The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Vitamins for Chronic Disease Prevention in Adults: Scientific Review
Abstract
CONTEXT: Although vitamin deficiency is encountered infrequently in developed countries, inadequate intake of several vitamins is associated with chronic disease. OBJECTIVE: To review the clinically important vitamins with regard to their biological effects, food sources, deficiency syndromes, potential for toxicity, and relationship to chronic disease. DATA SOURCES AND STUDY SELECTION: We searched MEDLINE for English-language articles about vitamins in relation to chronic diseases and their references published from 1966 through January 11, 2002. DATA EXTRACTION: We reviewed articles jointly for the most clinically important information, emphasizing randomized trials where available. DATA SYNTHESIS: Our review of 9 vitamins showed that elderly people, vegans, alcohol-dependent individuals, and patients with malabsorption are at higher risk of inadequate intake or absorption of several vitamins. Excessive doses of vitamin A during early pregnancy and fat-soluble vitamins taken anytime may result in adverse outcomes. Inadequate folate status is associated with neural tube defect and some cancers. Folate and vitamins B(6) and B(12) are required for homocysteine metabolism and are associated with coronary heart disease risk. Vitamin E and lycopene may decrease the risk of prostate cancer. Vitamin D is associated with decreased occurrence of fractures when taken with calcium. CONCLUSIONS: Some groups of patients are at higher risk for vitamin deficiency and suboptimal vitamin status. Many physicians may be unaware of common food sources of vitamins or unsure which vitamins they should recommend for their patients. Vitamin excess is possible with supplementation, particularly for fat-soluble vitamins. Inadequate intake of several vitamins has been linked to chronic diseases, including coronary heart disease, cancer, and osteoporosis
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Cites
(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737
Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease
Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341802 · Cited by 3,638
Stephens, N. G., Parsons, A., Brown, M. J., Schofield, P. M., Kelly, F., Cheeseman, K., & Mitchinson, M. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90866-1 · Cited by 2,148
Vitamin E Supplementation and Cardiovascular Events in High-Risk Patients
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420302 · Cited by 1,957
The Effect of Fruit and Vegetable Intake on Risk for Coronary Heart Disease
Joshipura, K. J., Hu, F. B., Manson, J. E., Stampfer, M. J., Rimm, E. B., Speizer, F. E., Colditz, G., Ascherio, A., Rosner, B., Spiegelman, D., et al. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-12-200106190-00010 · Cited by 1,396
Probucol and Multivitamins in the Prevention of Restenosis after Coronary Angioplasty
Tardif, J.-C., Côté, G., Lespérance, J., Bourassa, M., Lambert, J., Doucet, S., Bilodeau, L., Nattel, S., & de Guise, P. (1997) · New England Journal of Medicine · doi:10.1056/nejm199708073370601 · Cited by 565
Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture
Hodges, S. J., Akesson, K., Vergnaud, P., Obrant, K., & Prof. Delmas, P. D. (1993) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650081012 · Cited by 202
Vitamin K Nutrition and Osteoporosis
Binkley, N. C., & Suttie, J. W. (1995) · The Journal of Nutrition · doi:10.1093/jn/125.7.1812 · Cited by 185
ELECTROCHEMICAL DETECTION OF DEPRESSED CIRCULATING LEVELS OF VITAMIN K1IN OSTEOPOROSIS
HART, J. P., SHEARER, M. J., KLENERMAN, L., CATTERALL, A., REEVE, J., SAMBROOK, P. N., DODOS, R. A., BITENSKY, L., & CHAYEN, J. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-6-1268 · Cited by 165
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Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases
Pedersen, B. K., & Saltin, B. (2015) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12581 · Cited by 3,514
Evidence for prescribing exercise as therapy in chronic disease
Pedersen, B. K., & Saltin, B. (2006) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/j.1600-0838.2006.00520.x · Cited by 1,384
Vitamin C pharmacokinetics: Implications for oral and intravenous use
Padayatty, S. J., Sun, H., Wang, Y., Riordan, H. D., Hewitt, S. M., Katz, A., Wesley, R. A., & Levine, M. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-7-200404060-00010 · Cited by 992
ISSN exercise & sports nutrition review update: research & recommendations
Kerksick, C. M., Wilborn, C. D., Roberts, M. D., Smith-Ryan, A., Kleiner, S. M., Jäger, R., Collins, R., Cooke, M., Davis, J. N., Galvan, E., et al. (2018) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-018-0242-y · Cited by 945
Food insecurity is associated with adverse health outcomes among human infants and toddlers.
Cook, J. T., Frank, D. A., Meyers, A. F., Berkowitz, C., Black, M. M., Casey, P. H., Cutts, D. B., Zaldivar, N., Skalicky, A., Levenson, S., et al. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.6.1432 · Cited by 665
Metadata
- Authors
- Fairfield, K. M., & Fletcher, R. H.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2002-06-19
- Volume
- 287
- Issue
- 23
- Pages
- 3116
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2069930390
- Cited by
- 533
- References
- 9
- FWCI
- 40.99
- Type
- journal article
- Language
- en
- Open access
- closed
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