Cited by 723Respiratory Support and MechanismsSepsis Diagnosis and TreatmentNosocomial Infections in ICU

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Effect of Conservative vs Conventional Oxygen Therapy on Mortality Among Patients in an Intensive Care Unit: The Oxygen-ICU Randomized Clinical Trial

Open access

Girardis, Massimo, Busani, Stefano, Damiani, Elisa, Donati, Abele, Rinaldi, Laura, Marudi, Andrea, Morelli, Andrea, Antonelli, Massimo, Singer, Mervyn·2016·JAMA

DOI 10.1001/jama.2016.11993

Open this paper in CoChat — free account Open PDF

Abstract

Importance: Despite suggestions of potential harm from unnecessary oxygen therapy, critically ill patients spend substantial periods in a hyperoxemic state. A strategy of controlled arterial oxygenation is thus rational but has not been validated in clinical practice. Objective: To assess whether a conservative protocol for oxygen supplementation could improve outcomes in patients admitted to intensive care units (ICUs). Design, Setting, and Patients: Oxygen-ICU was a single-center, open-label, randomized clinical trial conducted from March 2010 to October 2012 that included all adults admitted with an expected length of stay of 72 hours or longer to the medical-surgical ICU of Modena University Hospital, Italy. The originally planned sample size was 660 patients, but the study was stopped early due to difficulties in enrollment after inclusion of 480 patients. Interventions: Patients were randomly assigned to receive oxygen therapy to maintain Pao2 between 70 and 100 mm Hg or arterial oxyhemoglobin saturation (Spo2) between 94% and 98% (conservative group) or, according to standard ICU practice, to allow Pao2 values up to 150 mm Hg or Spo2 values between 97% and 100% (conventional control group). Main Outcomes and Measures: The primary outcome was ICU mortality. Secondary outcomes included occurrence of new organ failure and infection 48 hours or more after ICU admission. Results: A total of 434 patients (median age, 64 years; 188 [43.3%] women) received conventional (n = 218) or conservative (n = 216) oxygen therapy and were included in the modified intent-to-treat analysis. Daily time-weighted Pao2 averages during the ICU stay were significantly higher (P < .001) in the conventional group (median Pao2, 102 mm Hg [interquartile range, 88-116]) vs the conservative group (median Pao2, 87 mm Hg [interquartile range, 79-97]). Twenty-five patients in the conservative oxygen therapy group (11.6%) and 44 in the conventional oxygen therapy group (20.2%) died during their ICU stay (absolute risk reduction [ARR], 0.086 [95% CI, 0.017-0.150]; relative risk [RR], 0.57 [95% CI, 0.37-0.90]; P = .01). Occurrences were lower in the conservative oxygen therapy group for new shock episode (ARR, 0.068 [95% CI, 0.020-0.120]; RR, 0.35 [95% CI, 0.16-0.75]; P = .006) or liver failure (ARR, 0.046 [95% CI, 0.008-0.088]; RR, 0.29 [95% CI, 0.10-0.82]; P = .02) and new bloodstream infection (ARR, 0.05 [95% CI, 0.00-0.09]; RR, 0.50 [95% CI, 0.25-0.998; P = .049). Conclusions and Relevance: Among critically ill patients with an ICU length of stay of 72 hours or longer, a conservative protocol for oxygen therapy vs conventional therapy resulted in lower ICU mortality. These preliminary findings were based on unplanned early termination of the trial, and a larger multicenter trial is needed to evaluate the potential benefit of this approach. Trial Registration: clinicaltrials.gov Identifier: NCT01319643.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1001/jama.2016.11993

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: How Does High-Concentration Supplemental Perioperative Oxygen Influence Surgical Outcomes after Thyroid Surgery? A Prospective, Randomized, Double-Blind, Controlled, Monocentric Trial
Schietroma, M., Piccione, F., Cecilia, E. M., Carlei, F., Santis, G. D., Sista, F., & Amicucci, G. (2015) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2015.01.046 · Cited by 21
Retracted
A New Simplified Acute Physiology Score (SAPS II) Based on a European/North American Multicenter Study
Le Gall, J.-R. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.270.24.2957 · Cited by 7,773
CDC/NHSN surveillance definition of health care–associated infection and criteria for specific types of infections in the acute care setting
Horan, T. C., Andrus, M., & Dudeck, M. A. (2008) · American Journal of Infection Control · doi:10.1016/j.ajic.2008.03.002 · Cited by 6,646
Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: Results of a multicenter, prospective study
Vincent, J.-L., de Mendonca, A., Cantraine, F., Moreno, R., Takala, J., Suter, P. M., Sprung, C. L., Colardyn, F., & Blecher, S. (1998) · Critical Care Medicine · doi:10.1097/00003246-199811000-00016 · Cited by 3,463
Albumin Replacement in Patients with Severe Sepsis or Septic Shock
Caironi, P., Tognoni, G., Masson, S., Fumagalli, R., Pesenti, A. M., Romero, M., Fanizza, C., Caspani, L., Faenza, S., Grasselli, G., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1305727 · Cited by 1,342
Self-citation
The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective, multicentre study
Moreno, R. P., Vincent, J., Matos, R., de Mendonça, A., Cantraine, F. R. L., THIJS, L. G., Takala, J., Sprung, C. L., Antonelli, M. M., Bruining, H. A., et al. (1999) · Intensive Care Medicine · doi:10.1007/s001340050931 · Cited by 1,050
Self-citation
Pulmonary Lesions Associated with Oxygen Therapy and Artificial Ventilation
Nash, G., Blennerhassett, J. B., & Pontoppidan, H. (1967) · New England Journal of Medicine · doi:10.1056/nejm196702162760702 · Cited by 548
Air Versus Oxygen in ST-Segment–Elevation Myocardial Infarction
Stub, D. A., Smith, K. L., Bernard, S., Nehme, Z., Stephenson, M., Bray, J., Cameron, P. A., Barger, B., Ellims, A., Taylor, A. J., et al. (2015) · Circulation · doi:10.1161/circulationaha.114.014494 · Cited by 534
Association between administered oxygen, arterial partial oxygen pressure and mortality in mechanically ventilated intensive care unit patients
de Jonge, E., Peelen, L. M., Keijzers, P., Joore, H. C. A., de Lange, D. W., van der Voort, P. H., Bosman, R. J., de Waal, R. A. L., Wesselink, R. M. J., & de Keizer, N. F. (2008) · Critical Care · doi:10.1186/cc7150 · Cited by 425
Effect of High Perioperative Oxygen Fraction on Surgical Site Infection and Pulmonary Complications After Abdominal Surgery
Meyhoff, C. S., Wetterslev, J., Jørgensen, L. N., Henneberg, S. W., Høgdall, C. K., Lundvall, L., Svendsen, P.-E., Mollerup, H., Lunn, T. H., Simonsen, I., et al. (2009) · JAMA · doi:10.1001/jama.2009.1452 · Cited by 418

Flagged first, then by citations

Show all 35 references

Sorted by citations

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06506-y · Cited by 5,082
Self-citation
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005337 · Cited by 2,935
Self-citation
Sepsis and septic shock
Cecconi, M., Evans, L., Levy, M., & Rhodes, A. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30696-2 · Cited by 2,254
Contemporary Management of Cardiogenic Shock: A Scientific Statement From the American Heart Association
van Diepen, S., Katz, J. N., Albert, N. M., Henry, T. D., Jacobs, A. K., Kapur, N. K., Kılıç, A., Menon, V., Ohman, E. M., Sweitzer, N. K., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000525 · Cited by 1,936
Acute Respiratory Distress Syndrome
Fan, E., Brodie, D., & Slutsky, A. S. (2018) · JAMA · doi:10.1001/jama.2017.21907 · Cited by 1,482
Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial
Villar, J., Ferrando, C., Martínez, D., Ambrós, A., Muñoz, T., Soler, J. A., Aguilar, G., Alba, F., González-Higueras, E., Conesa, L. A., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(19)30417-5 · Cited by 1,241
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock
Marik, P. E., Khangoora, V., Rivera, R., Hooper, M. H., & Catravas, J. (2017) · Chest · doi:10.1016/j.chest.2016.11.036 · Cited by 887
Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis
Chu, D. K., Kim, L. H.-Y., Young, P. J., Zamiri, N., Almenawer, S. A., Jaeschke, R., Szczeklik, W., Schünemann, H. J., Neary, J. D., & Alhazzani, W. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30479-3 · Cited by 778
BTS guideline for oxygen use in adults in healthcare and emergency settings
O’Driscoll, B. R., Howard, L., Earis, J. E., & Mak, V. H. F. (2017) · Thorax · doi:10.1136/thoraxjnl-2016-209729 · Cited by 710
Conservative Oxygen Therapy during Mechanical Ventilation in the ICU
The ICU-ROX Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1903297 · Cited by 511
Liberal or Conservative Oxygen Therapy for Acute Respiratory Distress Syndrome
Barrot, L., Asfar, P., Mauny, F., Winiszewski, H., Montini, F., Badie, J., Quenot, J.-P., Pili-Floury, S., Bouhemad, B., Louis, G., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1916431 · Cited by 467
The REMAP-CAP (Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia) Study. Rationale and Design
Angus, D. C., Berry, S. M., Lewis, R. J., Al-Beidh, F., Arabi, Y. M., van Bentum-Puijk, W., Bhimani, Z., Bonten, M. J. M., Broglio, K. R., Brunkhorst, F. M., et al. (2020) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202003-192sd · Cited by 471
Organ Dysfunction, Injury and Failure in Acute Heart Failure: From Pathophysiology to Diagnosis and Management. A Review on Behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)
Harjola, V., Müllens, W., Banaszewski, M., Bauersachs, J. K., Rocca, H. B., Chioncel, O., Collins, S. P., Doehner, W., Filippatos, G. S., Flammer, A. J., et al. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.872 · Cited by 435
Mechanical Ventilation: State of the Art
Pham, T. O., Brochard, L. J., & Slutsky, A. S. (2017) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.05.004 · Cited by 404
Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure
Schjørring, O. L., Klitgaard, T. L., Perner, A., Wetterslev, J., Lange, T., Siegemund, M., Bäcklund, M., Keus, F., Laake, J. H., Morgan, M., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2032510 · Cited by 377
Effect of High-Flow Nasal Oxygen vs Standard Oxygen on 28-Day Mortality in Immunocompromised Patients With Acute Respiratory Failure
Azoulay, É., Lemiale, V., Mokart, D., Nseir, S., Argaud, L., Pène, F., Kontar, L., Bruneel, F., Klouche, K., Barbier, F., et al. (2018) · JAMA · doi:10.1001/jama.2018.14282 · Cited by 339
Guidelines for Reporting Trial Protocols and Completed Trials Modified Due to the COVID-19 Pandemic and Other Extenuating Circumstances: The CONSERVE 2021 Statement
Orkin, A. M., Gill, P. J., Ghersi, D., Campbell, L., Sugarman, J., Emsley, R., Steg, P. G., Weijer, C., Simes, J., Rombey, T., et al. (2021) · JAMA · doi:10.1001/jama.2021.9941 · Cited by 299
Hyperoxia and hypertonic saline in patients with septic shock (HYPERS2S): a two-by-two factorial, multicentre, randomised, clinical trial
Asfar, P., Schortgen, F., Helms, J., Charpentier, J., Guérot, E., Mégarbane, B., Grimaldi, D., Grelon, F., Anguel, N., Lasocki, S., et al. (2017) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(17)30046-2 · Cited by 295
Dangers of hyperoxia
Singer, M., Young, P. J., Laffey, J. G., Asfar, P., Taccone, F. S., Skrifvars, M. B., Meyhoff, C. S., & Radermacher, P. (2021) · Critical Care · doi:10.1186/s13054-021-03815-y · Cited by 304
Self-citation
Positive pressure ventilation in the cardiac intensive care unit
Alviar, C. L., Miller, P. E., McAreavey, D., Katz, J. N., Lee, B., Moriyama, B., Soble, J., van Diepen, S., Solomon, M. A., & Morrow, D. A. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.06.074 · Cited by 271
Healthful aging mediated by inhibition of oxidative stress
Vatner, S. F., Zhang, J., Oydanich, M. K., Berkman, T., Naftalovich, R., & Vatner, D. E. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101194 · Cited by 243
The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020)
Egi, M., Ogura, H., Yatabe, T., Atagi, K., Inoue, S., Iba, T., Kakihana, Y., Kawasaki, T., Kushimoto, S., Kuroda, Y., et al. (2021) · Journal of Intensive Care · doi:10.1186/s40560-021-00555-7 · Cited by 232
Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism
Jain, I. H., Calvo, S. E., Markhard, A. L., Skinner, O. S., To, T.-L., Ast, T., & Mootha, V. K. (2020) · Cell · doi:10.1016/j.cell.2020.03.029 · Cited by 224
Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation
Semler, M. W., Casey, J. D., Lloyd, B. D., Hastings, P. G., Hays, M. A., Stollings, J. L., Buell, K. G., Brems, J. H., Qian, E. T., Seitz, K. P., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2208415 · Cited by 221
Mitochondrial lactate metabolism: history and implications for exercise and disease
Glancy, B. C., Kane, D. A., Kavazis, A. N., Goodwin, M. L., Willis, W. T., & Gladden, L. B. (2020) · The Journal of Physiology · doi:10.1113/jp278930 · Cited by 216
High intraoperative inspiratory oxygen fraction and risk of major respiratory complications
Staehr-Rye, A. K., Meyhoff, C. S., Scheffenbichler, F. T., Melo, M. F. V., Gätke, M. R., Walsh, J. L., Ladha, K. S., Grabitz, S. D., Nikolov, M., Kurth, T., et al. (2017) · British Journal of Anaesthesia · doi:10.1093/bja/aex128 · Cited by 173
Lung and gut microbiota are altered by hyperoxia and contribute to oxygen-induced lung injury in mice
Ashley, S. L., Sjoding, M. W., Popova, A. P., Cui, T. X., Hoostal, M. J., Schmidt, T. M., Branton, W. R., Dieterle, M. G., Falkowski, N. R., Baker, J. M., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aau9959 · Cited by 170
Pulmonary infections complicating ARDS
Luyt, C. E., Bouadma, L., Morris, A. C., Dhanani, J., Kollef, M. H., Lipman, J., Martín‐Loeches, I., Nseir, S., Ranzani, O., Roquilly, A., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06292-z · Cited by 177
Update of Sepsis in the Intensive Care Unit
Genga, K. R., & Russell, J. A. (2017) · Journal of Innate Immunity · doi:10.1159/000477419 · Cited by 167
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
Ast, T., Meisel, J. D., Patra, S., Wang, H., Grange, R. M. H., Kim, S. H., Calvo, S. E., Orefice, L. L., Nagashima, F., Ichinose, F., et al. (2019) · Cell · doi:10.1016/j.cell.2019.03.045 · Cited by 160
F ifty Y ears of R esearch in ARDS. Gas Exchange in Acute Respiratory Distress Syndrome
Radermacher, P., Maggiore, S. M., & Mercat, A. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201610-2156so · Cited by 151
Intra-abdominal sepsis: new definitions and current clinical standards
Hecker, A., Reichert, M., Reuß, C. J., Schmoch, T., Riedel, J. G., Schneck, E., Padberg, W. M., Weigand, M. A., & Hecker, M. (2019) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-019-01752-7 · Cited by 159
Emergency department hyperoxia is associated with increased mortality in mechanically ventilated patients: a cohort study
Page, D., Ablordeppey, E., Wessman, B. T., Mohr, N. M., Trzeciak, S., Kollef, M. H., Roberts, B. W., & Fuller, B. M. (2018) · Critical Care · doi:10.1186/s13054-017-1926-4 · Cited by 140
Individualized Treatment Effects of Oxygen Targets in Mechanically Ventilated Critically Ill Adults
Buell, K. G., Spicer, A. B., Casey, J. D., Seitz, K. P., Qian, E. T., Linck, E. J. G., Self, W. H., Rice, T. W., Sinha, P., Young, P. J., et al. (2024) · JAMA · doi:10.1001/jama.2024.2933 · Cited by 134
Oxygen in the critically ill
Damiani, E., Donati, A., & Girardis, M. (2018) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000559 · Cited by 129
Self-citation
Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients
Gelissen, H. P. M. M., de Grooth, H., Smulders, Y. M., Wils, E., de Ruijter, W., Vink, R., Smit, B., Röttgering, J. G., Atmowihardjo, L. N., Girbes, A. R. J., et al. (2021) · JAMA · doi:10.1001/jama.2021.13011 · Cited by 131
Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study
Laffey, J. G., Madotto, F., Bellani, G., Pham, T. O., Fan, E., Brochard, L. J., Amin, P. R., Arabi, Y. M., Bajwa, E. K., Bruhn, A. R., et al. (2017) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(17)30213-8 · Cited by 125
The oxygen reserve index (ORI): a new tool to monitor oxygen therapy
Scheeren, T., Belda, F. J., & Perel, A. (2017) · Journal of Clinical Monitoring and Computing · doi:10.1007/s10877-017-0049-4 · Cited by 125
Reclassifying Acute Respiratory Distress Syndrome
Maiolo, G., Collino, F., Vasques, F., Rapetti, F., Tonetti, T., Romitti, F., Cressoni, M., Chiumello, D., Moerer, O., Herrmann, P., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201709-1804oc · Cited by 122
Hemodynamic effects of acute hyperoxia: systematic review and meta-analysis
Smit, B., Smulders, Y. M., van der Wouden, J. C., Straaten, H. M. O., & de Man, A. (2018) · Critical Care · doi:10.1186/s13054-018-1968-2 · Cited by 122
Considerations for target oxygen saturation in COVID-19 patients: are we under-shooting?
Shenoy, N. K., Luchtel, R. A., & Gulani, P. (2020) · BMC Medicine · doi:10.1186/s12916-020-01735-2 · Cited by 126
Acute Respiratory Distress Syndrome
Williams, G. W., Berg, N. K., Reskallah, A., Yuan, X., & Eltzschig, H. K. (2020) · Anesthesiology · doi:10.1097/aln.0000000000003571 · Cited by 123
Lung-Protective Ventilation Initiated in the Emergency Department (LOV-ED): A Quasi-Experimental, Before-After Trial
Fuller, B. M., Ferguson, I. T., Mohr, N. M., Drewry, A. M., Palmer, C., Wessman, B. T., Ablordeppey, E., Keeperman, J. B., Stephens, R. J., Briscoe, C. C., et al. (2017) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2017.01.013 · Cited by 120
Prevention of complications in the cardiac intensive care unit: a scientific statement from the American Heart Association
Fordyce, C. B., Katz, J. N., Alviar, C. L., Arslanian-Engoren, C., Bohula, E. A., Geller, B. J., Hollenberg, S. M., Jentzer, J. C., Sims, D. B., Washam, J. B., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000909 · Cited by 116
The Search for Optimal Oxygen Saturation Targets in Critically Ill Patients
van den Boom, W., Hoy, M., Sankaran, J., Liu, M., Chahed, H., Feng, M., & See, K. C. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.09.015 · Cited by 116
Recomendaciones para el tratamiento de los pacientes críticos de los Grupos de Trabajo de la Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias (SEMICYUC)
Hernández-Tejedor, A., Peñuelas, Ó., Sirgo, G., Llompart-Pou, J. A., Herrejon, E. P., Estella, Á., Cabanes, M. P. F., Alcalá-Llorente, M. A., Galleymore, P. R., Azuara, B. O., et al. (2017) · Medicina Intensiva · doi:10.1016/j.medin.2017.03.004 · Cited by 105
Respiratory support in patients with acute respiratory distress syndrome: an expert opinion
Chiumello, D., Brochard, L. J., Marini, J. J., Slutsky, A. S., Mancebo, J., Ranieri, V. M., Thompson, B., Papazian, L., Schultz, M. J., Amato, M. B. P., et al. (2017) · Critical Care · doi:10.1186/s13054-017-1820-0 · Cited by 104
Management of cardiogenic shock: a narrative review
Laghlam, D., Benghanem, S., Ortuno, S., Bouabdallaoui, N., Manzo‐Silberman, S., Hamzaoui, O., & Aïssaoui, N. (2024) · Annals of Intensive Care · doi:10.1186/s13613-024-01260-y · Cited by 110
The continuum of critical care
Vincent, J. (2019) · Critical Care · doi:10.1186/s13054-019-2393-x · Cited by 100
The Association between Supraphysiologic Arterial Oxygen Levels and Mortality in Critically Ill Patients: A Multicenter Observational Cohort Study
Palmer, E., Post, B., Klapaukh, R., Marra, G., MacCallum, N. S., Brealey, D. A., Ercole, A., Jones, A., Ashworth, S., Watkinson, P., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201904-0849oc · Cited by 99
Self-citation
Harmful Effects of Hyperoxia in Postcardiac Arrest, Sepsis, Traumatic Brain Injury, or Stroke: The Importance of Individualized Oxygen Therapy in Critically Ill Patients
Vincent, J., Taccone, F. S., & He, X. (2017) · Canadian Respiratory Journal · doi:10.1155/2017/2834956 · Cited by 94
Oxygen Thresholds and Mortality During Extracorporeal Life Support in Adult Patients*
Munshi, L., Kiss, A., Cypel, M., Keshavjee, S. H., Ferguson, N. D., & Fan, E. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002643 · Cited by 92
Targeting Hypoxia Signaling for Perioperative Organ Injury
Yuan, X., Lee, J. W., Bowser, J. L., Neudecker, V., Sridhar, S., & Eltzschig, H. K. (2017) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000002288 · Cited by 92
ARDS Clinical Practice Guideline 2021
Tasaka, S., Ohshimo, S., Takeuchi, M., Yasuda, H., Ichikado, K., Tsushima, K., Egi, M., Hashimoto, S., Shime, N., Saitô, O., et al. (2022) · Journal of Intensive Care · doi:10.1186/s40560-022-00615-6 · Cited by 91
The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J‐SSCG 2020)
Egi, M., Ogura, H., Yatabe, T., Atagi, K., Inoue, S., Iba, T., Kakihana, Y., Kawasaki, T., Kushimoto, S., Kuroda, Y., et al. (2021) · Acute Medicine & Surgery · doi:10.1002/ams2.659 · Cited by 88
Conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): a UK multicentre, open, parallel-group, randomised clinical trial
Peters, M. J., Gould, D. W., Ray, S., Thomas, K., Chang, I., Orzol, M., O’Neill, L., Agbeko, R., Au, C., Draper, E. S., et al. (2023) · The Lancet · doi:10.1016/s0140-6736(23)01968-2 · Cited by 85
Oxygen Exposure Resulting in Arterial Oxygen Tensions Above the Protocol Goal Was Associated With Worse Clinical Outcomes in Acute Respiratory Distress Syndrome*
Aggarwal, N. R., Brower, R. G., Hager, D. N., Thompson, B., Netzer, G., Shanholtz, C. B., Lagakos, A., & Checkley, W. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002886 · Cited by 87
Perioperative Oxidative Stress: The Unseen Enemy
Stevens, J. L., Feelisch, M., & Martín, D. (2019) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000004455 · Cited by 82
Higher versus lower fraction of inspired oxygen or targets of arterial oxygenation for adults admitted to the intensive care unit
Barbateskovic, M., Schjørring, O. L., Krauss, S. R., Jakobsen, J. C., Meyhoff, C. S., Dahl, R. M., Rasmussen, B. S., Perner, A., & Wetterslev, J. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012631.pub2 · Cited by 82
Oxygen Toxicity in Critically Ill Adults
Hochberg, C. H., Semler, M. W., & Brower, R. G. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202102-0417ci · Cited by 85
Comparative Response of Brain to Chronic Hypoxia and Hyperoxia
Terraneo, L., & Samaja, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091914 · Cited by 82
The effectiveness of two silicone dressings for sacral and heel pressure ulcer prevention compared with no dressings in high‐risk intensive care unit patients: a randomized controlled parallel‐group trial
Hahnel, E., Genedy‐Kalyoncu, M. E., Tomova‐Simitchieva, T., Hauß, A., Stroux, A., Lechner, A., Richter, C., Akdeniz, M., Blume‐Peytavi, U., Löber, N., et al. (2019) · British Journal of Dermatology · doi:10.1111/bjd.18621 · Cited by 80
Conservative or liberal oxygen therapy in adults after cardiac arrest
Young, P. J., Bailey, M., Bellomo, R., Bernard, S. A., Bray, J., Jakkula, P., Kuisma, M., Mackle, D., Martín, D., Nolan, J. P., et al. (2020) · Resuscitation · doi:10.1016/j.resuscitation.2020.09.036 · Cited by 79
Effect of a Lower vs Higher Positive End-Expiratory Pressure Strategy on Ventilator-Free Days in ICU Patients Without ARDS
Algera, A. G., Pisani, L., Neto, A. S., den Boer, S. S., Bosch, F. H., Bruin, K., Klooster, P. M., van der Meer, N. J. M., Nowitzky, R. O., Purmer, I. M., et al. (2020) · JAMA · doi:10.1001/jama.2020.23517 · Cited by 79
The intensive care medicine research agenda on septic shock
Perner, A., Gordon, A. C., Angus, D. C., Lamontagne, F., Machado, F. R., Russell, J. A., Timsit, J., Marshall, J. C., Myburgh, J., Shankar‐Hari, M., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4821-1 · Cited by 78
Self-citation
Optimising organ perfusion in the high-risk surgical and critical care patient: a narrative review
Parker, T., Brealey, D. A., Dyson, A., & Singer, M. (2019) · British Journal of Anaesthesia · doi:10.1016/j.bja.2019.03.027 · Cited by 73
Self-citation
Conservative versus Liberal Oxygenation Targets in Intensive Care Unit Patients (ICONIC): A Randomized Clinical Trial
van der Wal, L. I., Grim, C. C. A., del Prado, M. R., van Westerloo, D. J., Boerma, E. C., Jong, H. G. R.-D., Reidinga, A. C., Loef, B. G., van der Heiden, P. L. J., Sigtermans, M. J., et al. (2023) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202303-0560oc · Cited by 73
Hyperoxia in anaesthesia and intensive care
Horncastle, E., & Lumb, A. B. (2019) · BJA Education · doi:10.1016/j.bjae.2019.02.005 · Cited by 70
Higher vs Lower Oxygenation Strategies in Acutely Ill Adults
Barbateskovic, M., Schjørring, O. L., Krauss, S. R., Meyhoff, C. S., Jakobsen, J. C., Rasmussen, B. S., Perner, A., & Wetterslev, J. (2020) · CHEST Journal · doi:10.1016/j.chest.2020.07.015 · Cited by 67
Ventilator Management and Respiratory Care After Cardiac Arrest
Johnson, N. J., Carlbom, D., & Gaieski, D. F. (2017) · CHEST Journal · doi:10.1016/j.chest.2017.11.012 · Cited by 66
Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation
Kiers, D., Wielockx, B., Peters, E., van Eijk, L. T., Gerretsen, J., John, A. T., Janssen, E., Groeneveld, R., Peters, M., Damen, L., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.06.021 · Cited by 68
Mechanical Ventilation and Extracorporeal Membrane Oxygenation in Acute Respiratory Insufficiency
Fichtner, F., Moerer, O., Laudi, S., Weber‐Carstens, S., Nothacker, M., & Kaisers, U. X. (2018) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2018.0840 · Cited by 67
AARC Clinical Practice Guideline: Management of Adult Patients With Oxygen in the Acute Care Setting
Piraino, T., Madden, M., Roberts, K. J., Lamberti, J. P., Capellari, E. C., & Strickland, S. L. (2021) · Respiratory Care · doi:10.4187/respcare.09294 · Cited by 63
Hyperoxia and oxidative stress in anesthesia and critical care medicine
Ottolenghi, S., Sabbatini, G., Brizzolari, A., Samaja, M., & Chiumello, D. (2020) · Minerva Anestesiologica · doi:10.23736/s0375-9393.19.13906-5 · Cited by 62
Oxygen Therapy for the Critically Ill
Angus, D. C. (2020) · New England Journal of Medicine · doi:10.1056/nejme2000800 · Cited by 60
Conservative versus liberal oxygenation targets in critically ill children: the randomised multiple-centre pilot Oxy-PICU trial
Peters, M. J., Jones, G. A. L., Wiley, D., Wulff, J., Ramnarayan, P., Ray, S., Inwald, D. P., Grocott, M. P. W., Griksaitis, M. J., Pappachan, J., et al. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5232-7 · Cited by 59
Association between arterial hyperoxia and mortality in critically ill patients: A systematic review and meta-analysis
You, J., Fan, X., Bi, X., Xian, Y., Xie, D., Fan, M., Xu, W., & Zhang, K. (2018) · Journal of Critical Care · doi:10.1016/j.jcrc.2018.07.014 · Cited by 59
Intraoperative Oxygen Concentration and Neurocognition after Cardiac Surgery
Shaefi, S., Shankar, P., Mueller, A., O’Gara, B., Spear, K., Khabbaz, K. R., Bagchi, A., Chu, L. M., Banner‐Goodspeed, V., Leaf, D. E., et al. (2020) · Anesthesiology · doi:10.1097/aln.0000000000003650 · Cited by 59
Hyperoxia and Lungs: What We Have Learned From Animal Models
Amarelle, L., Quintela, L., Hurtado, J., & Malacrida, L. S. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.606678 · Cited by 58
Fully automated postoperative ventilation in cardiac surgery patients: a randomised clinical trial
Dekker, A. D. B., Neto, A. S., van Meenen, D. M. P., Bouwman, R. A., Roos, A. N., Lameijer, J. R. C., Korsten, E. H. H. M., Schultz, M. J., & Bindels, A. J. G. H. (2020) · British Journal of Anaesthesia · doi:10.1016/j.bja.2020.06.037 · Cited by 55
Monitoring During Mechanical Ventilation
Rackley, C. R. (2020) · Respiratory Care · doi:10.4187/respcare.07812 · Cited by 56
German S3 Guideline: Oxygen Therapy in the Acute Care of Adult Patients
Gottlieb, J., Capetian, P., Hamsen, U., Janssens, U., Karagiannidis, C., Kluge, S., Nothacker, M., Roiter, S., Volk, T. J., Worth, H., et al. (2021) · Respiration · doi:10.1159/000520294 · Cited by 56
Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes
Baik, A. H., Haribowo, A. G., Chen, X., Queliconi, B. B., Barrios, A. M., Garg, A., Maishan, M., Campos, A. R., Matthay, M. A., & Jain, I. H. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.02.013 · Cited by 56
Oxygen therapy in acute hypoxemic respiratory failure: guidelines from the SRLF-SFMU consensus conference
Helms, J., Catoire, P., Vuillaume, L. A., Bannelier, H., Douillet, D., Dupuis, C., Federici, L., Jezequel, M., Jozwiak, M., Kuteifan, K., et al. (2024) · Annals of Intensive Care · doi:10.1186/s13613-024-01367-2 · Cited by 56
Benefits and risks of oxygen therapy during acute medical illness: Just a matter of dose!
Allardet-Servent, J., Sicard, G., Metz, V., & Chiche, L. (2019) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2019.04.003 · Cited by 51
The intensive care medicine research agenda for airways, invasive and noninvasive mechanical ventilation
Jaber, S., Bellani, G., Blanch, L. L., Demoule, A., Esteban, A., Gattinoni, L., Guérin, C., Hill, N. S., Laffey, J. G., Maggiore, S. M., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4896-8 · Cited by 51
A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients: Should We Aim for Less?
Stolmeijer, R., Bouma, H. R., Zijlstra, J. G., Klerck, A. M. D.-D., ter Maaten, J. C., & Ligtenberg, J. J. M. (2018) · BioMed Research International · doi:10.1155/2018/7841295 · Cited by 49
Effect of high-flow nasal cannula oxygen therapy compared with conventional oxygen therapy in postoperative patients: a systematic review and meta-analysis
Lu, Z., Chang, W., Meng, S., Zhang, X., Xie, J., Xu, J., Qiu, H., Yang, Y., & Guo, F. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-027523 · Cited by 48
Oxygen administration for postoperative surgical patients: a narrative review
Suzuki, S. (2020) · Journal of Intensive Care · doi:10.1186/s40560-020-00498-5 · Cited by 51
Hyperoxia toxicity in septic shock patients according to the Sepsis-3 criteria: a post hoc analysis of the HYPER2S trial
Demiselle, J., Wepler, M., Hartmann, C., Radermacher, P., Schortgen, F., Meziani, F., Singer, M., Seegers, V., & Asfar, P. (2018) · Annals of Intensive Care · doi:10.1186/s13613-018-0435-1 · Cited by 47
Self-citation
Hypoxia‐inducible factors in metabolic reprogramming during sepsis
Vanderhaeghen, T., Vandewalle, J., & Libert, C. (2020) · FEBS Journal · doi:10.1111/febs.15222 · Cited by 47
High arterial oxygen levels and supplemental oxygen administration in traumatic brain injury: insights from CENTER-TBI and OzENTER-TBI
Rezoagli, E., Petrosino, M., Rebora, P., Menon, D. K., Mondello, S., Cooper, D. J., Maas, A. I. R., Wiegers, E., Galimberti, S., Citerio, G., et al. (2022) · Intensive Care Medicine · doi:10.1007/s00134-022-06884-x · Cited by 46
Higher versus lower fractions of inspired oxygen or targets of arterial oxygenation for adults admitted to the intensive care unit
Klitgaard, T., Schjørring, O. L., Nielsen, F. M., Meyhoff, C. S., Perner, A., Wetterslev, J., Rasmussen, B. S., & Barbateskovic, M. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012631.pub3 · Cited by 48
Who Can Make Sense of the WHO Guidelines to Prevent Surgical Site Infection?
Hedenstierna, G., Perchiazzi, G., Meyhoff, C. S., & Larsson, A. (2017) · Anesthesiology · doi:10.1097/aln.0000000000001604 · Cited by 47
Associations between intraoperative ventilator settings during one-lung ventilation and postoperative pulmonary complications: a prospective observational study
Okahara, S., Shimizu, K., Suzuki, S., Ishii, K., & Morimatsu, H. (2018) · BMC Anesthesiology · doi:10.1186/s12871-018-0476-x · Cited by 47
Using machine learning models to predict oxygen saturation following ventilator support adjustment in critically ill children: A single center pilot study
Ghazal, S., Sauthier, M., Brossier, D., Bouachir, W., Jouvet, P. A., & Noumeir, R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0198921 · Cited by 45
Perioperative high inspired oxygen fraction induces atelectasis in patients undergoing abdominal surgery: A randomized controlled trial
Park, M., Jung, K., Sim, W. S., Kim, D. K., Chung, I. S., Choi, J. W., Lee, E. J., Lee, N. Y., & Kim, J. A. (2021) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2021.110285 · Cited by 45
Classification and effectiveness of different oxygenation goals in mechanically ventilated critically ill patients: network meta-analysis of randomised controlled trials
Zhao, X., Xiao, H., Dai, F., Brodie, D., & Meng, L. (2021) · European Respiratory Journal · doi:10.1183/13993003.02928-2020 · Cited by 45
Mitochondria and oxygen homeostasis
Mori, M. P., Penjweini, R., Knutson, J. R., Wang, P., & Hwang, P. M. (2021) · FEBS Journal · doi:10.1111/febs.16115 · Cited by 46
Hyperoxia: At what level of SpO 2 is a patient safe? A study in mechanically ventilated ICU patients
Durlinger, E. M. J., de Man, A., Smit, B., de Grooth, H., Girbes, A. R. J., Straaten, H. M. O., & Smulders, Y. M. (2017) · Journal of Critical Care · doi:10.1016/j.jcrc.2017.02.031 · Cited by 44

Authors: Girardis, M., Busani, S., Damiani, E., Donati, A., Rinaldi, L., Marudi, A., Morelli, A., Antonelli, M., & Singer, M.
Affiliations: Azienda Ospedaliero-Universitaria di Modena (IT)
Marche Polytechnic University (IT)
Intensive Care Unit, Department of Anaesthesiology and Intensive Care, NOCSAE Hospital, Modena, Italy
Sapienza University of Rome (IT)
Università Cattolica del Sacro Cuore (IT)
University College London (GB)
Corresponding author: Girardis, Massimo
ORCID: Girardis, Massimo
Busani, Stefano
Damiani, Elisa
Donati, Abele
Morelli, Andrea
Antonelli, Massimo
Singer, Mervyn
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2016-10-18
Volume: 316
Issue: 15
Pages: 1583
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2016.11993
OpenAlex: W2528556615
Cited by: 723
References: 35
Citations by year: 2026: 34 · 2025: 58 · 2024: 61 · 2023: 66 · 2022: 89 · 2021: 105 · 2020: 97 · 2019: 59 · 2018: 73 · 2017: 75 · 2016: 4
FWCI: 63.04
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
Funders: Università Degli Studi di Modena e Reggio Emila
InflaRx
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
Keywords: conservative oxygen therapy, hyperoxemia, arterial oxygenation, ICU mortality, critically ill patients, supplemental oxygen, arterial oxygen partial pressure, oxygen saturation, organ failure, infection, mechanical ventilation, intensive care unit admission criteria
MeSH terms: Adult, Aged, Cross Infection, Female, Humans, Intensive Care Units, Length of Stay, Male, Middle Aged, Oxygen, Oxygen Inhalation Therapy, Partial Pressure, Shock, Critical Illness, Hospital Mortality, Liver Failure, Hyperoxia, Early Termination of Clinical Trials

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effect of Conservative vs Conventional Oxygen Therapy on Mortality Among Patients in an Intensive Care Unit: The Oxygen-ICU Randomized Clinical Trial

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks