Exercise Is Medicine: At Any Dose?
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Higher levels of physical activity are associated with a lower risk of cardiovascular events.
“Higher levels of physical activity are associated with a lower risk of cardiovascular events 4, 5”
From Relationship between lifelong exercise volume and coronary atherosclerosis in athletes. (2017) · cites this paper as [5]
Plaque composition with fewer mixed plaques and more only calcified plaques seems to be more benign in the most active athletes, resulting in a lower risk profile for future cardiovascular disease.
“The combination of these plaque types results in a lower risk profile for future CVD.”
From Relationship between lifelong exercise volume and coronary atherosclerosis in athletes. (2017) · cites this paper as [5]
The Conclusions (p. 7) discuss physical activity and mortality, but do not discuss plaque composition. Searches for mixed and calcified plaques in athletes returned no passage connecting a combination of plaque types to lower future cardiovascular risk. (LLM, conf=0.76)
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Cites
Fihn, S. D., Blankenship, J. C., Alexander, K. P., Bittl, J. A., Byrne, J. G., Fletcher, B. J., Fonarow, G. C., Lange, R. A., Levine, G. N., Maddox, T. M., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000095 · Cited by 1,029 · see citing works
Leisure-time running reduces all-cause and cardiovascular mortality risk.
Lee, D.-C., Pate, R. R., Lavie, C. J., Sui, X., Church, T. S., & Blair, S. N. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.04.058 · Cited by 819 · see citing works
Dose of Jogging and Long-Term Mortality
Schnohr, P., O’Keefe, J. H., Marott, J. L., Lange, P., & Jensen, G. B. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.11.023 · Cited by 416 · see citing works
Armstrong, M. E. G., Green, J., Reeves, G. K., Beral, V., & Cairns, B. J. (2015) · Circulation · doi:10.1161/circulationaha.114.010296 · Cited by 219 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- [1]1. Schnohr P, O'Keefe JH, Marott JL, Lange P, Jensen GB. Dose of jogging and longterm mortality: the copenhagen city heart study. Journal of the American College of Cardiology. Feb 10 2015;65(5):411-419.
- [2]2. Williams PT, Thompson PD. Increased cardiovascular disease mortality associated with excessive exercise in heart attack survivors. Mayo Clinic proceedings. Sep 2014;89(9):1187-1194.
- [5]5. Wmir s n m ' r i ced mortality and extended life expectancy: a prospective cohort study. Lancet. Oct 1 2011;378(9798):1244-1253.
Cited by
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Franklin, B. A., Thompson, P. D., Al-Zaiti, S. S., Albert, C. M., Hivert, M.-F., Levine, B. D., Lobelo, F., Madan, K., Sharrief, A. Z., Eijsvogels, T. M. H., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000749 · Cited by 410 · see citing works
Self-citationRelationship between lifelong exercise volume and coronary atherosclerosis in athletes.
Aengevaeren, V. L., Mosterd, A., Braber, T. L., Prakken, N. H. J., Doevendans, P. A., Grobbee, D. E., Thompson, P. D., Eijsvogels, T. M. H., & Velthuis, B. K. (2017) · Circulation · doi:10.1161/circulationaha.117.027834 · Cited by 309 · see citing works
Self-citationBullard, T., Ji, M., An, R., Trinh, L., Mackenzie, M., & Mullen, S. P. (2019) · BMC Public Health · doi:10.1186/s12889-019-6877-z · Cited by 255 · see citing works
Is exercise a senolytic medicine? A systematic review
Chen, X., Yi, Z., Wong, G. T., Hasan, K. M. M., Kwan, J. S., Ma, A. C., & Chang, R. C. (2021) · Aging Cell · doi:10.1111/acel.13294 · Cited by 88 · see citing works
Nagata, J. M., Vittinghoff, E., Gabriel, K. P., Rana, J. S., Garber, A. K., Moran, A. E., Reis, J. P., Lewis, C. E., Sidney, S., & Bibbins-Domingo, K. (2022) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-022-01357-2 · Cited by 54 · see citing works
- Authors
- Eijsvogels, T. M. H., & Thompson, P. D.
- Affiliations
- Radboud University Medical Center (NL)
- Hartford Hospital (US)
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2015-11-10
- Volume
- 314
- Issue
- 18
- Pages
- 1915
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2141482713
- Cited by
- 112
- References
- 4
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 10 · 2023: 11 · 2022: 12 · 2021: 7 · 2020: 11 · 2019: 9 · 2018: 11 · 2017: 15 · 2016: 19 · 2015: 1
- FWCI
- 11.28
- Type
- journal article
- Language
- en
- Open access
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Liverpool John Moores University (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Surgery › Medical research and treatments
- Keywords
- physical activity, health promotion, disease prevention
- MeSH terms
- Cardiovascular Diseases, Cause of Death, Physical Exertion, Health Status, Humans, Life Expectancy, Motor Activity, Reference Values, Running, Time Factors, Exercise, Walking
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