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Diagnosis and Management of Obstructive Sleep Apnea: A Review
Abstract
Importance: Obstructive sleep apnea (OSA) affects 17% of women and 34% of men in the US and has a similar prevalence in other countries. This review provides an update on the diagnosis and treatment of OSA. Observations: The most common presenting symptom of OSA is excessive sleepiness, although this symptom is reported by as few as 15% to 50% of people with OSA in the general population. OSA is associated with a 2- to 3-fold increased risk of cardiovascular and metabolic disease. In many patients, OSA can be diagnosed with home sleep apnea testing, which has a sensitivity of approximately 80%. Effective treatments include weight loss and exercise, positive airway pressure, oral appliances that hold the jaw forward during sleep, and surgical modification of the pharyngeal soft tissues or facial skeleton to enlarge the upper airway. Hypoglossal nerve stimulation is effective in select patients with a body mass index less than 32. There are currently no effective pharmacological therapies. Treatment with positive airway pressure lowers blood pressure, especially in patients with resistant hypertension; however, randomized clinical trials of OSA treatment have not demonstrated significant benefit on rates of cardiovascular or cerebrovascular events. Conclusions and Relevance: OSA is common and the prevalence is increasing with the increased prevalence of obesity. Daytime sleepiness is among the most common symptoms, but many patients with OSA are asymptomatic. Patients with OSA who are asymptomatic, or whose symptoms are minimally bothersome and pose no apparent risk to driving safety, can be treated with behavioral measures, such as weight loss and exercise. Interventions such as positive airway pressure are recommended for those with excessive sleepiness and resistant hypertension. Managing asymptomatic OSA to reduce cardiovascular and cerebrovascular events is not currently supported by high-quality evidence.
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“Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder that affects approximately 25% of adults in the US and similar amounts in other high-income countries, although estimates vary depending on its definition (Gottlieb & Punjabi, 2020;Benjafield et al., 2019).”
From Effects of mindfulness meditation and Acceptance and commitment therapy in patients with obstructive sleep apnea with residual excessive sleepiness: A randomized controlled pilot study (2023) · cites this paper as Gottlieb & Punjabi, 2020
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“Airway dysfunction causes autonomic nervous system dysregulation, sleep fragmentation, insulin resistance, systemic inflammation, oxidative stress, and vascular endothelial dysfunction [3].”
From Pregnancy outcomes in infertility patients diagnosed with sleep disordered breathing with wireless wearable sensors (2022) · cites this paper as [3]
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“SDB may be associated with adverse early pregnancy rates given increases in stress, fatigue, overnight hypoxemia and systemic inflammation [3].”
From Pregnancy outcomes in infertility patients diagnosed with sleep disordered breathing with wireless wearable sensors (2022) · cites this paper as [3]
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“, assessment of the autonomic nervous system or EEG) and [3] individual response to therapy (e.”
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Metadata
- Authors
- Gottlieb, D. J., & Punjabi, N. M.
- Affiliations
- Brigham and Women's Hospital (US)
- Johns Hopkins University (US)
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2020-04-14
- Volume
- 323
- Issue
- 14
- Pages
- 1389
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W3015537361
- Semantic Scholar
- 0172e9c7f7ea58bd5623bd24ef5636cfe5f6c7df
- Cited by
- 1,482
- References
- 112
- Citations by year
- 2026: 266 · 2025: 330 · 2024: 287 · 2023: 230 · 2022: 225 · 2021: 109 · 2020: 32
- FWCI
- 19.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL146709, R01HL137234)
- National Institute of Nursing Research (R01NR018335)
- National Institute of Diabetes and Digestive and Kidney Diseases (U34DK120051)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- obstructive sleep apnea, sleep apnea diagnosis, home sleep apnea testing, positive airway pressure, oral appliances, hypoglossal nerve stimulation, weight loss, physical activity, obesity, daytime sleepiness, resistant hypertension, cardiovascular risk, cerebrovascular risk, pharyngeal surgery, pharmacotherapy
- MeSH terms
- Female, Humans, Male, Prognosis, Risk Factors, Weight Loss, Health Behavior, Exercise, Mandibular Advancement, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure
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