Cited by 162Statistical Methods in Clinical TrialsAdvanced Causal Inference TechniquesMeta-analysis and systematic reviews

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Adjustment for Baseline Characteristics in Randomized Clinical Trials

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Holmberg, Mathias J., Andersen, Lars W.·2022·JAMA

DOI 10.1001/jama.2022.21506

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This Guide to Statistics and Methods provides an overview of the use of adjustment for baseline characteristics in the analysis of randomized clinical trials and emphasizes several important considerations.

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Authors: Holmberg, M. J., & Andersen, L. W.
Affiliations: Aarhus University (DK)
Corresponding author: Andersen, Lars W.
ORCID: Holmberg, Mathias J.
Andersen, Lars W.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2022-12-06
Volume: 328
Issue: 21
Pages: 2155
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2022.21506
OpenAlex: W4309183852
Cited by: 161
References: 8
Citations by year: 2026: 55 · 2025: 45 · 2024: 40 · 2023: 21
FWCI: 19.69
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
Keywords: baseline characteristics, adjustment, randomized controlled trials, covariate adjustment, treatment effect estimation, confounding
MeSH terms: Research Design, Randomized Controlled Trials as Topic

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Adjustment for Baseline Characteristics in Randomized Clinical Trials

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