The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The Definition of Anemia in Older Persons
Abstract
CONTEXT: Whether hemoglobin concentrations defined as anemia by the World Health Organization (WHO) are associated with increased mortality in older persons is not known. OBJECTIVE: To investigate the association between hemoglobin concentration and cause-specific mortality in older persons. DESIGN: Community-based study conducted from 1986 to 1996 (follow-up period, 10 years). SETTING: Leiden, the Netherlands. PARTICIPANTS: A total of 1016 community residents aged 85 years and older were eligible and 872 agreed to have a blood sample taken. Hemoglobin concentration was measured in 755 persons (74%). MAIN OUTCOME MEASURES: Hemoglobin concentration, 10-year survival, and primary cause of death. According to the WHO criteria, anemia was defined as a hemoglobin concentration below 7.5 mmol/L (120 g/L) in women and below 8.1 mmol/L (130 g/L) in men. RESULTS: Compared with persons with a normal hemoglobin concentration, the mortality risk was 1.60 (95% confidence interval [CI], 1.24-2.06; P<.001) in women with anemia, and 2.29 (95% CI, 1.60-3.26; P<.001) in men with anemia. In both sexes, the mortality risk increased with lower hemoglobin concentrations. In persons without self-reported clinical disease at baseline, the mortality risk of anemia was 2.21 (95% CI, 1.37-3.57; P=.002). Mortality from malignant and infectious diseases was higher in persons with anemia. CONCLUSIONS: Anemia defined by the WHO criteria was associated with an increased mortality risk in persons aged 85 years and older. The criteria are thus appropriate for older persons. A low hemoglobin concentration at old age signifies disease.
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“Serum hepcidin was measured by enzyme-linked immunosorbent assay (Intrinsic Life Sciences) with sensitivity of 5 ng/mL, interassay coefficient of variation 12%, and range 29-254 ng/ mL in men (12,15).”
From Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point (2014) · cites this paper as [15]
In the citing paper
“Serum hepcidin and ferritin levels were within the reported reference ranges for men and similar between groups (15).”
From Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point (2014) · cites this paper as [15]
Citations
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
International Classification of Diseases, Ninth Revision
National Cancer Institute (2020) · Definitions · doi:10.32388/bd1nux · Cited by 891
Total cholesterol and risk of mortality in the oldest old
Weverling-Rijnsburger, A. W., Blauw, G. J., Lagaay, A. M., Knock, D. L., Meinders, A. E., & Westendorp, R. G. (1997) · The Lancet · doi:10.1016/s0140-6736(97)04430-9 · Cited by 474
Incidence of Anemia in Older People: An Epidemiologic Study in a Well Defined Population
Anía, B. J., Suman, V. J., Fairbanks, V. F., Rademacher, D. M., & Melton, L. J. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb01509.x · Cited by 286
Anemia and Hemoglobin Levels in Older Persons: Relationship with Age, Gender, and Health Status
Salive, M. E., Cornoni‐Huntley, J. C., Guralnik, J. M., Phillips, C. L., Wallace, R. B., Ostfeld, A. M., & Cohen, H. J. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb02017.x · Cited by 259
Prevalence and Causes of Anaemia in a Geriatric Hospitalized Population
Joosten, E., Pelemans, W., Hiele, M. I., Noyen, J., Verhaeghe, R., & Boogaerts, M. A. (2009) · Gerontology · doi:10.1159/000213315 · Cited by 222
Timiras, M., & Brownstein, H. (1987) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1987.tb04340.x · Cited by 62
Lagaay, A. M., Meij, J., & Hijmans, W. (1992) · BMJ · doi:10.1136/bmj.304.6834.1091 · Cited by 59
Nilsson‐Ehle, H., JAGENBURG, R., Landahl, S., Svanborg, A., & Westin, J. (1989) · British Journal of Haematology · doi:10.1111/j.1365-2141.1989.tb04303.x · Cited by 43
Three-year follow-up of Mini-Mental State Examination score in community residents aged 85 and over
Izaks, G. J., Gussekloo, J., Dermout, K. M. T., Heeren, T. J., & Ligthart, G. J. (1995) · Psychological Medicine · doi:10.1017/s0033291700035091 · Cited by 36
Self-citationIzaks, G. J., van Houwelingen, H. C., Schreuder, G. M. T., & Ligthart, G. J. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb00978.x · Cited by 19
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Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study
Hurria, A., Togawa, K., Mohile, S. G., Owusu, C., Klepin, H. D., Gross, C. P., Lichtman, S. M., Gajra, A., Bhatia, S., Katheria, V., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.34.7625 · Cited by 1,841
Guralnik, J. M., Eisenstaedt, R. S., Ferrucci, L., Klein, H. G., & Woodman, R. C. (2004) · Blood · doi:10.1182/blood-2004-05-1812 · Cited by 1,450
Use of comprehensive geriatric assessment in older cancer patients:
Extermann, M., Aapro, M., Bernabei, R., Cohen, H. J., Droz, J.-P., Lichtman, S., Mor, V., Monfardini, S., Repetto, L., Sørbye, L., et al. (2005) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2005.06.003 · Cited by 1,098
Management of Cancer in the Older Person: A Practical Approach
Balducci, L., & Extermann, M. (2000) · The Oncologist · doi:10.1634/theoncologist.5-3-224 · Cited by 937
Systolic and Diastolic Heart Failure in the Community
Bursi, F., Weston, S. A., Redfield, M. M., Jacobsen, S. J., Pakhomov, S., Nkomo, V. T., Meverden, R. A., & Roger, V. L. (2006) · JAMA · doi:10.1001/jama.296.18.2209 · Cited by 891
Metadata
- Authors
- Izaks, G. J.
- Affiliations
- Leiden University Medical Center (NL)
- Corresponding author
- Izaks, Gerbrand J.
- ORCID
- Izaks, Gerbrand J.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1999-05-12
- Volume
- 281
- Issue
- 18
- Pages
- 1714
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2034859046
- Cited by
- 495
- References
- 11
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 10 · 2023: 12 · 2022: 17 · 2021: 13 · 2020: 14 · 2019: 21 · 2018: 21 · 2017: 16 · 2016: 12 · 2015: 24 · 2014: 24 · 2013: 21 · 2012: 34
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r01ag006354-01)
- National Institute on Aging (AG-06354)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- anemia, hemoglobin levels, older adults, mortality, cause-specific mortality, survival, sex differences, infectious disease mortality
- MeSH terms
- Aged, Aged, 80 and over, Anemia, Cause of Death, Female, Hemoglobins, Humans, Male, Risk, Proportional Hazards Models, Survival Analysis
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