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Cited by 325BRCA gene mutations in cancerWomen's cancer prevention and managementBreast Implant and Reconstruction

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Long-term Satisfaction and Psychological and Social Function Following Bilateral Prophylactic Mastectomy

Frost, Marlene H.·2000·JAMA
DOI 10.1001/jama.284.3.319
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Abstract

CONTEXT: Prophylactic mastectomy is a preventive option for women who wish to reduce their risk of breast cancer. There has been concern about possible negative psychological sequelae following this procedure. However, few data are available regarding long-term satisfaction and psychological and social function following this procedure. OBJECTIVE: To evaluate patients' long-term satisfaction and psychological and social function following prophylactic mastectomy. DESIGN, SETTING, AND PARTICIPANTS: Descriptive study of all women known to be alive (n = 609) who had a family history of breast cancer and elected to undergo bilateral prophylactic mastectomy at a large, tertiary US health care clinic between 1960 and 1993, 94% (n = 572) of whom completed a study questionnaire. MAIN OUTCOME MEASURES: Satisfaction with procedure and effects on psychological and social function, based on responses to the study-specific questionnaire. RESULTS: Mean time from prophylactic mastectomy to last follow-up was 14.5 years. Most women (70%) were satisfied with the procedure; 11% were neutral; and 19% were dissatisfied. Among the psychological and social variables, the most striking finding was that 74% reported a diminished level of emotional concern about developing breast cancer. The majority of women reported no change/favorable effects in levels of emotional stability (68%/23%), level of stress (58%/28%), self-esteem (69%/13%), sexual relationships (73%/4%), and feelings of femininity (67%/8%). Forty-eight percent reported no change in their level of satisfaction with body appearance; 16% reported favorable effects. However, 9%, 14%, 18%, 23%, 25%, and 36% reported negative effects in these 6 variables, respectively. CONCLUSIONS: This study suggests that positive outcomes following prophylactic mastectomy include decreased emotional concern about developing breast cancer and generally favorable psychological and social outcomes. These must be weighed against the irreversibility of the decision, potential problems with implants and reconstructive surgery, and occurrence of adverse psychological and social outcomes in some women. JAMA. 2000;284:319-324

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Metadata

Authors
Frost, M. H.
Affiliations
Mayo Clinic (US)
Corresponding author
Frost, Marlene H.
Venue
JAMA
Publisher
American Medical Association (AMA)
Published
2000-07-19
Volume
284
Issue
3
Pages
319
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.284.3.319
OpenAlex
W2104836626
Cited by
325
References
14
Citations by year
2026: 5 · 2025: 3 · 2024: 5 · 2023: 7 · 2022: 8 · 2021: 14 · 2020: 10 · 2019: 10 · 2018: 16 · 2017: 20 · 2016: 12 · 2015: 7 · 2014: 10 · 2013: 9 · 2012: 14
FWCI
9.72
Type
journal article
Language
en
Open access
closed
Locations
  • JAMA (publishedVersion)
  • PubMed (publishedVersion)
Funders
U.S. Public Health Service (R01-80181)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
  • Health Sciences › Medicine › Surgery › Breast Implant and Reconstruction
Keywords
prophylactic mastectomy, bilateral mastectomy, breast cancer prevention, patient satisfaction, psychological outcomes, social functioning, self-esteem, body image, family history of breast cancer, long-term outcomes
MeSH terms
Adaptation, Psychological, Adult, Breast Neoplasms, Female, Follow-Up Studies, Humans, Mastectomy, Middle Aged, Social Behavior, Linear Models, Patient Satisfaction, Statistics, Nonparametric

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