Cited by 1,735Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychotherapy Techniques and Applications

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Fluoxetine, Cognitive-Behavioral Therapy, and Their Combination for Adolescents With Depression: Treatment for Adolescents With Depression Study (TADS) Randomized Controlled Trial

Open access

Treatment for Adolescents With Depression Study (TADS) Team·2004·JAMA

DOI 10.1001/jama.292.7.807

Open this paper in CoChat — free account Open PDF

Abstract

CONTEXT: Initial treatment of major depressive disorder in adolescents may include cognitive-behavioral therapy (CBT) or a selective serotonin reuptake inhibitor (SSRI). However, little is known about their relative or combined effectiveness. OBJECTIVE: To evaluate the effectiveness of 4 treatments among adolescents with major depressive disorder. DESIGN, SETTING, AND PARTICIPANTS: Randomized controlled trial of a volunteer sample of 439 patients between the ages of 12 to 17 years with a primary Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, diagnosis of major depressive disorder. The trial was conducted at 13 US academic and community clinics between spring 2000 and summer 2003. INTERVENTIONS: Twelve weeks of (1) fluoxetine alone (10 to 40 mg/d), (2) CBT alone, (3) CBT with fluoxetine (10 to 40 mg/d), or (4) placebo (equivalent to 10 to 40 mg/d). Placebo and fluoxetine alone were administered double-blind; CBT alone and CBT with fluoxetine were administered unblinded. MAIN OUTCOME MEASURES: Children's Depression Rating Scale-Revised total score and, for responder analysis, a (dichotomized) Clinical Global Impressions improvement score. RESULTS: Compared with placebo, the combination of fluoxetine with CBT was statistically significant (P =.001) on the Children's Depression Rating Scale-Revised. Compared with fluoxetine alone (P =.02) and CBT alone (P =.01), treatment of fluoxetine with CBT was superior. Fluoxetine alone is a superior treatment to CBT alone (P =.01). Rates of response for fluoxetine with CBT were 71.0% (95% confidence interval [CI], 62%-80%); fluoxetine alone, 60.6% (95% CI, 51%-70%); CBT alone, 43.2% (95% CI, 34%-52%); and placebo, 34.8% (95% CI, 26%-44%). On the Clinical Global Impressions improvement responder analysis, the 2 fluoxetine-containing conditions were statistically superior to CBT and to placebo. Clinically significant suicidal thinking, which was present in 29% of the sample at baseline, improved significantly in all 4 treatment groups. Fluoxetine with CBT showed the greatest reduction (P =.02). Seven (1.6%) of 439 patients attempted suicide; there were no completed suicides. CONCLUSION: The combination of fluoxetine with CBT offered the most favorable tradeoff between benefit and risk for adolescents with major depressive disorder.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1001/jama.292.7.807

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial Reliability and Validity Data
KAUFMAN, J., BIRMAHER, B., BRENT, D., RAO, U., FLYNN, C., MORECI, P., WILLIAMSON, D., & RYAN, N. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199707000-00021 · Cited by 10,148
Untitled work
(1976) · Medical Entomology and Zoology · Cited by 8,899
Mediators and Moderators of Treatment Effects in Randomized Clinical Trials
Kraemer, H. C., Wilson, G. T., Fairburn, C. G., & Agras, W. S. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.10.877 · Cited by 2,562
Applied Mixed Models in Medicine
Brown, H., & Presco, R. (2000) · Technometrics · doi:10.1080/00401706.2000.10485742 · Cited by 1,699
A Comparison of Nefazodone, the Cognitive Behavioral-Analysis System of Psychotherapy, and Their Combination for the Treatment of Chronic Depression
Keller, M. B., McCullough, J. P., Klein, D. N., Arnow, B., Dunner, D. L., Gelenberg, A. J., Markowitz, J. C., Nemeroff, C. B., Russell, J. M., Thase, M. E., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005183422001 · Cited by 1,331
Psychiatric Diagnosis in Child and Adolescent Suicide
Shaffer, D. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830040075012 · Cited by 1,250
Contrasts and Effect Sizes in Behavioral Research
Rosenthal, R., Rosnow, R. L., & Rubin, D. B. (1999) · Cambridge University Press eBooks · doi:10.1017/cbo9780511804403 · Cited by 1,147
Selective serotonin reuptake inhibitors in childhood depression: systematic review of published versus unpublished data.
Whittington, C. J., Kendall, T., Fonagy, P., Cottrell, D., Cotgrove, A., & Boddington, E. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16043-1 · Cited by 1,006
A Double-blind, Randomized, Placebo-Controlled Trial of Fluoxetine in Children and Adolescents With Depression
Emslie, G. J. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830230069010 · Cited by 971
A Clinical Psychotherapy Trial for Adolescent Depression Comparing Cognitive, Family, and Supportive Therapy
Brent, D. A. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830210125017 · Cited by 753

Show all 43 references

Research works printed but not linked: 9

Essau C, Dobson K. Epidemiology of depressive dis- orders. In: Essau C, Petermann F, eds. Depressive Dis- orders in Children and Adolescents: Epidemiology, Course and Treatment. Northvale, NJ: Jason Aron- son Inc; 1999:69-103.
Emslie GJ, Heiligenstein JH, Wagner KD, et al. Fluoxetine for acute treatment of depression in chil- dren and adolescents: a placebo-controlled, random- ized clinical trial. J Am Acad Child Adolesc Psychia- try. 2002;41:1205-1215.
Friedman MA, Detweiler JB, Leventhal HE, Horne R, Keitner G, Miller IW. Combined psychotherapy and pharmacotherapy for the treatment of major depres- sion. Clin Psychol Sci Prac. 2004;11:47-68.
Pamplona S, Bollini P, Gibaldi G, Kupelnick B, Mu- nizza C. Combined pharmacotherapy and psychologi- cal treatment for depression. Arch Gen Psychiatry. 2004;61:714-719.
March J, Wells K. Combining medication and psy- chotherapy. In: Martin A, Scahill L, Charney DS, Leck- man JF, eds. Pediatric Psychopharmacology: Prin- ciples and Practice. London, England: Oxford University Press; 2003:326-346.
Clarke G, Lewinshoh P, Hops H. Instructor's Manual for the Adolescent Coping With Depression Course. 4th ed. Eugene, Oregon: Castalia Press; 1990.
Weinfert K. Repeated measures analyses: ANOVA, MANOVA, HLM. In: Grimm L, Yarnold P, eds. Read- ing and Understanding More Multivariate Statistics. Washington, DC: American Psychological Press; 2000: 317-362.
Gueorguieva R, Krystal JH. Move over ANOVA: progress in analyzing repeated-measures data and its reflection in papers published in the Archives of Gen- eral Psychiatry. Arch Gen Psychiatry. 2004;61:310- 317.
Shea MT, Elkin I, Imber SD, et al. Course of de- pressive symptoms over follow-up: findings from the National Institute of Mental Health Treatment of De- pression Collaborative Research Program. Arch Gen Psychiatry. 1992;49:782-787.

Sorted by citations

The empirical status of cognitive-behavioral therapy: A review of meta-analyses
Butler, A. C., Chapman, J. E., Forman, E. M., & Beck, A. T. (2006) · Clinical Psychology Review · doi:10.1016/j.cpr.2005.07.003 · Cited by 3,215
Mental health of young people: A global public-health challenge
Patel, V., Flisher, A. J., Hetrick, S., & McGorry, P. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60368-7 · Cited by 3,126
Depression in adolescence
Thapar, A., Collishaw, S., Pine, D. S., & Thapar, A. K. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60871-4 · Cited by 2,365
Self-harm and suicide in adolescents
Hawton, K., Saunders, K. E., & O'Connor, R. C. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60322-5 · Cited by 2,306
PRACTICE GUIDELINE FOR THE Treatment of Patients With Major Depressive Disorder
Gelenberg, A. J., Freeman, P. B., Markowitz, J. C., Rosenbaum, J. F., Thase, M. E., Trivedi, M. H., & Rhoads, R. S. (2010) · Cited by 1,372
Adolescent suicide and suicidal behavior
Bridge, J. A., Goldstein, T. R., & Brent, D. A. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01615.x · Cited by 1,361
Clinical Response and Risk for Reported Suicidal Ideation and Suicide Attempts in Pediatric Antidepressant Treatment: A Meta-analysis of Randomized Controlled Trials
Bridge, J. A., Iyengar, S., Salary, C. B., Barbe, R. P., Birmaher, B., Pincus, H. A., Ren, L., & Brent, D. A. (2007) · JAMA · doi:10.1001/jama.297.15.1683 · Cited by 1,086
Practice parameter for the assessment and treatment of children and adolescents with depressive disorders
Birmaher, B., & Brent, D. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318145ae1c · Cited by 1,056
Suicidality in Pediatric Patients Treated With Antidepressant Drugs
Hammad, T. A., Laughren, T., & Racoosin, J. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.3.332 · Cited by 1,054
Comorbidity of anxiety and depression in children and adolescents: 20 years after
Cummings, C. M., Caporino, N. E., & Kendall, P. C. (2014) · Psychological Bulletin · doi:10.1037/a0034733 · Cited by 1,028
Effects of psychotherapy for depression in children and adolescents: A meta-analysis
Weisz, J. R., McCarty, C. A., & Valeri, S. M. (2006) · Psychological Bulletin · doi:10.1037/0033-2909.132.1.132 · Cited by 942
Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2000 British Association for Psychopharmacology guidelines
Anderson, I. M., Ferrier, I. N., Baldwin, R., Cowen, P. J., Howard, L. M., Lewis, G., Matthews, K., McAllister-Williams, H., Peveler, R. C., Scott, J. L., et al. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881107088441 · Cited by 909
What five decades of research tells us about the effects of youth psychological therapy: A multilevel meta-analysis and implications for science and practice
Weisz, J. R., Kuppens, S., Ng, M. Y., Eckshtain, D., Ugueto, A. M., Vaughn-Coaxum, R., Jensen-Doss, A., Hawley, K. M., Krumholz Marchette, L. S., Chu, B. C., et al. (2017) · American Psychologist · doi:10.1037/a0040360 · Cited by 862
Psychosocial Aspects of the Functional Gastrointestinal Disorders
Levy, R. L., Olden, K. W., Naliboff, B. D., Bradley, L. A., Francisconi, C., Drossman, D. A., & Creed, F. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.057 · Cited by 776
Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines
Cleare, A., Pariante, C., Young, A., Anderson, I., Christmas, D., Cowen, P., Dickens, C., Ferrier, I., Geddes, J., Gilbody, S., et al. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115581093 · Cited by 759
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis
Cipriani, A., Zhou, X., Del Giovane, C., Hetrick, S. E., Qin, B., Whittington, C., Coghill, D., Zhang, Y., Hazell, P., Leucht, S., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30385-3 · Cited by 734
Switching to Another SSRI or to Venlafaxine With or Without Cognitive Behavioral Therapy for Adolescents With SSRI-Resistant Depression
Brent, D. A., Emslie, G. J., Clarke, G. N., Wagner, K. D., Asarnow, J. R., Keller, M., Vitiello, B., Ritz, L., Iyengar, S., Abebe, K. Z., et al. (2008) · JAMA · doi:10.1001/jama.299.8.901 · Cited by 713
Clinical and psychosocial predictors of suicide attempts and nonsuicidal self-injury in the Adolescent Depression Antidepressants and Psychotherapy Trial (ADAPT)
Wilkinson, P., Kelvin, R., Roberts, C., Dubicka, B., & Goodyer, I. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10050718 · Cited by 645
Screening for Obesity in Children and Adolescents: US Preventive Services Task Force Recommendation Statement
US Preventive Services Task Force (2010) · PEDIATRICS · doi:10.1542/peds.2009-2037 · Cited by 619
Comorbidity of anxiety and depression in youth: Implications for treatment and prevention.
Garber, J., & Weersing, V. R. (2010) · Clinical Psychology Science and Practice · doi:10.1111/j.1468-2850.2010.01221.x · Cited by 649
Understanding complexity in the human brain
Bassett, D. S., & Gazzaniga, M. S. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.03.006 · Cited by 572
Is mood chemistry?
Castrén, E. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1629 · Cited by 563
Memory reconsolidation, emotional arousal, and the process of change in psychotherapy: New insights from brain science
Lane, R. D., Ryan, L., Nadel, L., & Greenberg, L. S. (2014) · Behavioral and Brain Sciences · doi:10.1017/s0140525x14000041 · Cited by 611
State of the Science on Psychosocial Interventions for Ethnic Minorities
Miranda, J. M., Bernal, G., Lau, A. S., Kohn, L. P., Hwang, W., & LaFromboise, T. D. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143822 · Cited by 540
Prevention of Depression in At-Risk Adolescents
Garber, J., Clarke, G. N., Weersing, V. R., Beardslee, W. R., Brent, D. A., Gladstone, T. R. G., DeBar, L., Lynch, F. L., D’Angelo, E. J., Hollon, S. D., et al. (2009) · JAMA · doi:10.1001/jama.2009.788 · Cited by 526
Evidence Base Update of Psychosocial Treatments for Child and Adolescent Depression
Weersing, V. R., Jeffreys, M., Do, M.-C. T., Schwartz, K. T. G., & Bolano, C. (2017) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2016.1220310 · Cited by 505
Loss-of-Function Mutation in Tryptophan Hydroxylase-2 Identified in Unipolar Major Depression
Zhang, X., Gainetdinov, R. R., Beaulieu, J.-M., Sotnikova, T. D., Burch, L. H., Williams, R. B., Schwartz, D. A., Krishnan, K. R. R., & Caron, M. G. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.014 · Cited by 473
National Trends in the Mental Health Care of Children, Adolescents, and Adults by Office-Based Physicians
Olfson, M., Blanco, C., Wang, S., Laje, G., & Correll, C. U. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.3074 · Cited by 449
Childhood and Adolescent Depression
Bhatia, S. K., & Bhatia, S. C. (2011) · PsycEXTRA Dataset · doi:10.1037/e552642011-001 · Cited by 444
Multicenter Pilot Treatment Trial for Psychogenic Nonepileptic Seizures: A Randomized Clinical Trial
LaFrance, W. C., Baird, G. L., Barry, J. J., Blum, A. S., Frank Webb, A., Keitner, G. I., Machan, J. T., Miller, I., & Szaflarski, J. P. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.817 · Cited by 440
Adolescence as a unique developmental period
Jaworska, N., & MacQueen, G. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.150268 · Cited by 432
Predictors and Moderators of Acute Outcome in the Treatment for Adolescents With Depression Study (TADS)
Curry, J. F., Rohde, P., Simons, A. D., Silva, S. G., Vitiello, B., Kratochvil, C. J., Reinecke, M. A., Feeny, N. C., Wells, K., Pathak, S., et al. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000240838.78984.e2 · Cited by 429
Performance of Evidence-Based Youth Psychotherapies Compared With Usual Clinical Care: A Multilevel Meta-analysis
Weisz, J. R., Kuppens, S., Eckshtain, D., Ugueto, A. M., Hawley, K. M., & Jensen-Doss, A. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1176 · Cited by 412
Trends in Mental Health Care among Children and Adolescents
Olfson, M., Druss, B. G., & Marcus, S. C. (2015) · New England Journal of Medicine · doi:10.1056/nejmsa1413512 · Cited by 408
Adolescent depression: Description, causes, and interventions
Hankin, B. L. (2005) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2005.10.012 · Cited by 413
Evidence-Based Psychosocial Treatments for Child and Adolescent Depression
David-Ferdon, C. F., & Kaslow, N. J. (2008) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374410701817865 · Cited by 420
Suicide and Suicide Attempts in Adolescents
SHAIN, B. N. (2007) · PEDIATRICS · doi:10.1542/peds.2007-1908 · Cited by 392
Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies
Yatham, L. N., Kennedy, S. H., O'Donovan, C., Parikh, S., MacQueen, G., McIntyre, R., Sharma, V., Silverstone, P., Alda, M., Baruch, P., et al. (2005) · Bipolar Disorders · doi:10.1111/j.1399-5618.2005.00219.x · Cited by 388
Cognitive-Behavioral Interventions to Reduce Suicide Behavior: A Systematic Review and Meta-Analysis
Tarrier, N., Taylor, K., & Gooding, P. (2008) · Behavior Modification · doi:10.1177/0145445507304728 · Cited by 384
Understanding Migraine through the Lens of Maladaptive Stress Responses: A Model Disease of Allostatic Load
Borsook, D., Maleki, N., Becerra, L. R., & McEwen, B. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.001 · Cited by 370
A Systematic Review of Medical Treatments for Children With Autism Spectrum Disorders
McPheeters, M. L., Warren, Z., Sathe, N., Bruzek, J. L., Krishnaswami, S., Jerome, R. N., & Veenstra-VanderWeele, J. (2011) · Pediatrics · doi:10.1542/peds.2011-0427 · Cited by 356
Efficacy and Safety of Selective Serotonin Reuptake Inhibitors, Serotonin-Norepinephrine Reuptake Inhibitors, and Placebo for Common Psychiatric Disorders Among Children and Adolescents: A Systematic Review and Meta-analysis
Locher, C., Koechlin, H., Zion, S. R., Werner, C., Pine, D. S., Kirsch, I., Kessler, R. C., & Kossowsky, J. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.2432 · Cited by 360
Selective serotonin reuptake inhibitors (SSRIs) and routine specialist care with and without cognitive behaviour therapy in adolescents with major depression: randomised controlled trial
Goodyer, I., Dubicka, B., Wilkinson, P., Kelvin, R., Roberts, C., Byford, S., Breen, S., Ford, C., Barrett, B., Leech, A., et al. (2007) · BMJ · doi:10.1136/bmj.39224.494340.55 · Cited by 352
Treating depression with physical activity in adolescents and young adults: a systematic review and meta-analysis of randomised controlled trials
Bailey, A. P., Hetrick, S. E., Rosenbaum, S., Purcell, R., & Parker, A. G. (2018) · Psychological Medicine · doi:10.1017/s0033291717002653 · Cited by 338
Guidelines for Adolescent Depression in Primary Care (GLAD-PC): II. Treatment and ongoing management
Cheung, A. H., Zuckerbrot, R. A., Jensen, P. S., Ghalib, K., Laraque, D., Stein, R. E. K., & and the GLAD-PC Steering Group (2007) · Pediatrics · doi:10.1542/peds.2006-1395 · Cited by 336
Child/Adolescent Anxiety Multimodal Study (CAMS): rationale, design, and methods
Compton, S. N., Walkup, J. T., Albano, A. M., Piacentini, J. C., Birmaher, B. B., Sherrill, J. T., Ginsburg, G. S., Rynn, M. A., McCracken, J. T., WASLICK, B. D., et al. (2010) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/1753-2000-4-1 · Cited by 341
Abnormal Amygdala Resting-State Functional Connectivity in Adolescent Depression
Cullen, K. R., Westlund, M. K., Klimes-Dougan, B., Mueller, B. A., Houri, A., Eberly, L. E., & Lim, K. O. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1087 · Cited by 324
Safety of 80 antidepressants, antipsychotics, anti-attention-deficit/hyperactivity medications and mood stabilizers in children and adolescents with psychiatric disorders: a large scale systematic meta-review of 78 adverse effects
Solmi, M., Fornaro, M., Ostinelli, E. G., Zangani, C., Croatto, G., Monaco, F., Krinitski, D., Fusar‐Poli, P., & Correll, C. U. (2020) · World Psychiatry · doi:10.1002/wps.20765 · Cited by 324
National Trends in Outpatient Psychotherapy
Olfson, M., & Marcus, S. C. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10040570 · Cited by 315
National trends in the treatment for depression from 1998 to 2007
Marcus, S. C., & Olfson, M. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.151 · Cited by 312
Randomized Controlled Trial: Multimodal Anxiety and Social Skill Intervention for Adolescents with Autism Spectrum Disorder
White, S. W., Ollendick, T. H., Albano, A. M., Oswald, D. P., Johnson, C. R., Southam‐Gerow, M. A., Kim, I., & Scahill, L. D. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1577-x · Cited by 330
The role of peer rejection in adolescent depression
Platt, B., Kadosh, K. C., & Lau, J. Y. F. (2013) · Depression and Anxiety · doi:10.1002/da.22120 · Cited by 300
Guidelines for Adolescent Depression in Primary Care (GLAD-PC): Part II. Treatment and Ongoing Management
Cheung, A. H., Zuckerbrot, R. A., Jensen, P. S., Laraque, D., Stein, R. E. K., GLAD-PC STEERING GROUP, Levitt, A., Birmaher, B., Campo, J., Clarke, G., et al. (2018) · Pediatrics · doi:10.1542/peds.2017-4082 · Cited by 299
Non-suicidal self-injury
Wilkinson, P. O., & Goodyer, I. M. (2011) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-010-0156-y · Cited by 331
Preventing Depression Among Early Adolescents in the Primary Care Setting: A Randomized Controlled Study of the Penn Resiliency Program
Gillham, J. E., Hamilton, J. D., Freres, D. R., Patton, K., & Gallop, R. (2006) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-005-9014-7 · Cited by 312
Suicidal Thoughts and Behavior With Antidepressant Treatment: Reanalysis of the Randomized Placebo-Controlled Studies of Fluoxetine and Venlafaxine
Gibbons, R. D., Brown, C. H., Hur, K., Davis, J. M., & Mann, J. J. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2048 · Cited by 291
Newer generation antidepressants for depressive disorders in children and adolescents
Hetrick, S. E., McKenzie, J. E., Cox, G. R., Simmons, M. B., & Merry, S. N. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004851.pub3 · Cited by 291
Impact of Comorbidity on Cognitive-Behavioral Therapy Response in Pediatric Obsessive-Compulsive Disorder
Storch, E. A., Merlo, L. J., Larson, M. J., Geffken, G. R., Lehmkuhl, H. D., Jacob, M. L., Murphy, T. K., & Goodman, W. K. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31816774b1 · Cited by 302
The Relationship Between Antidepressant Prescription Rates and Rate of Early Adolescent Suicide
Gibbons, R. D., Hur, K., Bhaumik, D. K., & Mann, J. J. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.11.1898 · Cited by 289
Collaborative Care for Adolescents With Depression in Primary Care: A Randomized Clinical Trial
Richardson, L. P., Ludman, E., McCauley, E., Lindenbaum, J., Larison, C., Zhou, C., Clarke, G., Brent, D., & Katon, W. (2014) · JAMA · doi:10.1001/jama.2014.9259 · Cited by 281
Remission and Residual Symptoms After Short-Term Treatment in the Treatment of Adolescents With Depression Study (TADS)
Kennard, B. D., Silva, S. G., Vitiello, B., Curry, J. F., Kratochvil, C. J., Simons, A. D., Hughes, J. L., Feeny, N. C., Weller, E. B., SWEENEY, M., et al. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000242228.75516.21 · Cited by 279
A Review of Co-Morbid Depression in Pediatric ADHD: Etiologies, Phenomenology, and Treatment
Daviss, W. B. (2008) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2008.032 · Cited by 269
Benefits From Antidepressants: Synthesis of 6-Week Patient-Level Outcomes From Double-blind Placebo-Controlled Randomized Trials of Fluoxetine and Venlafaxine
Gibbons, R. D., Hur, K., Brown, C. H., Davis, J. M., & Mann, J. J. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2044 · Cited by 271
Cognitive behavioural therapy and short-term psychoanalytical psychotherapy versus a brief psychosocial intervention in adolescents with unipolar major depressive disorder (IMPACT): a multicentre, pragmatic, observer-blind, randomised controlled superiority trial
Goodyer, I. M., Reynolds, S., Barrett, B., Byford, S., Dubicka, B., Hill, J., Holland, F., Kelvin, R., Midgley, N., Roberts, C., et al. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)30378-9 · Cited by 259
Depression in Children and Adolescents
Garber, J. (2006) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2006.07.007 · Cited by 263
Comorbidity of internalizing disorders in children with oppositional defiant disorder
Boylan, K., Vaillancourt, T., Boyle, M., & Szatmári, P. (2007) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-007-0624-1 · Cited by 285
Placebo Response in Randomized Controlled Trials of Antidepressants for Pediatric Major Depressive Disorder
Bridge, J. A., Birmaher, B., Iyengar, S., Barbe, R. P., & Brent, D. A. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08020247 · Cited by 256
Cognitive-behavioral therapy for adolescent depression: a Meta-analytic investigation of changes in effect-size estimates
KLEIN, J. B., JACOBS, R. H., & REINECKE, M. A. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3180592aaa · Cited by 254
National Trends in Child and Adolescent Psychotropic Polypharmacy in Office-Based Practice, 1996-2007
Comer, J. S., Olfson, M., & Mojtabai, R. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.07.007 · Cited by 253
Treatment of Young People With Antipsychotic Medications in the United States
Olfson, M., King, M. D., & Schoenbaum, M. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.0500 · Cited by 252
Family processes in the development of youth depression: Translating the evidence to treatment
Restifo, K., & Bögels, S. M. (2009) · Clinical Psychology Review · doi:10.1016/j.cpr.2009.02.005 · Cited by 247
Attachment-based family therapy for depressed adolescents.
Diamond, G. S., Diamond, G. M., & Levy, S. A. (2014) · American Psychological Association eBooks · doi:10.1037/14296-000 · Cited by 246
Psychopharmacological Treatment for Very Young Children: Contexts and Guidelines
Gleason, M. M., EGGER, H. L., Emslie, G. J., Greenhill, L. L., Kowatch, R. A., Lieberman, A. F., Luby, J. L., Owens, J. A., Scahill, L. D., Scheeringa, M. S., et al. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3181570d9e · Cited by 247
Untitled work
Mangione (2022) · doi:10.1001/jama.2022.16946 · Cited by 239
Priority medicines for Europe and the world
Kaplan, W. A., Laing, R. O., & Neal, B. C. (2004) · Cited by 244
Altered White Matter Microstructure in Adolescents With Major Depression: A Preliminary Study
Cullen, K. R., Klimes‐Dougan, B., Muetzel, R. L., Mueller, B. A., Camchong, J., Houri, A. K., Kurma, S., & Lim, K. O. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-201002000-00011 · Cited by 246
Novel psychopharmacological therapies for psychiatric disorders: psilocybin and MDMA
Mithoefer, M. C., Grob, C. S., & Brewerton, T. D. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00576-3 · Cited by 253
Meta-analysis of functional neuroimaging of major depressive disorder in youth
Miller, C. H., Hamilton, J. P., Sacchet, M. D., & Gotlib, I. H. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.1376 · Cited by 229
Meta-analysis: 13-year follow-up of psychotherapy effects on youth depression
Eckshtain, D., Kuppens, S., Ugueto, A., Ng, M. Y., Vaughn-Coaxum, R., Corteselli, K., & Weisz, J. R. (2020) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2019.04.002 · Cited by 224
Comorbidity as a predictor and moderator of treatment outcome in youth with anxiety, affective, attention deficit/hyperactivity disorder, and oppositional/conduct disorders
Ollendick, T. H., Jarrett, M. A., Grills, A. E., Hovey, L. D., & Wolff, J. C. (2008) · Clinical Psychology Review · doi:10.1016/j.cpr.2008.09.003 · Cited by 256
Screening for Child and Adolescent Depression in Primary Care Settings: A Systematic Evidence Review for the US Preventive Services Task Force
Williams, S. B., O’Connor, E., Eder, M. L., & Whitlock, E. P. (2009) · PEDIATRICS · doi:10.1542/peds.2008-2415 · Cited by 235
Head circumference and height abnormalities in autism revisited: the role of pre- and perinatal risk factors
Schrieken, M., Visser, J. C., Oosterling, I. J., van Steijn, D. J., Bons, D. M. A., Draaisma, J. M. T., van der Gaag, R. J., Buitelaar, J. K., Donders, R., & Rommelse, N. N. J. (2012) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-012-0318-1 · Cited by 233
Recovery and Recurrence Following Treatment for Adolescent Major Depression
Curry, J. F., Silva, S. G., Rohde, P., Ginsburg, G. S., Kratochvil, C. J., Simons, A. D., Kirchner, J., MAY, D. E., Kennard, B. D., Mayes, T. L., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.150 · Cited by 232
Parent–Child Interaction Therapy for Mexican Americans: A Randomized Clinical Trial
McCabe, K. M., & Yeh, M. (2009) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374410903103544 · Cited by 238
Changes in antidepressant use by young people and suicidal behavior after FDA warnings and media coverage: quasi-experimental study
Lu, C. Y., Zhang, F., Lakoma, M. D., Madden, J. M., Rusinak, D., Penfold, R. B., Simon, G. E., Ahmedani, B. K., Clarke, G. N., Hunkeler, E. M., et al. (2014) · BMJ · doi:10.1136/bmj.g3596 · Cited by 229
Internalizing Problems During Adolescence
Graber, J. A., & Sontag, L. M. (2009) · Wiley eBooks · doi:10.1002/9780470479193.adlpsy001020 · Cited by 231
Toward a neurobiology of psychotherapy: basic science and clinical applications
Etkin, A., Pittenger, C., Polan, H. J., & Kandel, E. R. (2005) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.17.2.145 · Cited by 244
A preliminary study of functional connectivity in comorbid adolescent depression
Cullen, K. R., Gee, D. G., Klimes‐Dougan, B., Gabbay, V., Hulvershorn, L. A., Mueller, B. A., Camchong, J., Bell, C. J., Houri, A. K., Kumra, S., et al. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.05.022 · Cited by 235
The SLC transporter in nutrient and metabolic sensing, regulation, and drug development
Zhang, Y., Zhang, Y., Sun, K., Meng, Z., & Chen, L. (2018) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjy052 · Cited by 218
Predictors and moderators of treatment response in childhood anxiety disorders: Results from the CAMS trial.
Compton, S. N., Peris, T. S., Almirall, D., Birmaher, B., Sherrill, J., Kendall, P. C., March, J. S., Gosch, E. A., Ginsburg, G. S., Rynn, M. A., et al. (2014) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0035458 · Cited by 226
Impact of adolescent social experiences on behavior and neural circuits implicated in mental illnesses
Burke, A. R., McCormick, C. M., Pellis, S. M., & Lukkes, J. L. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.018 · Cited by 225
Youth Depression in the Family Context: Familial Risk Factors and Models of Treatment
Sander, J. B., & McCarty, C. A. (2005) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-005-6666-3 · Cited by 222
Impact of Multifamily Psychoeducational Psychotherapy in Treating Children Aged 8 to 12 Years With Mood Disorders
Fristad, M. A., Verducci, J. S., Walters, K. A., & Young, M. E. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.112 · Cited by 222
Mental Health Competencies for Pediatric Practice
Foy, J. M., Green, C. M., Earls, M. F., COMMITTEE ON PSYCHOSOCIAL ASPECTS OF CHILD AND FAMILY HEALTH, M. H. L. W. G., Lavin, A., Askew, G. L., Baum, R., Berger-Jenkins, E., Gambon, T. B., Nasir, A. A., et al. (2019) · Pediatrics · doi:10.1542/peds.2019-2757 · Cited by 221
Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive‐compulsive disorder
Lin, H., Katsovich, L., Ghebremichael, M. S., Findley, D. B., Grantz, H., Lombroso, P. J., King, R. A., Zhang, H., & Leckman, J. F. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01687.x · Cited by 216
Major depressive disorder in children and adolescents
Mullen, S. (2018) · Mental Health Clinician · doi:10.9740/mhc.2018.11.275 · Cited by 219
Methodological Recommendations for Trials of Psychological Interventions
Guidi, J., Brakemeier, E.-L., Bockting, C. L. H., Cosci, F., Cuijpers, P., Jarrett, R. B., Linden, M., Marks, I., Peretti, C. S., Rafanelli, C., et al. (2018) · Psychotherapy and Psychosomatics · doi:10.1159/000490574 · Cited by 205
Escitalopram in the Treatment of Adolescent Depression: A Randomized Placebo-Controlled Multisite Trial
Emslie, G. J., Ventura, D., Korotzer, A., & Tourkodimitris, S. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3181a2b304 · Cited by 210
A Double-Blind, Randomized, Placebo-Controlled Trial of Escitalopram in the Treatment of Pediatric Depression
Wagner, K. D., Jonas, J. M., Findling, R. L., Ventura, D., & Saikali, K. G. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000192250.38400.9e · Cited by 210
Screening and Treatment for Major Depressive Disorder in Children and Adolescents: US Preventive Services Task Force Recommendation Statement
US Preventive Services Task Force (2009) · PEDIATRICS · doi:10.1542/peds.2008-2381 · Cited by 205

Authors: Treatment for Adolescents With Depression Study (TADS) Team
Affiliations: Duke Medical Center (US)
Corresponding author: Treatment for Adolescents With Depression Study (TADS) Team
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2004-08-18
Volume: 292
Issue: 7
Pages: 807
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.292.7.807
OpenAlex: W2254051562
Cited by: 1,735
References: 43
Citations by year: 2026: 43 · 2025: 35 · 2024: 72 · 2023: 41 · 2022: 63 · 2021: 60 · 2020: 50 · 2019: 64 · 2018: 54 · 2017: 42 · 2016: 79 · 2015: 75 · 2014: 83 · 2013: 85 · 2012: 92
FWCI: 81.91
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Funders: Yale University
Kaiser Permanente
University of Pittsburgh
Carnegie Mellon University
University of Texas at Austin
National Institutes of Health (98DS-0008)
National Institute of Mental Health
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Keywords: fluoxetine, cognitive behavioral therapy, adolescent depression, major depressive disorder, selective serotonin reuptake inhibitors, combination therapy, treatment response, suicidal ideation, Children's Depression Rating Scale-Revised, clinical global impression, placebo response, medication adherence, relapse prevention, psychoeducation, psychotherapy dropout
MeSH terms: Adolescent, Combined Modality Therapy, Major Depressive Disorder, Depressive Disorder, Major, Female, Fluoxetine, Humans, Male, Psychiatric Status Rating Scales, Risk, Suicide, Cognitive Behavioral Therapy, Selective Serotonin Reuptake Inhibitors, Antidepressive Agents, Second-Generation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Fluoxetine, Cognitive-Behavioral Therapy, and Their Combination for Adolescents With Depression: Treatment for Adolescents With Depression Study (TADS) Randomized Controlled Trial

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks