The aftermath of boxing
Abstract
SYNOPSIS The brains of 15 retired boxers have been studied and the lives of the men concerned have been investigated in retrospect. A characteristic pattern of cerebral change has been identified which appears not only to be a result of the boxing but also to underlie many features of the punch-drunk syndrome.
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Historical cases of dementia pugilistica have pathological descriptions in some cases that appear indistinguishable from PART, consistent with Jordan's hypothesis that dementia pugilistica may in some cases represent the aging process superimposed on fixed structural pathology.
“Historical cases of dementia pugilistica are interesting in this regard, in that the pathological descriptions in some cases appear indistinguishable from PART [6], consistent with Jordan’s hypothesis that dementia pugilistica may in some cases represent the aging process superimposed on fixed structural pathology [17].”
From The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features (2017) · cites this paper as [6]
Dementia pugilistica shows considerable intraneuronal Aβ42.
“In addition, dementia pugilistica that develops in professional boxers [31], while characterized by significant tauopathy and comparably less amyloid pathology, limited mainly to diffuse plaques [27], also shows considerable intraneuronal Aβ42 (Fig. 4c).”
From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [31]
Senile plaques are found in 27% of CTE cases.
“Senile plaques were found in 27 % of cases.”
From The neuropathology of sport (2014) · cites this paper as [38]
The clinical symptoms associated with CTE were examined in case summaries throughout the twentieth century; however, the disease presentation described in these reports was inconsistent.
“The clinical symptoms associated with this disease were examined in case summaries throughout the twentieth century; however, the disease presentation described in these reports was inconsistent [38, 65, 92, 100, 126].”
From The neuropathology of sport (2014) · cites this paper as [38]
In CTE, neuronal loss occurs in the cerebellar tonsils and substantia nigra, and neurofibrillary degeneration occurs in the substantia nigra and cerebral cortex.
“Neuronal loss was noted in the cerebellar tonsils and substantia nigra with Cresyl violet stain, and there was neurofibrillary degeneration of the substantia nigra and cerebral cortex using Von Braunmühl’s silver stain.”
From The neuropathology of sport (2014) · cites this paper as [38]
CTE has a relatively stereotyped pathological pattern of structural brain abnormalities including cerebral atrophy with enlargement of the lateral and third ventricles, thinning of the corpus callosum, cavum septum pellucidum with fenestrations, and cerebellar scarring.
“These changes included cerebral atrophy with enlargement of the lateral and third ventricles, thinning of the corpus callosum, cavum septum pellucidum with fen-estrations, and cerebellar scarring.”
From The neuropathology of sport (2014) · cites this paper as [38]
CTE has been diagnosed neuropathologically in American football players, professional and amateur boxers, ice hockey players, professional wrestlers, soccer players, rugby players, and a professional baseball player.
“Although CTE was first identified in association with boxing, CTE has been diagnosed neuropathologically in American football players, professional and amateur boxers, ice hockey players, professional wrestlers, soccer players, rugby players, and a professional baseball player (Figs. 3, 4, 5, 6) [38, 65, 66, 88, 91, 127, 128, 146–148].”
From The neuropathology of sport (2014) · cites this paper as [38]
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Randolph, C., Karantzoulis, S., & Guskiewicz, K. (2013) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617713000805 · Cited by 103 · see citing works
Clinical appraisal of chronic traumatic encephalopathy: current perspectives and future directions
Gavett, B. E., Cantu, R. C., Shenton, M., Lin, A. P., Nowinski, C. J., McKee, A. C., & Stern, R. A. (2011) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32834cd477 · Cited by 101 · see citing works
Current understanding of chronic traumatic encephalopathy
Baugh, C. M., Robbins, C. A., Stern, R. A., & McKee, A. C. (2014) · Current Treatment Options in Neurology · doi:10.1007/s11940-014-0306-5 · Cited by 94 · see citing works
Traumatic encephalopathy: Review and provisional research diagnostic criteria
Victoroff, J. (2013) · Neurorehabilitation · doi:10.3233/nre-130839 · Cited by 91 · see citing works
Johnson, V. E., Stewart, W., Trojanowski, J. Q., & Smith, D. H. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0909-9 · Cited by 87 · see citing works
Self-reported head injury and risk of late-life impairment and AD pathology in an AD center cohort
Abner, E. L., Nelson, P. T., Schmitt, F. A., Browning, S. R., Fardo, D. W., Wan, L., Jicha, G. A., Cooper, G. E., Smith, C. D., Caban-Holt, A. M., et al. (2014) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000355478 · Cited by 84 · see citing works
The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features
Iverson, G. L., Keene, C. D., Perry, G., & Castellani, R. J. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-170654 · Cited by 72 · see citing works
“PART refers to neuronal tau pathology and ARTAG is characterized by astrocytic tau pathology, although they are not mutually exclusive, and appear to be more a manifestation of age than a subtype of neurodegenerative disease.”
ResultInfluentialPost–traumatic Alzheimer's disease: preponderance of a single plaque type
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Apolipoprotein E ϵ4 and fatal cerebral amyloid angiopathy associated with dementia pugilistica
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Chronic trauma in sports as a cause of hypopituitarism
Keleştimur, F. (2005) · Pituitary · doi:10.1007/s11102-006-6051-3 · Cited by 43 · see citing works
Chronic Effects of Mild Neurotrauma: Putting the Cart Before the Horse?
Castellani, R. J., Perry, G., & Iverson, G. L. (2015) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000193 · Cited by 40 · see citing works
Psychiatric phenotypes in chronic traumatic encephalopathy
Mahar, I., Alosco, M. L., & McKee, A. C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.023 · Cited by 36 · see citing works
Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer
Ling, H., Kara, E., Revesz, T., Lees, A. J., Plant, G. T., Martino, D., Houlden, H., Hardy, J., & Holton, J. L. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-24 · Cited by 27 · see citing works
Schwab, N., & Hazrati, L.-N. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-180373 · Cited by 18 · see citing works
Antonius, D., Mathew, N., Picano, J., Hinds, A., Cogswell, A., Olympia, J., Brooks, T., DiGiacomo, M., Baker, J., Willer, B., et al. (2014) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/appi.neuropsych.13090201 · Cited by 14 · see citing works
Neurodegenerative Changes after Mild Traumatic Brain Injury
Fakhran, S., & Alhilali, L. (2014) · Progress in Neurological Surgery · doi:10.1159/000358787 · Cited by 12 · see citing works
- Authors
- Corsellis, J. A. N., Bruton, C. J., & Freeman-Browne, D.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 1973-08
- Volume
- 3
- Issue
- 3
- Pages
- 270-303
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W1894924936
- Cited by
- 836
- References
- 43
- Citations by year
- 2026: 9 · 2025: 21 · 2024: 13 · 2023: 25 · 2022: 26 · 2021: 26 · 2020: 48 · 2019: 54 · 2018: 32 · 2017: 44 · 2016: 43 · 2015: 54 · 2014: 49 · 2013: 39 · 2012: 20
- FWCI
- 7.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Social Sciences › Safety Research › Martial Arts: Techniques, Psychology, and Education
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- boxing, brain changes, brain damage, boxing injuries
- MeSH terms
- Adult, Aged, Boxing, Brain, Brain Damage, Chronic, Brain Stem, Cerebellum, Cerebral Cortex, Dementia, Demyelinating Diseases, Hippocampus, Humans, Male, Middle Aged, Movement Disorders, Nerve Degeneration, Septum Pellucidum, Substantia Nigra
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