Is exercise a senolytic medicine? A systematic review
Open accessAbstract
Cellular senescence, a state of irreversible growth arrest triggered by various stressors, engages in a category of pathological processes, whereby senescent cells accumulate in mitotic tissues. Senolytics as novel medicine against aging and various diseases through the elimination of senescent cells has emerged rapidly in recent years. Exercise is a potent anti-aging and anti-chronic disease medicine, which has shown the capacity to lower the markers of cellular senescence over the past decade. However, whether exercise is a senolytic medicine for aging and various diseases remains unclear. Here, we have conducted a systematic review of the published literature studying the senolytic effects of exercise or physical activity on senescent cells under various states in both human and animal models. Exercise can reduce the markers of senescent cells in healthy humans, while it lowered the markers of senescent cells in obese but not healthy animals. The discrepancy between human and animal studies may be due to the relatively small volume of research and the variations in markers of senescent cells, types of cells/tissues, and health conditions. These findings suggest that exercise has senolytic properties under certain conditions, which warrant further investigations.
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A wealth of literature shows that exercise or physical activity might be the most cost-effective senolytic therapy, although there is large heterogeneity among published studies.
“However, a wealth of literature shows that exercise or physical activity might be the most costeffective senolytic therapy, although there is large heterogeneity among published studies.54”
From The costs and benefits of senotherapeutics for human health (2022) · cites this paper as [54]
A recent review on the senolytic effects of exercise noted high heterogeneity in animal studies and the need for additional investigations.
“They noted the high heterogeneity observed in animal studies and the need for additional investigations.”
From Exercise Counters the Age-Related Accumulation of Senescent Cells (2022) · cites this paper as [59]
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- Authors
- Chen, X., Yi, Z., Wong, G. T., Hasan, K. M. M., Kwan, J. S., Ma, A. C., & Chang, R. C.
- Affiliations
- University of Hong Kong (HK)
- Hong Kong Polytechnic University (HK)
- Imperial College London (GB)
- Department of Health Technology and Informatics Hong Kong Polytechnic University Hong Kong China
- Corresponding author
- Kwan, Joseph Shiu‐Kwong
- Chang, Raymond Chuen‐Chung
- ORCID
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2020-12-30
- Volume
- 20
- Issue
- 1
- Pages
- e13294-e13294
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC7811843
- OpenAlex
- W3117525571
- Cited by
- 88
- References
- 64
- Citations by year
- 2026: 22 · 2025: 14 · 2024: 10 · 2023: 13 · 2022: 9 · 2021: 20
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Aging Cell (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PolyU Institutional Research Archive (Hong Kong Polytechnic University) (publishedVersion, cc-by)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- physical activity, senolytics, cellular senescence, senescent cells, aging, obesity, anti-aging, senescence markers
- MeSH terms
- Adolescent, Adult, Humans, Middle Aged, Exercise, Cellular Senescence, Young Adult
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