Cited by 495Iron Metabolism and DisordersErythropoietin and Anemia TreatmentNutrition and Health in Aging

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The Definition of Anemia in Older Persons

Izaks, Gerbrand J.·1999·JAMA

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Abstract

CONTEXT: Whether hemoglobin concentrations defined as anemia by the World Health Organization (WHO) are associated with increased mortality in older persons is not known. OBJECTIVE: To investigate the association between hemoglobin concentration and cause-specific mortality in older persons. DESIGN: Community-based study conducted from 1986 to 1996 (follow-up period, 10 years). SETTING: Leiden, the Netherlands. PARTICIPANTS: A total of 1016 community residents aged 85 years and older were eligible and 872 agreed to have a blood sample taken. Hemoglobin concentration was measured in 755 persons (74%). MAIN OUTCOME MEASURES: Hemoglobin concentration, 10-year survival, and primary cause of death. According to the WHO criteria, anemia was defined as a hemoglobin concentration below 7.5 mmol/L (120 g/L) in women and below 8.1 mmol/L (130 g/L) in men. RESULTS: Compared with persons with a normal hemoglobin concentration, the mortality risk was 1.60 (95% confidence interval [CI], 1.24-2.06; P<.001) in women with anemia, and 2.29 (95% CI, 1.60-3.26; P<.001) in men with anemia. In both sexes, the mortality risk increased with lower hemoglobin concentrations. In persons without self-reported clinical disease at baseline, the mortality risk of anemia was 2.21 (95% CI, 1.37-3.57; P=.002). Mortality from malignant and infectious diseases was higher in persons with anemia. CONCLUSIONS: Anemia defined by the WHO criteria was associated with an increased mortality risk in persons aged 85 years and older. The criteria are thus appropriate for older persons. A low hemoglobin concentration at old age signifies disease.

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“Mini-mental state”
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
International Classification of Diseases, Ninth Revision
National Cancer Institute (2020) · Definitions · doi:10.32388/bd1nux · Cited by 891
Total cholesterol and risk of mortality in the oldest old
Weverling-Rijnsburger, A. W., Blauw, G. J., Lagaay, A. M., Knock, D. L., Meinders, A. E., & Westendorp, R. G. (1997) · The Lancet · doi:10.1016/s0140-6736(97)04430-9 · Cited by 474
Incidence of Anemia in Older People: An Epidemiologic Study in a Well Defined Population
Anía, B. J., Suman, V. J., Fairbanks, V. F., Rademacher, D. M., & Melton, L. J. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb01509.x · Cited by 286
Anemia and Hemoglobin Levels in Older Persons: Relationship with Age, Gender, and Health Status
Salive, M. E., Cornoni‐Huntley, J. C., Guralnik, J. M., Phillips, C. L., Wallace, R. B., Ostfeld, A. M., & Cohen, H. J. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb02017.x · Cited by 259
Prevalence and Causes of Anaemia in a Geriatric Hospitalized Population
Joosten, E., Pelemans, W., Hiele, M. I., Noyen, J., Verhaeghe, R., & Boogaerts, M. A. (2009) · Gerontology · doi:10.1159/000213315 · Cited by 222
Prevalence of Anemia and Correlation of Hemoglobin with Age in a Geriatric Screening Clinic Population
Timiras, M., & Brownstein, H. (1987) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1987.tb04340.x · Cited by 62
Validation of medical history taking as part of a population based survey in subjects aged 85 and over.
Lagaay, A. M., Meij, J., & Hijmans, W. (1992) · BMJ · doi:10.1136/bmj.304.6834.1091 · Cited by 59
Decline of blood haemoglobin in the aged: a longitudinal study of an urban Swedish Population from age 70 to 81
Nilsson‐Ehle, H., JAGENBURG, R., Landahl, S., Svanborg, A., & Westin, J. (1989) · British Journal of Haematology · doi:10.1111/j.1365-2141.1989.tb04303.x · Cited by 43
Three-year follow-up of Mini-Mental State Examination score in community residents aged 85 and over
Izaks, G. J., Gussekloo, J., Dermout, K. M. T., Heeren, T. J., & Ligthart, G. J. (1995) · Psychological Medicine · doi:10.1017/s0033291700035091 · Cited by 36
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Authors: Izaks, G. J.
Affiliations: Leiden University Medical Center (NL)
Corresponding author: Izaks, Gerbrand J.
ORCID: Izaks, Gerbrand J.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 1999-05-12
Volume: 281
Issue: 18
Pages: 1714
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.281.18.1714
OpenAlex: W2034859046
Cited by: 495
References: 11
Citations by year: 2026: 2 · 2025: 8 · 2024: 10 · 2023: 12 · 2022: 17 · 2021: 13 · 2020: 14 · 2019: 21 · 2018: 21 · 2017: 16 · 2016: 12 · 2015: 24 · 2014: 24 · 2013: 21 · 2012: 34
FWCI: 3.93
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1r01ag006354-01)
National Institute on Aging (AG-06354)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Keywords: anemia, hemoglobin levels, older adults, mortality, cause-specific mortality, survival, sex differences, infectious disease mortality
MeSH terms: Aged, Aged, 80 and over, Anemia, Cause of Death, Female, Hemoglobins, Humans, Male, Risk, Proportional Hazards Models, Survival Analysis

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The Definition of Anemia in Older Persons

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