Effect of a Nurse-Led Preventive Psychological Intervention on Symptoms of Posttraumatic Stress Disorder Among Critically Ill Patients: A Randomized Clinical Trial
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Importance: A meta-analysis of outcomes during the 6 months after intensive care unit (ICU) discharge indicate a prevalence for clinically important posttraumatic stress disorder (PTSD) symptoms of 25%. Objective: To determine whether a nurse-led preventive, complex psychological intervention, initiated in the ICU, reduces patient-reported PTSD symptom severity at 6 months. Design, Setting, and Participants: A multicenter, parallel-group, cluster-randomized clinical trial with integrated economic and process evaluations conducted in 24 ICUs in the United Kingdom. Participants were critically ill patients who regained mental capacity following receipt of level 3 (intensive) care. A total of 2961 eligible patients were identified from September 2015 to January 2017. A total of 2048 were approached for participation in the ICU, of which 1458 provided informed consent. Follow-up was completed December 2017. Interventions: Twenty four ICUs were randomized 1:1 to the intervention or control group. Intervention ICUs (n = 12; 669 participants) delivered usual care during a baseline period followed by an intervention period. The preventive, complex psychological intervention comprised promotion of a therapeutic ICU environment plus 3 stress support sessions and a relaxation and recovery program delivered by trained ICU nurses to high-risk (acutely stressed) patients. Control ICUs (n = 12; 789 participants) delivered usual care in both baseline and intervention periods. Main Outcomes and Measures: The primary clinical outcome was PTSD symptom severity among survivors at 6 months measured using the PTSD Symptom Scale-Self-Report questionnaire (score range, 0-51, with higher scores indicating greater symptom severity; the minimal clinically important difference was considered to be 4.2 points). Results: Among 1458 enrolled patients (mean [SD] age, 58 [16] years; 599 women [41%]), 1353 (93%) completed the study and were included in the final analysis. At 6 months, the mean PTSD Symptom Scale-Self-Report questionnaire score in intervention ICUs was 11.8 (baseline period) compared with 11.5 (intervention period) (difference, -0.40 [95% CI, -2.46 to 1.67]) and in control ICUs, 10.1 (baseline period) compared with 10.2 (intervention period) (difference, 0.06 [95% CI, -1.74 to 1.85]) between periods. There was no significant difference in PTSD symptom severity at 6 months (treatment effect estimate [difference in differences] of -0.03 [95% CI, -2.58 to 2.52]; P = .98). Conclusions and Relevance: Among critically ill patients in the ICU, a nurse-led preventive, complex psychological intervention did not significantly reduce patient-reported PTSD symptom severity at 6 months. These findings do not support the use of this psychological intervention. Trial Registration: ISRCTN53448131.
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There is limited evidence that psychologically informed interventions whilst in intensive care prevents the development of ICU related PTSD.
“There is limited evidence that psychologically informed interventions whilst in intensive care prevents the development of ICU related PTSD.42,43”
From “It saved me”: A thematic analysis of experiences of psychological therapy following critical illness and intensive care (2024) · cites this paper as [42]
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- Authors
- Wade, D. M., Mouncey, P. R., Richards-Belle, A., Wulff, J., Harrison, D. A., Sadique, M. Z., Grieve, R. D., Emerson, L. M., Mason, A. J., Aaronovitch, D., Als, N., Brewin, C. R., Harvey, S. E., Howell, D. C. J., Hudson, N., Mythen, M. G., Smyth, D., Weinman, J., Welch, J., Whitman, C., Rowan, K. M., & for the POPPI Trial Investigators
- Affiliations
- University College London Hospitals NHS Foundation Trust (GB)
- Intensive Care National Audit & Research Centre (GB)
- Clinical Trials Unit, Intensive Care National Audit & Research Centre, London, United Kingdom
- London School of Hygiene & Tropical Medicine, London, United Kingdom
- London School of Hygiene & Tropical Medicine (GB)
- Queen's University Belfast (GB)
- Patient representative, United Kingdom
- University College London (GB)
- National Institute for Health and Care Research (GB)
- King's College London (GB)
- ORCID
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2019-02-19
- Volume
- 321
- Issue
- 7
- Pages
- 665
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC6439605
- OpenAlex
- W2911285781
- Cited by
- 124
- References
- 39
- Citations by year
- 2026: 17 · 2025: 11 · 2024: 8 · 2023: 12 · 2022: 21 · 2021: 23 · 2020: 19 · 2019: 12 · 2018: 1
- FWCI
- 17.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Edinburgh Napier Research Repository (Edinburgh Napier University) (submittedVersion)
- Funders
- National Institute for Health and Care Research (12/64/124, SRF-2013-06-016)
- University of Warwick
- Royal College of Anaesthetists
- James Cook University
- University Hospitals Coventry and Warwickshire NHS Trust
- Medical Research Council (MR/L004933/1, MR/L004933/2)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Health Professions › Radiological and Ultrasound Technology › Family and Patient Care in Intensive Care Units
- Keywords
- post-traumatic stress disorder, critical illness, intensive care unit survivors, nurse-led intervention, psychological intervention, PTSD symptom severity, intensive care unit discharge
- MeSH terms
- Adult, Aged, Female, Follow-Up Studies, Humans, Intensive Care Units, Male, Middle Aged, Psychotherapy, Surveys and Questionnaires, Severity of Illness Index, Stress Disorders, Post-Traumatic, Critical Illness, Treatment Failure, Nurse's Role, Self Report
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