Statins and Cognitive Function: A Systematic Review
Abstract
Background Despite the U.S. Food and Drug Administration (FDA) warning regarding cognitive impairment, the relationship between statins and cognition remains unknown. Purpose To examine the effect of statins on cognition. Data sources PubMed, Embase, and Cochrane Library from inception through October 2012; FDA databases from January 1986 through March 2012. Study selection Randomized, controlled trials (RCTs) and cohort, case-control, and cross-sectional studies evaluating cognition in patients receiving statins. Data extraction Two reviewers extracted data, 1 reviewer assessed study risk of bias, and 1 reviewer checked all assessments. Data synthesis Among statin users, low-quality evidence suggested no increased incidence of Alzheimer disease and no difference in cognitive performance related to procedural memory, attention, or motor speed. Moderate-quality evidence suggested no increased incidence of dementia or mild cognitive impairment or any change in cognitive performance related to global cognitive performance scores, executive function, declarative memory, processing speed, or visuoperception. Examination of the FDA postmarketing surveillance databases revealed a low reporting rate for cognitive-related adverse events with statins that was similar to the rates seen with other commonly prescribed cardiovascular medications. Limitations The absence of many well-powered RCTs for most outcomes resulted in final strengths of evidence that were low or moderate. Imprecisio…
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Systematic reviews of randomized controlled trials and prospective cohort studies evaluating cognition in individuals receiving statins found that published data do not reveal an adverse effect of statins on cognition.
“In addition, systematic reviews of randomized controlled trials and prospective cohort studies evaluating cognition in individuals receiving statins found that published data do not reveal an adverse effect of statins on cognition (171,172).”
From 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2025 (2025) · cites this paper as [172]
Systematic reviews of randomized controlled trials and prospective cohort studies evaluating cognition in individuals receiving statins found that published data do not reveal an adverse effect of statins on cognition.
“In addition, systematic reviews of randomized controlled trials and prospective cohort studies evaluating cognition in individuals receiving statins found that published data do not reveal an adverse effect of statins on cognition (165,166).”
From 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2026 (2026) · cites this paper as [166]
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- Authors
- Richardson, K., Schoen, M., French, B., Umscheid, C. A., Mitchell, M. D., Arnold, S. E., Heidenreich, P. A., Rader, D. J., & deGoma, E. M.
- Affiliations
- Stanford Medicine (US)
- ORCID
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 2013-11-19
- Volume
- 159
- Issue
- 10
- Pages
- 688-697
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2017872978
- Cited by
- 250
- References
- 84
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 8 · 2023: 8 · 2022: 12 · 2021: 12 · 2020: 16 · 2019: 24 · 2018: 25 · 2017: 19 · 2016: 41 · 2015: 34 · 2014: 28 · 2013: 1
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- statins, cognitive function, cognitive impairment, Alzheimer's disease, dementia, mild cognitive impairment, executive function, memory, processing speed, post-marketing surveillance, adverse drug reactions, high-intensity statin therapy
- MeSH terms
- Alzheimer Disease, Cognition Disorders, Dementia, Humans, Memory Disorders, United States, United States Food and Drug Administration, Adverse Drug Reaction Reporting Systems, Hydroxymethylglutaryl-CoA Reductase Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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