Cited by 1,482Obstructive Sleep Apnea ResearchSleep and related disordersNeuroscience of respiration and sleep

The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.

Diagnosis and Management of Obstructive Sleep Apnea: A Review

Gottlieb, Daniel J., Punjabi, Naresh M.·2020·JAMA

DOI 10.1001/jama.2020.3514

Open this paper in CoChat — free account

Abstract

Importance: Obstructive sleep apnea (OSA) affects 17% of women and 34% of men in the US and has a similar prevalence in other countries. This review provides an update on the diagnosis and treatment of OSA. Observations: The most common presenting symptom of OSA is excessive sleepiness, although this symptom is reported by as few as 15% to 50% of people with OSA in the general population. OSA is associated with a 2- to 3-fold increased risk of cardiovascular and metabolic disease. In many patients, OSA can be diagnosed with home sleep apnea testing, which has a sensitivity of approximately 80%. Effective treatments include weight loss and exercise, positive airway pressure, oral appliances that hold the jaw forward during sleep, and surgical modification of the pharyngeal soft tissues or facial skeleton to enlarge the upper airway. Hypoglossal nerve stimulation is effective in select patients with a body mass index less than 32. There are currently no effective pharmacological therapies. Treatment with positive airway pressure lowers blood pressure, especially in patients with resistant hypertension; however, randomized clinical trials of OSA treatment have not demonstrated significant benefit on rates of cardiovascular or cerebrovascular events. Conclusions and Relevance: OSA is common and the prevalence is increasing with the increased prevalence of obesity. Daytime sleepiness is among the most common symptoms, but many patients with OSA are asymptomatic. Patients with OSA who are asymptomatic, or whose symptoms are minimally bothersome and pose no apparent risk to driving safety, can be treated with behavioral measures, such as weight loss and exercise. Interventions such as positive airway pressure are recommended for those with excessive sleepiness and resistant hypertension. Managing asymptomatic OSA to reduce cardiovascular and cerebrovascular events is not currently supported by high-quality evidence.

Integrity signals

Registry

Crossref · 10.1001/jama.2020.3514

Cites

112 of 112 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale
Johns, M. W. (1991) · Sleep · doi:10.1093/sleep/14.6.540 · Cited by 17,364
The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults
Young, T., Palta, M., Dempsey, J., Skatrud, J., Weber, S., & Badr, S. (1993) · New England Journal of Medicine · doi:10.1056/nejm199304293281704 · Cited by 10,183
Sleep–Related Breathing Disorders in Adults: Recommendations for Syndrome Definition and Measurement Techniques in Clinical Research
(1999) · Sleep · doi:10.1093/sleep/22.5.667 · Cited by 5,147
Increased Prevalence of Sleep-Disordered Breathing in Adults
Peppard, P. E., Young, T., Barnet, J. H., Palta, M., Hagen, E. W., & Hla, K. M. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kws342 · Cited by 4,618
Epidemiology of Obstructive Sleep Apnea: A Population Health Perspective
Young, T., Peppard, P. E., & Gottlieb, D. J. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2109080 · Cited by 4,244
Self-citation
Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force.
McNicholas, W. T., Strohl, K. P., White, D. P., Levy, P. A., Schmidt, W., Wheatley, J. R., Redline, S. S., Carley, D. W., Buysse, D. J., Young, T. B., et al. (1999) · PubMed · Cited by 3,665
Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline
Kapur, V. K., Auckley, D. H., Chowdhuri, S., Kuhlmann, D. C., Mehra, R., Ramar, K., & Harrod, C. G. (2017) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.6506 · Cited by 3,253
Using the Berlin Questionnaire To Identify Patients at Risk for the Sleep Apnea Syndrome
Netzer, N. C., Stoohs, R. A., Netzer, C. M., Clark, K., & Strohl, K. P. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-131-7-199910050-00002 · Cited by 2,973
Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study
Heinzer, R., Vat, S., Marques-Vidal, P., Marti-Soler, H., Andries, D., Tobback, N., Mooser, V, Preisig, M., Malhotra, A., Waeber, G., et al. (2015) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00043-0 · Cited by 2,481
The epidemiology of adult obstructive sleep apnea
Punjabi, N. M. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200709-155mg · Cited by 2,361
Self-citation

Show all 112 references

Sorted by citations

Items 701–800 of 1,001

Obstructive sleep apnea is associated with the long-term prognosis of patients in acute coronary syndromes with prior myocardial infarction: Insights from OSA-ACS study
Hao, W., Wang, B., Fan, J., Que, B., Ai, H., Wang, X., & Nie, S. (2023) · Sleep Medicine · doi:10.1016/j.sleep.2023.10.009 · Cited by 4
Digital forensics in healthcare: An analysis of data associated with a CPAP machine
Schmitt, V., & Butterfield, E. (2023) · Forensic Science International Digital Investigation · doi:10.1016/j.fsidi.2023.301661 · Cited by 3
Association between risk of obstructive sleep apnea severity and risk of severe COVID-19 symptoms: insights from salivary and serum cytokines
Dinh, Y., Alawady, A., Alhazmi, H., Altabtbaei, K., Freire, M., Alghounaim, M., Devarajan, S., Al‐Mulla, F., Bin‐Hasan, S., & Alqaderi, H. E. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1348441 · Cited by 5
Exploring obstructive sleep apnea and sleep architecture in Parkinson's disease motor subtypes
Scanga, A., Benedetti, A., Kimoff, R. J., Lafontaine, A., Robinson, A. R., Gingras, M., & Kamińska, M. (2024) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2024.106064 · Cited by 3
Clinical efficacy and mechanism study of mid-frequency anti-snoring device in treating moderate obstructive sleep apnea-hypopnea syndrome
Qian, B., Chen, Z.-J., Wang, Y., Hu, X.-Y., Hu, X.-B., & Zheng, Y. (2024) · World Journal of Clinical Cases · doi:10.12998/wjcc.v12.i5.942 · Cited by 3
Current Medical Treatment of Obstructive Sleep Apnoea: A Narrative Review
Swain, S. K. (2024) · Apollo Medicine · doi:10.1177/09760016241252317 · Cited by 3
The causality between leisure sedentary behaviors, physical activity and obstructive sleep apnea: a bidirectional Mendelian randomization study
Tian, H., Wang, A., Wu, H., Zhou, C., Zhang, Z., & Wang, J. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1425060 · Cited by 4
Achieving adherence to positive airway pressure in commercial drivers using an employer-mandated remote management programme
Kneeland, E., Ali, N., Maislin, D. G., Chang, Y. H., Epelboim, J., Keenan, B. T., & Pack, A. I. (2024) · ERJ Open Research · doi:10.1183/23120541.00132-2024 · Cited by 3
“Supporting this, almost no driver in our sample indicated excessive sleepiness, despite a large proportion of drivers ultimately being diagnosed with OSA and the known impact of undiagnosed OSA on sleepiness [16].”
Measures of overnight oxygen saturation to characterize sleep apnea severity and predict postoperative respiratory depression
Assadi, A., Chung, F. F., & Yadollahi, A. (2024) · BioMedical Engineering OnLine · doi:10.1186/s12938-024-01254-8 · Cited by 3
Estimating the prevalence and clinical causality of obstructive sleep apnea in paediatric narcolepsy patients
Geng, C., & Chen, C. (2024) · Sleep And Breathing · doi:10.1007/s11325-024-03100-6 · Cited by 3
“Obstructive sleep apnea, a common yet frequently underestimated disorder, involves repeated interruptions in airflow due to obstructions in the upper airway, result - ing in periodic hypoxia and disrupted sleep [7–9].”
GRU-TSMixers: Sleep Apnea and Hypopnea Detection Based on Multi Scale MLP-Mixers
Huang, Z., & He, K. (2024) · International Joint Conference on Neural Networks (IJCNN) · doi:10.1109/ijcnn60899.2024.10650636 · Cited by 3
“Sleep Apnea Syndrome (SAS), a prevalent global health concern, affects a signiﬁcant portion of the adult population [1], [2], with studies suggesting a prevalence range from 9% to 38% [3]in the general adult population.”
Background
Asthma and Obstructive Sleep Apnea Overlap in a Sample of Older American Indian Adults: The Strong Heart Study
Wu, H., Rhoades, D. A., Reese, J. A., & Jones, K. R. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13185492 · Cited by 3
“OSA affects approximately 25% of adults in the U.S., and its prevalence increased by about 30% between 1990 and 2010 [2].”
BackgroundInfluential
From Screening at Clinic to Diagnosis at Home: How AI/ML/DL Algorithms Are Transforming Sleep Apnea Detection
Lee, P., Gu, W., Huang, W.-C., & Chiang, A. A.-P. (2024) · Springer optimization and its applications · doi:10.1007/978-3-031-68263-6_4 · Cited by 3
Effects of sesamin on sleep quality and the antioxidative status in patients with low arousal threshold obstructive sleep apnea syndrome and those at risk of obstructive sleep apnea syndrome
Fu, L.-C., Liu, W., Shirakawa, H., Chen, Y.-H., Xiao, Q., & Yang, S. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106564 · Cited by 3
Diagnostic value of transnasal fibrolaryngoscopy with a Muller test in the choice of treatment techniques in a patient with moderate ronchopathy and obstructive sleep apnea syndrome: A clinical case
Ryabova, M. А., & Kralina, D. О. (2024) · Folia Otorhinolaryngologiae et Pathologiae Respiratoriae · doi:10.33848/fopr627122 · Cited by 3
Cholinergic modulation of upper airway control: maturational changes and mechanisms at cellular and synaptic levels
Osbourne, A., Melliza, A., Dudley, S. K., da Silva, G. S. F., Zoccal, D. B., & Revill, A. L. (2024) · Journal of Neurophysiology · doi:10.1152/jn.00165.2024 · Cited by 3
Dynamic Risk Status of OSA and Its Association with COPD Incidence and Progression to Oxygen Therapy: Insights from a US National Cohort
Wang, Y., Luo, J., Huang, R., & Xiao, Y. (2025) · International Journal of COPD · doi:10.2147/copd.s496086 · Cited by 3
Oral appliance therapy for the management of obstructive sleep apnea in adults: an umbrella review
Ghosh, P., Janakiram, C., Varma, N. S., Sarika, K., & Vv, A. (2025) · JBI Evidence Synthesis · doi:10.11124/jbies-23-00539 · Cited by 3
Intermittent hypoxemia during hemodialysis: AI-based identification of arterial oxygen saturation saw-tooth pattern
Zhang, H., Ban, A. N., & Kotanko, P. (2025) · BMC Nephrology · doi:10.1186/s12882-025-04133-z · Cited by 3
Cardiovascular risks in non-dipper OSA patients: insights from ABPM, echocardiography, and Holter monitoring
Elsanan, M., Soliman, M. H., Meawad, B. M. N., Kandeel, N. T., Elshora, A. E., & Shehata, I. E. (2025) · Sleep And Breathing · doi:10.1007/s11325-025-03365-5 · Cited by 3
Bariatric Surgery and GLP-1/GIP Medications for the Treatment of Obstructive Sleep Apnoea: A Comprehensive Review
Alnagar, A., Sinha, Y., Ahmad, A. N., Ahmed, A., & Noormohamed, M. S. (2025) · Current Obesity Reports · doi:10.1007/s13679-025-00640-0 · Cited by 4
Linking obstructive sleep apnea with pulmonary hypertension via pooled prevalence and causal association: A systematic review, meta-analysis and Mendelian randomization
Du, D., Qin, J., Hu, X., Xu, D., Gao, L., Wu, Y., Chen, M., Chen, Z., Luo, F., & Shen, Y. (2025) · Heart & Lung · doi:10.1016/j.hrtlng.2025.06.009 · Cited by 3
Maxillomandibular Advancement (MMA) Surgery Improves Obstructive Sleep Apnea: CAD/CAM vs. Traditional Surgery
Marcelli, V. A., Pistilli, R., Govoni, F. A., Nezza, S. D., Tarascio, L., Pica, F., Paolis, L. D., Celebrini, A., Magliacani, V., Bellocchi, G., et al. (2025) · Applied Sciences · doi:10.3390/app15169149 · Cited by 3
Sleep‐disordered breathing in pediatric heart transplant recipients
Powell, W. T., Chen, M. L., Kraft, D., & Albers, E. L. (2020) · Pediatric Transplantation · doi:10.1111/petr.13888 · Cited by 3
“Other indications included restless sleep and frequent awakenings (1), short sleep (1), or capped tracheostomy study for decannulation (1).”
Background
Prevalence and analysis of respiratory and anthropometric parameters in patients with obstructive sleep apnea
Fernandes, D. S. D. S., Guimarães, M. P., de Brito, E. Z. A., Lima, J. D. C., Rodrigues, M. D. S., Neves, V. R., Gambassi, B. B., Schwingel, P. A., & Mesquita, F. O. D. S. (2021) · Research Society and Development · doi:10.33448/rsd-v10i3.13455 · Cited by 2
Human experimental models: seeking to enhance multiscale research in sleep apnoea
Farré, R., Gozal, D., & Almendros, I. (2021) · European Respiratory Journal · doi:10.1183/13993003.01169-2021 · Cited by 3
Obstructive Sleep Apnea: Diagnosis with Polysomnography and Portable Monitors
Raphelson, J. R., Feldman, E. B., & Malhotra, A. (2022) · Respiratory medicine · doi:10.1007/978-3-030-93739-3_6 · Cited by 3
The impact of obstructive sleep apnea on exercise capacity in a cardiac rehabilitation program
Sonners, C., Schmickl, C. N., Raphelson, J. R., Sykes, A. V., Roberts, E., Świątkiewicz, I., Malhotra, A., & Taub, P. R. (2022) · Sleep And Breathing · doi:10.1007/s11325-022-02704-0 · Cited by 3
Lipoprotein Subfractions Associated with Endothelial Function in Previously Healthy Subjects with Newly Diagnosed Sleep Apnea—A Pilot Study
Hlucháňová, A., Kollár, B., Klobučníková, K., Hardoňová, M., Poddaný, M., Žitňanová, I., Dvořáková, M., Koňariková, K., Tedla, M., Urík, M., et al. (2023) · Life · doi:10.3390/life13020441 · Cited by 3
“weight loss, positive airway pressure, oral appliances, surgical modification of the pharyngeal soft tissues or facial skeleton, and hypoglossal nerve stimulation in selected cases [2].”
Background
Upper airway assessment in obstructive sleep apnea patients: can computed tomography with lateral cephalometry replace drug-induced sleep endoscopy (DISE)?
Campos, A., Cebola, P., Dias, S. S., Pais, J. P., Sousa, S., Cardoso, S., Paço, J. C., & Caroça, C. (2023) · Acta Otorrinolaringológica Española · doi:10.1016/j.otorri.2022.10.004 · Cited by 3
Positive Airway Pressure Prescription and Management for Patients with Obstructive Sleep Apnea
Choi, J. H. (2020) · Journal of rhinology · doi:10.18787/jr.2020.00319 · Cited by 3
Ambulatory surgical patients and sleep apnea
Azizad, O., & Joshi, G. P. (2022) · International Anesthesiology Clinics · doi:10.1097/aia.0000000000000356 · Cited by 3
POINT: Should Asymptomatic OSA Be Treated in Patients With Significant Cardiovascular Disease? Yes
Mehra, R., & Orbea, C. P. (2022) · CHEST Journal · doi:10.1016/j.chest.2021.05.081 · Cited by 3
Elevated fasting insulin results in snoring: A view emerged from causal evaluation of glycemic traits and snoring
Yi, M., Fei, Q., Liu, K., Zhao, W., Chen, Z., & Zhang, Y. (2022) · European Journal of Clinical Investigation · doi:10.1111/eci.13852 · Cited by 3
Obstructive Sleep Apnea
Ainge‐Allen, H. W., Yee, B. J., & Grunstein, R. R. (2022) · Wiley eBooks · doi:10.1002/9781119695257.ch15 · Cited by 4
Investigation of the Effectiveness of Traditional Breathing Therapy on Pulmonary Function in College Students with Obstructive Sleep Apnea
Pei, Y., Fan, Y., Kong, X., Sun, H., Zhou, J., & Wu, H. (2022) · Contrast Media & Molecular Imaging · doi:10.1155/2022/1674973 · Cited by 2
[Effects of orofacial myofunctional therapy on postoperative outcomes of upper airway surgery for adults with severe obstructive sleep apnea].
Wu, C., Lu, Z., Chen, L., Nie, G., Lu, Y., & Tao, J. (2022) · PubMed Central · doi:10.13201/j.issn.2096-7993.2022.12.005 · Cited by 2
Nocturnal Urinary Symptoms as Screening Tools for Obstructive Sleep Apnea
Burr, E. F., Myer, E. N. B., Kikuchi, J. Y., & Chen, C. C. G. (2024) · Urogynecology · doi:10.1097/spv.0000000000001503 · Cited by 2
The effect of PAP on UACR and metabolic indexes in patients with MS and OSAHS
Shen, F., Zhou, R.-K., Qiu, D.-Q., & Li, L. (2024) · Sleep And Breathing · doi:10.1007/s11325-024-03044-x · Cited by 2
“The objective is to reduce the Apnea-Hypopnea Index (AHI), ameliorate hypoxia, and alleviate clinical symptoms, such as daytime fatigue and somnolence [13].”
Background
Demographics of Adults With Obstructive Sleep Apnea Who Undergo Nasal Surgery
Shah, S., Darbinian, J., Collazo, S. A., Nguyen, D., & Durr, M. L. (2024) · OTO Open · doi:10.1002/oto2.70005 · Cited by 1
Precision medicine approaches in obstructive sleep apnoea: The role of dentist–sleep physician partnerships
Stewart, G., Tong, B., & Cistulli, P. A. (2024) · Australian Dental Journal · doi:10.1111/adj.13039 · Cited by 2
“17 Despite the limitations of AHI-and ODI-based criteria, adequate treatment of moderate-to-severe OSA is associated with major improvements in both OSA symptoms and clinical outcomes, 19,20 and untreated OSA is associated with serious long-term adverse outcomes.”
Effects of multilevel OSA surgery on patients with poor cardiopulmonary performance: A prospective pilot study
Lin, C., Lin, P.-W., Chiu, L.-W., Su, M., Chai, H.-T., Chang, C., Friedman, M., Salapatas, A. M., & Lin, H. (2024) · Auris Nasus Larynx · doi:10.1016/j.anl.2024.10.005 · Cited by 2
Knowledge, attitude, and practice of inpatients with cardiovascular disease regarding obstructive sleep apnea
Yu, F., Zhou, F., Hao, Q., Cao, W., Xie, L., Xu, X., Zhen, P., Song, S., Liu, Z., Song, S., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-77546-9 · Cited by 2
Exploring the silent connection: unveiling the intricate relationship between gastroesophageal reflux disease and sleep apnea syndrome
Wang, J., Wang, P., Lv, J., Chen, R., Yan, W., & He, D. (2025) · Human Genomics · doi:10.1186/s40246-025-00728-7 · Cited by 2
“…the development of targeted interventions, such as personalized weight loss and exercise programs tailored [17] to control BMI indices in SAS patients with/without GERD (34.0 ± 7.0 vs. 33.1 ± 6.8, P = 0.049) [18], thereby alleviating mechanical pressure and improving ventilation function [17].”
Influential
The role of insomnia in the development of resistant hypertension in uncontrolled hypertensive patients with obstructive sleep apnea: A prospective study
Wu, H., Xie, J., & Wu, C. (2025) · Sleep Medicine · doi:10.1016/j.sleep.2025.106508 · Cited by 2
Relationship between sleep apnea and dizziness: a scoping review
Kim, E., Wi, D., Kim, Y., & Lee, J. (2025) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.11710 · Cited by 2
Effect of a Mediterranean Diet Adapted to the Mexican Population on Indicators of Metabolic Risk in Patients With Obstructive Sleep Apnea: Protocol for a Randomized Controlled Trial
Miguel, G. P. T. S., Sevilla-González, M. D. L. L., Ramírez, E. L., López, M. F. F., & López, L. V. (2025) · JMIR Research Protocols · doi:10.2196/72513 · Cited by 2
“Daytime symptoms of patients with OSA include excessive daytime drowsiness, complaints of unrefreshing sleep, morning headaches resolved with breathing regulation, irritability, apathy, depression, difficulty to focus, and memory loss, among others [6].”
Effects of obstructive sleep apnea on postoperative outcomes following total hip arthroplasty: A matched cohort analysis
Bohn, C., Hand, C., Angotti, M. L., Eilen, H., Varano, M., & Forsythe, B. (2025) · Journal of Orthopaedic Reports · doi:10.1016/j.jorep.2025.100670 · Cited by 2
The Association Between Craniofacial Morphological Parameters and the Severity of Obstructive Sleep Apnea: A Multivariate Analysis Using the Apnea–Hypopnea Index and Nocturnal Oxygen Desaturation
Dong, Z., Wu, J., Wu, L., & Hong, H. (2025) · Healthcare · doi:10.3390/healthcare13080913 · Cited by 2
“The severity of OSA can be classified as mild (6 ≤ AHI ≤ 15), moderate (16 ≤ AHI ≤ 29), or severe (AHI ≥ 30) [17].”
Clinical utility of limited channel sleep studies versus polysomnography for obstructive sleep apnoea
van Doorn, S., Idema, D. L., Heus, P., Damen, J. A., Spijker, R., Japenga, E. J., Reesink, H. J., & Hooft, L. (2025) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013810.pub2 · Cited by 2
Quantitative and qualitative assessment of the complete blood count in patients with obstructive sleep apnea and chronic ischemia
Rubina, S. S., Макарова, И. И., & Slyusar', N. N. (2025) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202512505195 · Cited by 2
Sleep Dysfunction in Older Age Parkinson’s Disease
Matar, E., Lazcano‐Ocampo, C., & Padmakumar, C. (2025) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2025.05.005 · Cited by 2
Integrative multi-omics investigation of sleep apnea: gut microbiome metabolomics, proteomics and phenome-wide association study
Wei, S., Shen, R., Lu, X., Li, X., He, L., Zhang, Y., Huang, X., & Shu, Z. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-00925-0 · Cited by 2
“These factors comprise craniofacial structural differences, reduced upper airway width, elevated body mass index (BMI), and impaired pharyngeal dilator muscle function, all contributing to upper airway collapse and subsequent episodes of apnea and hypopnea [6–9].”
Evaluating outcomes of hyoid suspension combined with other upper airway surgery for obstructive sleep apnea
Schaaff, C., Patel, T., Alazawi, D., Thomas, E. A., Kress, M. H., Lenze, N. R., Stanley, J. J., & Hoff, P. T. (2025) · Sleep And Breathing · doi:10.1007/s11325-025-03370-8 · Cited by 2
Association between nocturnal continuous positive airway pressure and renal function decline in a cohort of elderly patients with obstructive sleep apnoea syndrome—An observational study
Armentaro, G., Condoleo, V., Francica, M., Severini, G., Pastura, C. A., Divino, M., Panza, A., Panza, M., Capilupi, F., Maruca, F., et al. (2025) · European Journal of Clinical Investigation · doi:10.1111/eci.70098 · Cited by 2
“1,2 5 There is definite biological plausibility to support a role for OSA in the pathogenesis of accelerated decline in kidney function.”
Velopharyngeal Complete Concentric Collapse in Patients with CPAP-Intolerant OSA: A Review of Management Strategies
Estephan, L. E., White, S. F., Ideker, H. C., & Huntley, C. T. (2025) · Current Otorhinolaryngology Reports · doi:10.1007/s40136-025-00524-w · Cited by 2
Women’s Experiences with Continuous Positive Airway Pressure for Treatment of Obstructive Sleep Apnea: A Qualitative study
Morris, J. L., Patel, S. R., & Luyster, F. S. (2025) · Behavioral Sleep Medicine · doi:10.1080/15402002.2025.2549552 · Cited by 2
“Consistent treatment with continuous positive airway pressure (CPAP) improves nighttime breathing, daytime sleepiness, and quality of life, and may reduce cardiovascular disease risk (Gottlieb & Punjabi, 2020; Punjabi et al., 2020; Patil et al., 2019).”
A Prediction Model for Obstructive Sleep Apnea in Bariatric Surgery Candidates with Obesity
Zhu, X., Xu, B., Yang, C., Ma, S., Hao, G., Gu, F., Wang, B., & Yao, Y. (2025) · Obesity Surgery · doi:10.1007/s11695-025-08093-z · Cited by 2
“Obstructive sleep apnea (OSA) is a common sleep disorder characterized by repetitive episodes of upper airway collapse during sleep, leading to intermittent hypoxia and sleep disruption [1–3].”
High burden of moderate-to-severe obstructive sleep apnea: comparative accuracy of screening tools against polysomnography
Ali, A. M. M., Wu, L., Elfeky, S. E. F., Alhassoon, M. H., Aldrees, D. S., Moazen, E. M. M., Alghulayqah, A., & Saleh, M. M. (2025) · Sleep Epidemiology · doi:10.1016/j.sleepe.2025.100114 · Cited by 2
Robotic surgery: The convergence of digital innovations in head and neck surgery
Liu, Y., Zhao, X., Yu, D., Yu, D., & Liu, X. (2025) · Journal of Cranio-Maxillofacial Surgery · doi:10.1016/j.jcms.2025.08.018 · Cited by 3
Three-Dimensional Airway Assessment as Diagnostic Aid in Obstructive Sleep Apnea
Benítez-Cárdenas, O. A., Herrera-Salguero, N. O., Torres-Hernández, E. M., Noyola-Frías, M. Á., Martínez-Rider, R., & Vitales‐Noyola, M. (2025) · Pathophysiology · doi:10.3390/pathophysiology32040050 · Cited by 2
“The clinical recognition of sleep-disordered breathing has evolved significantly over recent decades [3,4].”
Validation of obstructive sleep apnea questionnaires in high-risk pregnancy
Sheehan, K. N., Xiang, K. R., ROWLAND, C., Saha, A. K., Millard, M. J., Dean, L. S., Shirk, S., Kozakiewicz, M. L., Carter, D. W., SCHERTZ, A. R., et al. (2025) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.11906 · Cited by 2
“1,3,33 Our results may suggest that similar characteristics, such as those included in our questionnaire, that make a patient a high-risk pregnancy also put them at risk for OSA.”
Effect of Continuous Positive Airway Pressure Treatment on Hearing and Inner Ear Function in Patients with Obstructive Sleep Apnoea—Original Research
Čerkez, M. G., Zubčić, Ž., Jurić, S., Jurić, J. Š., Kovačević, J., Klarić, Ž. L., & Birtić, D. (2025) · Medicina · doi:10.3390/medicina61101833 · Cited by 2
“The device uses tubing and a nasal or oronasal mask to deliver positively pressurised air into the upper airway and keep it open [1,5,6].”
Health state utilities associated with obstructive sleep apnea: preferences of patients with OSA and obesity in the UK and the US
Stewart, K. D., Matza, L. S., Dunn, J. P., Neff, L. M., Niemeyer, A., Boye, K. S., & Shinde, S. (2025) · Journal of Medical Economics · doi:10.1080/13696998.2025.2572051 · Cited by 2
Micro-arousals during REM and NREM sleep and lipid profile in obstructive sleep apnea: evidence from the shanghai sleep health study
Peng, Y., Gao, Y., Huang, L., Xiao, X., Liu, Y., Wu, C., Li, C., Li, X., Xu, H., Guan, J., et al. (2025) · Sleep And Breathing · doi:10.1007/s11325-025-03470-5 · Cited by 2
Dose–response relationship of sleep apnea therapy and healthcare use in patients with comorbidities
Malhotra, A., More, S., Alpert, N., Pépin, J., Cole, K. V., Woodford, C., Benjafield, A., Cistulli, P. A., Sterling, K. L., medXcloud Group, et al. (2025) · SLEEP · doi:10.1093/sleep/zsaf333 · Cited by 4
AI-Assisted Awake Endoscopic Video Analysis for Obstructive Sleep Apnea Detection
Lai, W.-S., Li, T.-W., Kuo, C. J., & Liu, S. (2025) · Nature and Science of Sleep · doi:10.2147/nss.s559788 · Cited by 2
Preliminary analysis of gut microbiome characteristics in children with obstructive sleep apnea hypopnea syndrome
Wang, Z., Zhou, L., He, Y., Xv, X., Lv, M., Zhang, Z., Wang, F., Wang, S., & Wang, Y. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1615891 · Cited by 2
OSA Initiates Histone Lactylation That Drives PDE4B / FUS / AGT Axis to Pulmonary Hypertension
Yang, L., Ni, Q., He, Y., Liu, S., Gan, L., Dai, A., Hu, Y., Liu, Q., Yang, X.-C., Li, J., et al. (2025) · Cell Proliferation · doi:10.1111/cpr.70145 · Cited by 2
Potential diagnostic markers and therapeutic targets for obstructive sleep apnea with comorbid depression based on bioinformatics analysis
Lu, Y., Tang, Z., Zhou, X., Lin, W., & Guo, X. (2025) · Frontiers in Genetics · doi:10.3389/fgene.2025.1655000 · Cited by 2
Screening of obstructive sleep apnea in patients with hypertension: review of the literature and results of an Italian survey
Buffolo, F., Votta, S., Goi, J., Burrello, J., Dalmazi, G. D., Cicero, A. F. G., Mancusi, C., Moia, E. C., Iaccarino, G., Borghi, C., et al. (2025) · Journal of Hypertension · doi:10.1097/hjh.0000000000004200 · Cited by 2
The No-Apnea score for early obstructive sleep apnea detection in a sleep clinic: a study of diagnostic accuracy and comparative performance of three screening instruments
Jameie, M., Bayat, M., Akbarpour, S., Amanollahi, M., Amirifard, H., Sadeghniiat‐Haghighi, K., Edalatifard, M., Heidari, R., Rahimi, B., & Najafi, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-16694-y · Cited by 2
Improving Nocturia Management Through Sleep Apnea Diagnosis and Treatment
Kudlata, F. P., Bedore, S. R., Gelernter, B. S. A. M., Scanlan, L. G., Sakhalkar, O. V., Ange, B., Terris, M. K., & SantaMaria, P. J. (2025) · Neurourology and Urodynamics · doi:10.1002/nau.70187 · Cited by 2
Systematic review of changes in extracellular vesicles associated with obstructive sleep apnoea: implications for diagnosis and treatment
Santos, B., Ramalho, B., Relógio, A., Cavadas, C., Gaspar, L. S., & Álvaro, A. R. (2025) · European Respiratory Review · doi:10.1183/16000617.0073-2025 · Cited by 2
“…contribute to increased OSA prevalence, a significant risk factor for the development of several comorbidities including cardiovascular diseases [14, 15], metabolic disorders [16], neurocognitive impairments [17, 18], osteoarthritis [19] and increased risk of mental health issues such as…”
Hydrogen alleviates cardiac ferroptosis damage under chronic intermittent hypoxia conditions by targeting Nrf2
Song, J., Han, H., Liu, Q.-Q., Sun, M.-F., Yu, B., Zhao, Y., Guo, Y., & Ji, E. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115974 · Cited by 2
Pharyngeal Airway Changes After Functional Orthodontic Treatment in Growing Class II Patients: A Retrospective Cephalometric Comparison of Twin Block, RPE and AMCOP®
Inchingolo, A. D., Inchingolo, A. M., Palumbo, I., Venere, D. D., Maspero, C. M. N., Inchingolo, F., Cardarelli, F., Marinelli, G., & Dipalma, G. (2025) · Life · doi:10.3390/life15121939 · Cited by 2
Incretin Receptor Agonists and CPAP Use in Adults With Diabetes, Obesity, and Obstructive Sleep Apnea
Tang, H., Zhang, B., Lu, Y., Zhang, D., Lu, Y., Asch, D. A., & Yong, C. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.50978 · Cited by 2
Preoperative Comorbidities Associated With Weight Loss Following Metabolic and Bariatric Surgery: A Rapid Review
Atlantis, E. E., Mariadasan, G., Brooks, C., Piya, M. K., & Fahey, P. P. (2025) · Obesity Reviews · doi:10.1111/obr.70084 · Cited by 2
“Sleep apnea may negatively impact weight loss outcomes by disrupting sleep quality and leading to excessive daytime fatigue [48].”
Co-exposure to multiple fine particulate matter constituents and adults obstructive sleep apnoea (OSA) in Southern China
Wang, S., Chen, G., Dong, P., Xiong, H., Liu, Y., Zhou, R., Zhang, R., & Ou, Q. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.127636 · Cited by 2
Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and atherogenic index of plasma with obstructive sleep apnea
Li, G., Deng, M., He, G., Jiang, Y., Wang, Z., Zhou, C., Xu, W., Feng, T., Zeng, W., Peng, J., et al. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1597820 · Cited by 2
Self-Supervised Speech Representations for Sleep Apnea Severity Prediction
TaghiBeyglou, B., Geng, J., McDaulid, D., Gnaneswaran, P., Yasokaran, O., Chow, A., Ng, R. H. W., Chervin, R. D., Brown, D. L., & Yadollahi, A. (2026) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2026.3656326 · Cited by 2
“OSA is characterized by recurrent episodes of partial (hypopnea) or complete (apnea) obstruction of the upper airway during sleep [2].”
Clinical effects of the use of a novel oropharyngeal airway in painless gastroscopy in patients with obstructive sleep apnoea–hypopnoea syndrome: a randomised controlled trial protocol
You, Q., Liu, X., Meng, Y., Zhu, Y., Sun, C., & Wu, J. (2026) · BMJ Open · doi:10.1136/bmjopen-2024-094885 · Cited by 2
Resistant Hypertension: Integration of Novel Agents and Interventional Approaches in Clinical Practice
Arriola‐Montenegro, J., Chapoñan-Lavalle, A., Nombera-Aznaran, N., Abdalla, M. S., Bizer, B., Mohan, A., Verdugo, I. A. M., Zardoost, P., Ordaya-Gonzales, K., Rizzo, A. V., et al. (2026) · Reviews in Cardiovascular Medicine · doi:10.31083/rcm45429 · Cited by 2
“Screening for OSA should be prioritized in patients with suggestive symptoms such as daytime somnolence or loud snoring, and in those with risk factors including advanced age, male sex, obesity, and increased neck circumference [26].”
Comparative effectiveness and safety of novel antidiabetic agents in the management of obstructive sleep apnea: a systematic review, meta-analysis, and network meta-analysis
Yang, Y.-T., Hou, X.-Z., Zhang, X.-R., Zhang, Z., & Wang, S.-H. (2026) · Respiratory Medicine · doi:10.1016/j.rmed.2026.108671 · Cited by 2
Intelligent nanoliposome ameliorate chronic intermittent hypoxia-mediated neuronal injury via a dual regulation microglial inflammation strategy
Wang, H., Wang, X., Zhu, Y., Niu, Z., Ou, X., Zhang, W., Zhuang, S., Ke, Y., Yang, F., Pei, M., et al. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.102865 · Cited by 2
“Obstructive sleep apnea syndrome (OSAS), a highly prevalent sleep-related breathing disorder characterized by hypopnea and apnea in ventilation, resulting in chronic intermittent hypoxia (CIH), which ultimately lead to severe neurocognitive deficits [1,2].”
Comparative effects of hypnotic agents on sleep architecture and respiratory outcomes in obstructive sleep apnea: A systematic review and network meta‐analysis
Kishi, T., Ikuta, T., Sakuma, K., Hatano, M., Kishi, T., Kitajima, T., & Iwata, N. (2026) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.70036 · Cited by 3
Reduced Baroreflex Sensitivity in High-Normal Blood Pressure and its Association with Plasma Atherogenicity
Janeckova, K., Šiarnik, P., Kollár, B., Waczulı́ková, I., Wawruch, M., Poddaný, M., & Čelovská, D. (2026) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/s44411-026-00543-z · Cited by 2
Five-year longitudinal changes in oxygen saturation parameters in Obstructive Sleep Apnoea: Impact of age, body mass index, and comorbidities
Howarth, T. P., Karhu, T., Leppänen, T., Saad, H. B., Bahammam, A., & Nikkonen, S. (2026) · Sleep Medicine · doi:10.1016/j.sleep.2026.108866 · Cited by 2
Patients’ Experiences of Obstructive Sleep Apnea and Tirzepatide Treatment: An Exit Interview Study
Shinde, S., Kanu, C., Varnado, O. J., Bednařík, J., Dennehy, E. B., Dias-Barbosa, C., & Taylor, N. C. (2026) · Patient · doi:10.1007/s40271-026-00808-3 · Cited by 3
“Obstructive sleep apnea management involves a multi-modal approach that ranges from positional therapy to surgical interventions [10, 11].”
Effect of CPAP Therapy in Poststroke Patients with Sleep-Disordered Breathing: A Systematic Review and Meta-Analysis
Suusgaard, J., Karottki, N. F. L. C., West, A. S., Rauen, K., Iversen, H. K., Ibsen, T., Bendsen, N. B., Kruuse, C., & Jennum, P. (2026) · European Neurology · doi:10.1159/000551243 · Cited by 2
“By counter-acting intermittent hypoxia, blood pressure variability, and sympathetic overactivation, PAP likely reduces oxidative stress, endothelial dysfunction, and arrhythmogenic potential, all of which are mechanisms central to secondary vascular risk [7, 8].”
Autonomic imbalance mediates sleep apnea-specific hypoxic burden and glucose metabolism in obstructive sleep apnea: A large-scale observational study
Li, C., Li, L., Zhou, Z., Zou, J., Zhu, X. A., Guan, J., Zhang, X., Liu, Y., Huang, W., Yi, H., et al. (2026) · Respiratory Medicine · doi:10.1016/j.rmed.2026.108759 · Cited by 2
Systemic immune-inflammation index and systemic inflammation response index: novel hematological predictors of obstructive sleep apnea
He, G., Deng, M., Tong, Y., Wan, Z., Xu, W., Feng, T., Zeng, W., Xiao, L., Yang, D., Song, K., et al. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1716598 · Cited by 2
Association of Prognostic Nutritional Index With Mortality in High-Risk OSA Individuals and with Disease Severity in Clinical OSA Patients
Li, Y., Deng, S., Zhai, L., Wang, L., Zhang, L., ‍Zhao, B., Niu, H., & Gao, X. (2026) · Nature and Science of Sleep · doi:10.2147/nss.s595054 · Cited by 2
Is obstructive sleep apnea a driver of cancer and chronic disease risk? A real-world analysis of over 3 million patients
Bigus, S., Kern, N. L., Elter, T., Heiland, M., Preißner, R., & Preißner, S. (2026) · BMC Pulmonary Medicine · doi:10.1186/s12890-026-04329-5 · Cited by 2
Multimodal neuro-ophthalmologic changes and the impact of CPAP therapy in severe obstructive sleep apnea: a prospective OCT, OCTA, and visual field study
Gemici, Y. İ., Öztürk, Ü., Erdoğan, M., İlker, S. S., Yılmaz, H., & Ak, A. K. (2026) · Documenta Ophthalmologica · doi:10.1007/s10633-026-10122-w · Cited by 2
Disrupted erythrocyte S1P-eNOS axis promotes hypoxia, hypertension and fibrosis in obstructive sleep apnoea-hypopnoea syndrome
Fan, Y., Chen, C., Luo, C., Zhou, S., Lu, H., Yu, F., He, Z., Wang, Y., Chou, Y., Li, Y., et al. (2026) · European Heart Journal · doi:10.1093/eurheartj/ehag405 · Cited by 2
Objective and subjective adherence to oral appliance therapy in adults with obstructive sleep apnea: pilot data from a one-year longitudinal study
Zhang, W., Yu, M., Gong, X., Dang, W., & Gao, X. (2026) · Journal of Clinical Sleep Medicine · doi:10.1007/s44470-026-00123-6 · Cited by 2
Optic Nerve Thickness Assessed by Ocular Ultrasonography in Obstructive Sleep Apnea
Kerget, B., Çetin, E., Aksakal, A., Çetin, S. M., & Coşkuner, M. B. (2026) · Journal of Ultrasound in Medicine · doi:10.1002/jum.70381 · Cited by 2
Obstructive Sleep Apnea: Epidemiology, Pathophysiology, Complications, Diagnosis, Management, and Emerging Fibrosis‐Linked Remodeling
Thuy, N. H. T., Phan, T. H. G., Eid, A. H., Maccioccu, P., Camboni, S., Casu, G., Posadino, A. M., Giordo, R., & Pintus, G. (2026) · MedComm · doi:10.1002/mco2.70877 · Cited by 2
The importance of classifying central hypopneas: a call to action
Ahn, A. P., Azarbarzin, A., Badr, M. S., Berry, R., DeYoung, P., Dupuy-McCauley, K. L., Morgenthaler, T. I., Pépin, J., Randerath, W. J., Sands, S. A., et al. (2026) · Journal of Clinical Sleep Medicine · doi:10.1007/s44470-026-00177-6 · Cited by 2
“Obstructive sleep apnea (OSA) is a common condition with major neurocognitive and cardiometabolic sequelae [1].”

Authors: Gottlieb, D. J., & Punjabi, N. M.
Affiliations: Brigham and Women's Hospital (US)
Johns Hopkins University (US)
ORCID: Gottlieb, Daniel J.
Punjabi, Naresh M.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2020-04-14
Volume: 323
Issue: 14
Pages: 1389
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2020.3514
OpenAlex: W3015537361
Semantic Scholar: 0172e9c7f7ea58bd5623bd24ef5636cfe5f6c7df
Cited by: 1,482
References: 112
Citations by year: 2026: 266 · 2025: 330 · 2024: 287 · 2023: 230 · 2022: 225 · 2021: 109 · 2020: 32
FWCI: 19.00
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL146709, R01HL137234)
National Institute of Nursing Research (R01NR018335)
National Institute of Diabetes and Digestive and Kidney Diseases (U34DK120051)
Topics: Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: obstructive sleep apnea, sleep apnea diagnosis, home sleep apnea testing, positive airway pressure, oral appliances, hypoglossal nerve stimulation, weight loss, physical activity, obesity, daytime sleepiness, resistant hypertension, cardiovascular risk, cerebrovascular risk, pharyngeal surgery, pharmacotherapy
MeSH terms: Female, Humans, Male, Prognosis, Risk Factors, Weight Loss, Health Behavior, Exercise, Mandibular Advancement, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Diagnosis and Management of Obstructive Sleep Apnea: A Review

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks