When Will Mendelian Randomization Become Relevant for Clinical Practice and Public Health?

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

Bowden, J., Davey Smith, G., & Burgess, S. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv080 · Cited by 9,816 · see citing works

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

Davey Smith, G., & Ebrahim, S. (2003) · International Journal of Epidemiology · doi:10.1093/ije/dyg070 · Cited by 5,882 · see citing works

Raise standards for preclinical cancer research

Begley, C. G., & Ellis, L. M. (2012) · Nature · doi:10.1038/483531a · Cited by 2,979 · see citing works

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

Hung, R. J., McKay, J. D., Gaborieau, V., Boffetta, P., Hashibe, M., Zaridze, D., Mukeria, A., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., et al. (2008) · Nature · doi:10.1038/nature06885 · Cited by 1,275 · see citing works

Variation in<i>PCSK9</i>and<i>HMGCR</i>and Risk of Cardiovascular Disease and Diabetes

Ference, B. A., Robinson, J. G., Brook, R. D., Catapano, A. L., Chapman, M. J., Neff, D. R., Voros, S., Giugliano, R. P., Davey Smith, G., Fazio, S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1604304 · Cited by 743 · see citing works

Mendelian randomization studies: a review of the approaches used and the quality of reporting

Boef, A. G. C., Dekkers, O. M., & le Cessie, S. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv071 · Cited by 610 · see citing works

Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies

Haycock, P., Burgess, S., Wade, K. H., Bowden, J., Relton, C. L., & Smith, G. D. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.118216 · Cited by 602 · see citing works

Failure of Investigational Drugs in Late-Stage Clinical Development and Publication of Trial Results

Hwang, T. J., Carpenter, D. P., Lauffenburger, J. C., Wang, B., Franklin, J. M., & Kesselheim, A. S. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.6008 · Cited by 447 · see citing works

Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study

Mokry, L. E., Ross, S., Ahmad, O. S., Forgetta, V., Smith, G. D., Leong, A., Greenwood, C. M. T., Thanassoulis, G., & Richards, J. B. (2015) · PLOS Medicine · doi:10.1371/journal.pmed.1001866 · Cited by 445 · see citing works

Data dredging, bias, or confounding: They can all get you into the BMJ and the Friday papers

Smith, G. D., & Ebrahim, S. (2002) · BMJ · doi:10.1136/bmj.325.7378.1437 · Cited by 434 · see citing works

Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease

Emdin, C. A., Khera, A. V., Natarajan, P., Klarin, D., Zekavat, S. M., Hsiao, A. J., & Kathiresan, S. (2017) · JAMA · doi:10.1001/jama.2016.21042 · Cited by 378 · see citing works

Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease

Lee, J. C., Biasci, D., Roberts, R., Gearry, R. B., Mansfield, J. C., Ahmad, T., Prescott, N. J., Satsangi, J., Wilson, D. C., Jostins, L., et al. (2017) · Nature Genetics · doi:10.1038/ng.3755 · Cited by 304 · see citing works

Challenges and novel approaches for investigating molecular mediation

Richmond, R. C., Hemani, G., Tilling, K. M., Smith, G. D., & Relton, C. L. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw197 · Cited by 133 · see citing works

MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associationsPreprint

Hemani, G., Zheng, J., Wade, K. H., Laurin, C., Elsworth, B., Burgess, S., Bowden, J., Langdon, R., Tan, V. Y., Yarmolinsky, J., et al. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/078972 · Cited by 133 · see citing works

A fatter, healthier but more unequal world

Smith, G. D. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00588-2 · Cited by 28 · see citing works

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

Davies, N. M., Holmes, M. V., & Davey Smith, G. (2018) · BMJ · doi:10.1136/bmj.k601 · Cited by 4,404 · see citing works

Mendelian randomization

Sanderson, E., Glymour, M. M., Holmes, M. V., Kang, H., Morrison, J., Munafò, M. R., Palmer, T., Schooling, C. M., Wallace, C., Zhao, Q., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-021-00092-5 · Cited by 2,229 · see citing works

Recent Developments in Mendelian Randomization Studies

Zheng, J., Baird, D. A., Borges, M. C., Bowden, J., Hemani, G., Haycock, P., Evans, D. M., & Smith, G. D. (2017) · Current Epidemiology Reports · doi:10.1007/s40471-017-0128-6 · Cited by 1,132 · see citing works

Mendelian Randomization: Concepts and Scope

Richmond, R. C., & Davey Smith, G. (2022) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a040501 · Cited by 841 · see citing works

Mendelian randomization in cardiometabolic disease: challenges in evaluating causality

Holmes, M. V., Ala-Korpela, M., & Smith, G. D. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.78 · Cited by 679 · see citing works

Genetic epidemiology and Mendelian randomization for informing disease therapeutics: Conceptual and methodological challenges

Paternoster, L., Tilling, K., & Davey Smith, G. (2017) · PLOS Genetics · doi:10.1371/journal.pgen.1006944 · Cited by 271 · see citing works

Causal relationships between obesity and the leading causes of death in women and men

Censin, J. C., Peters, S. A. E., Bovijn, J., Ferreira, T. C., Pulit, S. L., Mägi, R., Mahajan, A., Holmes, M. V., & Lindgren, C. M. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008405 · Cited by 204 · see citing works

Stroke genetics: discovery, biology, and clinical applications

Dichgans, M., Pulit, S. L., & Rosand, J. M. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30043-2 · Cited by 184 · see citing works

Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis

Reilly, J. P., Wang, F., Jones, T. K., Palakshappa, J. A., Anderson, B. J., Shashaty, M. G. S., Dunn, T. G., Johansson, E. D., Riley, T. R., Lim, B., et al. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5328-0 · Cited by 126 · see citing works

Bias in two-sample Mendelian randomization when using heritable covariable-adjusted summary associations

Hartwig, F. P., Tilling, K. M., Smith, G. D., Lawlor, D. A., & Borges, M. C. (2021) · International Journal of Epidemiology · doi:10.1093/ije/dyaa266 · Cited by 116 · see citing works

Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases

Zhao, H., Rasheed, H., Nøst, T. H., Cho, Y., Liu, Y., Bhatta, L., Bhattacharya, A., Initiative, G. B. M.-A., Hemani, G., Smith, G. D., et al. (2022) · Cell Genomics · doi:10.1016/j.xgen.2022.100195 · Cited by 89 · see citing works

Challenges and opportunities in stroke genetics

Malik, R., & Dichgans, M. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy068 · Cited by 90 · see citing works

Lung function and cardiovascular disease: a two-sample Mendelian randomisation study

Higbee, D., Granell, R., Sanderson, E. C. M., Smith, G. D., & Dodd, J. W. (2021) · European Respiratory Journal · doi:10.1183/13993003.03196-2020 · Cited by 87 · see citing works

The Effect of Weight on Labor Market Outcomes: An Application of Genetic Instrumental Variables

Böckerman, P., Cawley, J., Viinikainen, J., Lehtimäki, T. J., Rovio, S., Seppälä, I., Pehkonen, J., & Raitakari, O. T. (2016) · Health Economics · doi:10.1002/hec.3828 · Cited by 86 · see citing works

Plasma sRAGE Acts as a Genetically Regulated Causal Intermediate in Sepsis-associated Acute Respiratory Distress Syndrome

Jones, T. K., Feng, R., Kerchberger, V. E., Reilly, J. P., Anderson, B. J., Shashaty, M. G. S., Wang, F., Dunn, T. G., Riley, T. R., Abbott, J. A., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201810-2033oc · Cited by 74 · see citing works

Does higher education protect against obesity? Evidence using Mendelian randomization

Böckerman, P., Viinikainen, J., Pulkki-Råbäck, L., Hakulinen, C. A., Pitkänen, N., Lehtimäki, T. J., Pehkonen, J., & Raitakari, O. T. (2017) · Preventive Medicine · doi:10.1016/j.ypmed.2017.06.015 · Cited by 68 · see citing works

Can Mendelian Randomization Shift into Reverse Gear?

Holmes, M. V., & Smith, G. D. (2019) · Clinical Chemistry · doi:10.1373/clinchem.2018.296806 · Cited by 67 · see citing works

Both lean and fat body mass associate with blood pressure

Korhonen, P. E., Mikkola, T. M., Kautiainen, H., & Eriksson, J. G. (2021) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2021.04.025 · Cited by 59 · see citing works

Association Between Myopic Refractive Error and Primary Open-Angle Glaucoma

Choquet, H., Khawaja, A. P., Jiang, C., Yin, J., Melles, R. B., Glymour, M. M., Hysi, P. G., & Jorgenson, E. (2022) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2022.2762 · Cited by 58 · see citing works

F ifty Y ears of R esearch in ARDS. Genomic Contributions and Opportunities

Reilly, J. P., Christie, J. D., & Meyer, N. J. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201702-0405cp · Cited by 58 · see citing works

Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies

Gorski, M., Rasheed, H., Teumer, A., Thomas, L. F., Graham, S. E., Sveinbjörnsson, G., Winkler, T. W., Günther, F., Stark, K. J., Chai, J. F., et al. (2022) · Kidney International · doi:10.1016/j.kint.2022.05.021 · Cited by 56 · see citing works

A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology

de Vries, P. S., Sabater‐Lleal, M., Huffman, J. E., Marten, J., Song, C., Pankratz, N., Bartz, T. M., de Haan, H. G., Delgado, G. E., Eicher, J. D., et al. (2019) · Blood · doi:10.1182/blood-2018-05-849240 · Cited by 55 · see citing works

Impact of Serum Calcium Levels on Alzheimer’s Disease: A Mendelian Randomization Study

He, Y., Zhang, H., Wang, T., Han, Z., Ni, Q., Wang, K., Wang, L., Zhang, Y., Hu, Y., Jin, S., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191249 · Cited by 45 · see citing works

Interleukin-18 as a drug repositioning opportunity for inflammatory bowel disease: A Mendelian randomization study

Mokry, L. E., Zhou, S., Guo, C., Scott, R. A., Devey, L. R., Langenberg, C., Wareham, N. J., Waterworth, D. M., Cardon, L. R., Sanséau, P., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-45747-2 · Cited by 41 · see citing works

Examining the shared etiology of psychopathology with genome-wide association studies

Mallard, T. T., Grotzinger, A. D., & Smoller, J. W. (2023) · Physiological Reviews · doi:10.1152/physrev.00016.2022 · Cited by 38 · see citing works

Inference in Psychiatry via 2-Sample Mendelian Randomization—From Association to Causal Pathway?

Byrne, E. M., Yang, J., & Wray, N. R. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.3162 · Cited by 38 · see citing works

Association of Behavioral and Clinical Risk Factors With Cataract: A Two-Sample Mendelian Randomization Study

Chen, J., Melles, R. B., Sangani, P. K., Hoffmann, T. J., Hysi, P. G., Glymour, M. M., Jorgenson, E., Lachke, S. A., & Choquet, H. (2023) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.64.10.19 · Cited by 37 · see citing works

Thyroid function and ischemic heart disease: a Mendelian randomization study

Zhao, J. V., & Schooling, C. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-07592-z · Cited by 34 · see citing works

LDL-C plays a causal role on T2DM: a Mendelian randomization analysis

Pan, W., Sun, W., Yang, S., Zhuang, H., Jiang, H., Ju, H., Wang, D., & Han, Y. (2020) · Aging · doi:10.18632/aging.102763 · Cited by 30 · see citing works

Rheumatoid Arthritis and Cardio-Cerebrovascular Disease: A Mendelian Randomization Study

Qiu, S., Li, M., Jin, S., Lu, H., & Hu, Y. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.745224 · Cited by 30 · see citing works

Causal Associations between Serum Urea and Cancer: A Mendelian Randomization Study

Sun, Y., Li, J., Qu, Z., Yang, Z. R., Jia, X., Lin, Y., He, Q., Zhang, L., & Luo, Y. (2021) · Genes · doi:10.3390/genes12040498 · Cited by 28 · see citing works

Inferring the direction of a causal link and estimating its effect via a Bayesian Mendelian randomization approach

Bucur, I. G., Claassen, T., & Heskes, T. (2019) · Statistical Methods in Medical Research · doi:10.1177/0962280219851817 · Cited by 28 · see citing works

Mendelian randomization highlights the causal association of obesity with periodontal diseases

Dong, J., Gong, Y., Chu, T., Wu, L., Li, S., Deng, H., Hu, R., & Wang, Y. (2022) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13640 · Cited by 27 · see citing works

Lung function, COPD and cognitive function: a multivariable and two sample Mendelian randomization study

Higbee, D., Granell, R., Hemani, G., Smith, G. D., & Dodd, J. W. (2021) · BMC Pulmonary Medicine · doi:10.1186/s12890-021-01611-6 · Cited by 26 · see citing works

Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage

Steinhauer, E. G., Jiménez-Baladó, J., Pérez, I. F., Rey-Álvarez, L., Rodríguez-Campello, A., Ois, Á., Cuadrado‐Godia, E., Jiménez-Conde, J., & Roquer, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126479 · Cited by 24 · see citing works

Use of Mendelian Randomization for Identifying Risk Factors for Brain Tumors

Howell, A., Zheng, J., Haycock, P., McAleenan, A., Relton, C. L., Martin, R. M., & Kurian, K. M. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00525 · Cited by 24 · see citing works

Problems in interpreting and using GWAS of conditional phenotypes illustrated by 'alcohol GWAS'

Holmes, M. V., & Smith, G. D. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0037-1 · Cited by 23 · see citing works

Evaluating marginal genetic correlation of associated loci for complex diseases and traits between European and East Asian populations

Lu, H., Wang, T., Zhang, J., Zhang, S., Huang, S., & Zeng, P. (2021) · Human Genetics · doi:10.1007/s00439-021-02299-8 · Cited by 21 · see citing works

Causal effects of hypertension on risk of erectile dysfunction: A two-sample Mendelian randomization study

Wang, Z., Wang, Y., Xiong, J., Gan, X., Bao, Y., Jiang, A., Zhou, Y., Huangfu, Z., Yang, Y., Liu, Z., et al. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1121340 · Cited by 18 · see citing works

Causal Factors for Osteoarthritis: A Scoping Review of Mendelian Randomization Studies

Alhassan, E., Nguyen, K., Hochberg, M. C., & Mitchell, B. D. (2023) · Arthritis Care & Research · doi:10.1002/acr.25252 · Cited by 17 · see citing works

A Mendelian randomization study between chronic periodontitis and non‐alcoholic fatty liver disease

Tan, L., He, Y., Wang, T., Gao, X., Fan, W., & Fan, B. (2023) · Journal of Periodontal Research · doi:10.1111/jre.13218 · Cited by 17 · see citing works

Homocysteine and female fertility, pregnancy loss and offspring birthweight: a two-sample Mendelian randomization study

Kjaergaard, A. D., Wu, Y., Ming, W., Wang, Z., Kjaergaard, M. N., & Ellervik, C. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00898-2 · Cited by 17 · see citing works

How to interpret studies using Mendelian randomisation

Kim, M. S., Song, M., Shin, J. I., & Won, H. (2023) · BMJ Evidence-Based Medicine · doi:10.1136/bmjebm-2022-112149 · Cited by 16 · see citing works

Bias in two-sample Mendelian randomization when using heritable covariable-adjusted summary associationsPreprint

Hartwig, F. P., Tilling, K., Smith, G. D., Lawlor, D. A., & Borges, M. C. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/816363 · Cited by 14 · see citing works

Assessing causal estimates of the association of obesity-related traits with coronary artery disease using a Mendelian randomization approach

Zhang, X., Lv, W., Qiu, B., Zhang, L., Qin, J., Tang, F., Wang, H., Li, H., & Hao, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-25305-y · Cited by 14 · see citing works

Mendelian Randomization Methods for Causal Inference: Estimands, Identification and Inference

Yao, M., Wang, A., Li, X., & Liu, Z. (2026) · Statistics in Medicine · doi:10.1002/sim.70394 · Cited by 11 · see citing works

Deciphering genetic causality between inflammatory bowel disease and periodontitis through bi-directional two-sample Mendelian randomization

Yu, F., Yang, Y., Wu, D., Chang, M., Han, C., Wang, Q., Li, Y., & He, D. (2023) · Scientific Reports · doi:10.1038/s41598-023-45527-z · Cited by 11 · see citing works

Endometriosis and epithelial ovarian cancer: a two-sample Mendelian randomization analysis

Wang, L., Li, X., Wang, Y., Li, G., Dai, S.-Z., Cao, M., Meng, Z. H., & Ren, S. (2023) · Scientific Reports · doi:10.1038/s41598-023-49276-x · Cited by 11 · see citing works

Examining the Causal Role of Leptin in Alzheimer Disease: A Mendelian Randomization Study

Romo, M., & Schooling, C. (2017) · Neuroendocrinology · doi:10.1159/000475713 · Cited by 14 · see citing works

Mendelian randomization study confirms causal relationship between myopia and vitreous disorders

Xu, J., & Mo, Y. (2023) · BMC Medical Genomics · doi:10.1186/s12920-023-01673-x · Cited by 9 · see citing works

CLEC11A-Driven Molecular Mechanisms in Intervertebral Disc Degeneration: A Comprehensive Multi-Omics Study

Jiang, N., Wang, Q., Hu, Z., & Tian, X. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s505296 · Cited by 8 · see citing works

No association effect of genetic polymorphism was observed between polycystic ovary syndrome and cardiovascular diseases risk: a mendelian randomization study

Zhang, X., Huangfu, Z., & Wang, S. (2023) · Endocrine · doi:10.1007/s12020-023-03467-8 · Cited by 8 · see citing works

Improving precision in estimating diet–disease relationships with metabolomics

Mente, A., Britz‐McKibbin, P., & Yusuf, S. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac616 · Cited by 8 · see citing works

Interleukin-1 receptor antagonist, mode of analgesia and risk of Caesarean delivery after onset of labour: a Mendelian randomisation analysis

Ackland, G. L., van Duijvenboden, S., Abbott, T. E. F., del Arroyo, A. G., Wilson, M., David, A. L., Ali, A., Wikner, M., Noblet, J., Usman, N., et al. (2021) · British Journal of Anaesthesia · doi:10.1016/j.bja.2021.09.039 · Cited by 7 · see citing works

Mendelian Randomization in Case Only Studies: A Promising Approach to be Applied With Caution

Mitchell, R. E., Paternoster, L., & Smith, G. D. (2018) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2018.09.035 · Cited by 7 · see citing works

Diet and health: the need for new and reliable approaches

Mente, A., Dehghan, M., & Yusuf, S. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa317 · Cited by 7 · see citing works

Interleukin-1 receptor antagonist polymorphisms in women receiving epidural analgesia who develop maternal intrapartum fever: a prospective, multicentre Mendelian randomised study

Ali, A., Noblet, J., Usman, N., Wray, S., Blake, H., del Arroyo, A. G., Abbott, T. E. F., Begum, S., Dias, P., Weber, V., et al. (2025) · British Journal of Anaesthesia · doi:10.1016/j.bja.2025.03.037 · Cited by 6 · see citing works

Genetic Studies Help Clarify the Complexities of Lipid Biology and Treatment

Sniderman, A. D., & Peterson, E. D. (2017) · JAMA · doi:10.1001/jama.2017.11750 · Cited by 6 · see citing works

Study Design and Statistics

Livingston, E. H. (2020) · Oxford University Press eBooks · doi:10.1093/jama/9780190246556.003.0019 · Cited by 5 · see citing works

Ambient air pollution and risk of allergic respiratory diseases in European and East Asian populations: A Mendelian randomization study

Lin, Y., Zhu, Z., Aodeng, S., Wang, X., Wang, L., Wang, W., & Lv, W. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.117205 · Cited by 6 · see citing works

Causal relationship between affect disorders and endometrial cancer: a Mendelian randomisation study

Sun, Y., Geng, S., Fu, C., Song, X., Lin, H., & Xu, Y. (2024) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443615.2024.2321321 · Cited by 5 · see citing works

Genetic causal inference between amblyopia and perinatal factors

Lee, J., Lee, S., & Park, S. K. (2022) · Scientific Reports · doi:10.1038/s41598-022-22121-3 · Cited by 5 · see citing works

IL-1ra polymorphisms and risk of epidural-related maternal fever (EPIFEVER-2): study protocol for a multicentre, observational mechanistic cohort study

Ali, A., Weber, V., Thompson, S. J., Abbott, T. E. F., Harmston, R., David, A. L., & Ackland, G. L. (2022) · International Journal of Obstetric Anesthesia · doi:10.1016/j.ijoa.2022.103540 · Cited by 4 · see citing works

Genetic effect modification of cis-acting C-reactive protein variants in cardiometabolic disease statusPreprint

Zheng, J., Tang, H., Lyon, M., Davies, N. M., Walker, V. M., Floyd, J. S., Austin, T. R., Shojaie, A., Psaty, B. M., Gaunt, T. R., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.23.461369 · Cited by 4 · see citing works

A two sample Mendelian randomized study of the association of sex hormones and behavioral and clinical risk factors with macular hole

Nie, Z., Duan, N., Zhang, X., Liu, B., Bai, S., Li, X., Li, W., & Hu, B. (2025) · Scientific Reports · doi:10.1038/s41598-024-83469-2 · Cited by 3 · see citing works

Mendelian randomization study reveals causal association between skin microbiome and skin cancers

He, Y., Li, L., Li, Y., Wang, X., Qian, L., Yang, J., & Jiang, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-07265-2 · Cited by 3 · see citing works

Low density lipoprotein cholesterol but not statins is the direct cause of intracerebral hemorrhage

Shi, S., Zheng, Z., Chen, W., Song, Y., & Dou, K. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177443 · Cited by 3 · see citing works

Biomarker de-Mendelization: principles, potentials and limitations of a strategy to improve biomarker prediction by reducing the component of variance explained by genotypePreprint

Kjaergaard, A. D., Bojesen, S. E., Nordestgaard, B. G., Johansen, J. S., & Smith, G. D. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/428276 · Cited by 3 · see citing works

“Mendelian Randomization” Approach in Economic Assessment of Health Conditions

Gupta, V., SACHDEVA, M. P., & Walia, G. K. (2019) · Frontiers in Public Health · doi:10.3389/fpubh.2019.00002 · Cited by 2 · see citing works

Deciphering the Causality between Gut Microbiota Dysbiosis and Poisoning by Narcotics and Psychodysleptics: A Mendelian Randomization Analysis

Wang, N., & Su, Z. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22999240729092453 · Cited by 2 · see citing works

Vitamin D and dementia risk: the cause and consequence story

Mao, Y., & Yu, H. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.155408 · Cited by 2 · see citing works

Application of Mendelian Randomization in Cardiovascular Disease: Bibliometric Analysis and Visualization from 2003 to 2024

Guo, S., Xu, D., Qin, S., Chen, C., & Chen, X. (2025) · Cardiology · doi:10.1159/000545277 · Cited by 1 · see citing works

Causal relationship between gut microbiome, immune cell, and systemic lupus erythematosus: A Mendelian randomization analysis

Wang, H., Zhang, J., Yang, M., Chen, J., Yang, X., Yang, N., & Zhao, B. (2025) · Medicine · doi:10.1097/md.0000000000043703 · Cited by 1 · see citing works

Linking Personality Traits to Mediterranean Diet Adherence and Exploring Gene–Diet Interactions in Neuroticism

Sorlí, J. V., Ortega‐Azorín, C., Coltell, Ó., Fernández-Carrión, R., Asensio, E. M., Portolés, O., Fidalgo, J. A. P., Sabio, J. B. R., Saiz, J. G., Costa, J. A., et al. (2025) · Nutrients · doi:10.3390/nu17233791 · Cited by 1 · see citing works

Hyperuricemia Beyond Gout: The Unknown Culprit in Rheumatic and Musculoskeletal Diseases

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