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Reports of Anaphylaxis After Receipt of mRNA COVID-19 Vaccines in the US—December 14, 2020-January 18, 2021
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This JAMA Insights review provides clinical details of anaphylactic reactions reported to and verified by the CDC in the first month of use of the Pfizer-BioNTech and Moderna COVID-19 vaccines in the US, December 14, 2020-January 18, 2021.
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“Anaphylactic reactions have been observed in approximately 4.7 per million anti-COVID-19 vaccinations with the Pfizer–BioNTech vaccine and 2.5 per million vaccinations with the Moderna vaccine213”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [213]
In the citing paper
“Anaphylactic reactions have been observed in approximately 4.7 per million anti-COVID-19 vaccinations with the Pfizer–BioNTech vaccine and 2.5 per million vaccinations with the Moderna vaccine213”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [213]
In the citing paper
“Rare events of anaphylaxis have been reported after vaccination with mRNA-1273 and BNT162b2, with an incidence currently estimated at approximately 1 in 100,000 [86].”
From The dawn of mRNA vaccines: the COVID-19 case (2021) · cites this paper as [86]
In the citing paper
“Of the confirmed cases, most of the individuals had a documented history of allergic reactions and/or anaphylaxis.”
From The dawn of mRNA vaccines: the COVID-19 case (2021) · cites this paper as [86]
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Metadata
- Authors
- Shimabukuro, T. T., Cole, M., & Su, J. R.
- Affiliations
- Centers for Disease Control and Prevention (US)
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2021-03-16
- Volume
- 325
- Issue
- 11
- Pages
- 1101
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC8890485
- OpenAlex
- W3128551684
- Cited by
- 475
- References
- 8
- Citations by year
- 2026: 22 · 2025: 27 · 2024: 30 · 2023: 104 · 2022: 136 · 2021: 156
- FWCI
- 33.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (CC999999)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Keywords
- anaphylaxis, COVID-19 mRNA vaccine, BNT162b2, Moderna vaccine, vaccine adverse events, vaccine safety
- MeSH terms
- COVID-19 Vaccines, Adult, Anaphylaxis, Female, Hospitalization, Humans, Male, Middle Aged, United States, Adverse Drug Reaction Reporting Systems
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