Cited by 495Iron Metabolism and DisordersErythropoietin and Anemia TreatmentNutrition and Health in Aging

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

The Definition of Anemia in Older Persons

Izaks, Gerbrand J.·1999·JAMA

Open this paper in CoChat — free account

Abstract

CONTEXT: Whether hemoglobin concentrations defined as anemia by the World Health Organization (WHO) are associated with increased mortality in older persons is not known. OBJECTIVE: To investigate the association between hemoglobin concentration and cause-specific mortality in older persons. DESIGN: Community-based study conducted from 1986 to 1996 (follow-up period, 10 years). SETTING: Leiden, the Netherlands. PARTICIPANTS: A total of 1016 community residents aged 85 years and older were eligible and 872 agreed to have a blood sample taken. Hemoglobin concentration was measured in 755 persons (74%). MAIN OUTCOME MEASURES: Hemoglobin concentration, 10-year survival, and primary cause of death. According to the WHO criteria, anemia was defined as a hemoglobin concentration below 7.5 mmol/L (120 g/L) in women and below 8.1 mmol/L (130 g/L) in men. RESULTS: Compared with persons with a normal hemoglobin concentration, the mortality risk was 1.60 (95% confidence interval [CI], 1.24-2.06; P<.001) in women with anemia, and 2.29 (95% CI, 1.60-3.26; P<.001) in men with anemia. In both sexes, the mortality risk increased with lower hemoglobin concentrations. In persons without self-reported clinical disease at baseline, the mortality risk of anemia was 2.21 (95% CI, 1.37-3.57; P=.002). Mortality from malignant and infectious diseases was higher in persons with anemia. CONCLUSIONS: Anemia defined by the WHO criteria was associated with an increased mortality risk in persons aged 85 years and older. The criteria are thus appropriate for older persons. A low hemoglobin concentration at old age signifies disease.

Integrity signals

Registry

Crossref · 10.1001/jama.281.18.1714

Cites

11 of 11 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

“Mini-mental state”
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
International Classification of Diseases, Ninth Revision
National Cancer Institute (2020) · Definitions · doi:10.32388/bd1nux · Cited by 891
Total cholesterol and risk of mortality in the oldest old
Weverling-Rijnsburger, A. W., Blauw, G. J., Lagaay, A. M., Knock, D. L., Meinders, A. E., & Westendorp, R. G. (1997) · The Lancet · doi:10.1016/s0140-6736(97)04430-9 · Cited by 474
Incidence of Anemia in Older People: An Epidemiologic Study in a Well Defined Population
Anía, B. J., Suman, V. J., Fairbanks, V. F., Rademacher, D. M., & Melton, L. J. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb01509.x · Cited by 286
Anemia and Hemoglobin Levels in Older Persons: Relationship with Age, Gender, and Health Status
Salive, M. E., Cornoni‐Huntley, J. C., Guralnik, J. M., Phillips, C. L., Wallace, R. B., Ostfeld, A. M., & Cohen, H. J. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb02017.x · Cited by 259
Prevalence and Causes of Anaemia in a Geriatric Hospitalized Population
Joosten, E., Pelemans, W., Hiele, M. I., Noyen, J., Verhaeghe, R., & Boogaerts, M. A. (2009) · Gerontology · doi:10.1159/000213315 · Cited by 222
Prevalence of Anemia and Correlation of Hemoglobin with Age in a Geriatric Screening Clinic Population
Timiras, M., & Brownstein, H. (1987) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1987.tb04340.x · Cited by 62
Validation of medical history taking as part of a population based survey in subjects aged 85 and over.
Lagaay, A. M., Meij, J., & Hijmans, W. (1992) · BMJ · doi:10.1136/bmj.304.6834.1091 · Cited by 59
Decline of blood haemoglobin in the aged: a longitudinal study of an urban Swedish Population from age 70 to 81
Nilsson‐Ehle, H., JAGENBURG, R., Landahl, S., Svanborg, A., & Westin, J. (1989) · British Journal of Haematology · doi:10.1111/j.1365-2141.1989.tb04303.x · Cited by 43
Three-year follow-up of Mini-Mental State Examination score in community residents aged 85 and over
Izaks, G. J., Gussekloo, J., Dermout, K. M. T., Heeren, T. J., & Ligthart, G. J. (1995) · Psychological Medicine · doi:10.1017/s0033291700035091 · Cited by 36
Self-citation

Show all 11 references

Sorted by citations

Items 301–400 of 488

Persistent injury-associated anemia and aging: Novel insights
Loftus, T. J., Kannan, K. B., Carter, C. S., Plazas, J. M., Mira, J. C., Brakenridge, S. C., Leeuwenburgh, C., Efron, P. A., & Mohr, A. M. (2017) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000001766 · Cited by 8
Preventing complications by persistence with iron replacement therapy: a comprehensive literature review
Serati, M., & Torella, M. (2018) · Current Medical Research and Opinion · doi:10.1080/03007995.2018.1552850 · Cited by 8
Anémies carentielles du sujet âgé
Serraj, K. A., Fédérici, L., Kaltenbach, G., & Andrès, E. (2008) · La Presse Médicale · doi:10.1016/j.lpm.2007.08.022 · Cited by 8
Causes and correlates of anemia in 200 patients with acute cardiogenic pulmonary edema
Rovellini, A., Graziadei, G., Folli, C., Brambilla, A. M., Cosentini, R., Canetta, C., & Monzani, V. (2012) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2012.06.012 · Cited by 8
Cancer-related anemia: special considerations in the elderly.
Balducci, L. (2007) · PubMed · Cited by 8
Automated Analyzer Evaluation of Reticulocytes in Bone Marrow and Peripheral Blood of Hematologic Disorders
Hirose, A., Yamane, T., Shibata, H., Kamitani, T., & Hino, M. (2005) · Acta Haematologica · doi:10.1159/000087887 · Cited by 8
Treatment of Kidney Disease and Anemia in Elderly, Long-Term Care Residents
Tangalos, E. G., Hoggard, J. G., Murray, A. M., & Thomas, D. R. (2004) · Journal of the American Medical Directors Association · doi:10.1016/s1525-8610(04)70140-1 · Cited by 8
Short and long term survival following hospitalization with a primary versus non-primary diagnosis of acute heart failure
Erez, A., Klempfner, R., Goldenberg, I., & Elis, A. (2015) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2015.05.007 · Cited by 7
Impact and treatment of anemia in the elderly: clinical, epidemiological and economic perspectives
Duh, M. S., Latypova, A., & Greenberg, P. E. (2006) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1586/14737167.6.5.577 · Cited by 7
Management of Anaemia in Prostate Cancer
Colloca, G. A., Venturino, A., Vitucci, P., & Gianni, W. (2009) · Cancer Investigation · doi:10.3109/07357900903124480 · Cited by 7
Association of anemia and SRH in older people: the SONIC study
Noma, T., Kabayama, M., Gondo, Y., Yasumoto, S., Masui, Y., Sugimoto, K., Akasaka, H., Godai, K., Higuchi, A., Akagi, Y., et al. (2020) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13945 · Cited by 7
Association of lower extremity function with nutritional status and number of drugs in patients with chronic heart failure
Morimoto, Y., Kawano, H., Miyanaga, K., Yano, Y., Fukushima, T., Kozu, R., Eishi, K., & Maemura, K. (2020) · Journal of International Medical Research · doi:10.1177/0300060520964374 · Cited by 7
The Cardio‐Renal‐Anemia Syndrome in Elderly Subjects With Heart Failure and a Normal Ejection Fraction: A Comparison With Heart Failure and Low Ejection Fraction
Cohen, R. S., Mubashir, A., Wajahat, R., Mani, S., Hummel, S. L., & Maurer, M. S. (2006) · Congestive Heart Failure · doi:10.1111/j.1527-5299.2006.05412.x · Cited by 7
Prognostic value of hemodynamics and comorbidities in pulmonary hypertension due to advanced heart failure
Quan, R., Huang, L., Yang, T., Li, W., Gu, Q., Xiong, C., & He, J. (2019) · Heart & Lung · doi:10.1016/j.hrtlng.2019.10.003 · Cited by 6
Lower cognitive function as a risk factor for anemia among older Japanese women from the longitudinal observation in the SONIC study
Noma, T., Godai, K., Kabayama, M., Gondo, Y., Yasumoto, S., Masui, Y., Sugimoto, K., Akasaka, H., Takami, Y., Takeya, Y., et al. (2023) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.14571 · Cited by 6
The Urgent Need for Nutritional Medical Care in Geriatric Patients—Malnutrition in Nursing Homes
Widhalm, H., Keintzel, M., Ohrenberger, G., & Widhalm, K. (2023) · Nutrients · doi:10.3390/nu15204367 · Cited by 7
The Effect of Hematocrit on All-Cause Mortality in Geriatric Patients with Hip Fractures: A Prospective Cohort Study
Zhang, Y., Li, K., Cao, W.-W., Chen, S., & Zhang, B.-F. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12052010 · Cited by 6
Diagnosis of anaemia: old things rearranged
Halwachs‐Baumann, G. (2012) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-012-0149-1 · Cited by 7
Transfusion in the Critically Ill
Cannon-Diehl, M. R. (2010) · Critical Care Nursing Quarterly · doi:10.1097/cnq.0b013e3181f649d3 · Cited by 6
Les carences vitaminiques : du symptôme au traitement
Serraj, K. A., Fédérici, L., Ciobanu, E., & Andrès, E. (2007) · MT. Médecine thérapeutique · doi:10.1684/met.2007.0138 · Cited by 6
Anemia and incidence of dementia in patients with new-onset type 2 diabetes: a nationwide population-based cohort study
Choi, J. W., Kim, T. H., & Han, E. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2020-001289 · Cited by 6
Anaemia and transfusion in nonagenarians undergoing emergency, non‐traumatic surgery: a prospective observational study
Pelavski, A. D., Miguel, M. D., Lacasta, A., Rochera, M. I., & Roca, M. (2013) · Transfusion Medicine · doi:10.1111/tme.12011 · Cited by 6
Complications of cytotoxic chemotherapy in older patients: focus on myelotoxicity in lymphomas
Zinzani, P. L. (2003) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2003.04.002 · Cited by 6
Anemia and Cancer
Benson, K., Balducci, L., & Aapro, M. (2007) · Springer eBooks · doi:10.1007/978-0-387-49506-4_8 · Cited by 6
Biology of the Aging Process and Its Clinical Consequences
Núñez, J. F. M., Casado, J.-M. R., del Rey, M. D. L. F., Quiroga, G. B., Tresguerres, J. A. F., Ariznavarreta, C., & López-Novoa, J. M. (2007) · Springer eBooks · doi:10.1007/978-0-387-72659-5_4 · Cited by 6
Target Hemoglobin in Patients with Renal Failure
Eckardt, K. (2001) · The Nephron journals/Nephron journals · doi:10.1159/000046060 · Cited by 6
Association of anemia with all-cause mortality in Chinese centenarians: a prospective cohort study
Jia, W., Wang, S., Yang, S., Zhao, Y., Zhu, Q. L., Ning, C., Chen, Y., Fu, S., Chen, Y., He, Y., et al. (2024) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2024.100248 · Cited by 5
The Association of Anemia With Survival Among People With HIV Following Antiretroviral Initiation in the NA-ACCORD 2007–2016
Lang, R., Coburn, S. B., Gill, M. J., Grossman, J. K., Gebo, K. A., Horberg, M. A., Mayor, Á. M., Justice, A. C., Bosch, R. J., Silverberg, M. J., et al. (2024) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000003502 · Cited by 5
Anaemia in elderly patients at discharge from intensive care and hospital
Sinha, R. K., Hakendorf, P. H., Sobieraj‐Teague, M., & Roxby, D. J. (2021) · Vox Sanguinis · doi:10.1111/vox.13109 · Cited by 5
Insulin-like Growth Factor-Binding Protein 3 and Hemoglobin Concentration in Older Persons Living in the Community
Landi, F., Russo, A., Capoluongo, E., Cesari, M., Liperoti, R., Danese, P., Bernabei, R., & Onder, G. (2007) · International Journal of Hematology · doi:10.1532/ijh97.e0629 · Cited by 5
The red cell diameter width distribution, the forgotten haematological parameter for anaemia in the older person
Batool, S., Wang, Q., Qureshi, S., & Chua, E. (2013) · European Geriatric Medicine · doi:10.1016/j.eurger.2012.02.001 · Cited by 5
Assessing the Quality of Prescribing and Monitoring Erythropoiesis-Stimulating Agents in the Nursing Home Setting
Wong, A.-K. I., Stephens, S. B., Aspinall, M. B., Visweswaran, S., Hanlon, J. T., & Handler, S. M. (2009) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2009.03.010 · Cited by 5
Assesment of the patients presenting with severe anemia to the emergency internal medicine clinic
Akın, S. (2014) · Northern Clinics of Istanbul · doi:10.14744/nci.2014.10820 · Cited by 5
Effect of pre-operative hemoglobin level on early outcomes in patients undergoing urgent coronary artery bypass grafting
Sallam, A. A., & Hassan, E. (2018) · Journal of the Egyptian Society of Cardio-Thoracic Surgery · doi:10.1016/j.jescts.2018.11.006 · Cited by 5
The Role of Older Age in Normocytic Anaemia in Type 2 Diabetes Mellitus
Wee, Y. H., & Anpalahan, M. (2019) · Current Aging Science · doi:10.2174/1874609812666190627154316 · Cited by 5
Mild and moderate to severe early acute kidney injury following cardiac surgery among patients with heart failure and preserved vs. mid-range vs. reduced ejection fraction
Gao, Y., Wang, C., Li, J., Ji, B., Wang, J., Yan, F., & Wang, Y. (2022) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000001713 · Cited by 5
Agotamiento de las células madre hematopoyéticas y productos finales de la glicación avanzada en la anemia inexplicada de la persona mayor
Sestier, B. (2015) · Revista Española de Geriatría y Gerontología · doi:10.1016/j.regg.2015.03.006 · Cited by 5
Hematopoietic Capacity and Exceptional Survival: The Leiden Longevity Study
Willems, J. M., Trompet, S., Slagboom, P. E., de Craen, A. J. M., & Westendorp, R. G. J. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.01933.x · Cited by 5
Effect of urinary tract infection on the prevalence of anaemia among HIV patients in Benin City, Nigeria
Omoregie, R., & Eghafona, N. O. (2009) · Cited by 5
Relationship of hemoglobin, fatigue, and quality of life in anemic cancer patients
Butt, Z. A., & Cella, D. F. (2008) · Springer eBooks · doi:10.1007/978-3-211-69459-6_14 · Cited by 5
Acute Confusion in Terminally Ill Hospitalized Patients
Wakefield, B. J., & Johnson, J. A. (2001) · Journal of Gerontological Nursing · doi:10.3928/0098-9134-20010401-10 · Cited by 5
Current Status and Associated Factors of Anemia in Community-dwelling People Aged 75 Years or Older: A Cross-sectional Study
Kobayashi, K. (2025) · Asian Journal of Social Health and Behavior · doi:10.4103/shb.shb_381_24 · Cited by 4
Anemia is Associated with Mortality and Higher Hospitalization Rates in Elderly Patients Receiving Home Care: A Prospective Cohort Study
Yurt, N. Ş., & Yavuz, E. (2024) · Eurasian Journal of Family Medicine · doi:10.33880/ejfm.2024130102 · Cited by 4
Retrospective analysis of the prevalence and causes of anaemia in hospitalised elderly patients
Staden, A. M. V., & Weich, D. J. (2015) · South African Family Practice · doi:10.1080/20786190.2015.1071538 · Cited by 4
Descriptive study of the prevalence of anemia, hypertension, diabetes and quality of life in a randomly selected population of elderly subjects from São Paulo
Lacerda, J. U. C. E. T. D., Lopes, M. R., Ferreira, D. P., Fonseca, F. L. A., & Favaro, P. M. B. (2016) · Revista Brasileira de Hematologia e Hemoterapia · doi:10.1016/j.bjhh.2016.03.005 · Cited by 4
Every-Other-Week Darbepoetin Alfa in the Correction and Maintenance of Haemoglobin Levels in Elderly Patients with Chronic Kidney Disease
Krause, M. W., Raja, R. M., Agarwal, A. K., Silver, M. R., Scarlata, D., Sciarra, A., & Kewalramani, R. (2009) · Drugs & Aging · doi:10.2165/11316450-000000000-00000 · Cited by 4
Hazard classification of chemicals inducing haemolytic anaemia: An EU regulatory perspective
Müller, A., Jacobsen, H., Healy, E., McMickan, S., Istace, F., Blaude, M.-N., Howden, P. J., Fleig, H., & Schulte, A. (2006) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2006.04.004 · Cited by 4
Effects of Anemia on Rehabilitation Outcomes in Elderly Patients in the Post-Acute Care Setting
Witkoś, M., Uttaburanont, M., Lang, C., & Haddad, R. Y. (2009) · Topics in Geriatric Rehabilitation · doi:10.1097/tgr.0b013e3181b02d77 · Cited by 4
Pertinence des prescriptions de concentrés de globules rouges par le médecin urgentiste avant et après la mise en place d’un protocole
Langlais, M.-L., Dargère, M., Niger, C. L., & Goetghebeur, D. (2018) · Transfusion Clinique et Biologique · doi:10.1016/j.tracli.2018.03.003 · Cited by 4
The effects of beta blockade and clonidine on persistent injury-associated anemia
Loftus, T. J., Rosenthal, M. D., Croft, C. A., Smith, R. S., Moore, F. A., Brakenridge, S. C., Efron, P. A., & Mohr, A. M. (2018) · Journal of Surgical Research · doi:10.1016/j.jss.2018.06.001 · Cited by 4
Discharge Hemoglobin Impacts Functional Recovery After Lumbar Fusion
Nishizawa, M., Glassman, S. D., Djurasovic, M., Crawford, C. H., Gum, J. L., Dimar, J. R., Owens, R. K., Mathew, J., & Carreon, L. Y. (2025) · Spine · doi:10.1097/brs.0000000000005440 · Cited by 3
Incidence and factors associated with anemia among the geriatric population at a tertiary care hospital in southern India
Aithal, A. P., Amber, A. B., Hao, C., Gopalan, H. E., Krishnappan, S., Goonesinghe, V. U., & Kumar, N. (2023) · Rwanda medical journal · doi:10.4314/rmj.v80i1.4 · Cited by 4
Coexistent anemia modulates systemic inflammation and exacerbates disease severity and adverse treatment outcomes in tuberculosis
Dasan, B., Munisankar, S., Kumar, N. P., Moideen, K., Nancy, A., Nott, S., Viswanathan, V., Shanmugam, S., Hissar, S. S., Thiruvengadam, K., et al. (2025) · Frontiers in Tuberculosis · doi:10.3389/ftubr.2024.1462654 · Cited by 3
Anemia as a mediator: bridging the frailty index and hip fractures in older Chinese populations
Li, C., Zhao, X., Zhang, L., Ma, C., Zhang, W., & Ding, H. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1558074 · Cited by 3
Implication of antithrombotic agents on potential bleeding from endoscopically determined peptic ulcers, incidentally detected as surrogate markers for nsaids‐associated ulcers complication
Miyake, K., Kusunoki, M., Ueki, N., Nagoya, H., Kodaka, Y., Shindo, T., Kawagoe, T., Gudis, K., Futagami, S., Tsukui, T., et al. (2012) · Digestive Endoscopy · doi:10.1111/j.1443-1661.2012.01334.x · Cited by 3
Persistent injury-associated anemia in aged rats
Loftus, T. J., Kannan, K. B., Carter, C. S., Plazas, J. M., Mira, J. C., Brakenridge, S. C., Leeuwenburgh, C., Efron, P. A., & Mohr, A. M. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.01.001 · Cited by 3
Prognosis of Chronic Kidney Disease and Metabolic Syndrome in Adults With Congenital Heart Disease
Jang, S. Y., Kim, E. K., Chang, S., Huh, J., Song, J., Kang, I., & Park, S. W. (2023) · Journal of Korean Medical Science · doi:10.3346/jkms.2023.38.e375 · Cited by 3
Prevalence of Anemia among Adolescent Girls and Adult Women of Tea Garden Areas of Darjeeling and Jalpaiguri Districts of West Bengal
Manna, P. K., & Ghosh, D. (2014) · Journal of Life Sciences · doi:10.1080/09751270.2014.11885226 · Cited by 3
IJzergebreksanemie bij ouderen
Helsen, T., & Joosten, E. (2016) · Tijdschrift voor Gerontologie en Geriatrie · doi:10.1007/s12439-016-0171-7 · Cited by 3
CANCER-RELATED ANEMIA AND FRAILTY IN OLDER PERSONS
Cerullo, F., Gambassi, G., & Cesari, M. (2012) · The Journal of Frailty & Aging · doi:10.14283/jfa.2012.21 · Cited by 3
Single-and repeat-dose toxicity of HM10760A, a long-acting erythropoietin, in rats and monkeys
Lim, H.-K., Choi, J., Kim, D., Bae, S. M., Kim, D. K., Choi, I. Y., & Kim, H. H. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115126 · Cited by 3
Anemia and Aging or Anemia of Aging?
Balducci, L., & Aapro, M. (2007) · Springer eBooks · doi:10.1007/978-0-387-49506-4_2 · Cited by 3
Cancer Survivorship Issues in Older Adults
Malek, K. S., & Silliman, R. A. (2007) · Springer eBooks · doi:10.1007/978-0-387-68265-5_16 · Cited by 3
Impact of Chronic Anemia on the New-Onset Atrial Fibrillation in the Elderly: It May Not Be What We Have Thought.
Ganga, H. V., Kolla, N., Zimmerman, M. B., & Miller, W. L. (2012) · Europe PMC (PubMed Central) · doi:10.4022/jafib.515 · Cited by 3
Nutritional Anemia in Older Persons
Morley, J. E., & Thomas, D. R. (2007) · CRC Press eBooks · doi:10.1201/9781420005493-35 · Cited by 3
Hematologic Disorders
Grant, S. J., & Jiang, D. C. (2024) · Springer eBooks · doi:10.1007/978-3-030-74720-6_53 · Cited by 3
The prognostic value of anemia, right-heart catheterization and neurohormones in chronic heart failure
Gardner, R. S., & McDonagh, T. A. (2006) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.4.1.51 · Cited by 3
Acute Confusional State in Elderly Patients with Hip Fracture. Identification of risk factors and intervention using a prehospital and perioperative management program
Björkelund, K. B. (2008) · Lund University Publications (Lund University) · Cited by 3
The effect of somatic disorders on brain aging and dementia : Findings from population studies
Atti, A. R. (2009) · Figshare · Cited by 3
Anemia in Older Patients
Hassaballa, H. (1999) · JAMA · doi:10.1001/jama.282.21.2001 · Cited by 3
¿Puede la anemia del anciano ser una manifestación del envejecimiento normal?
Lafuente, B. J. A., & Almenara, J. L. S. (2001) · Revista Española de Geriatría y Gerontología · doi:10.1016/s0211-139x(01)74689-6 · Cited by 3
Prevalência de anemia em idosos, causas de persistência ou recorrência e sua relação com demência: resultados do São Paulo Ageing and Health Study
Santos, I. D. S. (2009) · doi:10.11606/t.5.2009.tde-05022010-164250 · Cited by 3
Radiomics-based prediction of intraoperative blood loss during intracranial meningiomas surgery
Filimonova, E., Pashkov, A. A., Poptsova, A., Abdilatipov, A. A., Barabanov, I., Uzhakova, E. K., Kalinovsky, A., & RZAEV, J. A. (2025) · Neurosurgical Review · doi:10.1007/s10143-025-03802-9 · Cited by 2
Hematologic Disorders
Grant, S. J., & Jiang, D. C. (2023) · Springer eBooks · doi:10.1007/978-3-030-01782-8_53-1 · Cited by 2
Anemia and Quality of Life: Association with Diagnosis and Treatment of Anemias
Thomas, D. R. (2009) · Springer eBooks · doi:10.1007/978-0-387-78665-0_111 · Cited by 2
Anemia and Physical Health Decline in Old Age
Penninx, B. W. J. H. (2007) · Springer eBooks · doi:10.1007/978-0-387-49506-4_10 · Cited by 2
Anémie et transfusion chez le patient âgé en médecine d’urgence
Zerah, L., & Boddaert, J. (2011) · Les cahiers de l année gérontologique · doi:10.1007/s12612-011-0185-2 · Cited by 2
Heart failure performance measures: Eligibility and implementation in the community
Berardi, C., Chamberlain, A. M., Bursi, F., Redfield, M. M., McNallan, S. M., Weston, S. A., Jiang, R., & Roger, V. L. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.03.008 · Cited by 2
Les syndromes myélodysplasiques
Beyne‐Rauzy, O. (2012) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2012.09.015 · Cited by 2
Nutritional Anemia in Elderly Patients of Developed Countries
Andrès, E. (2018) · InTech eBooks · doi:10.5772/intechopen.70566 · Cited by 2
Non-Pharmacological Interventions for Anemia Treatment: Systematic Review
Putri, S. Z., Budu, B., Gemini, G., & Natsir, R. (2021) · Muhammadiyah International Public Health and Medicine Proceeding · doi:10.53947/miphmp.v1i1.56 · Cited by 2
Oxidative stress in older patients with iron deficiency anaemia
Baccin, A. C., Lazzaretti, L. L., Brandao, V. D. M., Manfredini, V., Peralba, M. C. R., & Benfato, M. S. (2009) · The journal of nutrition health & aging · doi:10.1007/s12603-009-0125-7 · Cited by 2
Post-surgery survival and associated factors for cardiac patients in Ethiopia: applications of machine learning, semi-parametric and parametric modelling
Tadege, M., Tegegne, A. S., & Dessie, Z. G. (2024) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-024-02480-9 · Cited by 2
Iron deposit state and risk factors for anemia in the elderly.
Eliana, F., Soejono, C. H., Widjanarko, A., Albar, Z., & Bachtiar, A. (2005) · PubMed · Cited by 2
A threshold trajectory was revealed by isolating the effects of hemoglobin rate of rise in anemia of chronic kidney disease
Fusco, G., Hariri, A., Vallarino, C. R., Singh, A. K., Yu, P., & Wise, L. (2017) · Therapeutic Advances in Drug Safety · doi:10.1177/2042098617716819 · Cited by 2
The Vitamin D Status in Women in İzmir
Çolak, A., Dogan, N., Bozkurt, Ü., Avcı, R., & Karademirci, I. (2015) · The Anatolian Journal of General Medical Research · doi:10.5222/terh.2015.043 · Cited by 2
Geriatric assessment for the older adult with cancer
Hurria, A., & Cohen, H. J. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511763182.001 · Cited by 2
Anemia, Fatigue and Aging
Balducci, L. (2014) · Springer eBooks · doi:10.1007/978-1-4471-2837-3_2 · Cited by 2
Evaluation and Management of Anemia in Older Individuals
Thomas, D. R., & Cepeda, O. A. (2006) · Aging Health · doi:10.2217/1745509x.2.2.303 · Cited by 2
Wissenschaftliche Erläuterungen zur Stellungnahme Transfusionsassoziierte Immunmodulation (TRIM) des Arbeitskreises Blut vom 13. Februar 2020
(2020) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-020-03183-y · Cited by 2
Anemia Frequency in Geriatric Patients Receiving Home Health Care: A Retrospective Study
Turker, S., Seyis, E. C., Özkoç, M. N. S., Bektaş, F., Karakullukçu, S., & Ardıç, C. (2023) · Eurasian Journal of Family Medicine · doi:10.33880/ejfm.2023120306 · Cited by 1
The utility of inpatient work-up of incidental anemia during hospitalization for an acute medical condition: A retrospective cohort study
Drozdinsky, G., Halperin, E., Kushnir, S., Rudman, Y., & Gafter‐Gvili, A. (2025) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2025.02.009 · Cited by 1
Hematological patterns of anemic patients reporting to government teritiary care centre in Mandya, South Karnataka
Yogender, P., & L, S. K. (2020) · IP Archives of Cytology and Histopathology Research · doi:10.18231/j.achr.2019.063 · Cited by 1
Preoperative Anemia as a Predictor of Morbidity and Mortality in Coronary Artery Bypass Grafting Surgical Patients: Our Four Years’ Experience
Ahmad, I., Islam, M. U., Shahid, M. A. R., Jan, A., Khan, B., Shakil, R., Shah, A., & Ali, F. A. (2022) · Pakistan BioMedical Journal · doi:10.54393/pbmj.v5i1.288 · Cited by 1
Foundation model-based haemoglobin concentration estimation and anaemia risk assessment from retinal fundus images
Kwak, S., Kim, J. A., Lee, H., Han, C., Chang, J., & Park, S. M. (2026) · Eye · doi:10.1038/s41433-026-04743-3 · Cited by 1
Les syndromes myélodysplasiques
Beyne‐Rauzy, O. (2011) · Springer eBooks · doi:10.1007/978-2-8178-0142-1_18 · Cited by 1
Does Delirium Need Immediate Medical Referral in a Frail, Homebound Elder?
Miller, A., & Mangione, K. K. (2006) · Journal of Geriatric Physical Therapy · doi:10.1519/00139143-200608000-00003 · Cited by 1
[Anemia in the elderly].
Maerevoet, M., Sattar, L. J., Bron, D., Gulbis, B., & Pepersack, T. (2014) · PubMed · Cited by 1
Anemias and Bone Marrow Insufficiency
Nöebauer-Huhmann, I.-M., & Uffmann, M. (2012) · Medical radiology · doi:10.1007/174_2012_726 · Cited by 1
Impact of anemia and red blood cell transfusion on organ function
Nowrousian, M. R. (2008) · Springer eBooks · doi:10.1007/978-3-211-69459-6_13 · Cited by 1

Authors: Izaks, G. J.
Affiliations: Leiden University Medical Center (NL)
Corresponding author: Izaks, Gerbrand J.
ORCID: Izaks, Gerbrand J.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 1999-05-12
Volume: 281
Issue: 18
Pages: 1714
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.281.18.1714
OpenAlex: W2034859046
Cited by: 495
References: 11
Citations by year: 2026: 2 · 2025: 8 · 2024: 10 · 2023: 12 · 2022: 17 · 2021: 13 · 2020: 14 · 2019: 21 · 2018: 21 · 2017: 16 · 2016: 12 · 2015: 24 · 2014: 24 · 2013: 21 · 2012: 34
FWCI: 3.93
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1r01ag006354-01)
National Institute on Aging (AG-06354)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Keywords: anemia, hemoglobin levels, older adults, mortality, cause-specific mortality, survival, sex differences, infectious disease mortality
MeSH terms: Aged, Aged, 80 and over, Anemia, Cause of Death, Female, Hemoglobins, Humans, Male, Risk, Proportional Hazards Models, Survival Analysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Definition of Anemia in Older Persons

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks