Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions

Into the Eye of the Cytokine Storm

Tisoncik, J. R., Korth, M. J., Simmons, C. P., Farrar, J., Martin, T. R., & Katze, M. G. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05015-11 · Cited by 1,940

Is a “Cytokine Storm” Relevant to COVID-19?

Sinha, P., Matthay, M. A., & Calfee, C. S. (2020) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2020.3313 · Cited by 724

Multiplex bead array assays for detection of soluble cytokines: Comparisons of sensitivity and quantitative values among kits from multiple manufacturers

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Cytometry

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Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients

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Norepinephrine Contributes to Enterocyte Damage in Septic Shock Patients: A Prospective Cohort Study

Habes, Q. L. M., van Ede, L., Gerretsen, J., Kox, M., & Pickkers, P. (2017) · Shock · doi:10.1097/shk.0000000000000955 · Cited by 31

The Involvement of Danger-Associated Molecular Patterns in the Development of Immunoparalysis in Cardiac Arrest Patients

Timmermans, K., Kox, M., Gerretsen, J., Peters, E., Scheffer, G. J., van der Hoeven, J. G., Pickkers, P., & Hoedemaekers, C. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000001204 · Cited by 30

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

Karki, R., Sharma, B. R., Tuladhar, S., Williams, E. P., Zalduondo, L., Samir, P., Zheng, M., Sundaram, B., Banoth, B., Malireddi, R. K. S., et al. (2021) · Cell · doi:10.1016/j.cell.2020.11.025 · Cited by 1,734

Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

Bonaventura, A., Vecchié, A., Dagna, L., Martinod, K., Dixon, D. L., Tassell, B. W. V., Dentali, F., Montecucco, F., Maßberg, S., Levi, M. M., et al. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00536-9 · Cited by 1,039

Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia

Grant, R. A., Morales‐Nebreda, L., Markov, N. S., Swaminathan, S., Querrey, M., Rios-Guzman, E., Abbott, D. A., Donnelly, H. K., Donayre, A., Goldberg, I. A., et al. (2021) · Nature · doi:10.1038/s41586-020-03148-w · Cited by 718

COVID-19 and the human innate immune system

Schultze, J. L., & Aschenbrenner, A. C. (2021) · Cell · doi:10.1016/j.cell.2021.02.029 · Cited by 714

The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

Osuchowski, M. F., Winkler, M. S., Skirecki, T., Cajander, S., Shankar‐Hari, M., Lachmann, G., Monneret, G., Venet, F., Bauer, M. W., Brunkhorst, F. M., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00218-6 · Cited by 528

Pathophysiology of COVID-19-associated acute kidney injury

Legrand, M. M., Bell, S., Forni, L. G., Joannidis, M., Koyner, J. L., Liu, K. D., & Cantaluppi, V. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00452-0 · Cited by 527

Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial

Lenze, E. J., Mattar, C., Zorumski, C. F., Stevens, A., Schweiger, J., Nicol, G. E., Miller, J. P., Yang, L., Yingling, M., Avidan, M. S., et al. (2020) · JAMA · doi:10.1001/jama.2020.22760 · Cited by 495

Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial

Lanzoni, G., Linetsky, E., Correa, D., Messinger, S., Marttos, A. C., Jr., Alvarez, R. A., Marttos, A. C., Jr., Gil, A. A., Poggioli, R., Ruiz, P., et al. (2021) · Stem Cells Translational Medicine · doi:10.1002/sctm.20-0472 · Cited by 419

Vitamin D and cardiovascular health

de la Guía-Galipienso, F., Martínez‐Ferrán, M., Vallecillo, N., Lavie, C. J., Sanchis‐Gomar, F., & Pareja-Galeano, H. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.12.025 · Cited by 364

The role of co-infections and secondary infections in patients with COVID-19

Feldman, C. H., & Anderson, R. (2021) · Pneumonia · doi:10.1186/s41479-021-00083-w · Cited by 324

SARS CoV‐2 related microvascular damage and symptoms during and after COVID‐19: Consequences of capillary transit‐time changes, tissue hypoxia and inflammation

Østergaard, L. (2021) · Physiological Reports · doi:10.14814/phy2.14726 · Cited by 325

Cytokine Storm—Definition, Causes, and Implications

Jarczak, D., & Nierhaus, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911740 · Cited by 336

Biomarkers in COVID-19: An Up-To-Date Review

Samprathi, M., & Jayashree, M. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2020.607647 · Cited by 302

Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity

Mercola, J. M., Grant, W. B., & Wagner, C. L. (2020) · Nutrients · doi:10.3390/nu12113361 · Cited by 268

Monocytes and Macrophages in COVID-19

Knoll, R., Schultze, J. L., & Schulte-Schrepping, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.720109 · Cited by 279

Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial

Lescure, F.-X., Honda, H., Fowler, R., Lazar, J. S., Shi, G., Wung, P. K., Patel, N. R., HAGINO, O. R., Bazzalo, I. J., Casas, M. M., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00099-0 · Cited by 259

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

Thwaites, R. S., Uruchurtu, A. S. S., Siggins, M. K., Liew, F., Russell, C. D., Moore, S. C., Fairfield, C. J., Carter, E., Abrams, S. T., Short, C.-E. S., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abg9873 · Cited by 228

The Pathophysiology of Sepsis-Associated AKI

Kuwabara, S., Goggins, E. S., & Okusa, M. D. (2022) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.00850122 · Cited by 236

Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation (CYCOV): a single centre, open-label, randomised, controlled trial

Supady, A., Weber, E., Rieder, M., Lother, A., Niklaus, T., Zahn, T., Frech, F., Müller, S., Kuhl, M., Benk, C., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00177-6 · Cited by 205

Essential Fatty Acids and Their Metabolites in the Pathobiology of Inflammation and Its Resolution

Das, U. N. (2021) · Biomolecules · doi:10.3390/biom11121873 · Cited by 186

Coronavirus Disease 2019 as Cause of Viral Sepsis: A Systematic Review and Meta-Analysis*

Karakike, E., Giamarellos‐Bourboulis, E. J., Kyprianou, M., Fleischmann-Struzek, C., Pletz, M. W., Netea, M. G., Reinhart, K., & Kyriazopoulou, E. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005195 · Cited by 188

The Role of Interleukin-8 in Lung Inflammation and Injury: Implications for the Management of COVID-19 and Hyperinflammatory Acute Respiratory Distress Syndrome

Cesta, M. C., Zippoli, M., Marsiglia, C., Gavioli, E. M., Mantelli, F., Allegretti, M., & BALK, R. A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.808797 · Cited by 173

Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis

Kyriazopoulou, E., Huet, T., Cavalli, G., Gori, A., Kyprianou, M., Pickkers, P., Eugen‐Olsen, J., Clerici, M., Veas, F., Châtellier, G., et al. (2021) · The Lancet Rheumatology · doi:10.1016/s2665-9913(21)00216-2 · Cited by 169

Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19

Karagiannis, F., Peukert, K., Surace, L., Michla, M., Nikolka, F., Fox, M., Weiss, P., Feuerborn, C., Maier, P., Schulz, S., et al. (2022) · Nature · doi:10.1038/s41586-022-05128-8 · Cited by 152

COVID-19: Rethinking the Lockdown Groupthink

Joffe, A. R. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.625778 · Cited by 163

The role of IL-6 and IL-6 blockade in COVID-19

Potere, N., Batticciotto, A., Vecchié, A., Porreca, E., Cappelli, A., Abbate, A., Dentali, F., & Bonaventura, A. (2021) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2021.1919086 · Cited by 127

SARS‐CoV‐2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage

Ma, J., Zhu, F., Shao, F., Shao, F., Yu, D., Ma, J., Zhang, X., Li, W., Qian, Y., Zhang, Y., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2021108249 · Cited by 120

COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system

Rysz, S., Al-Saadi, J., Sjöström, A., Farm, M., Campoccia Jalde, F., Plattén, M., Eriksson, H., Klein, M., Vargas-Paris, R., Nyrén, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22713-z · Cited by 111

Complement Activation in the Disease Course of Coronavirus Disease 2019 and Its Effects on Clinical Outcomes

de Nooijer, A., Grondman, I., Janssen, N. A. F., Netea, M. G., Willems, L., van de Veerdonk, F. L., Giamarellos‐Bourboulis, E. J., Toonen, E. J. M., Joosten, L. A. B., RCI-COVID-19 study group, et al. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa646 · Cited by 114

Innate Receptor Activation Patterns Involving TLR and NLR Synergisms in COVID-19, ALI/ARDS and Sepsis Cytokine Storms: A Review and Model Making Novel Predictions and Therapeutic Suggestions

Root-Bernstein, R. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042108 · Cited by 112

Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody

Gebremeskel, S., Schanin, J., Coyle, K. M., Butuci, M., Luu, T. T., Brock, E. C., Xu, A., Wong, A., Leung, J., Korver, W., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.650331 · Cited by 111

Echocardiography findings in COVID-19 patients admitted to intensive care units: a multi-national observational study (the ECHO-COVID study)

Huang, S., Vignon, P., Dessap, A. M., Tran, S., Prat, G., Chew, M. S., Balík, M., Sanfilippo, F., Banauch, G., Clau-Terré, F., et al. (2022) · Intensive Care Medicine · doi:10.1007/s00134-022-06685-2 · Cited by 113

COVID-19 symptoms over time: comparing long-haulers to ME/CFS

Jason, L. A., Islam, M. F., Conroy, K. E., Cotler, J. H., Torres, C., Johnson, M., & Mabie, B. (2021) · Fatigue Biomedicine Health & Behavior · doi:10.1080/21641846.2021.1922140 · Cited by 125

Letter to the Editor: Vitamin D deficiency in COVID-19: Mixing up cause and consequence

Smolders, J., van den Ouweland, J., Geven, C., Pickkers, P., & Kox, M. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154434 · Cited by 96

Endothelial Cells in Emerging Viral Infections

Fosse, J. H., Haraldsen, G., Falk, K., & Edelmann, R. J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.619690 · Cited by 99

The Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness

Coopersmith, C. M., Antonelli, M. M., Bauer, S. R., Deutschman, C. S., Evans, L., Ferrer, R., Hellman, J., Jog, S., Kesecioğlu, J., Kissoon, N. “., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000004895 · Cited by 99

Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19

Jørgensen, M. J., Holter, J. C., Christensen, E. E., Schjalm, C., Tonby, K., Pischke, S. E., Jenum, S., Skeie, L. G., Nur, S., Lind, A., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-78710-7 · Cited by 89

Excessive Matrix Metalloproteinase-1 and Hyperactivation of Endothelial Cells Occurred in COVID-19 Patients and Were Associated With the Severity of COVID-19

Syed, F., Li, W., Relich, R. F., Russell, P. M., Zhang, S., Zimmerman, M. K., & Yu, Q. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab167 · Cited by 93

Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients

Anderberg, S. B., Luther, T., Berglund, M., Larsson, R. L., Rubertsson, S., Lipcsey, M., Larsson, A. O., Frithiof, R., & Hultström, M. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155389 · Cited by 89

Autoimmunity to annexin A2 predicts mortality among hospitalised COVID-19 patients

Zuniga, M., Gomes, C., Carsons, S. E., Bender, M. T., Cotzia, P., Miao, Q., Lee, D. C., & Rodrı́guez, A. (2021) · European Respiratory Journal · doi:10.1183/13993003.00918-2021 · Cited by 87

Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2–induced systemic toxicity

Li, S., Ma, F., Yokota, T., Garcia, G., Palermo, A., Wang, Y., Farrell, C. P., Wang, Y.-C., Wu, R., Zhou, Z., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.145027 · Cited by 85

Distinctive features of severe SARS-CoV-2 pneumonia

Budinger, G. R. S., Misharin, A. V., Ridge, K. M., Singer, B. D., & Wunderink, R. G. (2021) · Journal of Clinical Investigation · doi:10.1172/jci149412 · Cited by 87

COVID-19 and cytokine storm syndrome: are there lessons from macrophage activation syndrome?

Ombrello, M. J., & Schulert, G. S. (2021) · Translational research · doi:10.1016/j.trsl.2021.03.002 · Cited by 84

Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients

DeKosky, S. T., Kochanek, P. M., Valadka, A. B., Clark, R. S. B., Chou, S., Au, A. K., Horvat, C. M., Jha, R. M., Mannix, R., Wisniewski, S. R., et al. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2020.7332 · Cited by 87

Interleukine-6 in critically ill COVID-19 patients: A retrospective analysis

Gorham, J., Moreau, A., Corazza, F., Peluso, L., Ponthieux, F., Talamonti, M., Izzi, A., Nagant, C., Djangang, N. N., Garufi, A., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0244628 · Cited by 79

Serum ferritin at admission in hospitalized COVID-19 patients as a predictor of mortality

Lino, K., Guimarães, G. M. C., Alves, L. S., Oliveira, A. C., Faustino, R. D. S., Souza, C. F., Tupinambá, G., Medeiros, T., Silva, A. A., & Almeida, J. R. (2021) · The Brazilian Journal of Infectious Diseases · doi:10.1016/j.bjid.2021.101569 · Cited by 79

Stimulating the Resolution of Inflammation Through Omega-3 Polyunsaturated Fatty Acids in COVID-19: Rationale for the COVID-Omega-F Trial

Arnardottir, H. H., Pawelzik, S., Öhlund‐Wistbacka, U., Artiach, G., Hofmann, R., Reinholdsson, I., Braunschweig, F., Tornvall, P., Religa, D., & Bäck, M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.624657 · Cited by 75

Modulation of the NLRP3 inflammasome by Sars-CoV-2 Envelope protein

Yalçınkaya, M., Liu, W., Islam, M. N., Kotini, A. G., Gusarova, G. A., Fidler, T. P., Papapetrou, E. P., Bhattacharya, J., Wang, N., & Tall, A. R. (2021) · Scientific Reports · doi:10.1038/s41598-021-04133-7 · Cited by 76

Attributable Mortality of Ventilator-associated Pneumonia Among Patients with COVID-19

Vacheron, C., Lepape, A., Savey, A., Machut, A., Timsit, J., Comparot, S., Courno, G., Vanhems, P., Landel, V., Lavigne, T., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202202-0357oc · Cited by 68

Lenzilumab in hospitalised patients with COVID-19 pneumonia (LIVE-AIR): a phase 3, randomised, placebo-controlled trial

Temesgen, Z., Burger, C. D., Baker, J., Polk, C. M., Libertin, C. R., Kelley, C. F., Marconi, V. C., Orenstein, R., Catterson, V. M., Aronstein, W. S., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00494-x · Cited by 70

Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19

Pongrácz, T., Nouta, J., Wang, W., van Meijgaarden, K. E., Linty, F., Vidarsson, G., Joosten, S. A., Ottenhoff, T. H. M., Hokke, C. H., de Vries, J. J. C., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.103957 · Cited by 68

Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying miRNA as a Potential Multi Target Therapy to COVID-19: an In Silico Analysis

Schultz, I. C., Bertoni, A. P. S., & Wink, M. R. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10122-0 · Cited by 62

Identification of serum prognostic biomarkers of severe COVID-19 using a quantitative proteomic approach

Kimura, Y., Nakai, Y., Shin, J., Hara, M., Takeda, Y., Kubo, S., Jeremiah, S. S., Ino, Y., Akiyama, T. H., Moriyama, K., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-98253-9 · Cited by 63

Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients

Youngs, J., Provine, N. M., Lim, N. T. Y., Sharpe, H., Amini, A., Chen, Y., Luo, J. F., Edmans, M. D., Zacharopoulou, P., Chen, W., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009804 · Cited by 57

The immunology of sepsis: translating new insights into clinical practice

Kox, M., Bauer, M. W., Bos, L. D. J., Bouma, H. R., Calandra, T., Calfee, C. S., Chousterman, B. G., Derde, L. P. G., Giamarellos‐Bourboulis, E. J., Gómez, H., et al. (2025) · Nature Reviews Nephrology · doi:10.1038/s41581-025-01004-6 · Cited by 76

Clinical phenotypes and outcomes of SARS-CoV-2, influenza, RSV and seven other respiratory viruses: a retrospective study using complete hospital data

Hedberg, P., Valik, J. K., van der Werff, S. D., Tanushi, H., Requena‐Méndez, A., Granath, F. N., Bell, M., Mårtensson, J., Dyrdak, R., Hertting, O., et al. (2021) · Thorax · doi:10.1136/thoraxjnl-2021-216949 · Cited by 56

Single-cell analysis of COVID-19, sepsis, and HIV infection reveals hyperinflammatory and immunosuppressive signatures in monocytes

Liu, N., Jiang, C., Cai, P., Shen, Z., Sun, W., Xu, H. Y., Fang, M., Yao, X., Zhu, L., Gao, X., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109793 · Cited by 55

COVID-19-Related ARDS: Key Mechanistic Features and Treatments

Selickman, J., Vrettou, C. S., Mentzelopoulos, S. D., & Marini, J. J. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11164896 · Cited by 61

Comorbidity-associated glutamine deficiency is a predisposition to severe COVID-19

Matsuyama, T., Yoshinaga, S. K., Shibue, K., & Mak, T. W. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00892-y · Cited by 54

Electroanalytical point-of-care detection of gold standard and emerging cardiac biomarkers for stratification and monitoring in intensive care medicine - a review

Crapnell, R. D., Dempsey‐Hibbert, N., Sigley, E., Tridente, A., & Banks, C. E. (2022) · Microchimica Acta · doi:10.1007/s00604-022-05186-9 · Cited by 53

Precision Medicine for COVID-19

DeMerle, K. M., Angus, D., & Seymour, C. W. (2021) · JAMA · doi:10.1001/jama.2021.5248 · Cited by 51

Systemic inflammation alters the neuroinflammatory response: a prospective clinical trial in traumatic brain injury

Lassarén, P., Lindblad, C., Frostell, A., Carpenter, K. L. H., Guilfoyle, M. R., Hutchinson, P. J., Helmy, A. E., & Thelin, E. P. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02264-2 · Cited by 53

The anti-inflammatory cytokine response characterized by elevated interleukin-10 is a stronger predictor of severe disease and poor outcomes than the pro-inflammatory cytokine response in coronavirus disease 2019 (COVID-19)

Henry, B. M., Benoit, S. W., Vikse, J., Berger, B. A., Pulvino, C., Hoehn, J. M., Rose, J., de Oliveira, M. H. S., Lippi, G., & Benoit, J. L. (2020) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2020-1284 · Cited by 50

COVID-19 and immunothrombosis: Pathophysiology and therapeutic implications

Lim, M. S., & McRae, S. J. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103529 · Cited by 50

Differential Cytokine Signatures of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Influenza Infection Highlight Key Differences in Pathobiology

Karaba, A. H., Zhou, W., Hsieh, L. L., Figueroa, A., Massaccesi, G., Rothman, R. E., Fenstermacher, K. Z. J., Sauer, L. M., Shaw‐Saliba, K., Blair, P. W., et al. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciab376 · Cited by 52

MR-proADM as prognostic factor of outcome in COVID-19 patients

Sozio, E., Tascini, C., Fabris, M., D’Aurizio, F., Carlo, C. D., Graziano, E., Bassi, F., Sbrana, F., Ripoli, A., Pagotto, A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-84478-1 · Cited by 49

Cytokine and Chemokine Levels in Coronavirus Disease 2019 Convalescent Plasma

Bonny, T. S., Patel, E. U., Zhu, X., Bloch, E. M., Grabowski, M. K., Abraham, A. G., Littlefield, K. E., Shrestha, R., Benner, S. E., Laeyendecker, O. B., et al. (2020) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofaa574 · Cited by 52

Profile of Immunoglobulin G N-Glycome in COVID-19 Patients: A Case-Control Study

Hou, H., Yang, H., Liu, P., Huang, C., Wang, M., Li, Y., Zhu, M., Wang, J., Xu, Y., Wang, Y., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.748566 · Cited by 50

The role of extracellular histones in COVID‐19

de Vries, F., Huckriede, J., Wichapong, K., Reutelingsperger, C. P. M., & Nicolaes, G. A. F. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13585 · Cited by 49

Immunometabolic signatures predict risk of progression to sepsis in COVID-19

Oostdam, A. S. H.-V., Castañeda‐Delgado, J. E., Oropeza-Valdez, J. J., Borrego-Moreno, J. C., Monárrez‐Espino, J., Zheng, J., Mandal, R., Zhang, L., Soto-Guzmán, E., Fernández-Ruiz, J. C., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0256784 · Cited by 46

A digital protein microarray for COVID-19 cytokine storm monitoring

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Status of mannose-binding lectin (MBL) and complement system in COVID-19 patients and therapeutic applications of antiviral plant MBLs

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Immunomodulation as Treatment for Severe Coronavirus Disease 2019: A Systematic Review of Current Modalities and Future Directions

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Cytokine profiles dynamics in COVID-19 patients: a longitudinal analysis of disease severity and outcomes

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Pulmonary Procoagulant and Innate Immune Responses in Critically Ill COVID-19 Patients

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Review of the COVID-19 Risk in Multiple Sclerosis

Chaudhry, F., Jageka, C., Levy, P. D., Cerghet, M., & Lisak, R. P. (2021) · Journal of Cellular Immunology · doi:10.33696/immunology.3.080 · Cited by 42

Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier

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Impact of early corticosteroids on 60-day mortality in critically ill patients with COVID-19: A multicenter cohort study of the OUTCOMEREA network

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Comprehensive Immunologic Evaluation of Bronchoalveolar Lavage Samples from Human Patients with Moderate and Severe Seasonal Influenza and Severe COVID-19

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Covid-19: It's All About Sepsis

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Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes.Preprint

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Vitamin D and Cardiovascular Diseases: An Update

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Pathophysiology of the Acute Respiratory Distress Syndrome

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IgG N-glycome changes during the course of severe COVID-19: An observational study

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A comprehensive review on sarilumab in COVID-19

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Lung Protection vs. Infection Resolution: Interleukin 10 Suspected of Double-Dealing in COVID-19

Lindner, H. A., Velásquez, S. Y., Thiel, M., & Kirschning, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.602130 · Cited by 39

Evolution of the nutritional status of COVID-19 critically-ill patients: A prospective observational study from ICU admission to three months after ICU discharge

Rives‐Lange, C., Zimmer, A., Merazka, A., Carette, C., Martins-Bexinga, A., Hauw‐Berlemont, C., Guérot, E., Jannot, A., Diehl, J., Czernichow, S., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.05.007 · Cited by 38

COVID-19 Coagulopathy: From Pathogenesis to Treatment

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Clinical efficacy and safety of interleukin-6 receptor antagonists (tocilizumab and sarilumab) in patients with COVID-19: a systematic review and meta-analysis

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SARS-CoV-2: Immune Response Elicited by Infection and Development of Vaccines and Treatments

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An Immune Epigenetic Insight to COVID-19 Infection

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COVID-19 Sepsis: Pathogenesis and Endothelial Molecular Mechanisms Based on “Two-Path Unifying Theory” of Hemostasis and Endotheliopathy-Associated Vascular Microthrombotic Disease, and Proposed Therapeutic Approach with Antimicrothrombotic Therapy

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Mechanistic Insights Into the Immune Pathophysiology of COVID-19; An In-Depth Review

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Lung compartmentalization of inflammatory biomarkers in COVID-19-related ARDS

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Immune checkpoint inhibitors increase T cell immunity during SARS-CoV-2 infection

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Extracorporeal Blood Purification in Moderate and Severe COVID-19 Patients: A Prospective Cohort Study

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COVID-19: Lung-Centric Immunothrombosis

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Kidney Injury in COVID-19: Epidemiology, Molecular Mechanisms and Potential Therapeutic Targets

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LENZILUMAB EFFICACY AND SAFETY IN NEWLY HOSPITALIZED COVID-19 SUBJECTS: RESULTS FROM THE LIVE-AIR PHASE 3 RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIALPreprint

Temesgen, Z., Burger, C. D., Baker, J. V., Polk, C. M., Libertin, C. R., Kelley, C. F., Marconi, V. C., Orenstein, R., Durrant, C., Chappell, D. B., et al. (2021) · medRxiv · doi:10.1101/2021.05.01.21256470 · Cited by 32

Clearance of inflammatory cytokines in patients with septic acute kidney injury during renal replacement therapy using the EMiC2 filter (Clic-AKI study)

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Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

Leisman, D. E., Ronner, L., Pinotti, R., Taylor, M. D., Sinha, P., Calfee, C. S., Hirayama, A. V. V., Mastroianni, F., Turtle, C. J., Harhay, M. O., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30404-5 · Cited by 874

Selection of the Appropriate Control Group Is Essential in Evaluating the Cytokine Storm in COVID-19

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Covid-19 and Cytokine Storm

Vergara, L. L., Torralba, L., Diego, C. D., Lasierra, A., Lahoz, R., Abadía, C., de Gopegui, P. R., Godino, J., Cebollada, A., Jimeno, B., et al. (2022) · 10.01 - Respiratory infections and bronchiectasis · doi:10.1183/13993003.congress-2022.3255

COVID 19: in the eye of the cytokine storm

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Drastically elevated levels of Interleukin-6 and its soluble receptor complex in COVID-19 patients with acute respiratory distress

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