The Challenges of Improving Treatments for Depression
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Nevertheless, for patients with depression many do not benefit from treatment, and some only partially benefit or only experience short-term improvement.
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Schipper, M., Shadrin, A. A., Romero, C., Friligkou, E., Polimanti, R., Posthuma, D., Someren, E. J. W. V., & Tissink, E. (2025) · medRxiv · doi:10.1101/2025.10.18.25338281
“INS, DEP and ANX are the most prevalent mental health conditions with 12-month prevalences of 7%, 6.9%, and 14% respectively 4 , and show moderate response rates to existing treatment options 5 .”
InfluentialHusnain, M. I. U., Hajizadeh, M., Ahmad, H., & Khanam, R. (2025) · Archives of Public Health · doi:10.1186/s13690-025-01798-8 · Cited by 1 · see citing works
“PD has various severity levels that can impact HRQoL and its domains in different proportions such as physical function (PF), role physical (RP), mental health (MH) and role emotional (RE) [23, 24].”
Huhn, V., Isacsson, N. H., Bendix, M., Kraepelien, M., Sahlin, H., Kaldo, V., & Forsell, E. (2026) · Internet Interventions · doi:10.1016/j.invent.2026.100926
“A non-exhaustive and partially conceptually overlapping list includes: (a) The overall concept of spontaneous recovery or natural course (Cuijpers, 2018).”
Atuhumuza, E., Kasujja, R., Fraker, A., Nakalungi, S., Nabwire, R., Ndeezi, M., Ssanyu, J. N., Lovero, K. L., & Carlson, C. (2026) · Research Square · doi:10.21203/rs.3.rs-10081124/v1
- Authors
- Cuijpers, P.
- Affiliations
- Amsterdam Public Health (NL)
- Corresponding author
- Cuijpers, Pim
- ORCID
- Cuijpers, Pim
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2018-12-25
- Volume
- 320
- Issue
- 24
- Pages
- 2529
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2902980710
- Cited by
- 78
- References
- 10
- Citations by year
- 2026: 3 · 2025: 13 · 2024: 10 · 2023: 7 · 2022: 11 · 2021: 12 · 2020: 10 · 2019: 12
- FWCI
- 5.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- VU Research Portal (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- depression, antidepressant treatment, treatment response, treatment-resistant depression, partial response, treatment improvement
- MeSH terms
- Antidepressive Agents, Depressive Disorder, Humans, Psychotherapy, Remission, Spontaneous
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