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Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: US Preventive Services Task Force Recommendation Statement

Open access
US Preventive Services Task Force, Bibbins-Domingo, Kirsten, Grossman, David C., Curry, Susan J., Davidson, Karina W., Epling, John W., García, Francisco A. R., Gillman, Matthew W., Kemper, Alex R., Krist, Alex H., Kurth, Ann E., Landefeld, C. Seth, LeFevre, Michael L., Mangione, Carol M., Phillips, William R., Owens, Douglas K., Phipps, Maureen G., Pignone, Michael P.·2016·JAMA

Abstract

Importance: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States, accounting for 1 of every 3 deaths among adults. Objective: To update the 2008 US Preventive Services Task Force (USPSTF) recommendation on screening for lipid disorders in adults. Evidence Review: The USPSTF reviewed the evidence on the benefits and harms of screening for and treatment of dyslipidemia in adults 21 years and older; the benefits and harms of statin use in reducing CVD events and mortality in adults without a history of CVD events; whether the benefits of statin use vary by subgroup, clinical characteristics, or dosage; and the benefits of various treatment strategies in adults 40 years and older without a history of CVD events. Conclusions and Recommendations: The USPSTF recommends initiating use of low- to moderate-dose statins in adults aged 40 to 75 years without a history of CVD who have 1 or more CVD risk factors (dyslipidemia, diabetes, hypertension, or smoking) and a calculated 10-year CVD event risk of 10% or greater (B recommendation). The USPSTF recommends that clinicians selectively offer low- to moderate-dose statins to adults aged 40 to 75 years without a history of CVD who have 1 or more CVD risk factors and a calculated 10-year CVD event risk of 7.5% to 10% (C recommendation). The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of initiating statin use in adults 76 years and older (I statement).

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Metadata

Authors
US Preventive Services Task Force, Bibbins-Domingo, K., Grossman, D. C., Curry, S. J., Davidson, K. W., Epling, J. W., García, F. A. R., Gillman, M. W., Kemper, A. R., Krist, A. H., Kurth, A. E., Landefeld, C. S., LeFevre, M. L., Mangione, C. M., Phillips, W. R., Owens, D. K., Phipps, M. G., & Pignone, M. P.
Venue
JAMA
Published
2016-11-15
Volume
316
Issue
19
Pages
1997
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
OpenAlex
W2551232524
Cited by
589
References
9
FWCI
87.29
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: US Preventive Services Task Force Recommendation Statement. https://app.cochat.ai/papers/10.1001/jama.2016.15450
The paper
US Preventive Services Task Force, Bibbins-Domingo, K., Grossman, D. C., Curry, S. J., Davidson, K. W., Epling, J. W., García, F. A. R., Gillman, M. W., Kemper, A. R., Krist, A. H., Kurth, A. E., Landefeld, C. S., LeFevre, M. L., Mangione, C. M., Phillips, W. R., Owens, D. K., Phipps, M. G., & Pignone, M. P. (2016). Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: US Preventive Services Task Force Recommendation Statement. JAMA. https://doi.org/10.1001/jama.2016.15450

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.