barakat, A. F., Rubens, M., Saxena, A., Elbadawi, A., Kucharik, M., Luna, M., García, S., et al. (2022) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.30086 · Cited by 21
S2k-Leitlinie: Sekundärprophylaxe ischämischer Schlaganfall und transitorische ischämische Attacke (TIA) – Teil 1 und Teil 2
Hamann, G. F., Sander, D., Grau, A., & Röther, J. (2022) · DGNeurologie · doi:10.1007/s42451-022-00461-8 · Cited by 21
Real-Time Multiplanar Reconstruction Imaging Using 3-Dimensional Transesophageal Echocardiography in Structural Heart Interventions
Wollborn, J., Schüler, A., Sheu, R. D., Shook, D. C., & Nyman, C. B. (2022) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2022.11.011 · Cited by 21
Stroke Prevention in Atrial Fibrillation: Our Current Failures and Required Research
Gurol, M. E., Wright, C. B., Janis, S., Smith, E. E., Gökçal, E., Reddy, V. Y., Merino, J. G., & Hsu, J. C. (2023) · Stroke · doi:10.1161/strokeaha.123.040447 · Cited by 21
Self-citation
Efficacy and safety of percutaneous left atrial appendage closure to prevent thromboembolic events in atrial fibrillation patients with high stroke and bleeding risk
Seeger, J., Bothner, C., Dahme, T., Gonska, B., Scharnbeck, D., Markovic, S., Rottbauer, W., & Wöhrle, J. (2015) · Clinical Research in Cardiology · doi:10.1007/s00392-015-0910-8 · Cited by 21
Learning Curve Assessment for Percutaneous Left Atrial Appendage Closure With the WATCHMAN Occluder
Ledwoch, J., Krollmann, C., Staubach, S., Hug, M., Strohm, H., & Mudra, H. G. (2016) · Journal of Interventional Cardiology · doi:10.1111/joic.12316 · Cited by 21
Roles of real-time three-dimensional transesophageal echocardiography in peri-operation of transcatheter left atrial appendage closure
Zhou, Q., Song, H., Zhang, L., Deng, Q., Chen, J., Hu, B., Wang, Y., & Guo, R. (2017) · Medicine · doi:10.1097/md.0000000000005637 · Cited by 21
Atrial Fibrillation and Risk of Dementia/Cognitive Decline.
SHAH, A. D., Merchant, F. M., & DeLurgio, D. B. (2016) · PubMed · doi:10.4022/jafib.1353 · Cited by 21
Bleeding in advanced CKD patients on antithrombotic medication – A critical appraisal
Burlacu, A., Genovesi, S., Goldsmith, D. J. A., Rossignol, P., Ortíz, A., Kalra, P. A., Małyszko, J., Banach, M., Kanbay, M., & Covic, A. C. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.004 · Cited by 22
Real-world experience comparing two common left atrial appendage closure devices
Fastner, C., Hoffmann, L., Aboukoura, M., Behnes, M., Lang, S., Borggrefe, M. M., Akın, İ., & Nienaber, C. A. (2018) · BMC Cardiovascular Disorders · doi:10.1186/s12872-018-0899-9 · Cited by 21
Left atrial appendage occlusion in patients older than 85 years. Safety and efficacy in the EWOLUTION registry
Cruz‐González, I., Ince, H., Kische, S., Schmitz, T., Schmidt, B., Gori, T., Foley, D., Potter, T. J. R. D., Tschishow, W. N., Vireca, E., et al. (2019) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2019.02.008 · Cited by 21
Role of cardiac imaging and three-dimensional printing in percutaneous appendage closure
Iriart, X., Ciobotaru, V., Martin, C., Cochet, H., Jalal, Z., Thambo, J., & Quessard, A. (2018) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2018.04.005 · Cited by 21
Long-term outcomes following percutaneous left atrial appendage closure in patients with atrial fibrillation and contraindications to anticoagulation
Regueiro, A., Cruz‐González, I., Bethencourt, A., y, L. N.-F., Champagne, J., Asmarats, L., Jiménez‐Quevedo, P., Gabella, T. R., Rama-Merchán, J. C., Puri, R., et al. (2018) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-018-0356-9 · Cited by 20
Gastrointestinal Bleeding and Direct Oral Anticoagulants among Patients with Atrial Fibrillation: Risk, Prevention, Management, and Quality of Life
Zappulla, P., & Calvi, V. I. (2021) · TH Open · doi:10.1055/s-0041-1730035 · Cited by 21
Radiofrequency Energy Applications Targeting Significant Residual Leaks After Watchman Implantation
Rocca, D. G. D., Murtaza, G., Biase, L. D., Akella, K., Krishnan, S., Magnocavallo, M., Mohanty, S., Gianni, C., Trivedi, C. G., Lavalle, C., et al. (2021) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2021.06.002 · Cited by 20
Self-citation
Management of oral anticoagulant therapy after intracranial hemorrhage in patients with atrial fibrillation
Lucà, F., Colivicchi, F., Oliva, F. G., Abrignani, M. G., Caretta, G., Fusco, S. A. D., Giubilato, S., Cornara, S., Nora, C. D., Pozzi, A., et al. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1061618 · Cited by 20
Comparative Data of Procedural and Midterm Outcomes in Patients Who Underwent Percutaneous Left Atrial Appendage Closure Between the WATCHMAN FLX and WATCHMAN 2.5 Devices ― Insight From the OCEAN-LAAC Registry ―
Nakashima, M., Yamamoto, M., Sago, M., Tanaka, S., Chatani, R., Asami, M., Hachinohe, D., Naganuma, T., Ohno, Y., Tani, T., et al. (2024) · Circulation Journal · doi:10.1253/circj.cj-24-0062 · Cited by 20
Use of 3-Dimensional Models to Optimize Pre-Procedural Planning of Percutaneous Left Atrial Appendage Closure
Bieliauskas, G., Otton, J. M., Chow, D. H. F., Sawaya, F., Kofoed, K. F., Søndergaard, L., & Backer, O. D. (2017) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2017.02.027 · Cited by 20
Kidney function stratified outcomes of percutaneous left atrial appendage occlusion in patients with atrial fibrillation and high bleeding risk
Brockmeyer, M., Wolff, G., Krieger, T., Lin, Y., Karathanos, A., Afzal, S., Zeus, T., Westenfeld, R., Polzin, A., Heinen, Y., et al. (2019) · Acta cardiologica. Supplementum · doi:10.1080/00015385.2019.1585643 · Cited by 21
Left atrial appendage closure in a patient with left atrial appendage thrombus using a novel fish ball technique
Bellmann, B., Rillig, A., Leistner, D. M., Kašner, M., Skurk, C., Landmesser, U., & Park, J. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.12.141 · Cited by 20
Left atrial appendage closure: Initial experience with the ultraseal device
Regueiro, A., Bernier, M., O’Hara, G. E., O’Connor, K., Paradis, J., Beaudoin, J., Gabella, T. R., Champagne, J., & Rodés‐Cabau, J. (2016) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.26870 · Cited by 19
Left atrial appendage closure for primary primary prevention during percutaneous closure of septal defects in patients with large atria but no atrial fibrillation
Kuwata, S., Vierecke, J. K., Gloekler, S., Maisano, F., Meier, B., & Nietlispach, F. (2013) · Cardiology Journal · doi:10.5603/cj.a2017.0097 · Cited by 19
Bias and Loss to Follow‐Up in Cardiovascular Randomized Trials: A Systematic Review
Fong, L. C. W., Ford, T. J., da Costa, B. R., Jüni, P., & Berry, C. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.015361 · Cited by 19
Comparison of three left atrial appendage occlusion devices for stroke prevention in patients with non-valvular atrial fibrillation: a single-centre seven-year experience with WATCHMAN, AMPLATZER Cardiac Plug/Amulet, LAmbre
Cheung, G. S., So, K. C., Chan, C. K., Chan, A. K., Lee, A. P.-W., Lam, Y.-Y., & Yan, B. P. (2019) · AsiaIntervention · doi:10.4244/aij-d-18-00013 · Cited by 19
Looking for Optimal Antithrombotic Strategy after Transcatheter Left Atrial Appendage Occlusion: A Real-World Comparison of Different Antiplatelet Regimens
Vignali, L., Gurgoglione, F. L., Barocelli, F., Cattabiani, M. A., Solinas, E., Maini, A., Tadonio, I., Benatti, G., Pelà, G. M., Coli, S., et al. (2022) · International Journal of Cardiology · doi:10.1016/j.ijcard.2022.09.066 · Cited by 19
Catheter ablation in combined procedures is associated with residual leaks
Zhu, X., Li, W.-J., Chu, H., Zhong, L., Wang, C., Li, J., Liang, P., Wang, L., & Shi, L. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1091049 · Cited by 19
Serial Assessment of Natriuretic Peptides in Patients Undergoing Interventional Closure of the Left Atrial Appendage
Luani, B., Rauwolf, T., Groscheck, T., Tanev, I., Herold, J., Isermann, B., Schmeißer, A., & Braun-Dullaeus, R. C. (2017) · Heart Lung and Circulation · doi:10.1016/j.hlc.2017.07.001 · Cited by 19
Computed tomography detection and quantification of left atrial appendage residual patency as collateral finding after percutaneous closure
Angelillis, M., Gargiulo, G., Moschovitis, A., Fürholz, M., Shakir, S., Piazza, N., Räber, L., Meier, B., Gloekler, S., Windecker, S., et al. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.02.108 · Cited by 19
Percutaneous left atrial appendage closure with complex anatomy by using the staged ‘kissing-Watchman’ technology with double devices
Jiang, L., Duenninger, E., Muenzel, M., Xue, X., Fazakas, Á., Keil, T., & Yu, J. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.05.007 · Cited by 19
The Efficacy and Safety of the WATCHMAN Device in LAA Occlusion in Patients with Non-Valvular Atrial Fibrillation Contraindicated to Oral Anticoagulation: A Focused Review
Majule, D. N., Chang, J., Rutahoile, W. M., & Shonyela, F. S. (2018) · Annals of Thoracic and Cardiovascular Surgery · doi:10.5761/atcs.ra.18-00014 · Cited by 20
Efficacy and safety of catheter ablation combined with left atrial appendage occlusion for nonvalvular atrial fibrillation: A systematic review and meta‐analysis
Jiang, Y., Li, F., Li, D., Cheng, Y., Jia, Y., Fu, H., Pu, X., Hu, H., Jiang, J. D., & Zeng, R. (2019) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.13845 · Cited by 19
An overview of current and emerging devices for percutaneous left atrial appendage closure
Chow, D. H. F., Wong, Y.-H., Park, J., Lam, Y., Potter, T. J. R. D., Rodés‐Cabau, J., Asmarats, L., Sandri, M., Sideris, E. B., McCaw, T., et al. (2018) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2018.08.008 · Cited by 19
Self-citation
Correction: Oral anticoagulant re-initiation following intracerebral hemorrhage in non-valvular atrial fibrillation: Global survey of the practices of neurologists, neurosurgeons and thrombosis experts
Xu, Y., Shoamanesh, A., Schulman, S., Dowlatshahi, D. D., Salman, R. A., Moldovan, I. D., Wells, P. S., & Alkherayf, F. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198031 · Cited by 19
Anticoagulation for Atrial Fibrillation in Patients with Cerebral Microbleeds
Wilson, D., Jäger, H. R., & Werring, D. J. (2015) · Current Atherosclerosis Reports · doi:10.1007/s11883-015-0524-7 · Cited by 20
2015 ACC/HRS/SCAI left atrial appendage occlusion device societal overview
Masoudi, F. A., Calkins, H. G., Kavinsky, C. J., Drozda, J. P., Gainsley, P., Slotwiner, D. J., & Turi, Z. G. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.06.034 · Cited by 18
Clinical follow-up of left atrial appendage occlusion in patients with atrial fibrillation ineligible of oral anticoagulation treatment—a systematic review and meta-analysis
Labori, F., Bonander, C., Persson, J., & Svensson, M. (2021) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-021-00953-9 · Cited by 20
Stroke Prevention in Atrial Fibrillation
Chiang, C., Chao, T., Choi, E., Lim, T. W., Krittayaphong, R., Li, M., Chen, M., Guo, Y., Okumura, K., & Lip, G. Y. H. (2022) · JACC Asia · doi:10.1016/j.jacasi.2022.06.004 · Cited by 18
Risk of Ischemic Stroke after Intracranial Hemorrhage in Patients with Atrial Fibrillation
Lerario, M. P., Gialdini, G., Lapidus, D. M., Shaw, M. M., Navi, B. B., Merkler, A. E., Lip, G. Y. H., Healey, J. S., & Kamel, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145579 · Cited by 18
Transesophageal echocardiographic diagnosis of a WATCHMAN left atrial appendage closure device thrombus 10 years following implantation
Shamim, S., Magalski, A., Chhatriwalla, A. K., Allen, K. B., Huber, K. C., & Main, M. L. (2016) · Echocardiography · doi:10.1111/echo.13413 · Cited by 18
Self-citation
Left Atrial Appendage Occlusion for Stroke Prevention
Chanda, A., & Reilly, J. P. (2017) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2017.04.003 · Cited by 18
Transcatheter left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation: results from the Belgian registry
Kefer, J., Aminian, A., Vermeersch, P. H. M. J., Potter, T. J. R. D., Stammen, F., Benit, E., Budts, W., Missault, L. H., Drieghe, B., Buysschaert, I., et al. (2018) · EuroIntervention · doi:10.4244/eij-d-17-00076 · Cited by 18
A consensus checklist to help clinicians interpret clinical trial results analysed by Bayesian methods
Ferreira, D., Barthoulot, M., Pottecher, J., Torp, K. D., Diemunsch, P. A., & Meyer, N. (2020) · British Journal of Anaesthesia · doi:10.1016/j.bja.2020.04.093 · Cited by 18
Racial disparities in the utilization and in-hospital outcomes of percutaneous left atrial appendage closure among patients with atrial fibrillation
Vincent, L. T., Grant, J. K., Ebner, B., Potchileev, I., Maning, J., Olorunfemi, O. E., Olarte, N., Colombo, R. A., & de Marchena, E. (2021) · Heart Rhythm · doi:10.1016/j.hrthm.2021.02.008 · Cited by 18
Safety and efficacy of left atrial appendage occlusion with the ACP or Watchman device guided by intracardiac echocardiography from the left atrium
Pommier, T., Guénancia, C., Richard, C., Sagnard, A., Fichot, M., Salignon-Vernay, C., Porot, G., Laurent, G., & Lorgis, L. (2021) · Clinical Cardiology · doi:10.1002/clc.23696 · Cited by 18
Left atrial appendage closure: outcomes and challenges
Suradi, H. S., & Hijazi, Z. M. (2016) · Netherlands Heart Journal · doi:10.1007/s12471-016-0929-0 · Cited by 18
Towards personalized antithrombotic management with drugs and devices across the cardiovascular spectrum
Lüscher, T. F., Davies, A., Beer, J. H., Valgimigli, M., Nienaber, C. A., Camm, A. J., Baumgärtner, I., Diener, H., & Konstantinides, S. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab642 · Cited by 18
Efficacy and safety of left atrial appendage closure compared with oral anticoagulation in atrial fibrillation: a meta-analysis of randomized controlled trials and propensity-matched studies
Franchin, L., Piroli, F., Demola, P., Mantovani, F., Iannaccone, M., Manfredi, R., D’Ascenzo, F., Fortuni, F., Ugo, F., Meucci, F., et al. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1212161 · Cited by 17
Antithrombotic Therapy after Percutaneous Left Atrial Appendage Closure: Evidence, Challenges and Future Directions
Galea, R., & Räber, L. (2023) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2412343 · Cited by 17
Percutaneous left atrial appendage closure
Jazayeri, M., Vuddanda, V. L. K., Parikh, V. K., & Lakkireddy, D. (2016) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000367 · Cited by 17
Reducción de eventos a largo plazo tras el cierre de la orejuela izquierda. Resultados del Registro Ibérico II
López-Mínguez, J. R., Nogales‐Asensio, J. M., de Oliveira, E. I., Ribeiro, V. G., Ruiz-Salmeron, R. J., Arzamendi, D., da Costa, M. A. F., Gutiérrez-García, H., Díaz, J. A. F., Martín‐Yuste, V., et al. (2018) · Revista Española de Cardiología · doi:10.1016/j.recesp.2018.03.020 · Cited by 17
Long‐term outcome after totally thoracoscopic ablation for atrial fibrillation
Vos, L. M., Bentala, M., Geuzebroek, G. S. C., Molhoek, S. G., & van Putte, B. P. (2019) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14267 · Cited by 17
Use of a Novel Septal Occluder Device for Left Atrial Appendage Closure in Patients With Postsurgical and Postlariat Leaks or Anatomies Unsuitable for Conventional Percutaneous Occlusion
Rocca, D. G. D., Horton, R., Tarantino, N. M., Niekerk, C. J. V., Trivedi, C. G., Chen, Q., Mohanty, S., Anannab, A., Murtaza, G., Akella, K., et al. (2020) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.120.009227 · Cited by 17
Design and Rationale of the Swiss-Apero Randomized Clinical Trial: Comparison of Amplatzer Amulet vs Watchman Device in Patients Undergoing Left Atrial Appendage Closure
Galea, R., MARCO, F. D., Aminian, A., Meneveau, N. F., Anselme, F., Gräni, C., Huber, A. T., Teíger, E., Iriart, X., Angelillis, M., et al. (2021) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-020-10095-4 · Cited by 17
Long-term outcome of left atrial appendage occlusion with multiple devices
Radinovic, A., Falasconi, G., Marzi, A., D’Angelo, G., Limite, L. R., Paglino, G., Peretto, G., Frontera, A., Fierro, N., Sala, S., et al. (2021) · International Journal of Cardiology · doi:10.1016/j.ijcard.2021.09.051 · Cited by 17
Percutaneous Left Atrial Appendage Closure With LACBES® Occluder ― A Preclinical Feasibility Study ―
Tang, X., Zhang, Z., Wang, F., Bai, Y., Xu, X., Huang, X., Zhao, X., Gong, S., & Qin, Y. (2017) · Circulation Journal · doi:10.1253/circj.cj-17-0412 · Cited by 17
Incidence of Device-Related Thrombosis in Watchman Patients Undergoing a Genotype-Guided Antithrombotic Strategy
Rocca, D. G. D., Horton, R., Biase, L. D., Gianni, C., Trivedi, C. G., Mohanty, S., Anannab, A., Magnocavallo, M., Chen, Q., Tarantino, N. M., et al. (2021) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2021.04.012 · Cited by 17
Left Atrial Thrombus in Atrial Fibrillation/Flutter Patients in Relation to Anticoagulation Strategy: LATTEE Registry
Kapłon‐Cieślicka, A., Gawalko, M. M., Mah, B., Uziębło‐Życzkowska, B., pkj, P., Starzyk, K., G, I., Daniłowicz‐Szymanowicz, L., Singh, D., Wójcik, M., et al. (2022) · Journal of Clinical Medicine · doi:10.2139/ssrn.4035216 · Cited by 16
Delayed left atrial appendage contrast filling in computed tomograms after percutaneous left atrial appendage occlusion
Lim, Y.-M., Kim, J., Kim, T., Uhm, J., Shim, C. Y., Joung, B., Hong, G., Lee, M., Jang, Y., & Pak, H. (2017) · Journal of Cardiology · doi:10.1016/j.jjcc.2017.04.007 · Cited by 16
Atrial Fibrillation and Deterioration in Cognitive Function
Chinta, V., Askandar, S., Nanda, A. S., Sharma, A., Abader, P., Kabra, R., & Khouzam, R. N. (2018) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2018.07.001 · Cited by 16
Clinical Evidence for the Choice of the Direct Oral Anticoagulant in Patients with Atrial Fibrillation According to Creatinine Clearance
Vio, R., Proietti, R., Rigato, M., & Calò, L. A. (2021) · Pharmaceuticals · doi:10.3390/ph14030279 · Cited by 16

Authors: Reddy, V. Y., Sievert, H., Halperin, J., Doshi, S. K., Buchbinder, M., Neuzil, P., Huber, K., Whisenant, B., Kar, S., Swarup, V., Gordon, N., & Holmes, D.
Affiliations: Na Homolce Hospital (CZ)
Cardiovascular Center Frankfurt (DE)
Icahn School of Medicine at Mount Sinai (US)
Saint John's Health Center (US)
Foundation for Cardiovascular Medicine, La Jolla, California
Homolka Hospital, Prague, Czech Republic
Saint Luke's Hospital (US)
Intermountain Medical Center (US)
Cedars-Sinai Medical Center (US)
Arizona Heart Rhythm Center, Scottsdale
Boston Scientific (United States) (US)
Mayo Clinic (US)
Corresponding author: Reddy, Vivek Y.
ORCID: Reddy, Vivek Y.
Halperin, Jonathan
Doshi, Shephal K.
Buchbinder, Maurice
Whisenant, Brian
Kar, Saibal
Holmes, David
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2014-11-19
Volume: 312
Issue: 19
Pages: 1988
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2014.15192
OpenAlex: W2112970567
Cited by: 1,018
References: 25
Citations by year: 2026: 73 · 2025: 86 · 2024: 87 · 2023: 102 · 2022: 97 · 2021: 84 · 2020: 75 · 2019: 58 · 2018: 87 · 2017: 104 · 2016: 75 · 2015: 77 · 2014: 6
FWCI: 59.90
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords: left atrial appendage closure, warfarin, atrial fibrillation, stroke prevention, systemic embolism, cardiovascular mortality, non-inferiority, non-valvular atrial fibrillation, CHADS2 score, anticoagulation, international normalized ratio, bleeding complications, quality of life, patient satisfaction, patient-reported outcomes
MeSH terms: Aged, Aged, 80 and over, Anticoagulants, Atrial Fibrillation, Bayes Theorem, Cardiovascular Diseases, Embolism, Female, Cardiac Catheterization, Humans, Male, Middle Aged, Risk Factors, Warfarin, Survival Analysis, Treatment Outcome, Prosthesis Implantation, Atrial Appendage, Stroke

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Percutaneous Left Atrial Appendage Closure vs Warfarin for Atrial Fibrillation: A Randomized Clinical Trial

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks