Cited by 1,018Atrial Fibrillation Management and OutcomesCardiovascular and Diving-Related ComplicationsAcute Ischemic Stroke Management

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Percutaneous Left Atrial Appendage Closure vs Warfarin for Atrial Fibrillation: A Randomized Clinical Trial

Reddy, Vivek Y., Sievert, Horst, Halperin, Jonathan, Doshi, Shephal K., Buchbinder, Maurice, Neuzil, Petr, Huber, Kenneth, Whisenant, Brian, Kar, Saibal, Swarup, Vijay, Gordon, Nicole, Holmes, David·2014·JAMA

DOI 10.1001/jama.2014.15192

Open this paper in CoChat — free account

Abstract

IMPORTANCE: While effective in preventing stroke in patients with atrial fibrillation (AF), warfarin is limited by a narrow therapeutic profile, a need for lifelong coagulation monitoring, and multiple drug and diet interactions. OBJECTIVE: To determine whether a local strategy of mechanical left atrial appendage (LAA) closure was noninferior to warfarin. DESIGN, SETTING, AND PARTICIPANTS: PROTECT AF was a multicenter, randomized (2:1), unblinded, Bayesian-designed study conducted at 59 hospitals of 707 patients with nonvalvular AF and at least 1 additional stroke risk factor (CHADS2 score ≥1). Enrollment occurred between February 2005 and June 2008 and included 4-year follow-up through October 2012. Noninferiority required a posterior probability greater than 97.5% and superiority a probability of 95% or greater; the noninferiority margin was a rate ratio of 2.0 comparing event rates between treatment groups. INTERVENTIONS: Left atrial appendage closure with the device (n = 463) or warfarin (n = 244; target international normalized ratio, 2-3). MAIN OUTCOMES AND MEASURES: A composite efficacy end point including stroke, systemic embolism, and cardiovascular/unexplained death, analyzed by intention-to-treat. RESULTS: At a mean (SD) follow-up of 3.8 (1.7) years (2621 patient-years), there were 39 events among 463 patients (8.4%) in the device group for a primary event rate of 2.3 events per 100 patient-years, compared with 34 events among 244 patients (13.9%) for a primary event rate of 3.8 events per 100 patient-years with warfarin (rate ratio, 0.60; 95% credible interval, 0.41-1.05), meeting prespecified criteria for both noninferiority (posterior probability, >99.9%) and superiority (posterior probability, 96.0%). Patients in the device group demonstrated lower rates of both cardiovascular mortality (1.0 events per 100 patient-years for the device group [17/463 patients, 3.7%] vs 2.4 events per 100 patient-years with warfarin [22/244 patients, 9.0%]; hazard ratio [HR], 0.40; 95% CI, 0.21-0.75; P = .005) and all-cause mortality (3.2 events per 100 patient-years for the device group [57/466 patients, 12.3%] vs 4.8 events per 100 patient-years with warfarin [44/244 patients, 18.0%]; HR, 0.66; 95% CI, 0.45-0.98; P = .04). CONCLUSIONS AND RELEVANCE: After 3.8 years of follow-up among patients with nonvalvular AF at elevated risk for stroke, percutaneous LAA closure met criteria for both noninferiority and superiority, compared with warfarin, for preventing the combined outcome of stroke, systemic embolism, and cardiovascular death, as well as superiority for cardiovascular and all-cause mortality. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00129545.

Integrity signals

Registry

Crossref · 10.1001/jama.2014.15192

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Bayesian Data Analysis
Gelman, A., Carlin, J. B., Stern, H. S., & Rubin, D. B. (2003) · doi:10.1201/9780429258480 · Cited by 27,276
Dabigatran versus warfarin in patients with atrial fibrillation
Connolly, S. J., Ezekowitz, M. D., Yusuf, S., Eikelboom, J., Oldgren, J., Parekh, A., Pogue, J., Reilly, P. A., Themeles, E., Varrone, J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0905561 · Cited by 11,215
Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
Patel, M. R., Mahaffey, K. W., Garg, J., Pan, G., Singer, D. E., Hacke, W., Breithardt, G., Halperin, J. L., Hankey, G. J., Piccini, J. P., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1009638 · Cited by 9,430
Self-citation
Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation
Hart, R. G., Pearce, L. A., & Aguilar, M. I. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-12-200706190-00007 · Cited by 4,793 · cited 2×
“Carl Jacobs (Piedmont Hospital, Atlanta [2]); Rajesh Dave (Harrisburg Hospital, Harrisburg, Pennsylvania [1]); John Young (Lindner Clinical Trial Center, Cincinnati, Ohio [1]); David Lasorda (Allegheny General Hospital, Pittsburgh [1]).”
Background
Apixaban in patients with atrial fibrillation
Connolly, S. J., Eikelboom, J., Joyner, C., Diener, H.-C., Hart, R., Golitsyn, S., Flaker, G., Avezum, A., Hohnloser, S. H., Diaz, R., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1007432 · Cited by 2,483
Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial
Holmes, D. R., Reddy, V. Y., Turi, Z. G., Doshi, S. K., Sievert, H., Buchbinder, M., Mullin, C. M., & Sick, P. B. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61343-x · Cited by 2,242
Self-citation
Effect of clopidogrel added to aspirin in patients with atrial fibrillation
The ACTIVE Investigators (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0901301 · Cited by 2,102
A Method to Determine the Optimal Intensity of Oral Anticoagulant Therapy
Rosendaal, F. R., Cannegieter, S. C., van der Meer, F. J. M., & Briët, E. (1993) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1651587 · Cited by 2,070
HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Personnel, Policy, Procedures and Follow-Up
Calkins, H. G., Brugada, J., Packer, D. L., Cappato, R., Chen, S., Crijns, H. J. G. M., Damiano, R. J., Davies, D. W., Haines, D. E., Haı̈ssaguerre, M., et al. (2007) · Heart Rhythm · doi:10.1016/j.hrthm.2007.04.005 · Cited by 1,690
Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation
Blackshear, J. L., & Odell, J. A. (1996) · The Annals of Thoracic Surgery · doi:10.1016/0003-4975(95)00887-x · Cited by 1,686 · cited 3×
“Turi (Cooper Hospital, Camden, New Jersey [4]); Bryan Raybuck (INOVA Research Center, Falls Church, Virginia [3]); Ron Waksman, Horst Sievert (Washington Hospital Center, Washington, DC [4]); Steven Kalbfleisch (Ohio State University, Columbus [3]); Michael Mooney (Abbott Northwestern Hospital, Minneapolis [3]); Willi…”
Background

Show all 25 references

Sorted by citations

Items 501–600 of 1,000

Antithrombotic Therapy in Patients Undergoing Percutaneous Left Atrial Appendage Occlusion
Galea, R., & Räber, L. (2024) · Interventional Cardiology Clinics · doi:10.1016/j.iccl.2024.07.002 · Cited by 5
Pearls and Oy-sters: A Patient on Lecanemab Newly Diagnosed With Atrial Fibrillation
Ryan, D., Zwischenberger, B. A., & Liu, A. (2024) · Neurology · doi:10.1212/wnl.0000000000210125 · Cited by 5
Epidemiology of Atrial Fibrillation in Heart Failure
Chelikam, N., Katapadi, A., Pothineni, N. V. K., Darden, D. J., Kabra, R., Gopinathannair, R., & Lakkireddy, D. (2024) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2024.08.004 · Cited by 5
Safety and efficacy of a light antithrombotic regimen after left atrial appendage occlusion: Insights from the LOGIC (left atrial appendage occlusion in patients with gastrointestinal or IntraCranial bleeding) international multicenter registry
Gallo, F., d'Addazio, M., D’Amico, G., Rocca, D. G. D., Mazzone, P., Bordignon, S., Casu, G., Giannini, F., Berti, S. L., Horton, R., et al. (2025) · Cardiovascular revascularization medicine · doi:10.1016/j.carrev.2025.01.002 · Cited by 5
Association Between Use of WATCHMAN Device and 1-Year Mortality Using High-Dimensional Propensity Scores to Reduce Confounding
Zhao, J. Z., Ruzieh, M., Du, F., Yi, L., Foy, A., Platt, R. W., Segal, M. S., Coulombe, J., Winterstein, A. G., & Jiao, T. (2025) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.124.011188 · Cited by 5
Intracardiac versus transesophageal echocardiographic guidance for left atrial appendage occlusion: Design and rationale of the ICE-TEE trial
Al‐Azizi, K., Thomas, S., Hajar, M. B. A., Pickering, T. G., McCullough, K., Dorton, C. W., Moubarak, G., Ma, T., Banwait, J. K., Hale, S., et al. (2025) · Cardiovascular revascularization medicine · doi:10.1016/j.carrev.2025.05.029 · Cited by 5
Outcome measures for randomised clinical trials and multicentre observational studies of cardiovascular diseases published in major clinical journals: systematic review and evidence mapping
Bhatty, A., Wilkinson, C., Aktaa, S., Batra, G., Beska, B., Khaing, P. H., Wahab, A., Raveendra, K., Taha, A., Nadarajah, R., et al. (2025) · Heart · doi:10.1136/heartjnl-2025-326045 · Cited by 6
Multimodality imaging assessment of the left atrial appendage for percutaneous closure
Stankowski, K., Volpi, B., Balata, F., Buonamici, L., Biroli, M., Figliozzi, S., Maltagliati, A. C., Mancini, M. E., Mantegazza, V., Pepi, M., et al. (2025) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2025.09.003 · Cited by 5
Oral anticoagulant use in cardiovascular disorders: a perspective on present and potential indications for rivaroxaban
Camm, A. J., & Fox, K. A. A. (2018) · Current Medical Research and Opinion · doi:10.1080/03007995.2018.1467885 · Cited by 5
Clinical and multi-modality imaging approach in the selection of patients for left atrial appendage closure
Riegler, L., Palermi, S., Scarafile, R., Gioia, R., Pastore, F., Lombardi, A., Marrazzo, G., Ragni, M., Quaranta, G., Sirignano, C., et al. (2021) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2204128 · Cited by 5
Impact of Left Atrial Appendage Closure Combined with Catheter Ablation on Endocrine and Mechanical Cardiac Function in Patients with Atrial Fibrillation
Yang, J., You, L., Liu, M., Zhang, G., Feng, L., Liu, Y., Geng, X. H., Wu, J., & Xie, R. (2022) · Journal of Interventional Cardiology · doi:10.1155/2022/3932912 · Cited by 5
Peri-device leakage not CHA2DS2-VASc is associated with post-left atrial appendage closure cardiovascular event
Huang, P., Chiu, F., Cheng, H., Hsu, J.-C., Chua, S., Chu, C., Lin, T., Chen, J., & Tsai, C. (2022) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2022.106688 · Cited by 5
Percutaneous Treatment Approaches in Atrial Fibrillation: Current Landscape and Future Perspectives
Theofilis, P., Oikonomou, E. K., Antonopoulos, A. S., Siasos, G., Tsioufis, K. P., & Tousoulis, D. (2022) · Biomedicines · doi:10.3390/biomedicines10092268 · Cited by 5
Meta-Analysis Comparing Left Atrial Appendage Occlusion, Direct Oral Anticoagulants, and Warfarin for Nonvalvular Atrial Fibrillation
Abdelfattah, O., Sayed, A., Munir, M., Almotawally, S., Wilson, K., Gad, M. M., Abushouk, A. I., Elsayed, M., Wazni, O. M., Saliba, W. I., et al. (2022) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2022.08.012 · Cited by 5
Appropriate use criteria of left atrial appendage closure devices: latest evidences
Guarracini, F., Bonvicini, E., Preda, A., Martín, M. J., Muraglia, S., Casagranda, G., Mochen, M., Coser, A., Quintarelli, S., Branzoli, S., et al. (2023) · Expert Review of Medical Devices · doi:10.1080/17434440.2023.2208748 · Cited by 5
Percutaneous Left Atrial Appendage Occlusion Therapy: Evolution and Growing Evidence
Han, X.-Q., & Benditt, D. (2023) · Reviews in cardiovascular medicine · doi:10.31083/j.rcm2407211 · Cited by 5
Comparison of the Efficacy and Safety of Left Atrial Appendage Closure and Direct Oral Anticoagulants for Atrial Fibrillation: A Meta-Analysis of Randomized Control Trials and Observational Studies
Wei, C. R., Lim, R., Khan, S. A., Ahsan, S. A., Omari, M. A., Sherpa, N. D., Rashid, Z., & Khan, A. (2023) · Cureus · doi:10.7759/cureus.49827 · Cited by 5
Simultaneous Transcatheter Aortic Valve Implantation and Left Atrial Appendage Occlusion versus both Interventions as Stand-Alone Procedures
Gilhofer, T. S., Obeid, S. N., Lüscher, T. F., & Binder, R. K. (2018) · Structural Heart · doi:10.1080/24748706.2018.1512773 · Cited by 5
Left Atrial Appendage Anatomy: Implications for Endocardial Catheter-based Device Closure
Maan, A., & Heist, E. K. (2020) · Journal of Innovations in Cardiac Rhythm Management · doi:10.19102/icrm.2020.110704 · Cited by 5
Anticoagulation versus antiplatelet therapy after percutaneous left atrial appendage closure—subanalysis from the multicenter LAARGE registry
Ledwoch, J., Staubach, S., Akın, İ., İnce, H., Zeymer, U., Pleger, S. T., Sievert, H., Hochadel, M., Senges, J., Lewalter, T., et al. (2021) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-021-01080-1 · Cited by 5
Self-citation
Role of left atrial appendage occlusion in patients with HeartMate 3
Melehy, A., O’Connell, G. M., Ning, Y., Kurlansky, P. A., Kaku, Y., Topkara, V. K., yuzefpolskaya, M., Colombo, P. C., SAYER, G. T., Uriel, N. Y., et al. (2021) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivab285 · Cited by 5
An Overview of Left Atrial Appendage Occlusion Devices
Feldmann, K. J., Arshi, A., & Yakubov, S. J. (2015) · Current Cardiology Reports · doi:10.1007/s11886-015-0573-0 · Cited by 5
Patients With Atrial Fibrillation
Ezekowitz, M. D., Chandhok, S., & Arce, J. E. (2017) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2017.06.021 · Cited by 5
Percutaneous Closure of Left Atrial Appendage significantly affects Lipidome Metabolism
Yücel, G., Behnes, M., Barth, C., Wenke, A., Sartorius, B., Mashayekhi, K., Yazdani, B., Bertsch, T., Rusnak, J., Saleh, A., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-23935-w · Cited by 5
Percutaneous left atrial appendage occlusion in 2016
Tzikas, A., Sievert, H., & Holmes, D. R. (2016) · EuroIntervention · doi:10.4244/eijv11i14a307 · Cited by 5
Self-citation
‘Will the king ever be dethroned?’ The relationship and the future of oral anticoagulation therapy versus LAA closure devices
Burlacu, A., Genovesi, S., Artene, B., & Covic, A. C. (2020) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2021.1850267 · Cited by 5
Early and late Watchman device migration and embolization: Insights from the NCDR LAAO registry
LIN, A. C. (2023) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15942 · Cited by 5
Effect of Device Size on Outcomes Following Left Atrial Appendage Closure in Borderline-Sized Anatomy
Kuwabara, K., Kubo, S., Nakajima, Y., Matsumoto, T., Fukunaga, M., Kondo, Y., Sugane, H., Okubo, K., Nakagawa, K., Nagatomo, D., et al. (2026) · JACC Asia · doi:10.1016/j.jacasi.2025.11.015 · Cited by 4
A Cardiologist’s Perspective on Patent Foramen Ovale-Associated Conditions
Meier, B. (2024) · Cardiology Clinics · doi:10.1016/j.ccl.2024.02.002 · Cited by 4
Left atrial appendage occlusion in patients with cancer
Davis, N. E., Shabtaie, S. A., & Tan, N. Y. L. (2025) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-025-03098-y · Cited by 4
Optimal duration of anticoagulation after left atrial appendage closure: a systematic review and meta-analysis
Lu, X., Yang, Z., Fang, W., Niu, X., Wang, Q., & Li, Y. (2025) · BMC Cardiovascular Disorders · doi:10.1186/s12872-025-04736-2 · Cited by 4
Left atrial appendage occlusion procedure and antithrombotics: less may be enough for lower risk patients: A single-center observational study
Kim, M.-R., Dugal, J. K., Wang, S., Taylor, S., Goel, V. S., Shafi, A., Singh, A., & Batra, K. (2025) · Medicine · doi:10.1097/md.0000000000042885 · Cited by 4
Comparison of left atrial appendage occlusion with medical treatment for non-valvular atrial fibrillation: systematic review, network and reconstructed individual patient data meta-analysis
Lerman, T. T., Hershenson, R., Greenberg, N., Kheifets, M., Talmor‐Barkan, Y., Codner, P., Perl, L., Witberg, G., Rotholz, A., Vons, S. A., et al. (2025) · Clinical Research in Cardiology · doi:10.1007/s00392-025-02697-2 · Cited by 4
Long‐Term Outcomes Following Left Atrial Appendage Occlusion in Medicare Beneficiaries: Outcomes From the National Cardiovascular Data Registry
Higgins, A. Y., Zimmerman, S. L., Wang, Y., Friedman, D. J., Faridi, K. F., Price, M. J., Reddy, V. Y., Holmes, D. R., Curtis, J. P., & Freeman, J. V. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.039780 · Cited by 4
Self-citation
Evaluation of geometric, functional and mechanical parameters of left atrium remodeling after surgical treatment of isolated atrial fibrillation
Мухамедовна, Х. С., Tembotova, Z. K., Serguladze, S. Y., Проничева, И. В., Kvasha, B. I., Рашидовна, Х. Ф., & Вахаевна, М. З. (2018) · Annaly aritmologii · doi:10.15275/annaritmol.2018.1.2 · Cited by 4
Age-Based Trends in the Outcomes of Percutaneous Left Atrial Appendage Occlusion: Insights from a Real-World Database
Ashraf, M., Allaqaband, S. Q., BAJWA, T. K., Mortada, M. E., Sra, J. S., & Jan, M. F. (2023) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2023.08.177 · Cited by 4
Choosing Appropriate Candidates for Left Atrial Appendage Occlusion
Zhang, C., Lü, H., & Zhu, Y. (2023) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2412360 · Cited by 4
Minimally invasive epicardial surgical left atrial appendage exclusion for atrial fibrillation patients at high risk for stroke and for bleeding
Rose, D. Z., DiGiorgi, P. L., Ramlawi, B., Pulungan, Z., Teigland, C. L., & Calkins, H. G. (2024) · Heart Rhythm · doi:10.1016/j.hrthm.2024.01.046 · Cited by 4
Reporting of Demographics & Subgroup Analyses in Premarketing Studies of FDA Approved High-Risk Cardiovascular Devices, 2014–2022
Swanson, M. J., Uyeki, C. L., Yoder, S. R., Dhruva, S. S., Miller, J. E., & Ross, J. S. (2024) · Medical Devices Evidence and Research · doi:10.2147/mder.s457152 · Cited by 4
Segmentation of the left atrial appendage based on fusion attention
Zhang, G., Liang, K., Li, Y., Liang, T., Gong, Z., Ju, R., Zhao, D., & Zhang, Z. (2024) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-024-03104-0 · Cited by 4
Impact of Operator Experience on Left Atrial Appendage Occlusion Outcomes
Zhang, T., Gao, C., Liu, J., Fu, G., Li, B., Liu, H., Zhang, R., Wang, P., Ning, Z., Yang, B., et al. (2024) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2024.07.010 · Cited by 4
Current Endocardial Approaches for Left Atrial Appendage Closure
Rocca, D. G. D., Prete, A. D., Biase, L. D., Horton, R., Al‐Ahmad, A., Bassiouny, M., Mohanty, S., Trivedi, C. G., Romero, J. E., Gianni, C., et al. (2019) · European Journal of Arrhythmia & Electrophysiology · doi:10.17925/ejae.2019.5.1.40 · Cited by 4
Surgical Treatment of Atrial Fibrillation
Navaratnarajah, M., Luthra, S., & Ohri, S. K. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.91225 · Cited by 4
Percutaneous Transhepatic Venous Access for Left Atrial Appendage Closure in a Patient with Left Sided Inferior Vena Cava with Hemiazygos Continuation
Magnus, P. C., Chodosh, A., Salis, A. I., & Wicks, C. (2022) · Cardiovascular revascularization medicine · doi:10.1016/j.carrev.2022.05.027 · Cited by 4
Bailout left atrial appendage occluder for pulmonary vein isolation and electrical cardioversion in patients with atrial fibrillation and left atrial appendage thrombus: a pilot study
Tsai, C., Huang, P., Chiu, F.-C., Chen, J.-J., Chang, S.-N., Hsu, J.-C., Chua, S., Cheng, H., Hwang, J., Hwang, J.-J., et al. (2022) · Clinical Research in Cardiology · doi:10.1007/s00392-022-02085-0 · Cited by 4
Long‐term safety and efficacy of left atrial appendage closure in patients with small appendage orifices measured with transesophageal echocardiography
Wang, B., Wang, Z., Chu, H., He, B., Fu, G., Feng, M., Du, X., Liu, J., & Yu, Y. (2022) · Clinical Cardiology · doi:10.1002/clc.23950 · Cited by 4
Indications, evidence, and controversy in the closure of the left atrial appendage
Patti, G., & Ghiglieno, C. (2023) · European Heart Journal Supplements · doi:10.1093/eurheartjsupp/suad091 · Cited by 4
Review of the National Institute for Health and Care Excellence guidelines on the management of atrial and ventricular arrhythmias
Lambiase, P. D., & Maclean, E. (2023) · Heart · doi:10.1136/heartjnl-2022-322122 · Cited by 4
Impact of left atrial appendage orifice diameter on the safety and efficacy of left atrial appendage closure using the LAmbre device
Zhuo, W., Wang, B., Fu, G., Yu, Y., Feng, M., Liu, J., Du, X., & Chu, H. (2024) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2024.01.012 · Cited by 4
Prophylactic Left Atrial Appendage Ligation During Coronary Artery Bypass Graft Surgery Allows Safe Avoidance of Anticoagulation Regardless of Postoperative Atrial Fibrillation
Khalpey, Z. I., Aslam, U., Wilson, P., Deckwa, J., & Kumar, U. A. (2024) · Cureus · doi:10.7759/cureus.59876 · Cited by 4
Der katheterbasierte Verschluss des linken Vorhofohrs
Skurk, C., Leistner, D. M., Park, J.-W., & Landmesser, U. (2016) · Der Internist · doi:10.1007/s00108-016-0113-z · Cited by 4
Clinical Outcomes following Left Atrial Appendage Occlusion: A Single-Center Experience
Adedinsewo, D. A., Salwa, N., Sennhauser, S., Farhat, S., Winder, J., Lesser, E. R., White, L. J., Landolfo, C. K., Venkatachalam, K. L., Pollak, P. M., et al. (2020) · Cardiology · doi:10.1159/000509277 · Cited by 4
Long-Term Safety and Efficacy of Percutaneous Left Atrial Appendage Closure with the LAmbre Device
Wang, G., Kong, B., Liu, Y., & Huang, H. (2020) · Journal of Interventional Cardiology · doi:10.1155/2020/6613683 · Cited by 4
Ablation of Atrial Fibrillation in Combination with Left Atrial Appendage Occlusion in A Single Procedure. Rationale and Technique.
Bolao, I. G., Calvo, N., Macı́as, A., Barba, J., Salterain, N., Ramos, P., Ballesteros, G., & Neglia, R. (2016) · PubMed Central · doi:10.4022/jafib.1346 · Cited by 4
Risk stratification in patients undergoing interventional left atrial appendage occlusion—Prognostic impact of EuroSCORE II
Gotzmann, M., Choudhury, D. S., Hogeweg, M., Heringhaus, F., Mügge, A., & Pflaumbaum, A. (2020) · Clinical Cardiology · doi:10.1002/clc.23338 · Cited by 4
Vorhofohrverschluss bei Vorhofflimmern? Pro
Häusler, K. G., Landmesser, U., & Endres, M. (2015) · Der Nervenarzt · doi:10.1007/s00115-015-4290-0 · Cited by 4
Verschluss des linken Vorhofohrs bei nichtvalvulärem Vorhofflimmern
Häusler, K. G., & Landmesser, U. (2019) · Herz · doi:10.1007/s00059-019-4812-9 · Cited by 4
Progress Against Cardiovascular Disease
Greenland, P., Peterson, E. D., & Gaziano, J. M. (2014) · JAMA · doi:10.1001/jama.2014.15554 · Cited by 4
Anticoagulation in Cancer Patients With Atrial Fibrillation or Atrial Flutter
Russo, A. M. (2020) · JACC CardioOncology · doi:10.1016/j.jaccao.2020.11.002 · Cited by 4
Low-Dose Anticoagulation for Atrial Fibrillation
Halperin, J. L., & Rashed, E. R. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.01.024 · Cited by 4
Self-citation
Ischemic Stroke in Patients Under Oral Anticoagulation: The Achilles Heel of Atrial Fibrillation Management
Dimitriadis, K. S., Pyrpyris, N., Aznaouridis, K. A., Nayak, G., Kanatas, P., Theofilis, P., Tsioufis, P., Beneki, E., Papanikolaou, A., Fragoulis, C., et al. (2025) · Brain Sciences · doi:10.3390/brainsci15050454 · Cited by 3
How can we reduce thrombotic and hemorrhagic events in elderly patients with atrial fibrillation?
Palumbo, I., Bucci, T., Menichelli, D., Pannunzio, A., Valeriani, E., Pastori, D., Pignatelli, P., & Lip, G. Y. H. (2025) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2025.2551682 · Cited by 3
Heart Failure and Stroke: A Narrative Review
Katano, T., Mori, H., & Suda, S. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14176044 · Cited by 4
Percutaneous left atrial appendage closure for stroke prevention in atrial fibrillation: who should receive it in current clinical practice?
d’Entremont, M.-A., Healy, J., & Jolly, S. S. (2025) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000001270 · Cited by 3
Long-Term Clinical Outcomes Following the WATCHMAN Device Use in Medicare Beneficiaries
Zeitler, E. P., Bian, B., Griffiths, R. I., Allocco, D. J., Christen, T., Roy, K., Cohen, D. J., & Reynolds, M. R. (2024) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.124.011007 · Cited by 3
Cerebral Embolic Protection: Is There a Benefit for Left Atrial and Mitral Valve Procedures?
Besir, B., & Kapadia, S. R. (2024) · Current Cardiology Reports · doi:10.1007/s11886-024-02132-4 · Cited by 3
Percutaneous Left Atrial Appendage Closure: Supporting Evidence, Limitations and Future Directions
Imperatore, G., Lochy, S., Yedder, M. B., Galea, R., & Aminian, A. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14072300 · Cited by 3
Cerebrovascular Management Considerations in Patients on AATs
Ryan, D., Feng, W., & Liu, A. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14103420 · Cited by 4
Diagnosis and Management of Atrial Arrhythmias in Cancer Patients
Monsour, R., Seo, A., Wilcox, N. S., & Fradley, M. G. (2025) · Current Cardiology Reports · doi:10.1007/s11886-025-02261-4 · Cited by 3
A Novel Measurement of Percutaneous Left Atrial Appendage Occlusion Device Peri‐Device Leak Using Major and Minor Axes of a Three‐Dimensional Vena Contracta Area
Biscardi, A., Tannenbaum, J., Kott, A., Bhave, P. D., Seals, A. L., Corbett, J., & Richardson, K. M. (2025) · Echocardiography · doi:10.1111/echo.70334 · Cited by 3
Dealing With the Left Atrial Appendage for Stroke Prevention: Devices and Decision-Making
Phillips, K. P., & Paul, V. (2017) · Heart Lung and Circulation · doi:10.1016/j.hlc.2017.05.113 · Cited by 3
Does Left Atrial Appendage Closure Reduce Mortality? A Vital Status Analysis of the Randomized PROTECT AF and PREVAIL Clinical Trials
Whang, W. (2018) · Journal of Atrial Fibrillation · doi:10.4022/jafib.2119 · Cited by 3
Comparison of echocardiographic and fluoroscopic sizing of the left atrial appendage prior to percutaneous closure
Kiani, S., Patel, A. V., El‐Chami, M. F., Patel, A. M., Merchant, F. M., Westerman, S. B., Lurgio, D. B. D., & Hoskins, M. H. (2019) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-019-00643-7 · Cited by 3
Surgical Management of Atrial Fibrillation
Bedeir, K., & Ramlawi, B. (2020) · Springer eBooks · doi:10.1007/978-3-030-24174-2_79 · Cited by 3
Percutaneous Left Atrial Appendage Closure for Cerebrovascular Accident Prevention: rationale, indications, Technical aspects, Clinical Results and Future Perspective
D’Ancona, G., Ketterer, U., Kische, S., Murero, M., Feickert, S., Ortak, J., Öner, A. Ö., & İnce, H. (2020) · Future Cardiology · doi:10.2217/fca-2019-0086 · Cited by 4
Impact of individual stroke risk on outcome after Amplatzer left atrial appendage closure in patients with atrial fibrillation
Häner, J. D., Fürholz, M., Kleinecke, C., Galea, R., Streit, S. R., Fankhauser, M., Cherni, T., Valgimigli, M., Windecker, S., Meier, B., et al. (2020) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.29318 · Cited by 3
Non coronary applications of cardiac computed tomography: A review
Aziz, M. U., Manapragada, P. P., & Singh, S. P. (2021) · Journal of medical imaging and radiation sciences · doi:10.1016/j.jmir.2021.07.003 · Cited by 3
Trends and Outcomes of Left Atrial Appendage Occlusion in Renal and Liver Transplant Recipients: Insights From the United States National Inpatient and Readmission Database
Zahid, S., Sánchez-Nadales, A., Hashem, A. M., Sarkar, A. E. H., Sleiman, J. R., Lewis, A., Uppal, D., Nimmagadda, M., Ullah, W., Leiby, B. E., et al. (2022) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2022.101488 · Cited by 3
Left atrial appendage occlusion combined with cryoballoon or radiofrequency ablation: One-year follow-up comparison
Ma, Y., Guo, L., Hu, M., Yan, Q., Liu, H., & Fu, Y. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1153158 · Cited by 3
Transcatheter Left Atrial Appendage Closure: Devices Available, Pitfalls, Advantages, and Future Directions
Bavishi, C. (2023) · US Cardiology Review · doi:10.15420/usc.2022.37 · Cited by 3
Peri- and Post-procedural Anticoagulation with Left Atrial Appendage Occlusion Devices
Pradyumna, A., & Pujari, S. H. (2023) · Heart International · doi:10.17925/hi.2023.17.1.54 · Cited by 4
Efficacy and safety of the new generation Watchman FLX device compared to the Watchman 2.5: a systematic review and meta-analysis.
Najim, M., Mostafa, M. R., Eid, M. M., Al‐Abdouh, A., Awad, A. K., Elbanna, M., Mohamed, S., Alweis, R. L., Al‐Azizi, K., & Mamas, M. A. (2023) · PubMed Central · Cited by 3
Percutaneous left atrial appendage occlusion in mitral valve disease: A Nationwide Readmission Database analysis
Feroze, R. A., Ullah, W., Kang, P., Lobo, T. N., Alhabdan, N. A., Alghammass, M., Yoon, S., Dallan, L. A. P., & Filby, S. J. (2024) · Cardiovascular revascularization medicine · doi:10.1016/j.carrev.2024.01.007 · Cited by 3
Comparative Costs to Medicare and Medicare Beneficiaries of Alternative AF Stroke Risk Reduction Strategies
Reddy, V. Y., Zhong, Y., McGovern, A. M., Amorosi, S. L., Gavaghan, M. B., Hertz, D. S., Low, K., Freeman, S. V., & Holmes, D. R. (2024) · ClinicoEconomics and Outcomes Research · doi:10.2147/ceor.s440556 · Cited by 3
Self-citation
SCAI/HRS Technical Review on Transcatheter Left Atrial Appendage Occlusion
Cronin, E. M., Filby, S. J., Field, M. E., Huded, C. P., Indik, J. H., Sharma, A., Armah, C., Firestone, S., Fix, A. M., Senerth, E., et al. (2025) · Journal of the Society for Cardiovascular Angiography & Interventions · doi:10.1016/j.jscai.2025.103784 · Cited by 3
Vorhofohrverschluss bei Vorhofflimmern? Kontra
Schellinger, P. D., & Köhrmann, M. (2015) · Der Nervenarzt · doi:10.1007/s00115-015-4282-0 · Cited by 3
Bayesian Adaptive Trials for Rare Cardiovascular Conditions
Shohoudi, A., Stephens, D. A., & Khairy, P. (2018) · Future Cardiology · doi:10.2217/fca-2017-0040 · Cited by 2
Stroke Prevention After Intracerebral Hemorrhage: Where Are We Now?
Baang, H. Y., & Sheth, K. N. (2021) · Current Cardiology Reports · doi:10.1007/s11886-021-01594-0 · Cited by 3
Pre-cath Laboratory Planning for Left Atrial Appendage Occlusion – Optional or Essential?
Devgun, J. K., Potter, T. J. R. D., Fabbricatore, D., & Wang, D. D. (2022) · Interventional Cardiology Clinics · doi:10.1016/j.iccl.2021.11.003 · Cited by 3
Left Atrial Appendage Closure Is Preferred to Chronic Warfarin Therapy
Atoui, M., Gunda, S., & Lakkireddy, D. (2015) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2015.05.019 · Cited by 3
Role of Endovascular Closure of the Left Atrial Appendage in Stroke Prevention for Atrial Fibrillation
Kiani, J. G., & Holmes, D. R. (2015) · Current Atherosclerosis Reports · doi:10.1007/s11883-015-0542-5 · Cited by 3
Self-citation
Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation
Le, D. L., Morelli, R., Badhwar, N., & Lee, R. J. (2015) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2015.1057123 · Cited by 3
Atrial fibrillation ablation and left appendage closure in heart failure patients
Patel, M. R., & BIVIANO, A. B. (2015) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000168 · Cited by 3
Left Atrial Appendage Morphology in Patients with Non-Valvular Atrial Fibrillation
Joy, S., Bertog, S. C., Betts, T. R., Wilson, N., Myerson, S. G., & Sievert, H. (2017) · Journal of Structural Heart Disease · doi:10.12945/j.jshd.2016.003.16 · Cited by 3
Self-citation
Percutaneous left atrial appendage occlusion: New perspectives for the method
Gorczyca−Michta, I., & Wożakowska−Kapłon, B. (2017) · Cardiology Journal · doi:10.5603/cj.a2017.0029 · Cited by 3
Novel stroke risk reduction in atrial fibrillation: left atrial appendage occlusion with a focus on the Watchman closure device
Alipour, A., Wintgens, L. I. S., Swaans, M. J., Balt, J. C., Rensing, B. J. W. M., & Boersma, L. V. A. (2017) · Vascular Health and Risk Management · doi:10.2147/vhrm.s89213 · Cited by 3
Neurologic Complications of Cardiac and Aortic Disease
Klaas, J. P. (2017) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000471 · Cited by 3
Verschluss des linken Vorhofohrs bei nichtvalvulärem Vorhofflimmern
Häusler, K. G., Endres, M., & Landmesser, U. (2018) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-018-0500-4 · Cited by 3
Left Atrial Appendage Occlusion in the Management of Stroke in Patients With Atrial Fibrillation
Ojo, A. O., Yandrapalli, S., Veseli, G., Karim, M., Aronow, W. S., Sharma, M., Frishman, W. H., Naidu, S. S., Jacobson, J. T., & Iwai, S. (2018) · Cardiology in Review · doi:10.1097/crd.0000000000000240 · Cited by 3
Racial and ethnic differences in left atrial appendage occlusion wait time, complications, and periprocedural management
Haddad, A., Bocchese, M., Garber, R., O'Neill, B. P., Yesenosky, G. A., Patil, P. V., Keane, M. G., Islam, S., Sherrer, J., Basil, A. K., et al. (2021) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.14255 · Cited by 3

Authors: Reddy, V. Y., Sievert, H., Halperin, J., Doshi, S. K., Buchbinder, M., Neuzil, P., Huber, K., Whisenant, B., Kar, S., Swarup, V., Gordon, N., & Holmes, D.
Affiliations: Na Homolce Hospital (CZ)
Cardiovascular Center Frankfurt (DE)
Icahn School of Medicine at Mount Sinai (US)
Saint John's Health Center (US)
Foundation for Cardiovascular Medicine, La Jolla, California
Homolka Hospital, Prague, Czech Republic
Saint Luke's Hospital (US)
Intermountain Medical Center (US)
Cedars-Sinai Medical Center (US)
Arizona Heart Rhythm Center, Scottsdale
Boston Scientific (United States) (US)
Mayo Clinic (US)
Corresponding author: Reddy, Vivek Y.
ORCID: Reddy, Vivek Y.
Halperin, Jonathan
Doshi, Shephal K.
Buchbinder, Maurice
Whisenant, Brian
Kar, Saibal
Holmes, David
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2014-11-19
Volume: 312
Issue: 19
Pages: 1988
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2014.15192
OpenAlex: W2112970567
Cited by: 1,018
References: 25
Citations by year: 2026: 73 · 2025: 86 · 2024: 87 · 2023: 102 · 2022: 97 · 2021: 84 · 2020: 75 · 2019: 58 · 2018: 87 · 2017: 104 · 2016: 75 · 2015: 77 · 2014: 6
FWCI: 59.90
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords: left atrial appendage closure, warfarin, atrial fibrillation, stroke prevention, systemic embolism, cardiovascular mortality, non-inferiority, non-valvular atrial fibrillation, CHADS2 score, anticoagulation, international normalized ratio, bleeding complications, quality of life, patient satisfaction, patient-reported outcomes
MeSH terms: Aged, Aged, 80 and over, Anticoagulants, Atrial Fibrillation, Bayes Theorem, Cardiovascular Diseases, Embolism, Female, Cardiac Catheterization, Humans, Male, Middle Aged, Risk Factors, Warfarin, Survival Analysis, Treatment Outcome, Prosthesis Implantation, Atrial Appendage, Stroke

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Percutaneous Left Atrial Appendage Closure vs Warfarin for Atrial Fibrillation: A Randomized Clinical Trial

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks