The DOI matches its Crossref record; 7 of the 8 references it cites were found in a registry or an index.
Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions
Open accessAbstract
This study compares levels of tumor necrosis factor α, IL-6, and IL-8 in critically ill patients with coronavirus disease 2019 (COVID-19) vs those with other critical illness to better characterize the contribution of cytokine storm to COVID-19 pathophysiology.
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“observed elevated IL-6 levels are considerably lower than e.g., in septic shock or CRS due to other causes”
From COVID-19 and the human innate immune system (2021) · cites this paper as Kox et al., 2020
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Citations
Cites
Into the Eye of the Cytokine Storm
Tisoncik, J. R., Korth, M. J., Simmons, C. P., Farrar, J., Martin, T. R., & Katze, M. G. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05015-11 · Cited by 1,940
Is a “Cytokine Storm” Relevant to COVID-19?
Sinha, P., Matthay, M. A., & Calfee, C. S. (2020) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2020.3313 · Cited by 724
Khan, S. S., Smith, M. S., Reda, D., Suffredini, A. F., & McCoy, J. P. (2004) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.20021 · Cited by 357
Özgen, Ü., Savaşan, S., Buck, S. A., & Ravindranath, Y. (2010) · Cytometry · doi:10.1002/(issn)1097-0320 · Cited by 211
Timmermans, K., Kox, M., Vaneker, M., van den Berg, M. P., John, A. T., van Laarhoven, A., van der Hoeven, H., Scheffer, G. J., & Pickkers, P. (2016) · Intensive Care Medicine · doi:10.1007/s00134-015-4205-3 · Cited by 184
Self-citationNorepinephrine Contributes to Enterocyte Damage in Septic Shock Patients: A Prospective Cohort Study
Habes, Q. L. M., van Ede, L., Gerretsen, J., Kox, M., & Pickkers, P. (2017) · Shock · doi:10.1097/shk.0000000000000955 · Cited by 31
Self-citationTimmermans, K., Kox, M., Gerretsen, J., Peters, E., Scheffer, G. J., van der Hoeven, J. G., Pickkers, P., & Hoedemaekers, C. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000001204 · Cited by 30
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Karki, R., Sharma, B. R., Tuladhar, S., Williams, E. P., Zalduondo, L., Samir, P., Zheng, M., Sundaram, B., Banoth, B., Malireddi, R. K. S., et al. (2021) · Cell · doi:10.1016/j.cell.2020.11.025 · Cited by 1,734
Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19
Bonaventura, A., Vecchié, A., Dagna, L., Martinod, K., Dixon, D. L., Tassell, B. W. V., Dentali, F., Montecucco, F., Maßberg, S., Levi, M. M., et al. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00536-9 · Cited by 1,039
Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia
Grant, R. A., Morales‐Nebreda, L., Markov, N. S., Swaminathan, S., Querrey, M., Rios-Guzman, E., Abbott, D. A., Donnelly, H. K., Donayre, A., Goldberg, I. A., et al. (2021) · Nature · doi:10.1038/s41586-020-03148-w · Cited by 718
COVID-19 and the human innate immune system
Schultze, J. L., & Aschenbrenner, A. C. (2021) · Cell · doi:10.1016/j.cell.2021.02.029 · Cited by 714
“, in septic shock or CRS due to other causes (Kox et al., 2020; Monneret et al., 2021).”
BackgroundThe COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
Osuchowski, M. F., Winkler, M. S., Skirecki, T., Cajander, S., Shankar‐Hari, M., Lachmann, G., Monneret, G., Venet, F., Bauer, M. W., Brunkhorst, F. M., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00218-6 · Cited by 528
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Metadata
- Authors
- Kox, M., Waalders, N. J. B., Kooistra, E. J., Gerretsen, J., & Pickkers, P.
- Affiliations
- Radboud University Medical Center (NL)
- Corresponding author
- Pickkers, Peter
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2020-10-20
- Volume
- 324
- Issue
- 15
- Pages
- 1565
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC7489366
- OpenAlex
- W3082201689
- Cited by
- 333
- References
- 8
- Citations by year
- 2026: 5 · 2025: 17 · 2024: 27 · 2023: 32 · 2022: 74 · 2021: 135 · 2020: 43
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- JAMA (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- COVID-19 pandemic, cytokine storm, TNF-α, interleukin-6, interleukin-8, critically ill patients, cytokine levels, SARS-CoV-2, critical illness
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