Cited by 103Pelvic floor disorders treatmentsUterine Myomas and TreatmentsHernia repair and management

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Effect of Vaginal Mesh Hysteropexy vs Vaginal Hysterectomy With Uterosacral Ligament Suspension on Treatment Failure in Women With Uterovaginal Prolapse: A Randomized Clinical Trial

Open access

Nager, Charles W., Visco, Anthony G., Richter, Holly E., Rardin, Charles R., Rogers, Rebecca G., Harvie, Heidi S., Zyczynski, Halina M., Paraiso, Marie Fidela R., Mazloomdoost, Donna, Grey, Scott, Sridhar, Amaanti, Wallace, Dennis, NICHD Pelvic Floor Disorders Network·2019·JAMA

DOI 10.1001/jama.2019.12812PMC PMC6749543

Open this paper in CoChat — free account Open PDF

Abstract

Importance: Vaginal hysterectomy with suture apical suspension is commonly performed for uterovaginal prolapse. Transvaginal mesh hysteropexy is an alternative option. Objective: To compare the efficacy and adverse events of vaginal hysterectomy with suture apical suspension and transvaginal mesh hysteropexy. Design, Setting, Participants: At 9 clinical sites in the US Pelvic Floor Disorders Network, 183 postmenopausal women with symptomatic uterovaginal prolapse were enrolled in a randomized superiority clinical trial between April 2013 and February 2015. The study was designed for primary analysis when the last randomized participant reached 3 years of follow-up in February 2018. Interventions: Ninety-three women were randomized to undergo vaginal mesh hysteropexy and 90 were randomized to undergo vaginal hysterectomy with uterosacral ligament suspension. Main Outcomes and Measures: The primary treatment failure composite outcome (re-treatment of prolapse, prolapse beyond the hymen, or prolapse symptoms) was evaluated with survival models. Secondary outcomes included operative outcomes and adverse events, and were evaluated with longitudinal models or contingency tables as appropriate. Results: A total of 183 participants (mean age, 66 years) were randomized, 175 were included in the trial, and 169 (97%) completed the 3-year follow-up. The primary outcome was not significantly different among women who underwent hysteropexy vs hysterectomy through 48 months (adjusted hazard ratio, 0.62 [95% CI, 0.38-1.02]; P = .06; 36-month adjusted failure incidence, 26% vs 38%). Mean (SD) operative time was lower in the hysteropexy group vs the hysterectomy group (111.5 [39.7] min vs 156.7 [43.9] min; difference, -45.2 [95% CI, -57.7 to -32.7]; P = <.001). Adverse events in the hysteropexy vs hysterectomy groups included mesh exposure (8% vs 0%), ureteral kinking managed intraoperatively (0% vs 7%), granulation tissue after 12 weeks (1% vs 11%), and suture exposure after 12 weeks (3% vs 21%). Conclusions and Relevance: Among women with symptomatic uterovaginal prolapse undergoing vaginal surgery, vaginal mesh hysteropexy compared with vaginal hysterectomy with uterosacral ligament suspension did not result in a significantly lower rate of the composite prolapse outcome after 3 years. However, imprecision in study results precludes a definitive conclusion, and further research is needed to assess whether vaginal mesh hysteropexy is more effective than vaginal hysterectomy with uterosacral ligament suspension. Trial Registration: ClinicalTrials.gov Identifier: NCT01802281.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1001/jama.2019.12812

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction
Bump, R. C., Mattiasson, A., Bø, K., Brubaker, L. P., DeLancey, J. O. L., Klarskov, P., Shull, B. L., & Smith, A. R. B. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70243-0 · Cited by 4,275
Untitled work
Higgins (2002) · doi:10.1002/(issn)1097-0258 · Cited by 1,248
Surgical management of pelvic organ prolapse in women
Maher, C., Feiner, B., Baeßler, K., & Glazener, C. M. A. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004014.pub4 · Cited by 1,115
Lifetime risk of stress urinary incontinence or pelvic organ prolapse surgery
Wu, J. M., Matthews, C. A., Conover, M. M., Pate, V., & Jonsson Funk, M. (2014) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000000286 · Cited by 1,111
A body image scale for use with cancer patients
Hopwood, P., Fletcher, I., Lee, A., & Al Ghazal, S. (2001) · European Journal of Cancer · doi:10.1016/s0959-8049(00)00353-1 · Cited by 984
Validation of two global impression questionnaires for incontinence
Yalcin, I., & Bump, R. C. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2003.379 · Cited by 888
Surgical management of pelvic organ prolapse in women
Maher, C., Feiner, B., Baessler, K., & Schmid, C. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004014.pub5 · Cited by 784
Psychometric evaluation of 2 comprehensive condition-specific quality of life instruments for women with pelvic floor disorders
Barber, M. D., Kuchibhatla, M. N., Pieper, C. F., & Bump, R. C. (2001) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2001.118659 · Cited by 617
Women seeking treatment for advanced pelvic organ prolapse have decreased body image and quality of life
Jelovsek, J. E., & Barber, M. D. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.01.060 · Cited by 434
Comparison of 2 Transvaginal Surgical Approaches and Perioperative Behavioral Therapy for Apical Vaginal Prolapse: The OPTIMAL Randomized Trial
Barber, M. D., Brubaker, L., Burgio, K. L., Richter, H. E., Nygaard, I., Weidner, A. C., Menefee, S. A., Lukacz, E. S., Norton, P., Schaffer, J., et al. (2014) · JAMA · doi:10.1001/jama.2014.1719 · Cited by 428
Self-citation

Show all 36 references

Sorted by citations

Global burden and trends of pelvic organ prolapse associated with aging women: An observational trend study from 1990 to 2019
Wang, B., Chen, Y., Zhu, X., Wang, T., Li, M., Huang, Y., Xue, L., Zhu, Q., Gao, X., & Wu, M. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.975829 · Cited by 135
Surgery for women with apical vaginal prolapse
Maher, C., Yeung, E., Haya, N., Christmann-Schmid, C., Mowat, A., Chen, Z., & Baessler, K. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012376.pub2 · Cited by 114
Effect of sacrospinous hysteropexy with graft vs vaginal hysterectomy with uterosacral ligament suspension on treatment failure in women with uterovaginal prolapse: 5-year results of a randomized clinical trial
Nager, C. W., Visco, A. G., Richter, H. E., Rardin, C. R., Komesu, Y., Harvie, H. S., Zyczynski, H. M., Paraiso, M. F. R., Mazloomdoost, D., Sridhar, A., et al. (2021) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2021.03.012 · Cited by 67
“Vaginal infections or atypical vaginal discharge, number/total (%) 4/90 (4) 9/91 (10) 5 ( 13 to 2) .”
Self-citation
Apical Suspension Repair for Vaginal Vault Prolapse
Menefee, S. A., Richter, H. E., Myers, D. L., Moalli, P., Weidner, A. C., Harvie, H. S., Rahn, D. D., Meriwether, K. V., Paraiso, M. F. R., Whitworth, R., et al. (2024) · JAMA Surgery · doi:10.1001/jamasurg.2024.1206 · Cited by 43
Self-citation
Sexual function after pelvic organ prolapse surgery: a systematic review comparing different approaches to pelvic floor repair
Antosh, D. D., Dieter, A. A., Balk, E. M., Kanter, G., Kim-Fine, S., Meriwether, K. V., Mamik, M. M., Good, M. M., Singh, R., Alas, A., et al. (2021) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2021.05.042 · Cited by 33
Self-citation
Success and failure are dynamic, recurrent event states after surgical treatment for pelvic organ prolapse
Jelovsek, J. E., Gantz, M. G., Lukacz, E., Sridhar, A., Zyczynski, H., Harvie, H. S., Dunivan, G., Schaffer, J., Sung, V., Varner, R. E., et al. (2021) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.10.009 · Cited by 28
Self-citation
Clinician perspectives on hysterectomy versus uterine preservation in pelvic organ prolapse surgery: A systematic review and meta‐analysis
Porcari, I., Zorzato, P. C., Bosco, M., Garzon, S., Magni, F., Salvatore, S., Franchi, M. P., & Uccella, S. (2024) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.15343 · Cited by 28
“This difference in results may be mainly due to the exclusion of the study by Nager et al. 72 (because it used transvaginal mesh) from our meta-analysis.”
BackgroundResultInfluential
Sexual Activity and Dyspareunia 1 Year After Surgical Repair of Pelvic Organ Prolapse
Lukacz, E. S., Sridhar, A., Chermansky, C., Rahn, D. D., Harvie, H. S., Gantz, M. G., Varner, R. E., Korbly, N. B., & Mazloomdoost, D. (2020) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000003992 · Cited by 29
“Any cesarean delivery 6/63 (10) 46/561 (8.”
Self-citation
Transvaginal Mesh Compared With Native Tissue Repair for Pelvic Organ Prolapse
Kahn, B. S., Varner, R. E., Murphy, M., Sand, P. K., Thomas, S. L., Lipetskaia, L., Chung, D. E., Mahdy, A. E., & Noblett, K. L. (2022) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000004794 · Cited by 29
Perioperative Vaginal Estrogen as Adjunct to Native Tissue Vaginal Apical Prolapse Repair: A Randomized Clinical Trial
Rahn, D. D., Richter, H. E., Sung, V. W., Pruszynski, J. E., & Hynan, L. S. (2023) · JAMA · doi:10.1001/jama.2023.12317 · Cited by 28
Self-citation
Transvaginal mesh or grafts or native tissue repair for vaginal prolapse
Yeung, E., Baeßler, K., Christmann‐Schmid, C., Haya, N., Chen, Z., Wallace, S. A., Mowat, A., & Maher, C. (2024) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012079.pub2 · Cited by 30
A systematic review of the surgical management of apical pelvic organ prolapse
Chan, C. Y. W., Fernandes, R. A., Yao, H. H., O’Connell, H. E., Tse, V. W., & Gani, J. (2022) · International Urogynecology Journal · doi:10.1007/s00192-022-05408-x · Cited by 28
Defining mechanisms of recurrence following apical prolapse repair based on imaging criteria
Bowen, S. T., Moalli, P., Abramowitch, S. D., Lockhart, M. E., Weidner, A. C., Ferrando, C. A., Nager, C. W., Richter, H. E., Rardin, C. R., Komesu, Y. M., et al. (2021) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2021.05.041 · Cited by 24
Self-citation
Complications and objective outcomes of uterine preserving surgeries for the repair of pelvic organ prolapse versus procedures removing the Uterus, a systematic review
Azadi, A., Marchand, G., Masoud, A. T., Sainz, K., Govindan, M., Ware, K., King, A., Ruther, S., Brazil, G., Calteux, N., et al. (2021) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2021.10.020 · Cited by 21
Subgroups of failure after surgery for pelvic organ prolapse and associations with quality of life outcomes: a longitudinal cluster analysis
Jelovsek, J. E., Gantz, M. G., Lukacz, E. S., Zyczynski, H. M., Sridhar, A., Kery, C., Chew, R., Harvie, H. S., Dunivan, G., Schaffer, J., et al. (2021) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2021.06.068 · Cited by 20
Self-citation
Pelvic Organ Prolapse
Dieter, A. A. (2021) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2021.05.001 · Cited by 23
A randomized controlled trial of permanent vs absorbable suture for uterosacral ligament suspension
Kowalski, J. T., Genadry, R., Ten Eyck, P., & Bradley, C. S. (2021) · International Urogynecology Journal · doi:10.1007/s00192-020-04244-1 · Cited by 20
Hysteropreservation versus hysterectomy in uterine prolapse surgery: a systematic review and meta-analysis
He, L., Feng, D., Zha, X., Liao, X.-Y., Gong, Z., Gu, D., Lin, Y., & Huang, L. (2021) · International Urogynecology Journal · doi:10.1007/s00192-021-04913-9 · Cited by 16
Activity Restrictions After Gynecologic Surgery
Mueller, M. G., & Kenton, K. S. (2024) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000005501 · Cited by 15
Longitudinal Reoperation Risk After Apical Prolapse Procedures in Women Aged 65 Years and Older
Berger, A. A., Bretschneider, C. E., Gregory, W. T., & Sung, V. W. (2024) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000005511 · Cited by 14
Serious Complications and Recurrence following Sacrospinous Ligament Fixation for the Correction of Apical Prolapse
Gracia, S. D., Fatton, B., Cosson, M., Campagne-Loiseau, S., Ferry, P., Lucot, J.-P., Debodinance, P., Panel, L., Deffieux, X., Garbin, O., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12020468 · Cited by 13
“However, this risk seems lower than the previously reported rates [19,20].”
Result
Short-term outcomes of sacrospinous hysteropexy through an anterior approach
Plair, A. R., Dutta, R., Overholt, T. L., & Matthews, C. A. (2021) · International Urogynecology Journal · doi:10.1007/s00192-020-04641-6 · Cited by 13
Perioperative adverse events in women undergoing vaginal prolapse repair with uterine preservation versus concurrent hysterectomy: a matched cohort study
Yuan, A. S., Chang, O. H., & Ferrando, C. A. (2021) · Female Pelvic Medicine & Reconstructive Surgery · doi:10.1097/spv.0000000000001011 · Cited by 13
Long-term Urinary Outcomes After Transvaginal Uterovaginal Prolapse Repair With and Without Concomitant Midurethral Slings
Giugale, L. E., Sridhar, A., Ferrante, K. L., Komesu, Y. M., Meyer, I., Smith, A. L., Myers, D., Visco, A. G., Paraiso, M. F. R., Mazloomdoost, D., et al. (2022) · Urogynecology · doi:10.1097/spv.0000000000001160 · Cited by 11
Self-citation
Methods for the defining mechanisms of anterior vaginal wall descent (DEMAND) study
Moalli, P., Bowen, S. T., Abramowitch, S. D., Lockhart, M. E., Ham, M., Hahn, M., Weidner, A. C., Richter, H. E., Rardin, C. R., Komesu, Y. M., et al. (2020) · International Urogynecology Journal · doi:10.1007/s00192-020-04511-1 · Cited by 10
Self-citation
Utilizing Outpatient Pelvic Reconstructive Surgery in the Era of the COVID-19 Pandemic
Berger, A. A., Tan-Kim, J., & Menefee, S. A. (2021) · Urogynecology · doi:10.1097/spv.0000000000001044 · Cited by 9
“Despite growing evidence for outpatient surgery, a majority of pelvic reconstructive surgical procedures are performed as inpatient procedures.(12,15,16) We would expect, with further evidence, that surgeon’s and health systems will increase the use of outpatient surgery for the care of women with POP.”
Background
Association Between Enlarged Genital Hiatus and Composite Surgical Failure After Vaginal Hysterectomy With Uterosacral Ligament Suspension
Bradley, M. S., Sridhar, A., Ferrante, K. L., Andy, U. U., Visco, A. G., Rodriguez, M. E. F., Myers, D. L., Varner, E. R., Mazloomdoost, D., Gantz, M. G., et al. (2022) · Urogynecology · doi:10.1097/spv.0000000000001309 · Cited by 8
Self-citation
Vaginal morphology and position associated with prolapse recurrence after vaginal surgery: A secondary analysis of the DEMAND study
Bowen, S. T., Moalli, P., Abramowitch, S. D., Luchristt, D., Meyer, I., Rardin, C. R., Harvie, H. S., Hahn, M. E., Mazloomdoost, D., Iyer, P., et al. (2023) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.17620 · Cited by 8
Self-citation
Hysterectomy with uterosacral suspension or UpholdTM hysteropexy in women with apical prolapse: a parallel cohort study
Kulkarni, M., Young, N., Lee, J., & Rosamilia, A. (2020) · International Urogynecology Journal · doi:10.1007/s00192-020-04328-y · Cited by 8
Complications Reported to the Food and Drug Administration: A Cross-sectional Comparison of Urogynecologic Meshes
Artsen, A. M., Sassani, J. C., Moalli, P., & Bradley, M. S. (2022) · Urogynecology · doi:10.1097/spv.0000000000001193 · Cited by 8
Pelvic Organ Prolapse
Brincat, C. (2019) · JAMA · doi:10.1001/jama.2019.12245 · Cited by 7
Improved body image after uterovaginal prolapse surgery with or without hysterectomy
Rogers, R. G., Meyer, I., Smith, A. L., Ackenbom, M. F., Barden, L., Korbly, N. B., Mazloomdoost, D., Thomas, S., & Nager, C. W. (2021) · International Urogynecology Journal · doi:10.1007/s00192-021-04954-0 · Cited by 7
Self-citation
Twelve Month Outcomes of Pelvic Organ Prolapse Surgery in Patients With Uterovaginal or Posthysterectomy Vaginal Prolapse Enrolled in the Multicenter Pelvic Floor Disorders Registry
Ferrando, C. A., Bradley, C. S., Meyn, L. A., Brown, H. W., Moalli, P., Heisler, C. A., Murarka, S. M., Foster, R. T., Chung, D. E., Whitcomb, E. L., et al. (2023) · Urogynecology · doi:10.1097/spv.0000000000001410 · Cited by 7
Vaginal Colposuspension Using the Uphold Lite Mesh System versus Transvaginal Hysterectomy with Uterosacral Ligament Suspension for Treatment of Apical Prolapse: A Comparative Study
Chill, H. H., Navon, I., Salzman, A. R., Cohen, A., Dick, A., & Shveiky, D. (2021) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2021.03.002 · Cited by 7
Updating Evidence for Treatment of Pelvic Organ Prolapse
Nager, C. W. (2023) · JAMA · doi:10.1001/jama.2023.13733 · Cited by 7
Self-citation
Trends in patient characteristics, surgical techniques, and associated complications over time in pelvic organ prolapse repair
Rosenberg, H., Leybovitz‐Haleluya, N., Saban, A., Weintraub, A. Y., & Rotem, R. (2025) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2025.02.054 · Cited by 6
Pelvic Organ Prolapse: Overview, Diagnosis and Management
El‐Nashar, S. A., Singh, R., & Chen, A. H. (2022) · Journal of Gynecologic Surgery · doi:10.1089/gyn.2022.0049 · Cited by 9
“72,73 In the last decade, more studies have been published on both uterosacral and sacrospinous hysteropexy.”
Outcomes of vaginal hysterectomy combined with anterior and posterior colporrhaphy for pelvic organ prolapse: a single center retrospective study
Kim, J. H., Lee, S., Chae, H. D., Shin, Y. K., Lee, S. R., & Kim, S. H. (2021) · Obstetrics & Gynecology Science · doi:10.5468/ogs.21235 · Cited by 7
“Another RCT comparing vaginal mesh hysteropexy with VH USLS found that there was no difference between the two procedures in terms of re-treatment and recurrence of POP [23].”
BackgroundResult
Restriction of Surgical Options for Pelvic Floor Disorders.
(2024) · Urogynecology · doi:10.1097/spv.0000000000001507 · Cited by 4
Surgery for women with pelvic organ prolapse with or without stress urinary incontinence
Baeßler, K., Christmann‐Schmid, C., Haya, N., Mowat, A. P., Chen, Z., Wallace, S. A., Yeung, E., & Maher, C. (2026) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013108.pub2 · Cited by 5
Anterior approach sacrospinous hysteropexy: native tissue compared with mesh-augmented repair for primary uterovaginal prolapse management
Overholt, T. L., Velet, L., Xu, M., Dutta, R., & Matthews, C. A. (2023) · International Urogynecology Journal · doi:10.1007/s00192-023-05589-z · Cited by 5
3 Year outcome after treatment of uterovaginal prolapse with a 6-point fixation mesh.
Kuszka, A., Brandt, A., Niesel, A., Lutz, H., Mengel, M., Ulrich, D., & Fünfgeld, C. (2020) · European Journal of Obstetrics, Gynecology, and Reproductive Biology · doi:10.1016/j.ejogrb.2020.10.030 · Cited by 4
A comparison of modified laparoscopic uterine suspension and vaginal hysterectomy with sacrospinous ligament fixation for treating pelvic organ prolapse.
Zhu, H., Sun, Y., & Zheng, X. (2021) · PubMed Central · Cited by 5
The Role of Uterine Preservation at the Time of Pelvic Organ Prolapse Surgery
Chang, O. H., Carter Ramirez, A., Edwards, A., Chill, H. H., Letko, J., Woodburn, K. L., & Cundiff, G. W. (2025) · Urogynecology · doi:10.1097/spv.0000000000001667 · Cited by 4
Postoperative Sexual Function After Vaginal Surgery and Clitoral Size, Position, and Shape
Bowen, S. T., Moalli, P., Rogers, R. G., Corton, M. M., Andy, U. U., Rardin, C. R., Hahn, M. E., Weidner, A. C., Ellington, D. R., Mazloomdoost, D., et al. (2025) · JAMA Surgery · doi:10.1001/jamasurg.2024.6922 · Cited by 4
Self-citation
Urinary basement membrane graft-augmented sacrospinous ligament suspension: a description of technique and short-term outcomes
Luchristt, D., Weidner, A. C., & Siddiqui, N. Y. (2022) · International Urogynecology Journal · doi:10.1007/s00192-022-05159-9 · Cited by 4
Prospective analysis of transvaginal mesh hysteropexy in the treatment of uterine prolapse
Khandwala, S., & Cruff, J. P. (2020) · International Urogynecology Journal · doi:10.1007/s00192-020-04590-0 · Cited by 4
Impact of Genital Hiatus Size on Anatomic Outcomes After Mesh-Augmented Sacrospinous Ligament Fixation
Vaughan, M. H., Giugale, L. E., Siddiqui, N. Y., & Bradley, M. S. (2021) · Urogynecology · doi:10.1097/spv.0000000000000986 · Cited by 3
Underrepresentation in Pelvic Floor Disorder Patient-Reported Outcomes: Whose Outcomes Are We Measuring?
Shinnick, J. K., Siddique, M., Jarmale, S., Raker, C., Brown, O., Sung, V. W., & Carberry, C. L. (2022) · Urogynecology · doi:10.1097/spv.0000000000001248 · Cited by 3
Reoperation for prolapse recurrence after sacrospinous mesh hysteropexy: characteristics of women choosing retreatment
Napoé, G. S., Luchristt, D., Sridhar, A., Ellington, D. R., Ridgeway, B., Mazloomdoost, D., Sung, V. W., Ninivaggio, C. S., Harvie, H. S., Santiago‐Lastra, Y., et al. (2022) · International Urogynecology Journal · doi:10.1007/s00192-022-05411-2 · Cited by 3
“The Study of Uterine Prolapse Procedures–Randomized Trial (SUPeR) was designed to compare the effectiveness and outcomes of two transvaginal apical suspension interventions for uterovaginal prolapse: sacrospinous hysteropexy with mesh graft (mesh hysteropexy) versus transvaginal hysterectomy with bilateral uterosacral…”
MethodSelf-citation
Surgical outcomes in patients aged 70 years and older following uterosacral ligament suspension: a comparative study
Chill, H. H., Dick, A., Cohen, A., Ryvkin, I., Rosenbloom, J. I., Salzman, A. R., & Shveiky, D. (2023) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-023-06974-1 · Cited by 3
Bilateral posterior Richter sacrospinous fixation with native tissue: Anatomical and functional results and quality of life assessment over 10 years
Gaultier, V., Martel, C., Boisramé, T., Faller, É., Lecointre, L., & Akladios, C. Y. (2023) · Journal of Gynecology Obstetrics and Human Reproduction · doi:10.1016/j.jogoh.2023.102575 · Cited by 3
Etiology, Diagnosis, and Management of Pelvic Organ Prolapse: Overview
Wang, C., & Chung, D. E. (2023) · Springer eBooks · doi:10.1007/978-3-031-19598-3_29 · Cited by 3
Risk factors for ureteral obstruction and the diagnostic value of the “cysto-under-tension” technique at the time of uterosacral colpopexy
Chang, O. H., Tewari, S., Sun, J. Y., & Ferrando, C. A. (2021) · International Urogynecology Journal · doi:10.1007/s00192-020-04650-5 · Cited by 2
Outcomes at 12, 24, and 36 Months in Women Treated for Pelvic Organ Prolapse With Pessary or Surgery: Results From the Multicenter Pelvic Floor Disorders Registry
Andy, U. U., Meyn, L. A., Brown, H. W., Moalli, P., Ferrando, C. A., Shippey, S. H., Omosigho, U. R., Kowalski, J. T., Guaderrama, N. M., Anger, J. T., et al. (2025) · Urogynecology · doi:10.1097/spv.0000000000001669 · Cited by 2
Urge Incontinence After Pelvic Organ Prolapse Surgery: A Secondary Analysis
Gaddam, N. G., Getaneh, F. W., Mazloomdoost, D., Dieter, A. A., & Iglesia, C. B. (2025) · Urogynecology · doi:10.1097/spv.0000000000001764 · Cited by 2
Self-citation
Prolapse phenotypes and 12-month postoperative prolapse recurrence after apical native tissue surgery: a combined analysis using multicenter randomized trials and registry data
WESTON, K., Kenne, K. A., Bradley, C. S., Wendt, L. H., & Kowalski, J. T. (2026) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2026.04.012 · Cited by 2
Bilateral medial sacrospinous ligament suture for apical suspension through natural spaces: A single‐center study with low perioperative complications
OuYang, Y., Xu, W., Li, F., Chen, Y., Yuan, T., Wu, X., & Zhao, X. (2022) · Clinical Anatomy · doi:10.1002/ca.23975 · Cited by 2
“Urinary system injury usually occurs in USLS (Jackson et al., 2015; Nager et al., 2019).”
BackgroundResultInfluential
Surgical Outcomes Within 1 Year After Native-Tissue Apical Suspension for Pelvic Organ Prolapse: Sacrospinous Ligament Fixation Versus Uterosacral Ligament Suspension
Ghanbari, Z., Pourali, L., Eftekhar, T., Pesikhani, M. D., Darvish, S., Ayati, E., & Lotfi, Z. (2023) · Journal of Obstetrics Gynecology and Cancer Research · doi:10.30699/jogcr.8.5.431 · Cited by 2
“At least one trial has reported similar 36-month recurrence outcomes for transvaginal mesh hysteropexy compared with traditional vaginal hysterectomy with uterosacral ligament suspension (14) .”
Background
Workshop on cultivating shared decision making to improve surgical outcomes for pelvic organ prolapse
Cundiff, G. W., Sanaee, M., & Schulz, J. A. (2024) · Continence · doi:10.1016/j.cont.2024.101318 · Cited by 2
Different treatment tactics of the pelvic organ prolapse according to the type and the degree of the prolapse: A narrative review
Meirmanova, A. (2022) · Futurity Medicine. · doi:10.57125/fem.2022.03.25.04 · Cited by 2
Anatomic identification of laparoscopic uterosacral ligament suspension: A step-by-step procedure
OuYang, Y., Xu, W., Li, F., Wang, R., & Zhao, X. (2022) · International Urogynecology Journal · doi:10.1007/s00192-022-05257-8 · Cited by 2
Sacrospinous Hysteropexy With Mesh vs Vaginal Hysterectomy for Treatment of Uterovaginal Prolapse
Nager, C. W., Visco, A. G., Richter, H. E., Rardin, C. R., Meriwether, K., Harvie, H. S., Zyczynski, H. M., Paraiso, M. F. R., Mazloomdoost, D., Sridhar, A., et al. (2026) · JAMA Surgery · doi:10.1001/jamasurg.2026.2263 · Cited by 2
Self-citation
Apical prolapse surgery
Maher, C. (2021) · Pelvic Floor Disorders · doi:10.1007/978-3-030-40862-6_55 · Cited by 1
Brazilian Portuguese Translation and Validation of the Pelvic Organ Prolapse/Incontinence Sexual Questionnaire-IUGA revised
Freitas, L. P. G., Monaco, H. E. M. G., Pacetta, A. M., Nahas, S. C., Baracat, E. C., & Haddad, J. M. (2024) · International Urogynecology Journal · doi:10.1007/s00192-024-05889-y · Cited by 1
Pelvic Floor Reconstruction Using Mesh Versus Campbell Uterosacral Ligament Suspension: 2-Year Clinical Outcome
Zhao, T., Chen, Y. Q., Zhao, S., Huang, Y., & Yan, D.-H. (2025) · International Urogynecology Journal · doi:10.1007/s00192-025-06296-7 · Cited by 1
Pelvic organ prolapse, abdominal hernias, and inguinal hernias
Kirby, A. C., & Lentz, G. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-65399-2.00029-2 · Cited by 1
Error in Results Section
(2021) · JAMA · doi:10.1001/jama.2021.0535 · Cited by 1
Apical Support Procedures at the Time of Hysterectomy for Benign Indications
Wang, R., Tulikangas, P. K., & Harvie, H. S. (2022) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000004764 · Cited by 1
Self-citation
RETRACTED: Effect of different surgical techniques on postoperative wound infection in patients with uterine prolapse: A meta‐analysis
Wang, J., Shang, X., Huang, J., & Wang, J. (2024) · International Wound Journal · doi:10.1111/iwj.14588
Retracted
To err is human: lessons from prolapse studies to identify and strategies to reduce data errors
Myers, D. L., Werth, A. J., Whitworth, R., Menefee, S. A., Visco, A. G., Andy, U. U., Rahn, D. D., Meyer, I., Zyczynski, H. M., & Mazloomdoost, D. (2025) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2025.08.017 · Cited by 2
Self-citation
Female Sexuality in Pelvic Floor Disorders
Halder, G. E., White, A. B., & Rogers, R. G. (2021) · Urodynamics, neurourology and pelvic floor dysfunctions · doi:10.1007/978-3-030-57393-5_15 · Cited by 1
Self-citation
COMPARISON OF THE EFFECT OF DIFFERENT MESH IMPLANTS ON THE REPRODUCTIVE SYSTEM IN EXPERIMENTAL MODELS OF GYNECOLOGICAL SURGERIES
Сафонов, Р. А., Prokopіuk, V., Prokopyuk, O., Лазуренко, В. В., Тіщенко, О. М., & Овчаренко, О. Б. (2022) · World of Medicine and Biology · doi:10.26724/2079-8334-2022-2-80-227-231 · Cited by 1
Analysis on Effects of Laparoscopic Total Hysterectomy Combined with High Hysterosacral Ligament Suspension in the Treatment for Uterine Prolapse
Qiu, B. Q., Wang, A., Chen, Y., & Wang, Z. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/2585529 · Cited by 1
“e disease is manifested by uterine tissues descending around the vaginal axis, the level of the external os of cervix being the same as or lower than the ischial spine, and the cervix and uterine body all prolapsing out of the oricium vaginae [1].”
Background
Retracted
Etiology, Diagnosis, and Management of Pelvic Organ Prolapse: Overview
Wang, C., & Chung, D. E. (2023) · Springer eBooks · doi:10.1007/978-3-030-71112-2_29-1 · Cited by 1
Role of Vaginal Hysterectomy in the Treatment of Vaginal Middle Compartment Prolapse
Brito, L. G. O., Riccetto, C., & Palma, P. C. R. (2023) · Springer eBooks · doi:10.1007/978-3-031-19598-3_35 · Cited by 1
Database Updates and Resulting Changes in Data in Study of Vaginal Mesh Hysteropexy vs Vaginal Hysterectomy
Nager, C. W. (2021) · JAMA · doi:10.1001/jama.2021.0477 · Cited by 1
Self-citation
Sexual Function and Clitoral Anatomy after Vaginal Surgery with and without Midurethral SlingPreprint
Bowen, S. T., Moalli, P., Rogers, R. G., Corton, M. M., Andy, U. U., Rardin, C. R., Hahn, M. E., Weidner, A. C., Ellington, D. R., Mazloomdoost, D., et al. (2026) · medRxiv · doi:10.64898/2026.04.20.26351291 · Cited by 1
Self-citation
How Can We Improve the Assessment and Indifferent Outcomes From Pelvic Organ Prolapse Management From Conservative and Surgical Therapies? ICI‐RS 2025
Kearney, R., Wagg, A., Bower, W., Chapple, C., Khullar, V., Robinson, D., Taithongchai, A., Hobson, P. T., Wein, A., & Abrams, P. (2026) · Neurourology and Urodynamics · doi:10.1002/nau.70272 · Cited by 1
Changes in Performance of Apical Suspension at the Time of Surgery for Prolapse: Assessment of the Influence of the American Urogynecologic Society and American College of Obstetricians and Gynecologists Practice Bulletin.
Luchristt, D., Zemtsov, G. E., & Jelovsek, J. E. (2022) · PubMed · doi:10.1097/spv.0000000000001136
Transvaginal round-infundibulopelvic ligament colposuspension after vaginal hysterectomy in high-grade uterovaginal prolapse: 11-year outcome
Ekici, M. A., Çetin, Ç., Kayar, B., Albayrak, Ö., Topçuoğlu, M. A., & Ural, Ü. M. (2020) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2020.06.028
Vaginal mesh hysteropexy: a review
DiCarlo-Meacham, A., & Mazloomdoost, D. (2021) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000748
Self-citation
Robotic sacrohysteropexy: an instructional video for uterovaginal prolapse repair in patients with desired uterine preservation
Warehime, J. M., Cope, Z. S., Feroz, R. T., Lenger, S. M., Gupta, A., & Francis, S. L. (2022) · International Urogynecology Journal · doi:10.1007/s00192-022-05260-z
The American Urogynecologic Society Pelvic Floor Disorders Registry Bears Fruit
Barber, M. D., & Bradley, C. S. (2022) · Urogynecology · doi:10.1097/spv.0000000000001290
Role of Vaginal Hysterectomy in the Treatment of Vaginal Middle Compartment Prolapse
Brito, L. G. O., Riccetto, C., & Palma, P. C. R. (2023) · Springer eBooks · doi:10.1007/978-3-030-71112-2_35-1
Impactos de cirurgias ginecológicas em pacientes idosas
Bertin, L. M. M., Garcia, A. S., Marangoni, I. P., Batista, M. G. C., Viana, L. V., Viégas, J. D. V. O., Vieira, I. S. M., Aleixo, A. P., Silva, A. F. A., & Costa, M. A. G. (2023) · Seven Editora eBooks · doi:10.56238/ciesaudesv1-089
Clinical Study on the Comparison of Efficacyof Laparoscopic Cooper Ligament Suspension with Other Surgical Methods in the Treatment of Uterine Prolapse
曹, 佃. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.1391949
Immunohistochemical age changes of vagina tissues in women with pelvic prolaps
Сафонов, Р. А., Prokopіuk, V., Грищенко, О. В., Prokopіuk, O., Лазуренко, В. В., Gryshchenko, M., & Паращук, В. Ю. (2023) · Reproductive Endocrinology · doi:10.18370/2309-4117.2023.68.84-88
Critérios para indicação de histerectomia em pacientes na menopausa
Froza, B. E., Costa, A. D., Martins, C. C., Rateiro, F. S., Alcântara, J. P. D., Mendes, L. L. D. O., China, M. J. M., Ramos, V. H. M., & Bulsoni, L. B. D. A. (2023) · Brazilian Journal of Health Review · doi:10.34119/bjhrv6n6-471
Long-Term Costs of Minimally Invasive Sacral Colpopexy Compared to Native Tissue Vaginal Repair With Concomitant Hysterectomy
Haraki, A. S. E., Shepherd, J. P., Matthews, C. A., & Cadish, L. A. (2024) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2024.04.025
Tradução e validação em português do questionário Impacto do Prolapso de Órgãos Pélvicos, da Incontinência Urinária e da Incontinência Fecal na Função Sexual Feminina
Freitas, L. P. G. (2024) · doi:10.11606/d.5.2024.tde-16052024-145224
Management intra- und postoperativer Komplikationen
Tunn, R., & Antoci, G. (2024) · Elsevier eBooks · doi:10.1016/b978-3-437-21941-2.00020-x
The Pelvic Floor Disorders Network: Evolution Over Two Decades of Female Pelvic Floor Research
Richter, H. E., Visco, A. G., Brubaker, L. T., Sung, V. W., Nygaard, I. E., Arya, L. A., Menefee, S. A., Zyczynski, H. M., Schaffer, J. I., Rogers, R. G., et al. (2024) · Urogynecology · doi:10.1097/spv.0000000000001571
Self-citation
Retracted: Pilot Study: Descriptive-comparative Analysis of Anterior Vaginal Hysteropexies versus Vaginal Hysterectomies for the Treatment of Stage III-IV Uterine Prolapse
Reyes, P. C., López, M. G., Rojas, M. C., Reyes, B. P., & Minuesa, A. O. (2025) · Clinical Journal of Obstetrics and Gynecology · doi:10.29328/journal.cjog.1001181
Retracted
Hysteropexy
Haraki, A. S. E., & Matthews, C. A. (2025) · Springer eBooks · doi:10.1007/978-3-032-00339-3_10
Urethral Morphology and Support Associated with Urinary Symptoms after Vaginal Surgery with and without Midurethral SlingPreprint
Bowen, S. T., Moalli, P., Harvie, H. S., Rardin, C., Hahn, M., Weidner, A. C., Richter, H. E., Serna-Gallegos, T. R., Mazloomdoost, D., Sridhar, A., et al. (2026) · medRxiv · doi:10.64898/2026.05.17.26353431
Self-citation
MRI 2-D Parameters Associated with Native Tissue or Transvaginal Mesh Surgical Apical Prolapse Repair Failure
Lockhart, M. E., Moalli, P., Richter, H. E., Meyer, I., Weidner, A. C., Komesu, Y. M., Carper, B. A., Gantz, M. G., for the NICHD Pelvic Floor Disorders Network, Ferrante, K. L., et al. (2026) · International Urogynecology Journal · doi:10.1007/s00192-026-06699-0
Self-citation
Sexual function after urogynecologic surgery
Russell, C. B., & Sung, V. W. (2026) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000001132
Outcomes beyond 10 years after laparoscopic uterosacral ligament suspension combined with cervical amputation in young women with pelvic organ prolapse and cervical elongation: a prospective observational cohort study
Yan, J., Zhang, Y., Yin, R., Chen, J., & Zhu, L. (2026) · BMC Women s Health · doi:10.1186/s12905-026-04822-3
Surgical Strategies for Apical Pelvic Organ Prolapse: A Systematic Review and Network Meta-Analysis
Nguyen, T. T. T., Aryan, P., Taheri, M., Mol, B. W., Paraiso, M. F. R., Phung, J., Willison, N., Abbott, D., & Behnia‐Willison, F. (2026) · International Urogynecology Journal · doi:10.1007/s00192-026-06857-4
Self-citation

Authors: Nager, C. W., Visco, A. G., Richter, H. E., Rardin, C. R., Rogers, R. G., Harvie, H. S., Zyczynski, H. M., Paraiso, M. F. R., Mazloomdoost, D., Grey, S., Sridhar, A., Wallace, D., & NICHD Pelvic Floor Disorders Network
Affiliations: UC San Diego Health System (US)
Duke Medical Center (US)
University of Alabama at Birmingham (US)
Brown University (US)
University of New Mexico (US)
University of Pennsylvania (US)
Magee-Womens Research Institute (US)
Cleveland Clinic (US)
National Institutes of Health (US)
RTI International (US)
Corresponding author: Nager, Charles W.
ORCID: Nager, Charles W.
Visco, Anthony G.
Richter, Holly E.
Rardin, Charles R.
Rogers, Rebecca G.
Harvie, Heidi S.
Zyczynski, Halina M.
Paraiso, Marie Fidela R.
Mazloomdoost, Donna
Sridhar, Amaanti
Wallace, Dennis
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2019-09-17
Volume: 322
Issue: 11
Pages: 1054
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2019.12812
PMC: PMC6749543
OpenAlex: W2973277500
Cited by: 103
References: 36
Citations by year: 2026: 12 · 2025: 9 · 2024: 13 · 2023: 18 · 2022: 20 · 2021: 21 · 2020: 9 · 2019: 1
FWCI: 9.66
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: JAMA (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Yale University
Brown University
University of Pennsylvania
Cleveland Clinic
Cleveland Clinic Foundation
University of Connecticut
Johns Hopkins University
University of Pittsburgh
RTI International
Pennsylvania State University
Virginia Commonwealth University
Magee-Womens Research Institute
University of North Carolina at Chapel Hill
Johns Hopkins Bloomberg School of Public Health
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U10HD069025, U10HD041261, UG1HD041261, UG1HD069006, U10HD054215, U10HD069010, UG1HD054215, U10HD069006, U01HD069031, U10HD069013, U10HD041267, UG1HD054214, UG1HD069010, U24HD069031)
Topics: Health Sciences › Medicine › Urology › Pelvic floor disorders treatments
Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
Health Sciences › Medicine › Surgery › Hernia repair and management
Keywords: vaginal hysterectomy, uterosacral ligament suspension, uterovaginal prolapse, treatment failure, postmenopausal women, mesh exposure, operative time, surgical complications, pelvic organ prolapse surgery, adverse events, reoperation, granulation tissue
MeSH terms: Aged, Female, Follow-Up Studies, Humans, Hysterectomy, Vaginal, Ligaments, Middle Aged, Postoperative Complications, Gynecologic Surgical Procedures, Surgical Mesh, Uterine Prolapse, Uterus, Vagina, Treatment Outcome, Postmenopause, Kaplan-Meier Estimate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effect of Vaginal Mesh Hysteropexy vs Vaginal Hysterectomy With Uterosacral Ligament Suspension on Treatment Failure in Women With Uterovaginal Prolapse: A Randomized Clinical Trial

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks