Cited by 1,098Traumatic Brain Injury ResearchLong-Term Effects of COVID-19Automotive and Human Injury Biomechanics

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football

Open access

Mez, Jesse, Daneshvar, Daniel H., Kiernan, Patrick T., Abdolmohammadi, Bobak, Alvarez, Victor E., Huber, Bertrand R., Alosco, Michael L., Solomon, Todd M., Nowinski, Christopher J., McHale, Lisa, Cormier, Kerry A., Kubilus, Caroline A., Martin, Brett M., Murphy, Lauren, Baugh, Christine M., Montenigro, Phillip H., Chaisson, Christine E., Tripodis, Yorghos, Kowall, Neil W., Weuve, Jennifer, McClean, Michael D., Cantu, Robert C., Goldstein, Lee E., Katz, Douglas I., Stern, Robert A., Stein, Thor D., McKee, Ann C.·2017·JAMA

DOI 10.1001/jama.2017.8334PMC PMC5807097

Open this paper in CoChat — free account Open PDF

Abstract

Importance: Players of American football may be at increased risk of long-term neurological conditions, particularly chronic traumatic encephalopathy (CTE). Objective: To determine the neuropathological and clinical features of deceased football players with CTE. Design, Setting, and Participants: Case series of 202 football players whose brains were donated for research. Neuropathological evaluations and retrospective telephone clinical assessments (including head trauma history) with informants were performed blinded. Online questionnaires ascertained athletic and military history. Exposures: Participation in American football at any level of play. Main Outcomes and Measures: Neuropathological diagnoses of neurodegenerative diseases, including CTE, based on defined diagnostic criteria; CTE neuropathological severity (stages I to IV or dichotomized into mild [stages I and II] and severe [stages III and IV]); informant-reported athletic history and, for players who died in 2014 or later, clinical presentation, including behavior, mood, and cognitive symptoms and dementia. Results: Among 202 deceased former football players (median age at death, 66 years [interquartile range, 47-76 years]), CTE was neuropathologically diagnosed in 177 players (87%; median age at death, 67 years [interquartile range, 52-77 years]; mean years of football participation, 15.1 [SD, 5.2]), including 0 of 2 pre-high school, 3 of 14 high school (21%), 48 of 53 college (91%), 9 of 14 semiprofessional (64%), 7 of 8 Canadian Football League (88%), and 110 of 111 National Football League (99%) players. Neuropathological severity of CTE was distributed across the highest level of play, with all 3 former high school players having mild pathology and the majority of former college (27 [56%]), semiprofessional (5 [56%]), and professional (101 [86%]) players having severe pathology. Among 27 participants with mild CTE pathology, 26 (96%) had behavioral or mood symptoms or both, 23 (85%) had cognitive symptoms, and 9 (33%) had signs of dementia. Among 84 participants with severe CTE pathology, 75 (89%) had behavioral or mood symptoms or both, 80 (95%) had cognitive symptoms, and 71 (85%) had signs of dementia. Conclusions and Relevance: In a convenience sample of deceased football players who donated their brains for research, a high proportion had neuropathological evidence of CTE, suggesting that CTE may be related to prior participation in football.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1001/jama.2017.8334

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop
McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., et al. (1996) · Neurology · doi:10.1212/wnl.47.5.1113 · Cited by 3,960
Primary Progressive Aphasia
Weıntraub, S. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530120075013 · Cited by 3,018
National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach
Montine, T. J., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., Mirra, S. S., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-011-0910-3 · Cited by 2,894
Chronic traumatic encephalopathy in athletes: Progressive tauopathy after repetitive head injury
McKee, A. C., Cantu, R. C., Nowinski, C. J., Hedley-Whyte, E. T., Gavett, B. E., Budson, A. E., Santini, V. E., Lee, H.-S., Kubilus, C. A., & Stern, R. A. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181a9d503 · Cited by 2,295
Self-citation
The spectrum of disease in chronic traumatic encephalopathy
McKee, A. C., Stein, T. D., Nowinski, C. J., Stern, R. A., Daneshvar, D. H., Alvarez, V. E., Lee, H.-S., Hall, G., Wojtowicz, S. M., Baugh, C. M., et al. (2013) · Brain · doi:10.1093/brain/aws307 · Cited by 2,098
Self-citation
Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration
Cairns, N. J., Bigio, E. H., Mackenzie, I. R. A., Neumann, M., Lee, V. M.-Y., Hatanpaa, K. J., White, C. L., Schneider, J. A., Grinberg, L. T., Halliday, G., et al. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0237-2 · Cited by 1,110
Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update
Mackenzie, I. R. A., Neumann, M., Bigio, E. H., Cairns, N. J., Alafuzoff, I., Kril, J., Kovacs, G. G., Ghetti, B., Halliday, G., Holm, I. E., et al. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0612-2 · Cited by 1,012
Chronic Traumatic Encephalopathy in a National Football League Player
Omalu, B. I., DeKosky, S. T., Minster, R. L., Kamboh, M. I., Hamilton, R. L., & Wecht, C. H. (2005) · Neurosurgery · doi:10.1227/01.neu.0000163407.92769.ed · Cited by 894
The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy
the TBI/CTE group, McKee, A. C., Cairns, N. J., Dickson, D. W., Folkerth, R. D., Dirk Keene, C., Litvan, I., Perl, D. P., Stein, T. D., Vonsattel, J.-P., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1515-z · Cited by 885
Self-citation
The aftermath of boxing
Corsellis, J. A. N., Bruton, C. J., & Freeman-Browne, D. (1973) · Psychological Medicine · doi:10.1017/s0033291700049588 · Cited by 836

Show all 41 references

Sorted by citations

Items 401–500 of 999

Drill Intensity and Head Impact Exposure in Adolescent Football
Kercher, K. A., Steinfeldt, J. A., Macy, J. T., Seo, D., & Kawata, K. (2022) · PEDIATRICS · doi:10.1542/peds.2022-057725 · Cited by 13
‘Play’ing College Football: Campus Athletic Worker Experiences of Exploitation
Kalman-Lamb, N., & Silva, D. M. D. (2023) · Critical Sociology · doi:10.1177/08969205231208036 · Cited by 13
Concussion assessment in the emergency department: a preliminary study for a quality improvement project
Mistry, D. A., & Rainer, T. H. (2018) · BMJ Open Sport & Exercise Medicine · doi:10.1136/bmjsem-2018-000445 · Cited by 13
Anger and Depression in Middle-Aged Men: Implications for a Clinical Diagnosis of Chronic Traumatic Encephalopathy
Iverson, G. L., Terry, D. P., Luz, M., ZAFONTE, R. D., McCrory, P. R., Solomon, G. S., & Gardner, A. J. (2019) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.18110280 · Cited by 14
Analysis of Head Impact Biomechanics in Youth Female Soccer Players Following the Get aHEAD Safely in Soccer™ Heading Intervention
Wahlquist, V. E., & Kaminski, T. W. (2021) · Sensors · doi:10.3390/s21113859 · Cited by 13
Tau seeding in chronic traumatic encephalopathy parallels disease severity
Kaufman, S. K., Svirsky, S. E., Cherry, J. D., McKee, A. C., & Diamond, M. I. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02373-5 · Cited by 14
Self-citation
Biomarker evidence of neurodegeneration in mid-life former rugby players
Graham, N., Zimmerman, K. A., Hain, J., Rooney, E. J., Lee, Y., Giovane, M. D., Parker, T. D., Wilson, M. G., Malhotra, P., David, M., et al. (2025) · Brain · doi:10.1093/brain/awaf152 · Cited by 12
α-Synuclein seed amplification assay positivity beyond synucleinopathies
Martínez-Valbuena, I., Fullam, S., O’Dowd, S., Tartaglia, M. C., & Kovács, G. G. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105925 · Cited by 14
Tau Positron Emission Tomography and Neurocognitive Function Among Former Professional American-Style Football Players
Dhaynaut, M., Grashow, R. G., Normandin, M. D., Wu, O., Marengi, D. A., Terry, D. P., Sanchez, J. S., Weisskopf, M. G., Speizer, F. E., Taylor, H. A., et al. (2023) · Journal of Neurotrauma · doi:10.1089/neu.2022.0454 · Cited by 13
Self-citation
Microstructural Alterations in Tract Development in College Football and Volleyball Players
Goubran, M., Mills, B. D., Georgiadis, M., Karimpoor, M., Mouchawar, N., Sami, S., Dennis, E. L., Akers, C. S., Mitchell, L. A., Boldt, B. M., et al. (2023) · Neurology · doi:10.1212/wnl.0000000000207543 · Cited by 12
Vitamin D Supplementation and Cardiovascular Disease Risks in More Than 134000 Individuals in 29 Randomized Clinical Trials and 157000 Individuals in 30 Prospective Cohort Studies: An Updated Systematic Review and Meta-analysis
Rasouli, M. A., Darvishzadehdaledari, S., Alizadeh, Z., Moradi, G., Gholami, F., & Mahmoudian, A. (2023) · Journal of Research in Health Sciences · doi:10.34172/jrhs.2023.129 · Cited by 15
Profiling the neuroimmune cascade in 3xTg-AD mice exposed to successive mild traumatic brain injuries
Pybus, A. F., Bitarafan, S., Brothers, R. O., Rohrer, A., Khaitan, A., Moctezuma, F. R., Udeshi, K., Davies, B., Triplett, S., Griffin, M. N., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03128-1 · Cited by 12
Repetitive Head Impacts and Perivascular Space Volume in Former American Football Players
Jung, L., Wiegand, T. L. T., Tuz‐Zahra, F., Tripodis, Y., Iliff, J. J., Piantino, J. A., Arciniega, H., Kim, C. L., Pankatz, L., Sylvain Bouix, A., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.28687 · Cited by 14
Self-citation
Neurodegeneration in the cortical sulcus is a feature of chronic traumatic encephalopathy and associated with repetitive head impacts
Nicks, R., Shah, A., Stathas, S., Kirsch, D. A., Horowitz, S. M., Saltiel, N. A., Calderazzo, S. M., Butler, M. L. M. D., Cormier, K., Aytan, N., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02833-8 · Cited by 14
Self-citation
Traumatic Brain Injury and Chronic Traumatic Encephalopathy: Not Only Trigger for Neurodegeneration but Also for Cerebral Amyloid Angiopathy?
Zedde, M., Piazza, F., & Pascarella, R. (2025) · Biomedicines · doi:10.3390/biomedicines13040881 · Cited by 12
Making Football Safer: Assessing the Current National Football League Policy on the Type of Helmets Allowed on the Playing Field
Colello, R. J., Colello, I. A., AbdelHameid, D., Cresswell, K. G., Merchant, R. E., & Beckett, E. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5446 · Cited by 12
Social network structure and composition in former NFL football players
Dhand, A., McCafferty, L., Grashow, R. G., Corbin, I. M., Cohan, S., Whittington, A. J., Connor, A., Baggish, A. L., Weisskopf, M., ZAFONTE, R. D., et al. (2021) · Scientific Reports · doi:10.1038/s41598-020-80091-w · Cited by 12
Biomarkers of Neuroinflammation in Traumatic Brain Injury
Gerber, K. S., Alvarez, G., Alamian, A., Behar‐Zusman, V., & Downs, C. A. (2022) · Clinical Nursing Research · doi:10.1177/10547738221107081 · Cited by 12
Atomistic Insights into the Inhibitory Mechanism of Tyrosine Phosphorylation against the Aggregation of Human Tau Fragment PHF6
Zou, Y. F., Guan, L., Tan, J., Qi, B., Wang, Y., Zhang, Q., & Sun, Y. (2023) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.2c07568 · Cited by 12
Vested Interests and Perceived Risk of Concussion Consequences among Power-5 College Athletes
Adame, B. J., & Corman, S. R. (2018) · Health Communication · doi:10.1080/10410236.2018.1517707 · Cited by 12
A Systematic Review of Etiological Risk Factors Associated With Early Mortality Among National Football League Players
Owora, A. H., Kmush, B. L., Walia, B., & Sanders, S. D. (2018) · Orthopaedic Journal of Sports Medicine · doi:10.1177/2325967118813312 · Cited by 12
The Neuropathological and Clinical Diagnostic Criteria of Chronic Traumatic Encephalopathy: A Critical Examination in Relation to Other Neurodegenerative Diseases
Brett, B. L., Wilmoth, K., Cummings, P., Solomon, G. S., McCrea, M., & Zuckerman, S. L. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181058 · Cited by 12
Repetitive Head Impacts in Youth Football: Description and Relationship to White Matter Structure
Nilsson, K. J., Flint, H. A., Gao, Y., Kendrick, L. E., Cutchin, S., Pentecost, R., & Pardue, K. (2019) · Sports Health A Multidisciplinary Approach · doi:10.1177/1941738119865264 · Cited by 12
Chronic Traumatic Encephalopathy: A Comparison with Alzheimer's Disease and Frontotemporal Dementia
Lesman‐Segev, O. H., Edwards, L., & Rabinovici, G. D. (2020) · Seminars in Neurology · doi:10.1055/s-0040-1715134 · Cited by 13
Subacute to chronic Alzheimer-like alterations after controlled cortical impact in human tau transgenic mice
Zhang, Y., Wu, F., Iqbal, K., Gong, C., Hu, W. H., & Liu, F. (2019) · Scientific Reports · doi:10.1038/s41598-019-40678-4 · Cited by 15
Fighting in professional ice hockey: it’s time for a change
Plassche, G. C., Fortney, T. A., Morrissette, C. R., Korzelius, J. F., & Popkin, C. A. (2022) · The Physician and Sportsmedicine · doi:10.1080/00913847.2022.2078170 · Cited by 11
Brain pathology and symptoms linked to concussion history: beyond chronic traumatic encephalopathy
Taskina, D., Zhu, C., Schwab, N., & Hazrati, L. (2024) · Brain Communications · doi:10.1093/braincomms/fcad314 · Cited by 10
Aberrant protein aggregation in amyotrophic lateral sclerosis
Wang, H., & Zeng, R. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12485-z · Cited by 11
Brain health concerns in former rugby players: clinical and cognitive phenotypes
Parker, T. D., Hain, J., Rooney, E. J., Zimmerman, K. A., Lee, Y., Giovane, M. D., Graham, N., Patel, M. C., Hampshire, A., Wilson, M. G., et al. (2025) · Brain · doi:10.1093/brain/awae416 · Cited by 12
Scale for retrospective assessment of immediate concussion symptoms
Cernovsky, Z. Z., Istasy, P., Bureau, Y., & Chiu, S. (2018) · Mental Illness · doi:10.4081/mi.2018.7901 · Cited by 18
Acute Time-Course Changes in CCL11, CCL2, and IL-10 Levels After Controlled Subconcussive Head Impacts: A Pilot Randomized Clinical Trial
Huibregtse, M. E., Ejima, K., Chen, Z.-X., Kalbfell, R., Koppineni, A., & Kawata, K. (2020) · The journal of head trauma rehabilitation · doi:10.1097/htr.0000000000000597 · Cited by 9
Making Headway for Discussions About Concussions: Experiences of Former High School and Collegiate Student-Athletes
Oddo, A., O’Conor, E. C., Shore, S., Piraino, M., Gibney, K. D., Tsao, J. W., & Stanfill, A. G. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00698 · Cited by 11
A Decision-Analytic Approach to Addressing the Evidence About Football and Chronic Traumatic Encephalopathy
Brand, K. P., & Finkel, A. M. (2019) · Seminars in Neurology · doi:10.1055/s-0039-1688484 · Cited by 12
Repeated mild traumatic brain injuries impair visual discrimination learning in adolescent mice
Pinkowski, N. J., Guerin, J., Zhang, H., Carpentier, S. T., McCurdy, K. E., Pacheco, J. M., Mehos, C. J., Brigman, J. L., & Morton, R. A. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107315 · Cited by 11
Women Caring for Retired Men: A Continuation of Inequality in the Sport Marriage
Ortiz, S. M. (2021) · Sociology of Sport Journal · doi:10.1123/ssj.2020-0118 · Cited by 11
High-School Football and Midlife Brain Health Problems
Iverson, G. L., Merz, Z. C., & Terry, D. P. (2021) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0000000000000898 · Cited by 12
Traumatic Brain Injuries in Victims of Intimate Partner Violence: An Underappreciated Source of Neurological morbidity
Monahan, K., Goldfine, A. M., & Biegon, A. R. (2017) · Future Neurology · doi:10.2217/fnl-2017-0026 · Cited by 11
Intimate Partner Violence and Traumatic Brain Injury: A Public Health Issue
Monahan, K. (2018) · Journal of Neurology and Neuromedicine · doi:10.29245/2572.942x/2018/3.1181 · Cited by 11
Football Increases Future Risk of Symptomatic Radiographic Knee Osteoarthritis
Lo, G. H., McAlindon, T. E., Kriska, A. M., Price, L. L., Rockette‐Wagner, B., Mandl, L. A., Eaton, C. B., Hochberg, M. C., Jackson, R. D., Kwoh, C. K., et al. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002189 · Cited by 11
Internal Jugular Vein Compression Collar Mitigates Histopathological Alterations after Closed Head Rotational Head Impact in Swine: A Pilot Study
Mannix, R., Morriss, N. J., Conley, G. M., Meehan, W. P., III, Nedder, A. P., Qiu, J., Float, J., DiCesare, C. A., & Myer, G. D. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.04.009 · Cited by 11
Textbook of Medical Psychiatry
Silbersweig, D., Muskin, P. R., & Querques, J. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869 · Cited by 11
Astrocyte activation persists one year after TBI: a dynamic shift from inflammation to neurodegeneration
Abou‐El‐Hassan, H., Yahya, T., Zusman, B. E., Albastaki, O., Imkamp, H. T., Ye, J. J., Percopo, F., Christenson, J. R., Mansi, M. H. A., Lu, K.-J., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-09138-w · Cited by 15
The modulatory role of cannabis use in subconcussive neural injury
Kalbfell, R. M., Rettke, D. J., Mackie, K., Ejima, K., Harezlak, J., Alexander, I. L., Wager‐Miller, J., Johnson, B. D., Newman, S. D., & Kawata, K. (2023) · iScience · doi:10.1016/j.isci.2023.106948 · Cited by 10
Prospective cohort study of long-term neurological outcomes in retired elite athletes: the Advanced BiomaRker, Advanced Imaging and Neurocognitive (BRAIN) Health Study protocol
Zimmerman, K. A., Hain, J., Graham, N., Rooney, E. J., Lee, Y., Giovane, M. D., Parker, T. D., Friedland, D., Cross, M., Kemp, S. P. T., et al. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-082902 · Cited by 12
Five‐Year Serial Brain MRI Analysis of Military Members Exposed to Chronic Sub‐Concussive Overpressures
Glikstein, R. S., Melkus, G., de Oliveira, E. P., Brun‐Vergara, M. L., Schwarz, B. A., Ramsay, T., Zhang, T., & Skinner, C. (2024) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.29419 · Cited by 10
Biophysical characterization of the phase separation of TDP-43 devoid of the C-terminal domain
Staderini, T., Bigi, A., Lagrève, C., Marzi, I., Bemporad, F., & Chiti, F. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00615-4 · Cited by 14
Characterizing Neurobehavioral Dysregulation Among Former American Football Players: Findings From the DIAGNOSE CTE Research Project
Pulukuri, S. V., Fagle, T. R., Trujillo‐Rodriguez, D., van Amerongen, S., Bernick, C. B., Geda, Y. E., Wethe, J. V., Peskind, E. R., Katz, D. I., Alosco, M. L., et al. (2024) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.20230133 · Cited by 10
Self-citation
Chronic traumatic encephalopathy in athletes, players, boxers and military: systematic review
Barbosa, M. G. D. S., Francisco, G. G. D. O. A., de Souza, R. L. V., de Souza, J. M. A., Carneiro, R. A., Rabelo, N. N., & Chaurasia, B. K. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000002693 · Cited by 14
EEG hyperexcitability and hyperconnectivity linked to GABAergic inhibitory interneuron loss following traumatic brain injury
May, H. G., Tsikonofilos, K., Donat, C. K., Sastre, M., Kozlov, A. S., Sharp, D. J., & Bruyns‐Haylett, M. (2024) · Brain Communications · doi:10.1093/braincomms/fcae385 · Cited by 12
Chronic traumatic encephalopathy: State-of-the-science update and narrative review
Asken, B. M., Brett, B. L., Barr, W., Banks, S. J., Wethe, J. V., Dams-O’Connor, K., Stern, R. A., & Alosco, M. L. (2025) · The Clinical Neuropsychologist · doi:10.1080/13854046.2025.2454047 · Cited by 12
Self-citation
Recent Advances in Chronic Traumatic Encephalopathy
Babcock, K. J., Abdolmohammadi, B., & McKee, A. C. (2025) · American Journal Of Pathology · doi:10.1016/j.ajpath.2025.07.008 · Cited by 14
Self-citation
Traumatic brain injury in 2017: exploring the secrets of concussion
Maegele, M. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30419-2 · Cited by 10
Co-occurrence of chronic traumatic encephalopathy and prion disease
Nemani, S. K., Notari, S., Calì, I., Alvarez, V. E., Kofskey, D., Cohen, M. L., Stern, R. A., Appleby, B. S., Abrams, J. Y., Schonberger, L. B., et al. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0643-9 · Cited by 12
Self-citation
Football and Dementia: Understanding the Link
Neal, J., Hutchings, P. B., Phelps, C., & Williams, D. D. R. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.849876 · Cited by 10
Long-term risk and predictors of cerebrovascular events following sepsis hospitalization: A systematic review and meta-analysis
Arero, A. G., Vasheghani‐Farahani, A., Tigabu, B. M., Arero, G., Ayene, B. Y., & Soltani, D. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.1065476 · Cited by 9
The brain’s weakness in the face of trauma: How head trauma causes the destruction of the brain
Johnstone, D. M., Mitrofanis, J., & Stone, J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1141568 · Cited by 11
Self-injurious thoughts and behaviors in Russian patients with epilepsy: A prospective observational study
Zinchuk, M., Kustov, G., Pashnin, E., Rider, F. K., Sviatskaia, E., Popova, S. B., Voinova, N., Yakovlev, A. A., & Guekht, A. B. (2023) · Seizure · doi:10.1016/j.seizure.2023.03.010 · Cited by 11
Inhibitive and Destructive Mechanisms of Chronic Traumatic Encephalopathy-Related R3-R4 Tau Peptide Chains and Protofibril by Epigallocatechin Gallate: Evidence from Molecular Dynamics Simulation
Tang, J., Sun, R., Wan, J., Xu, Z., Gong, Y., Zou, Y. F., & Zhang, Q. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00103 · Cited by 10
An exhaustive analysis of post-traumatic brain injury dementia using bibliometric methodologies
Sang, X., Wang, C.-Q., Chen, W., Rong, H., & Hou, L.-J. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1165059 · Cited by 11
Three dimensional evaluation of cerebrovascular density and branching in chronic traumatic encephalopathy
Rosen, G. A., Kirsch, D. A., Horowitz, S., Cherry, J. D., Nicks, R., Kelley, H. J., Uretsky, M., Dell’Aquila, K., Mathias, R., Cormier, K., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01612-y · Cited by 9
Self-citation
Unifying Pathophysiological Explanations for Sports-Related Concussion and Concussion Protocol Management: Literature Review
Satarasinghe, P., Hamilton, D. K., Buchanan, R. J., & Koltz, M. T. (2019) · Journal of Experimental Neuroscience · doi:10.1177/1179069518824125 · Cited by 10
Self‐Reported Head Trauma Predicts Poor Dual Task Gait in Retired National Football League Players
Manor, B. D., Zhou, J., Lo, O., Zhu, H., Gouskova, N., Yu, W., ZAFONTE, R. D., Lipsitz, L. A., Travison, T. G., & Pascual‐Leone, Á. (2019) · Annals of Neurology · doi:10.1002/ana.25638 · Cited by 10
POINT/COUNTER-POINT—Links between traumatic brain injury and dementia remain poorly defined
Barr, W. (2020) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acz075 · Cited by 10
Developing a Japanese Version of the Baron Depression Screener for Athletes among Male Professional Rugby Players
Ojio, Y., Matsunaga, A., Hatakeyama, K., Kawamura, S., Horiguchi, M., Baron, D. A., & Fujii, C. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17155533 · Cited by 10
Super-resolved shear shock focusing in the human head
Tripathi, B. B., Chandrasekaran, S., & Pinton, G. (2021) · Brain Multiphysics · doi:10.1016/j.brain.2021.100033 · Cited by 10
Active immunotherapy against pathogenic Cis pT231-tau suppresses neurodegeneration in traumatic brain injury mouse models
Alipour, M., Tebianian, M., Tofigh, N., Taheri, R. S., Mousavi, S. A., Naseri, A., Ahmadi, A., Munawar, N., & Shahpasand, K. (2022) · Neuropeptides · doi:10.1016/j.npep.2022.102285 · Cited by 9
Traumatic brain injury: an enduring challenge
ZAFONTE, R. D. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30300-9 · Cited by 11
Chronic traumatic encephalopathy: understanding the facts and debate
LoBue, C., Schaffert, J., & Cullum, C. M. (2019) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000580 · Cited by 10
Chronic traumatic encephalopathy and aging-related tau astrogliopathy in community-dwelling older persons with and without moderate-to-severe traumatic brain injury
Agrawal, S., Leurgans, S. E., Barnes, L. L., Dams-O’Connor, K., Mez, J., Bennett, D. A. A., & Schneider, J. A. (2024) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlae007 · Cited by 9
Self-citation
The potential of gene delivery for the treatment of traumatic brain injury
Dooley, J., Hughes, J. G., Needham, E., Palios, K. A., & Liston, A. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03156-x · Cited by 9
Assessing Mild Traumatic Brain Injury-Associated Blood–Brain Barrier (BBB) Damage and Restoration Using Late-Phase Perfusion Analysis by 3D ASL MRI: Implications for Predicting Progressive Brain Injury in a Focused Review
Joseph, C. R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111522 · Cited by 11
Caffeine Inhibits Tau Aggregation and Destabilizes the Fibril Associated with Chronic Traumatic Encephalopathy: A REST2 and Conventional MD Simulations Study
Tang, J., Xu, Z., Wang, F., Guan, L., Qi, B., & Zou, Y. F. (2025) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.4c02353 · Cited by 9
Recent Preoperative Concussion and Postoperative Complications: A Retrospective Matched-cohort Study
D'Souza, R. S., Sexton, M. A., Schulte, P. J., Pasternak, J. J., & Abcejo, A. S. (2019) · Journal of Neurosurgical Anesthesiology · doi:10.1097/ana.0000000000000654 · Cited by 9
Wrestling-related concussions and closed head injuries predominantly occur in high school age athletes
Pirruccio, K., Parisien, R. L., Olsen, C., & Kelly, J. D. (2021) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.20.11194-0 · Cited by 9
Multifunctional Nanoparticles and Nanoclusters as a Theranostics and Symptoms Disappearing Agent for Traumatic Brain Injury
Zoey, F. L., Ghosh, K. K., Palanivel, M., Gulyás, B. Z., & Padmanabhan, P. (2023) · Advanced NanoBiomed Research · doi:10.1002/anbr.202300010 · Cited by 9
The bibliometric and altmetric analysis of chronic traumatic encephalopathy research: how great is the impact?
Guan, L., Tan, J., Qi, B., Chen, Y., Tong, E., Pan, J., & Zou, Y. F. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1294125 · Cited by 10
Toxic tau: The TAU gene polymorphisms associate with concussion history in rugby union players
Abrahams, S., Fie, S. M., Patricios, J., Suter, J., September, A. V., & Posthumus, M. (2018) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2018.06.012 · Cited by 8
A Mechanism for the Development of Chronic Traumatic Encephalopathy From Persistent Traumatic Brain Injury
Demock, M., & Kornguth, S. E. (2019) · Journal of Experimental Neuroscience · doi:10.1177/1179069519849935 · Cited by 10
Performance on auditory, vestibular, and visual tests is stable across two seasons of youth tackle football
White‐Schwoch, T., Krizman, J., McCracken, K., Burgess, J. K., Thompson, E. C., Nicol, T. G., LaBella, C. R., & Kraus, N. (2019) · Brain Injury · doi:10.1080/02699052.2019.1683899 · Cited by 9
Sport-related concussion and risk for suicide in athletes
Datoc, A. E., Horne, K., & Golden, C. J. (2020) · Aggression and Violent Behavior · doi:10.1016/j.avb.2020.101413 · Cited by 9
Cost-Reducing Traits for Agonistic Head Collisions: A Case for Neurophysiology
Tobiansky, D. J., Long, K. M., Hamden, J. E., Brawn, J. D., & Fuxjager, M. J. (2021) · Integrative and Comparative Biology · doi:10.1093/icb/icab034 · Cited by 9
Simultaneous flow cytometric characterization of multiple cell types and metabolic states in the rat brain after repeated mild traumatic brain injury
Anyaegbu, C. C., Mao, Y., McGonigle, T., Raja, S., Clarke, T. O., Solomon, T., Black, A. M. B., Fuller, K. A., & Fitzgerald, M. (2021) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2021.109223 · Cited by 9
Self-citation
DiaVis: Exploration and Analysis of Diabetes through Visual Interactive System
Rahman, M., Islam, M. R., Akter, S., Prome, S. A., Islam, L., & Xu, G. (2021) · Human-Centric Intelligent Systems · doi:10.2991/hcis.k.211025.001 · Cited by 9
What triggers tauopathy in chronic traumatic encephalopathy?
Chen, L. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.233439 · Cited by 9
Advances and Gaps in Understanding Chronic Traumatic Encephalopathy
Rabinovici, G. D. (2017) · JAMA · doi:10.1001/jama.2017.9353 · Cited by 9
Is gender equality in brain damage ‘progress’ for women and sport?
Hardwicke, J., AlHashmi, R., Forbes, D., Paechter, C., Pocock, M., Taylor, K., Yeagers, D., & Matthews, C. R. (2024) · International Review for the Sociology of Sport · doi:10.1177/10126902241239370 · Cited by 9
Speech in noise: hearing loss, neurocognitive disorders, aging, traumatic brain injury and more
Beck, D. L., Larsen, D. R., & Bush, E. J. (2018) · Journal of Otolaryngology-ENT Research · doi:10.15406/joentr.2018.10.00345 · Cited by 9
Chronic traumatic encephalopathy neuropathologic change is uncommon in men who played amateur American football
Iverson, G. L., Jamshidi, P., Fisher‐Hubbard, A., Deep‐Soboslay, A., Hyde, T. M., Kleinman, J. E., deJong, J. L., Shepherd, C. E., Hazrati, L., & Castellani, R. J. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1143882 · Cited by 9
Lack of Association of Informant-Reported Traumatic Brain Injury and Chronic Traumatic Encephalopathy
Culhane, J. E., Jackson, C. E., Tripodis, Y., Nowinski, C. J., Dams-O’Connor, K., Pettway, E. C., Uretsky, M., Abdolmohammadi, B., Nair, E. S., Martin, B. M., et al. (2024) · Journal of Neurotrauma · doi:10.1089/neu.2023.0391 · Cited by 9
Self-citation
Clinical implications of head trauma in frontotemporal dementia and primary progressive aphasia
Asken, B. M., Bove, J., Bauer, R. M., Tanner, J. A., Casaletto, K. B., Staffaroni, A. M., VandeVrede, L. A., Alosco, M. L., Mez, J., Stern, R. A., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01553-1 · Cited by 9
Self-citation
Limitations and Applications of Rodent Models in Tauopathy and Synucleinopathy Research
Szegvari, E., Holec, S. A. M., & Woerman, A. L. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70021 · Cited by 8
Overview of Traumatic Brain Injury in American Football Athletes
Canseco, J. A., Franks, R. R., Karamian, B. A., Divi, S. N., Reyes, A. A., Mao, J. Z., Saiegh, F. A., Donnally, C. J., Schroeder, G. D., Harrop, J. S., et al. (2021) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0000000000000918 · Cited by 9
Cellular regeneration treatments for traumatic brain injury
Fan, H., Duan, H., Hao, P., Gao, Y.-D., Zhao, W., Hao, F., Li, X.-G., & Yang, Z.-Y. (2022) · Medicine in Novel Technology and Devices · doi:10.1016/j.medntd.2022.100182 · Cited by 6
The use of ATR-FTIR spectroscopy for the diagnosis of Alzheimer’s disease using oral buccal cells
Paraskevaidi, M., Karim, S., Santos, M. C. D., Lima, K. M. G., & Crean, S. (2023) · Applied Spectroscopy Reviews · doi:10.1080/05704928.2023.2284283 · Cited by 9
Functional connectivity changes in neurodegenerative biomarker-positive athletes with repeated concussions
Cordero, I. R. G., Vasilevskaya, A., Taghdiri, F., Khodadadi, M., Mikulis, D. J., Tarazi, A., Mushtaque, A., Anssari, N., Colella, B., Green, R., et al. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12340-1 · Cited by 8
Integration of Biomarkers Into a Signature Profile of Persistent Traumatic Brain Injury Involving Autoimmune Processes Following Water Hammer Injury From Repetitive Head Impacts
Kornguth, S. E., & Rutledge, N. (2018) · Biomarker Insights · doi:10.1177/1177271918808216 · Cited by 9
Head acceleration event metrics in youth contact sports more dependent on sport than level of play
Lee, T. A., Lycke, R., Auger, J., Music, J. P., Dziekan, M., Newman, S. D., Talavage, T. M., Leverenz, L. J., & Nauman, E. A. (2020) · Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine · doi:10.1177/0954411920970812 · Cited by 10
Some problems of research exploring sex differences in sport-related concussions: a narrative review
Malcolm, D. (2023) · Research in Sports Medicine · doi:10.1080/15438627.2023.2271604 · Cited by 8
Concussion clinic presentation and symptom duration for pediatric sports-related concussions following Ohio concussion law
Cuff, S. C., Coxe, K. A., Young, J. A., Li, H., Yi, H., & Yang, J. G. (2018) · Research in Sports Medicine · doi:10.1080/15438627.2018.1502186 · Cited by 8
Sports-Related Concussion: Neurometabolic Aspects
Banks, R., & Domínguez, D. C. (2019) · Seminars in Speech and Language · doi:10.1055/s-0039-1679887 · Cited by 15

Authors: Mez, J., Daneshvar, D. H., Kiernan, P. T., Abdolmohammadi, B., Alvarez, V. E., Huber, B. R., Alosco, M. L., Solomon, T. M., Nowinski, C. J., McHale, L., Cormier, K. A., Kubilus, C. A., Martin, B. M., Murphy, L., Baugh, C. M., Montenigro, P. H., Chaisson, C. E., Tripodis, Y., Kowall, N. W., Weuve, J., McClean, M. D., Cantu, R. C., Goldstein, L. E., Katz, D. I., Stern, R. A., Stein, T. D., & McKee, A. C.
Affiliations: Boston University (US)
Concussion & CTE Foundation (US)
Boston Children's Hospital (US)
Corresponding author: McKee, Ann C.
ORCID: Mez, Jesse
Daneshvar, Daniel H.
Kiernan, Patrick T.
Abdolmohammadi, Bobak
Huber, Bertrand R.
Alosco, Michael L.
Solomon, Todd M.
Nowinski, Christopher J.
Martin, Brett M.
Baugh, Christine M.
Chaisson, Christine E.
Tripodis, Yorghos
Kowall, Neil W.
Weuve, Jennifer
McClean, Michael D.
Cantu, Robert C.
Goldstein, Lee E.
Katz, Douglas I.
Stern, Robert A.
Stein, Thor D.
McKee, Ann C.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2017-07-25
Volume: 318
Issue: 4
Pages: 360
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2017.8334
PMC: PMC5807097
OpenAlex: W2750121529
Cited by: 1,098
References: 41
Citations by year: 2026: 60 · 2025: 78 · 2024: 75 · 2023: 116 · 2022: 137 · 2021: 146 · 2020: 165 · 2019: 139 · 2018: 142 · 2017: 33
FWCI: 102.62
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: other-oa
Locations: JAMA (publishedVersion, other-oa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
OpenBU (Boston University) (submittedVersion)
Funders: U.S. Department of Veterans Affairs
Alzheimer's Association (NIRG-15-362697)
National Operating Committee on Standards for Athletic Equipment
National Institute on Aging (K23AG046377, P30AG013846, RF1AG057902)
National Institute of Neurological Disorders and Stroke (U01NS086659)
Topics: Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
Physical Sciences › Engineering › Biomedical Engineering › Automotive and Human Injury Biomechanics
Keywords: chronic traumatic encephalopathy, American football, neuropathology, neurodegenerative diseases, cognitive symptoms, dementia, head trauma, former athletes, military veterans, concussion
MeSH terms: Chronic Traumatic Encephalopathy, Adult, Aged, Athletic Injuries, Mental Disorders, Brain, Brain Concussion, Cause of Death, Cognition Disorders, Football, Humans, Male, Middle Aged, Severity of Illness Index, United States, tau Proteins, Substance-Related Disorders, Athletes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks