The DOI matches its Crossref record; 51 of the 52 references it cites were found in a registry or an index.
Age-Related Changes in Slow Wave Sleep and REM Sleep and Relationship With Growth Hormone and Cortisol Levels in Healthy Men
Abstract
CONTEXT: In young adults, sleep affects the regulation of growth hormone (GH) and cortisol. The relationship between decreased sleep quality in older adults and age-related changes in the regulation of GH and cortisol is unknown. OBJECTIVE: To determine the chronology of age-related changes in sleep duration and quality (sleep stages) in healthy men and whether concomitant alterations occur in GH and cortisol levels. DESIGN AND SETTING: Data combined from a series of studies conducted between 1985 and 1999 at 4 laboratories. SUBJECTS: A total of 149 healthy men, aged 16 to 83 years, with a mean (SD) body mass index of 24.1 (2.3) kg/m( 2), without sleep complaints or histories of endocrine, psychiatric, or sleep disorders. MAIN OUTCOME MEASURES: Twenty-four-hour profiles of plasma GH and cortisol levels and polygraphic sleep recordings. RESULTS: The mean (SEM) percentage of deep slow wave sleep decreased from 18.9% (1.3%) during early adulthood (age 16-25 years) to 3.4% (1.0%) during midlife (age 36-50 years) and was replaced by lighter sleep (stages 1 and 2) without significant increases in sleep fragmentation or decreases in rapid eye movement (REM) sleep. The transition from midlife to late life (age 71-83 years) involved no further significant decrease in slow wave sleep but an increase in time awake of 28 minutes per decade at the expense of decreases in both light non-REM sleep (-24 minutes per decade; P<.001) and REM sleep (-10 minutes per decade; P<.001). The decline in slow wave sleep from early adulthood to midlife was paralleled by a major decline in GH secretion (-372 microg per decade; P<.001). From midlife to late life, GH secretion further declined at a slower rate (-43 microg per decade; P<.02). Independently of age, the amount of GH secretion was significantly associated with slow wave sleep (P<.001). Increasing age was associated with an elevation of evening cortisol levels (+19. 3 nmol/L per decade; P<.001) that became significant only after age 50 years, when sleep became more fragmented and REM sleep declined. A trend for an association between lower amounts of REM sleep and higher evening cortisol concentrations independent of age was detected (P<.10). CONCLUSIONS: In men, age-related changes in slow wave sleep and REM sleep occur with markedly different chronologies and are each associated with specific hormonal alterations. Future studies should evaluate whether strategies to enhance sleep quality may have beneficial hormonal effects. JAMA. 2000;284:861-868
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“age-related changes are associated with a dysregulation of the circadian rhythm of the HPA axis (Al-Turk and Al-Dujaili, 2016;Heaney et al., 2012), further leading to sleep problems (Van Cauter et al., 2000).”
From The effects of physical activity on cortisol and sleep: A systematic review and meta-analysis. (2022) · cites this paper as Van Cauter et al., 2000
In the citing paper
“it was observed that a decrease in the amount of REM sleep (stable and unchanged until 50 years of age, decreased by approximately 50% in late life compared with young adulthood) occurred in synchrony with an elevation of evening cortisol levels.”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [49]
In the citing paper
“A trend for an association between lower amounts of REM sleep and higher evening cortisol concentrations, independently of age, was also detected [49].”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [49]
Citations
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Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol
Van Cauter, E. (1996) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.7.2468 · Cited by 951
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Human growth hormone and human aging
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Feast and Famine: Critical Role of Glucocorticoids with Insulin in Daily Energy Flow
Dallman, M. F., Strack, A. M., Akana, S. F., Bradbury, M. J., Hanson, E. S., Scribner, K. A., & Smith, M. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1010 · Cited by 796 · cited 2×
“Studies in both animals and humans have indicated that deleterious effects of HPA hyperactivity are more pronounced at the time of the trough of the rhythm than at the time of the peak.(25,54) Thus, modest elevations in evening cortisol levels could facilitate the development of central and peripheral disturbances ass…”
BackgroundSleep Loss Results in an Elevation of Cortisol Levels the Next Evening
(1997) · Sleep · doi:10.1093/sleep/20.10.865 · Cited by 745 · cited 1×
“Furthermore, even partial sleep deprivation results in an elevation of cortisol levels the following evening.(21) Thus, both decreased SW sleep and sleep loss resulting from increased sleep fragmentation could contribute to elevating cortisol levels.”
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Adler, N. E., Epel, E. S., Castellazzo, G., & Ickovics, J. R. (2000) · Health Psychology · doi:10.1037/0278-6133.19.6.586 · Cited by 5,080
Ohayon, M. M., Carskadon, M. A., Guilleminault, C., & Vitiello, M. V. (2004) · Sleep · doi:10.1093/sleep/27.7.1255 · Cited by 3,349
A marker for the end of adolescence
Roenneberg, T., Kuehnle, T., Pramstaller, P. P., Ricken, J., Havel, M., Guth, A., & Merrow, M. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.039 · Cited by 1,585
Epidemiology of the human circadian clock
Roenneberg, T., Kuehnle, T., Juda, M., Kantermann, T., Allebrandt, K., Gordijn, M., & Merrow, M. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.07.005 · Cited by 1,545
Mander, B. A., Winer, J. R., & Walker, M. P. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.004 · Cited by 1,281
Metadata
- Authors
- Van Cauter, E.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2000-08-16
- Volume
- 284
- Issue
- 7
- Pages
- 861
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2035490031
- Semantic Scholar
- 7e085c801202adf0cc333fa840264be285802ae2
- Cited by
- 773
- References
- 52
- Citations by year
- 2026: 25 · 2025: 31 · 2024: 35 · 2023: 28 · 2022: 28 · 2021: 51 · 2020: 40 · 2019: 35 · 2018: 36 · 2017: 22 · 2016: 35 · 2015: 33 · 2014: 31 · 2013: 33 · 2012: 38
- FWCI
- 10.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- National Institute on Aging (P01AG011412, AG-11412)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-41814, R01DK041814)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- age-related sleep changes, slow-wave sleep, REM sleep, growth hormone secretion, cortisol, sleep stages, sleep fragmentation, aging, men, sleep quality, circadian rhythm, NREM sleep, healthy men, polygraphic sleep recording, plasma hormone levels
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Aging, Analysis of Variance, Humans, Hydrocortisone, Male, Middle Aged, Sleep, Sleep, REM, Body Mass Index, Polysomnography, Human Growth Hormone
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