Cited by 773Sleep and Wakefulness ResearchSleep and related disordersCircadian rhythm and melatonin

The DOI matches its Crossref record; 51 of the 52 references it cites were found in a registry or an index.

Age-Related Changes in Slow Wave Sleep and REM Sleep and Relationship With Growth Hormone and Cortisol Levels in Healthy Men

Van Cauter, Eve·2000·JAMA

Open this paper in CoChat — free account

Abstract

CONTEXT: In young adults, sleep affects the regulation of growth hormone (GH) and cortisol. The relationship between decreased sleep quality in older adults and age-related changes in the regulation of GH and cortisol is unknown. OBJECTIVE: To determine the chronology of age-related changes in sleep duration and quality (sleep stages) in healthy men and whether concomitant alterations occur in GH and cortisol levels. DESIGN AND SETTING: Data combined from a series of studies conducted between 1985 and 1999 at 4 laboratories. SUBJECTS: A total of 149 healthy men, aged 16 to 83 years, with a mean (SD) body mass index of 24.1 (2.3) kg/m( 2), without sleep complaints or histories of endocrine, psychiatric, or sleep disorders. MAIN OUTCOME MEASURES: Twenty-four-hour profiles of plasma GH and cortisol levels and polygraphic sleep recordings. RESULTS: The mean (SEM) percentage of deep slow wave sleep decreased from 18.9% (1.3%) during early adulthood (age 16-25 years) to 3.4% (1.0%) during midlife (age 36-50 years) and was replaced by lighter sleep (stages 1 and 2) without significant increases in sleep fragmentation or decreases in rapid eye movement (REM) sleep. The transition from midlife to late life (age 71-83 years) involved no further significant decrease in slow wave sleep but an increase in time awake of 28 minutes per decade at the expense of decreases in both light non-REM sleep (-24 minutes per decade; P<.001) and REM sleep (-10 minutes per decade; P<.001). The decline in slow wave sleep from early adulthood to midlife was paralleled by a major decline in GH secretion (-372 microg per decade; P<.001). From midlife to late life, GH secretion further declined at a slower rate (-43 microg per decade; P<.02). Independently of age, the amount of GH secretion was significantly associated with slow wave sleep (P<.001). Increasing age was associated with an elevation of evening cortisol levels (+19. 3 nmol/L per decade; P<.001) that became significant only after age 50 years, when sleep became more fragmented and REM sleep declined. A trend for an association between lower amounts of REM sleep and higher evening cortisol concentrations independent of age was detected (P<.10). CONCLUSIONS: In men, age-related changes in slow wave sleep and REM sleep occur with markedly different chronologies and are each associated with specific hormonal alterations. Future studies should evaluate whether strategies to enhance sleep quality may have beneficial hormonal effects. JAMA. 2000;284:861-868

Integrity signals

Registry

Crossref · 10.1001/jama.284.7.861

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A manual for standardized terminology, techniques and scoring system for sleep stages in human subjects
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772
Stress, adaptation, and disease. Allostasis and allostatic load
McEWEN, B. S. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09546.x · Cited by 5,092
Stress and cognitive function
McEwen, B. S., & Sapolsky, R. M. (1995) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(95)80028-x · Cited by 1,889
Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans
Dijk, D., & Czeisler, C. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03526.1995 · Cited by 1,356
Sleep Apnea and Daytime Sleepiness and Fatigue: Relation to Visceral Obesity, Insulin Resistance, and Hypercytokinemia
Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Hopper, K. D., Lotsikas, A. J., LIN, H., Kales, A., & Chrousos, G. P. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6484 · Cited by 1,209
Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol
Van Cauter, E. (1996) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.7.2468 · Cited by 951
Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations
HO, K. Y., EVANS, W. S., BLIZZARD, R. M., VELDHUIS, J. D., MERRIAM, G. R., SAMOJLIK, E., FURLANETTO, R., ROGOL, A. D., KAISER, D. L., & THORNER, M. O. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-1-51 · Cited by 921
Human growth hormone and human aging
CORPAS, E., HARMAN, S. M., & BLACKMAN, M. R. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-1-20 · Cited by 911
Feast and Famine: Critical Role of Glucocorticoids with Insulin in Daily Energy Flow
Dallman, M. F., Strack, A. M., Akana, S. F., Bradbury, M. J., Hanson, E. S., Scribner, K. A., & Smith, M. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1010 · Cited by 796 · cited 2×
“Studies in both animals and humans have indicated that deleterious effects of HPA hyperactivity are more pronounced at the time of the trough of the rhythm than at the time of the peak.(25,54) Thus, modest elevations in evening cortisol levels could facilitate the development of central and peripheral disturbances ass…”
Background
Sleep Loss Results in an Elevation of Cortisol Levels the Next Evening
(1997) · Sleep · doi:10.1093/sleep/20.10.865 · Cited by 745 · cited 1×
“Furthermore, even partial sleep deprivation results in an elevation of cortisol levels the following evening.(21) Thus, both decreased SW sleep and sleep loss resulting from increased sleep fragmentation could contribute to elevating cortisol levels.”
Background

Show all 52 references

Sorted by citations

Relationship of subjective and objective social status with psychological and physiological functioning: Preliminary data in healthy, White women.
Adler, N. E., Epel, E. S., Castellazzo, G., & Ickovics, J. R. (2000) · Health Psychology · doi:10.1037/0278-6133.19.6.586 · Cited by 5,080
Meta-Analysis of Quantitative Sleep Parameters From Childhood to Old Age in Healthy Individuals: Developing Normative Sleep Values Across the Human Lifespan
Ohayon, M. M., Carskadon, M. A., Guilleminault, C., & Vitiello, M. V. (2004) · Sleep · doi:10.1093/sleep/27.7.1255 · Cited by 3,349
A marker for the end of adolescence
Roenneberg, T., Kuehnle, T., Pramstaller, P. P., Ricken, J., Havel, M., Guth, A., & Merrow, M. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.039 · Cited by 1,585
Epidemiology of the human circadian clock
Roenneberg, T., Kuehnle, T., Juda, M., Kantermann, T., Allebrandt, K., Gordijn, M., & Merrow, M. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.07.005 · Cited by 1,545
Sleep and Human Aging
Mander, B. A., Winer, J. R., & Walker, M. P. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.004 · Cited by 1,281
Slow-wave sleep and the risk of type 2 diabetes in humans
Tasali, E., Leproult, R., Ehrmann, D. A., & Van Cauter, E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706446105 · Cited by 921
Metabolic consequences of sleep and sleep loss
Van Cauter, E., Spiegel, K., Tasali, E., & Leproult, R. (2008) · Sleep Medicine · doi:10.1016/s1389-9457(08)70013-3 · Cited by 812
Sleep in Normal Aging
Li, J., Vitiello, M. V., & Gooneratne, N. S. (2018) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2017.09.001 · Cited by 742
The effects of age, sex, ethnicity, and sleep-disordered breathing on sleep architecture
Redline, S., Kirchner, H. L., Quan, S. F., Gottlieb, D. J., Kapur, V., & Newman, A. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.4.406 · Cited by 732
The aging clock: circadian rhythms and later life
Hood, S., & Amir, S. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90328 · Cited by 645
Sleep problems: an emerging global epidemic? Findings from the INDEPTH WHO-SAGE study among more than 40,000 older adults from 8 countries across Africa and Asia
Stranges, S., Tigbe, W., Gómez-Olivé, F. X., Thorogood, M., & Kandala, N.-B. (2012) · Sleep · doi:10.5665/sleep.2012 · Cited by 592
Bidirectional relationship between sleep and Alzheimer’s disease: role of amyloid, tau, and other factors
Wang, C., & Holtzman, D. M. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-019-0478-5 · Cited by 615
Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging
Mander, B. A., Rao, V., Lu, B., Saletin, J. M., Lindquist, J. R., Ancoli-Israel, S., Jagust, W., & Walker, M. P. (2013) · Nature Neuroscience · doi:10.1038/nn.3324 · Cited by 606
β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation
Mander, B. A., Marks, S. M., Vogel, J. W., Rao, V., Lu, B., Saletin, J. M., Ancoli-Israel, S., Jagust, W. J., & Walker, M. P. (2015) · Nature Neuroscience · doi:10.1038/nn.4035 · Cited by 569
The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids
Oster, H., Challet, E., Ott, V., Arvat, E., de Kloet, E. R., Dijk, D.-J., Lightman, S., Vgontzas, A., & Van Cauter, E. (2017) · Endocrine Reviews · doi:10.1210/er.2015-1080 · Cited by 548
Epidemiology of obstructive sleep apnea: a population-based perspective
Lee, W. J., Nagubadi, S., Kryger, M. H., & Mokhlesi, B. (2008) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2.3.349 · Cited by 528
Sleep and obesity
Beccuti, G., & Pannain, S. (2011) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e3283479109 · Cited by 507
Mindfulness Meditation and Improvement in Sleep Quality and Daytime Impairment Among Older Adults With Sleep Disturbances: A Randomized Clinical Trial
Black, D. S., O’Reilly, G. A., Olmstead, R., Breen, E. C., & Irwin, M. R. (2015) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2014.8081 · Cited by 491
Sleep and Alzheimer's disease
Peter‐Derex, L., Yammine, P., Bastuji, H., & Croisile, B. (2014) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.03.007 · Cited by 489
Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension
Scheer, F. A. J. L., Van Montfrans, G. A., van Someren, E. J. W., Mairuhu, G., & Buijs, R. M. (2004) · Hypertension · doi:10.1161/01.hyp.0000113293.15186.3b · Cited by 451
Sleep Disorders in the Older Adult – A Mini-Review
Neikrug, A. B., & Ancoli‐Israel, S. (2009) · Gerontology · doi:10.1159/000236900 · Cited by 438
Psychological and metabolic stress: A recipe for accelerated cellular aging?
Epel, E. S. (2009) · HORMONES · doi:10.14310/horm.2002.1217 · Cited by 424
A meta-analysis of cortisol response to challenge in human aging: importance of gender
Otte, C., Hart, S. L., Neylan, T. C., Marmar, C. R., Yaffe, K. S., & Mohr, D. C. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.06.002 · Cited by 438
Sleep, the hypothalamic-pituitary-adrenal axis, and cytokines: multiple interactions and disturbances in sleep disorders
Vgontzas, A. N., & Chrousos, G. P. (2002) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(01)00005-6 · Cited by 414
Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity
Balbo, M., Leproult, R., & Van Cauter, E. (2010) · International Journal of Endocrinology · doi:10.1155/2010/759234 · Cited by 408
“Most early studies investigating this topic, limited by small sample sizes and heterogeneous composition, seemed to indicate that there are no major sex and age differences in basal functioning of the HPA axis [27–29].”
Background
Invited Review: Integration of human sleep-wake regulation and circadian rhythmicity
Dijk, D., & Lockley, S. W. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00924.2001 · Cited by 394
Multilevel functional principal component analysis
Di, C., Crainiceanu, C. M., Caffo, B. S., & Punjabi, N. M. (2009) · The Annals of Applied Statistics · doi:10.1214/08-aoas206 · Cited by 376
Obstructive sleep apnea basics
Rundo, J. V. (2019) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.86.s1.02 · Cited by 403
Understanding sleep disturbance in athletes prior to important competitions
Juliff, L. E., Halson, S. L., & Peiffer, J. J. (2014) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2014.02.007 · Cited by 372
Reduced non–rapid eye movement sleep is associated with tau pathology in early Alzheimer’s disease
Lucey, B. P., McCullough, A. A., Landsness, E. C., Toedebusch, C. D., McLeland, J., Zaza, A., Fagan, A. M., McCue, L. M., Xiong, C., Morris, J. C., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau6550 · Cited by 386
Risk factors for sleep disturbances in older adults: Evidence from prospective studies
Smagula, S. F., Stone, K. L., Fabio, A., & Cauley, J. A. (2015) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.01.003 · Cited by 342
Sleep benefits subsequent hippocampal functioning
Van Der Werf, Y. D., Altena, E., Schoonheim, M. M., Sanz-Arigita, E. J., Vis, J. C., De Rijke, W., & Van Someren, E. J. W. (2009) · Nature Neuroscience · doi:10.1038/nn.2253 · Cited by 313
Aging of the Immune System as a Prognostic Factor for Human Longevity
Larbi, A., Franceschi, C., Mazzatti, D. J., Solana, R., Wikby, A., & Pawelec, G. (2008) · Physiology · doi:10.1152/physiol.00040.2007 · Cited by 316
Concurrent Impairments in Sleep and Memory in Amnestic Mild Cognitive Impairment
Westerberg, C. E., Mander, B. A., Florczak, S. M., Weıntraub, S., Mesulam, M. M., Zee, P. C., & Paller, K. A. (2012) · Journal of the International Neuropsychological Society · doi:10.1017/s135561771200001x · Cited by 318
Reduced risk for overweight and obesity in 5- and 6-y-old children by duration of sleep—a cross-sectional study
von Kries, R., Toschke, A. M., Wurmser, H., Sauerwald, T. U., & Koletzko, B. V. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801980 · Cited by 303
Dehydroepiandrosterone (DHEA) stimulates neurogenesis in the hippocampus of the rat, promotes survival of newly formed neurons and prevents corticosterone-induced suppression
Karishma, K. K., & Herbert, J. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02099.x · Cited by 297
Sleep disturbances are correlated with decreased morning awakening salivary cortisol
Backhaus, J., Junghanns, K., & Hohagen, F. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.01.010 · Cited by 301
Insomnia Symptoms in Older Adults: Associated Factors and Gender Differences
Jaussent, I., Dauvilliers, Y., Ancelin, M.-L., Dartigues, J.-F., Tavernier, B., Touchon, J., Ritchie, K., & Besset, A. (2011) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181e049b6 · Cited by 286
The effects of physical activity on cortisol and sleep: A systematic review and meta-analysis.
De Nys, L., Anderson, K., Ofosu, E. F., Ryde, G. C., Connelly, J., & Whittaker, A. C. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105843 · Cited by 279
Aging-Related Sleep Changes
Espiritu, J. R. D. (2007) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2007.08.007 · Cited by 276
Subjective and Objective Sleep Quality and Aging in the Sleep Heart Health Study
Unruh, M. L., Redline, S. S., An, M., Buysse, D. J., Nieto, F. J., Yeh, J.-L., & Newman, A. B. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.01755.x · Cited by 271
Age-Related Reduction in Daytime Sleep Propensity and Nocturnal Slow Wave Sleep
Dijk, D., Groeger, J. A., Stanley, N., & Deacon, S. (2010) · SLEEP · doi:10.1093/sleep/33.2.211 · Cited by 272
Slow-wave sleep: From the cell to the clinic
Léger, D., Debellemanière, E., Rabat, A., Bayon, V., Benchenane, K., & Chennaoui, M. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.01.008 · Cited by 284
Sleep, Anesthesiology, and the Neurobiology of Arousal State Control
Lydic, R., & Baghdoyan, H. A. (2005) · Anesthesiology · doi:10.1097/00000542-200512000-00024 · Cited by 253
Social relationships, sleep quality, and interleukin-6 in aging women
Friedman, E. M., Hayney, M. S., Love, G. D., Urry, H. L., Rosenkranz, M. A., Davidson, R. J., Singer, B. H., & Ryff, C. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509281102 · Cited by 247
Aging and Sleep: Physiology and Pathophysiology
Edwards, B. A., O’Driscoll, D. M., Ali, A., Jordan, A. S., Trinder, J. C., & Malhotra, A. (2010) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0030-1265902 · Cited by 263
Does inadequate sleep play a role in vulnerability to obesity?
Knutson, K. L. (2012) · American Journal of Human Biology · doi:10.1002/ajhb.22219 · Cited by 241
Timing and Consolidation of Human Sleep, Wakefulness, and Performance by a Symphony of Oscillators
Dijk, D., & von Schantz, M. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730405278292 · Cited by 243
Impaired Nighttime Sleep in Healthy OldVersusYoung Adults Is Associated with Elevated Plasma Interleukin-6 and Cortisol Levels: Physiologic and Therapeutic Implications
Vgontzas, A. N., Zoumakis, M., Bixler, E. O., Lin, H.-M., Prolo, P., Vela‐Bueno, A., Kales, A., & Chrousos, G. P. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021176 · Cited by 243
Spectral Analysis of the Sleep Electroencephalogram During Adolescence
(2004) · Sleep · doi:10.1093/sleep/27.4.774 · Cited by 231
The Bidirectional Relationship between Sleep and Immunity against Infections
Ibarra‐Coronado, E., Pantaleón-Martínez, A. M., Velázquez‐Moctezuma, J., Prospero-Garcia, O. E., Méndez‐Díaz, M., Pérez-Tapia, M., Pavón, L., & Morales‐Montor, J. (2015) · Journal of Immunology Research · doi:10.1155/2015/678164 · Cited by 233
Sleep Complaints in Community‐Living Older Persons: A Multifactorial Geriatric Syndrome
Fragoso, C. A. V., & Gill, T. M. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01399.x · Cited by 226
Women's sleep in health and disease
Dzaja, A., Arber, S., Hislop, J., Kerkhofs, M., Kopp, C., Pollmächer, T., Polo‐Kantola, P., Skene, D. J., Stenuit, P., Tobler, I., et al. (2004) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2004.05.008 · Cited by 227
Sex Differences in the Association between Sleep and Body Mass Index in Adolescents
Knutson, K. L. (2005) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2005.07.019 · Cited by 223
Impaired Declarative Memory Consolidation During Sleep in Patients With Primary Insomnia: Influence of Sleep Architecture and Nocturnal Cortisol Release
Backhaus, J., Junghanns, K., Born, J., Hohaus, K., Faasch, F., & Hohagen, F. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.051 · Cited by 265
BRUXISM AND OROFACIAL MOVEMENTS DURING SLEEP
Kato, T., Thie, N. M. R., Montplaisir, J. Y., & Lavigne, G. J. (2001) · Dental Clinics of North America · doi:10.1016/s0011-8532(22)00487-6 · Cited by 215
Sleep and sleep disturbances: biological basis and clinical implications
Zisapel, N. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6529-9 · Cited by 216
The impact of sleep on age-related sarcopenia: Possible connections and clinical implications
Piovezan, R. D., Abucham, J., dos Santos, R. V. T., de Mello, M. T., Tufik, S., & Poyares, D. R. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.07.003 · Cited by 222
Sleep associated regulation of T helper 1/T helper 2 cytokine balance in humans
Dimitrov, S., Lange, T., Tieken, S., Fehm, H. L., & Born, J. (2004) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2003.08.004 · Cited by 209
Obesity and obstructive sleep apnea in children
Tauman, R., & Gozal, D. (2006) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2006.08.003 · Cited by 207
Sleep after Vaccination Boosts Immunological Memory
Lange, T., Dimitrov, S., Bollinger, T., Diekelmann, S., & Born, J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100015 · Cited by 201
Normal and abnormal sleep in the elderly
Cooke, J. R., & Ancoli‐Israel, S. (2010) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52006-7.00041-1 · Cited by 204
Circadian and age-related modulation of thermoreception and temperature regulation: mechanisms and functional implications
Someren, E. J. W. V. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00030-2 · Cited by 195
Sleep Quality and Body Mass Index in College Students: The Role of Sleep Disturbances
Vargas, P. A., Flores, M. A., & Robles, E. (2014) · Journal of American College Health · doi:10.1080/07448481.2014.933344 · Cited by 201
Midlife decline in declarative memory consolidation is correlated with a decline in slow wave sleep
Backhaus, J., Born, J., Hoeckesfeld, R., Fokuhl, S., Hohagen, F., & Junghanns, K. (2007) · Learning & Memory · doi:10.1101/lm.470507 · Cited by 187
Postoperative Changes in Sleep-disordered Breathing and Sleep Architecture in Patients with Obstructive Sleep Apnea
Chung, F. F., Liao, P., Yegneswaran, B., Shapiro, C. M., & Kang, W. (2013) · Anesthesiology · doi:10.1097/aln.0000000000000040 · Cited by 192
Form and function of sleep spindles across the lifespan
Clawson, B. C., Durkin, J., & Aton, S. J. (2016) · Neural Plasticity · doi:10.1155/2016/6936381 · Cited by 178
Interferon-α effects on diurnal hypothalamic–pituitary–adrenal axis activity: relationship with proinflammatory cytokines and behavior
Raison, C. L., Borisov, A. S., Woolwine, B. J., Massung, B., Vogt, G., & Miller, A. H. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.58 · Cited by 183
Sleep, dreams, and memory consolidation: the role of the stress hormone cortisol
Payne, J. D., & Nadel, L. (2004) · Learning & Memory · doi:10.1101/lm.77104 · Cited by 184
Higher levels and blunted diurnal variation of cortisol in frail older women
Varadhan, R., Walston, J., Cappola, A. R., Carlson, M. C., Wand, G. S., & Fried, L. P. (2008) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/63.2.190 · Cited by 182
Sleep, memory, and aging: The link between slow-wave sleep and episodic memory changes from younger to older adults.
Scullin, M. K. (2013) · Psychology and Aging · doi:10.1037/a0028830 · Cited by 181
Circadian rhythm regulates the function of immune cells and participates in the development of tumors
Zeng, Y., Guo, Z., Wu, M., Chen, F., & Chen, L. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01960-1 · Cited by 197
Effects of sleep fragmentation on appetite and related hormone concentrations over 24 h in healthy men
Gonnissen, H. K. J., Hursel, R., Rutters, F., Martens, E. A. P., & Westerterp-Plantenga, M. S. (2013) · British Journal of Nutrition · doi:10.1017/s0007114512001894 · Cited by 170
Immediate as well as delayed post learning sleep but not wakefulness enhances declarative memory consolidation in children
Backhaus, J., Hoeckesfeld, R., Born, J., Hohagen, F., & Junghanns, K. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.010 · Cited by 168
Phase‐shifts of 24‐h rhythms of hormonal release and body temperature following early evening administration of the melatonin agonist agomelatine in healthy older men
Leproult, R., Van Onderbergen, A., L’Hermite‐Balériaux, M., Van Cauter, E., & Copinschi, G. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02341.x · Cited by 167
Factors underlying cognitive decline in old age and Alzheimer’s disease: the role of the hippocampus
Jaroudi, W., Garami, J. K., Garrido, S., Hornberger, M., Kéri, S., & Moustafa, A. A. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2016-0086 · Cited by 172
Treating insomnia: Current and investigational pharmacological approaches
Ebert, B., Wafford, K. A., & Deacon, S. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.04.014 · Cited by 169
GHRH and sleep
Obál, F., & Krueger, J. M. (2004) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.03.005 · Cited by 166
Age-Related Increase in Awakenings: Impaired Consolidation of NonREM Sleep at All Circadian Phases
Dijk, D., Duffy, J. F., & Czeisler, C. A. (2001) · SLEEP · doi:10.1093/sleep/24.5.565 · Cited by 159
Bedside‐to‐Bench Conference: Research Agenda for Idiopathic Fatigue and Aging
Alexander, N. B., Taffet, G. E., Horne, F. M., Eldadah, B. A., Ferrucci, L., Nayfield, S., & Studenski, S. A. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02811.x · Cited by 153
Bidirectional Communication between the Brain and the Immune System: Implications for Physiological Sleep and Disorders with Disrupted Sleep
Lorton, D., Lubahn, C. L., Estus, C., Millar, B. A., Carter, J. L., Wood, C. A., & Bellinger, D. L. (2006) · NeuroImmunoModulation · doi:10.1159/000104864 · Cited by 147
Illuminating the Effects of Dynamic Lighting on Student Learning
Mott, M. S., Robinson, D. H., Walden, A., Burnette, J. L., & Rutherford, A. S. (2012) · SAGE Open · doi:10.1177/2158244012445585 · Cited by 145
The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration
Lananna, B. V., & Musiek, E. S. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104832 · Cited by 147
Poor Sleep Quality and Changes in Objectively Recorded Sleep After Traumatic Brain Injury: A Preliminary Study
Parcell, D. L., Ponsford, J. L., Redman, J. R., & Rajaratnam, S. M. W. (2008) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2007.09.057 · Cited by 152
Physiological Features of Aging Persons
Aalami, O. (2003) · Archives of Surgery · doi:10.1001/archsurg.138.10.1068 · Cited by 145
Pharmacological and non-pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer’s disease: a systematic review.
Blackman, J., Swirski, M., Clynes, J., Harding, S., Leng, Y., & Coulthard, E. (2021) · Journal of Sleep Research · doi:10.1111/jsr.13229 · Cited by 141
Sleep Disorders in the Elderly
Yaremchuk, K. (2018) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2018.01.008 · Cited by 141
Defining osteoblast and adipocyte lineages in the bone marrow
Pierce, J. L., Begun, D. L., Westendorf, J. J., & McGee‐Lawrence, M. E. (2018) · Bone · doi:10.1016/j.bone.2018.05.019 · Cited by 134
Melatonin in Patients with Reduced REM Sleep Duration: Two Randomized Controlled Trials
Kunz, D., Mahlberg, R., Müller, C., Tilmann, A., & Bes, F. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021057 · Cited by 135
Poor sleep increases the prospective risk for recurrent events in middle-aged women with coronary disease
Leineweber, C., Kecklund, G., Janszky, I., Åkerstedt, T., & Orth‐Gomér, K. (2003) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00475-0 · Cited by 131
Psychosocial and endocrine features of chronic first-episode major depression in 8–16 year olds
Goodyer, I. M., Park, R. J., & Herbert, J. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01120-9 · Cited by 130
Daytime naps improve procedural motor memory
Backhaus, J., & Junghanns, K. (2006) · Sleep Medicine · doi:10.1016/j.sleep.2006.04.002 · Cited by 128
Sleep Habits and Insomnia in a Sample of Elderly Persons in China
Liu, X., & Liu, L. (2005) · SLEEP · doi:10.1093/sleep/28.12.1579 · Cited by 128
Molecular Endocrinology and Physiology of the Aging Central Nervous System
Smith, R. G., Betancourt, L., & Sun, Y. (2005) · Endocrine Reviews · doi:10.1210/er.2002-0017 · Cited by 129
Variation in sleep behaviour in free-living blue tits, Cyanistes caeruleus: effects of sex, age and environment
Steinmeyer, C., Schielzeth, H., Mueller, J. C., & Kempenaers, B. (2010) · Animal Behaviour · doi:10.1016/j.anbehav.2010.08.005 · Cited by 122
Happy as a lark: Morning-type younger and older adults are higher in positive affect.
Biss, R. K., & Hasher, L. (2012) · Emotion · doi:10.1037/a0027071 · Cited by 122
Progesterone Prevents Sleep Disturbances and Modulates GH, TSH, and Melatonin Secretion in Postmenopausal Women
Caufriez, A., Leproult, R., L’Hermite‐Balériaux, M., Kerkhofs, M., & Copinschi, G. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2558 · Cited by 122
Slow Wave Sleep Is a Promising Intervention Target for Alzheimer’s Disease
Lee, Y. F., Gerashchenko, D., Timofeev, I., Bacskai, B. J., & Kastanenka, K. V. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00705 · Cited by 127
Acute sleep deprivation has no lasting effects on the human antibody titer response following a novel influenza a H1N1 virus vaccination
Benedict, C., Brytting, M., Markström, A., Broman, J.-E., & Schiöth, H. B. (2012) · BMC Immunology · doi:10.1186/1471-2172-13-1 · Cited by 119
Sleep disorders and their impacts on healthy, dependent, and frail older adults
Cock, V. C. D., Arbus, C., Soto, M., Villars, H., Tiberge, M., Montemayor, T., Hein, C., Veccherini, M. F., Onen, S. ‐., Ghorayeb, I., et al. (2009) · The journal of nutrition health & aging · doi:10.1007/s12603-009-0030-0 · Cited by 121

Authors: Van Cauter, E.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2000-08-16
Volume: 284
Issue: 7
Pages: 861
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.284.7.861
OpenAlex: W2035490031
Semantic Scholar: 7e085c801202adf0cc333fa840264be285802ae2
Cited by: 773
References: 52
Citations by year: 2026: 25 · 2025: 31 · 2024: 35 · 2023: 28 · 2022: 28 · 2021: 51 · 2020: 40 · 2019: 35 · 2018: 36 · 2017: 22 · 2016: 35 · 2015: 33 · 2014: 31 · 2013: 33 · 2012: 38
FWCI: 10.15
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Funders: National Institute on Aging (P01AG011412, AG-11412)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-41814, R01DK041814)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: age-related sleep changes, slow-wave sleep, REM sleep, growth hormone secretion, cortisol, sleep stages, sleep fragmentation, aging, men, sleep quality, circadian rhythm, NREM sleep, healthy men, polygraphic sleep recording, plasma hormone levels
MeSH terms: Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Aging, Analysis of Variance, Humans, Hydrocortisone, Male, Middle Aged, Sleep, Sleep, REM, Body Mass Index, Polysomnography, Human Growth Hormone

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Age-Related Changes in Slow Wave Sleep and REM Sleep and Relationship With Growth Hormone and Cortisol Levels in Healthy Men

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks