Cited by 1,735Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychotherapy Techniques and Applications

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Fluoxetine, Cognitive-Behavioral Therapy, and Their Combination for Adolescents With Depression: Treatment for Adolescents With Depression Study (TADS) Randomized Controlled Trial

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Treatment for Adolescents With Depression Study (TADS) Team·2004·JAMA

DOI 10.1001/jama.292.7.807

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Abstract

CONTEXT: Initial treatment of major depressive disorder in adolescents may include cognitive-behavioral therapy (CBT) or a selective serotonin reuptake inhibitor (SSRI). However, little is known about their relative or combined effectiveness. OBJECTIVE: To evaluate the effectiveness of 4 treatments among adolescents with major depressive disorder. DESIGN, SETTING, AND PARTICIPANTS: Randomized controlled trial of a volunteer sample of 439 patients between the ages of 12 to 17 years with a primary Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, diagnosis of major depressive disorder. The trial was conducted at 13 US academic and community clinics between spring 2000 and summer 2003. INTERVENTIONS: Twelve weeks of (1) fluoxetine alone (10 to 40 mg/d), (2) CBT alone, (3) CBT with fluoxetine (10 to 40 mg/d), or (4) placebo (equivalent to 10 to 40 mg/d). Placebo and fluoxetine alone were administered double-blind; CBT alone and CBT with fluoxetine were administered unblinded. MAIN OUTCOME MEASURES: Children's Depression Rating Scale-Revised total score and, for responder analysis, a (dichotomized) Clinical Global Impressions improvement score. RESULTS: Compared with placebo, the combination of fluoxetine with CBT was statistically significant (P =.001) on the Children's Depression Rating Scale-Revised. Compared with fluoxetine alone (P =.02) and CBT alone (P =.01), treatment of fluoxetine with CBT was superior. Fluoxetine alone is a superior treatment to CBT alone (P =.01). Rates of response for fluoxetine with CBT were 71.0% (95% confidence interval [CI], 62%-80%); fluoxetine alone, 60.6% (95% CI, 51%-70%); CBT alone, 43.2% (95% CI, 34%-52%); and placebo, 34.8% (95% CI, 26%-44%). On the Clinical Global Impressions improvement responder analysis, the 2 fluoxetine-containing conditions were statistically superior to CBT and to placebo. Clinically significant suicidal thinking, which was present in 29% of the sample at baseline, improved significantly in all 4 treatment groups. Fluoxetine with CBT showed the greatest reduction (P =.02). Seven (1.6%) of 439 patients attempted suicide; there were no completed suicides. CONCLUSION: The combination of fluoxetine with CBT offered the most favorable tradeoff between benefit and risk for adolescents with major depressive disorder.

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Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial Reliability and Validity Data
KAUFMAN, J., BIRMAHER, B., BRENT, D., RAO, U., FLYNN, C., MORECI, P., WILLIAMSON, D., & RYAN, N. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199707000-00021 · Cited by 10,148
Untitled work
(1976) · Medical Entomology and Zoology · Cited by 8,899
Mediators and Moderators of Treatment Effects in Randomized Clinical Trials
Kraemer, H. C., Wilson, G. T., Fairburn, C. G., & Agras, W. S. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.10.877 · Cited by 2,562
Applied Mixed Models in Medicine
Brown, H., & Presco, R. (2000) · Technometrics · doi:10.1080/00401706.2000.10485742 · Cited by 1,699
A Comparison of Nefazodone, the Cognitive Behavioral-Analysis System of Psychotherapy, and Their Combination for the Treatment of Chronic Depression
Keller, M. B., McCullough, J. P., Klein, D. N., Arnow, B., Dunner, D. L., Gelenberg, A. J., Markowitz, J. C., Nemeroff, C. B., Russell, J. M., Thase, M. E., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005183422001 · Cited by 1,331
Psychiatric Diagnosis in Child and Adolescent Suicide
Shaffer, D. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830040075012 · Cited by 1,250
Contrasts and Effect Sizes in Behavioral Research
Rosenthal, R., Rosnow, R. L., & Rubin, D. B. (1999) · Cambridge University Press eBooks · doi:10.1017/cbo9780511804403 · Cited by 1,147
Selective serotonin reuptake inhibitors in childhood depression: systematic review of published versus unpublished data.
Whittington, C. J., Kendall, T., Fonagy, P., Cottrell, D., Cotgrove, A., & Boddington, E. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16043-1 · Cited by 1,006
A Double-blind, Randomized, Placebo-Controlled Trial of Fluoxetine in Children and Adolescents With Depression
Emslie, G. J. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830230069010 · Cited by 971
A Clinical Psychotherapy Trial for Adolescent Depression Comparing Cognitive, Family, and Supportive Therapy
Brent, D. A. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830210125017 · Cited by 753

Show all 43 references

Research works printed but not linked: 9

Essau C, Dobson K. Epidemiology of depressive dis- orders. In: Essau C, Petermann F, eds. Depressive Dis- orders in Children and Adolescents: Epidemiology, Course and Treatment. Northvale, NJ: Jason Aron- son Inc; 1999:69-103.
Emslie GJ, Heiligenstein JH, Wagner KD, et al. Fluoxetine for acute treatment of depression in chil- dren and adolescents: a placebo-controlled, random- ized clinical trial. J Am Acad Child Adolesc Psychia- try. 2002;41:1205-1215.
Friedman MA, Detweiler JB, Leventhal HE, Horne R, Keitner G, Miller IW. Combined psychotherapy and pharmacotherapy for the treatment of major depres- sion. Clin Psychol Sci Prac. 2004;11:47-68.
Pamplona S, Bollini P, Gibaldi G, Kupelnick B, Mu- nizza C. Combined pharmacotherapy and psychologi- cal treatment for depression. Arch Gen Psychiatry. 2004;61:714-719.
March J, Wells K. Combining medication and psy- chotherapy. In: Martin A, Scahill L, Charney DS, Leck- man JF, eds. Pediatric Psychopharmacology: Prin- ciples and Practice. London, England: Oxford University Press; 2003:326-346.
Clarke G, Lewinshoh P, Hops H. Instructor's Manual for the Adolescent Coping With Depression Course. 4th ed. Eugene, Oregon: Castalia Press; 1990.
Weinfert K. Repeated measures analyses: ANOVA, MANOVA, HLM. In: Grimm L, Yarnold P, eds. Read- ing and Understanding More Multivariate Statistics. Washington, DC: American Psychological Press; 2000: 317-362.
Gueorguieva R, Krystal JH. Move over ANOVA: progress in analyzing repeated-measures data and its reflection in papers published in the Archives of Gen- eral Psychiatry. Arch Gen Psychiatry. 2004;61:310- 317.
Shea MT, Elkin I, Imber SD, et al. Course of de- pressive symptoms over follow-up: findings from the National Institute of Mental Health Treatment of De- pression Collaborative Research Program. Arch Gen Psychiatry. 1992;49:782-787.

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Authors: Treatment for Adolescents With Depression Study (TADS) Team
Affiliations: Duke Medical Center (US)
Corresponding author: Treatment for Adolescents With Depression Study (TADS) Team
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2004-08-18
Volume: 292
Issue: 7
Pages: 807
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.292.7.807
OpenAlex: W2254051562
Cited by: 1,735
References: 43
Citations by year: 2026: 43 · 2025: 35 · 2024: 72 · 2023: 41 · 2022: 63 · 2021: 60 · 2020: 50 · 2019: 64 · 2018: 54 · 2017: 42 · 2016: 79 · 2015: 75 · 2014: 83 · 2013: 85 · 2012: 92
FWCI: 81.91
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Funders: Yale University
Kaiser Permanente
University of Pittsburgh
Carnegie Mellon University
University of Texas at Austin
National Institutes of Health (98DS-0008)
National Institute of Mental Health
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Keywords: fluoxetine, cognitive behavioral therapy, adolescent depression, major depressive disorder, selective serotonin reuptake inhibitors, combination therapy, treatment response, suicidal ideation, Children's Depression Rating Scale-Revised, clinical global impression, placebo response, medication adherence, relapse prevention, psychoeducation, psychotherapy dropout
MeSH terms: Adolescent, Combined Modality Therapy, Major Depressive Disorder, Depressive Disorder, Major, Female, Fluoxetine, Humans, Male, Psychiatric Status Rating Scales, Risk, Suicide, Cognitive Behavioral Therapy, Selective Serotonin Reuptake Inhibitors, Antidepressive Agents, Second-Generation

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Fluoxetine, Cognitive-Behavioral Therapy, and Their Combination for Adolescents With Depression: Treatment for Adolescents With Depression Study (TADS) Randomized Controlled Trial

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