Cited by 1,121Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsCardiac pacing and defibrillation studies

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Radiofrequency Ablation vs Antiarrhythmic Drugs as First-line Treatment of Symptomatic Atrial Fibrillation: A Randomized Trial

Wazni, Oussama M., Marrouche, Nassir F., Martin, David O., Verma, Atul, Bhargava, Mandeep, Saliba, Walid, Bash, Dianna, Schweikert, Robert, Brachmann, Johannes, Gunther, Jens, Gutleben, Klaus, Pisano, Ennio, Potenza, Dominico, Fanelli, Raffaele, Raviele, Antonio, Themistoclakis, Sakis, Rossillo, Antonio, Bonso, Aldo, Natale, Andrea·2005·JAMA

DOI 10.1001/jama.293.21.2634

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Abstract

CONTEXT: Treatment with antiarrhythmic drugs and anticoagulation is considered first-line therapy in patients with symptomatic atrial fibrillation (AF). Pulmonary vein isolation (PVI) with radiofrequency ablation may cure AF, obviating the need for antiarrhythmic drugs and anticoagulation. OBJECTIVE: To determine whether PVI is feasible as first-line therapy for treating patients with symptomatic AF. DESIGN, SETTING, AND PARTICIPANTS: A multicenter prospective randomized study conducted from December 31, 2001, to July 1, 2002, of 70 patients aged 18 to 75 years who experienced monthly symptomatic AF episodes for at least 3 months and had not been treated with antiarrhythmic drugs. INTERVENTION: Patients were randomized to receive either PVI using radiofrequency ablation (n=33) or antiarrhythmic drug treatment (n=37), with a 1-year follow-up. MAIN OUTCOME MEASURES: Recurrence of AF, hospitalization, and quality of life assessment. RESULTS: Two patients in the antiarrhythmic drug treatment group and 1 patient in the PVI group were lost to follow-up. At the end of 1-year follow-up, 22 (63%) of 35 patients who received antiarrhythmic drugs had at least 1 recurrence of symptomatic AF compared with 4 (13%) of 32 patients who received PVI (P<.001). Hospitalization during 1-year follow-up occurred in 19 (54%) of 35 patients in the antiarrhythmic drug group compared with 3 (9%) of 32 in the PVI group (P<.001). In the antiarrhythmic drug group, the mean (SD) number of AF episodes decreased from 12 (7) to 6 (4), after initiating therapy (P = .01). At 6-month follow-up, the improvement in quality of life of patients in the PVI group was significantly better than the improvement in the antiarrhythmic drug group in 5 subclasses of the Short-Form 36 health survey. There were no thromboembolic events in either group. Asymptomatic mild or moderate pulmonary vein stenosis was documented in 2 (6%) of 32 patients in the PVI group. CONCLUSION: Pulmonary vein isolation appears to be a feasible first-line approach for treating patients with symptomatic AF. Larger studies are needed to confirm its safety and efficacy.

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Untitled work
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Background
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“Three trials enrolled patients to receive pulmonary vein ablation as the first‑line therapy (10,17,18), whereas the remaining studies included patients that had failed at least one AAD treatment protocol or were intolerant of AADs.”
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Chang, C., Lin, J., Chiu, F., Caffrey, J. L., Wu, L., & Lai, M. (2014) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.113.000597 · Cited by 56
“Compared with antiarrhythmic drug therapy, RFA reduces the number of subsequent AF episodes, prolongs the time to treatment failure, and improves quality of life.(10,11) However, the current data available regarding the long-term effects of ablation therapy on preventing HF, stroke, and death are limited.”
Background
The Incidence of Asymptomatic Cerebral Microthromboembolism after Atrial Fibrillation Ablation: Comparison of Warfarin and Dabigatran
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Amponsah, M., Benjamin, E. J., & Magnani, J. W. (2013) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-013-0327-8 · Cited by 55
“RFA has been successfully used in the management of AF [87].”
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Adiyaman, A., Buist, T. J., Beukema, R. J., Smit, J. J. J., Delnoy, P. P. H. M., Hemels, M. E. W., Sie, H. T., Misier, A. R. R., & Elvan, A. (2018) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.118.006182 · Cited by 56
A randomized trial comparing effects of radiofrequency and cryoablation on the structural integrity of esophageal tissue
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“It is becoming increasingly effective in eliminating the arrhythmia [1, 2] and has been shown to improve quality of life when compared to pharmacologic rhythm management [3, 4].”
Background
Selective Complex Fractionated Atrial Electrograms Targeting for Atrial Fibrillation Study (SELECT AF)
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“We, therefore, chose a sample size of 80 patients (40 per arm) to be consistent with the sample sizes of other published comparative AF ablation pilot studies.(12,13) Only subjects undergoing ablation with both CFAE and PVI procedures completed were included for analysis.”
Result
Progression of Atrial Fibrillation After a Failed Initial Ablation Procedure in Patients With Paroxysmal Atrial Fibrillation
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Efficacy and Safety of Catheter Ablation for Long‐Standing Persistent Atrial Fibrillation in Women
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“This may be due to different inclusion criteria and rather reflect real-world experience than trial data from selected high-volume centers [13, 14].”
BackgroundResult
Radiofrequency Ablation Versus Antiarrhythmic Drug Therapy for Atrial Fibrillation
Siontis, K. C., Ioannidis, J. P. A., Katritsis, G., Noseworthy, P. A., Packer, D. L., Hummel, J. D., Jaı̈s, P., Krittayaphong, R., Mont, L., Morillo, C. A., et al. (2015) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2015.10.003 · Cited by 55
“In 3 trials (32,38,41), patients had never been treatedwith AAD (i.”
Background
Catheter ablation for atrial fibrillation
Lubitz, S. A., Fischer, A., & Fuster, V. (2008) · BMJ · doi:10.1136/bmj.39513.555150.be · Cited by 55
Catheter Ablation of Atrial Fibrillation
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The cost-effectiveness of radiofrequency catheter ablation as first-line treatment for paroxysmal atrial fibrillation: results from a MANTRA-PAF substudy
Aronsson, M., Walfridsson, H., Janzon, M., Walfridsson, U., Nielsen, J. C., HANSEN, P. S., Johannessen, A. C., Raatikainen, P. M. J., Hindricks, G., Kongstad, O., et al. (2014) · EP Europace · doi:10.1093/europace/euu188 · Cited by 53
Efficacy of Catheter Ablation in Nonparoxysmal Atrial Fibrillation Patients with Severe Enlarged Left Atrium and Its Impact on Left Atrial Structural Remodeling
Pump, A., Biase, L. D., Price, J., Mohanty, P. K., Bai, R., Santangeli, P., Mohanty, S., Trivedi, C. G., Yan, R., Horton, R., et al. (2013) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12253 · Cited by 53
The Clinical Benefits and Mortality Reduction Associated With Catheter Ablation in Subjects With Atrial Fibrillation
Khan, S. U., Rahman, H., Talluri, S., & Kaluski, E. (2018) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2018.03.003 · Cited by 53
Reverse Remodeling of the Mitral Valve Complex After Radiofrequency Catheter Ablation for Atrial Fibrillation
Nishino, S., Watanabe, N., Ashikaga, K., Morihisa, K., Kuriyama, N., Asada, Y., & Shibata, Y. (2019) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.119.009317 · Cited by 52
Efficacy and safety of pulmonary veins isolation by cryoablation for the treatment of paroxysmal and persistent atrial fibrillation
Defaye, P., Kane, A. D., Chaïb, A., & Jacon, P. (2011) · EP Europace · doi:10.1093/europace/eur036 · Cited by 50
Clinical and Echocardiographic Risk Factors Predict Late Recurrence after Radiofrequency Catheter Ablation of Atrial Fibrillation
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Ablation vs Medical Therapy in the Setting of Symptomatic Atrial Fibrillation and Left Ventricular Dysfunction
Choi, A. D., Hematpour, K., Kukin, M. L., Mittal, S., & Steinberg, J. S. (2009) · Congestive Heart Failure · doi:10.1111/j.1751-7133.2009.00116.x · Cited by 49
Update on atrial fibrillation catheter ablation technologies and techniques
Dewire, J., & Calkins, H. G. (2013) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2013.121 · Cited by 48
Radiofrequency ablation of atrial fibrillation in patients with mitral or aortic mechanical prosthetic valves: A feasibility, safety, and efficacy study
Lakkireddy, D., Nagarajan, D. V., Biase, L. D., Vanga, S. R., Mahapatra, S., Bunch, T. J., Day, J. D., BURKHARDT, D. J., Umbarger, L., Dendi, R., et al. (2011) · Heart Rhythm · doi:10.1016/j.hrthm.2011.02.012 · Cited by 48
Inducibility of Atrial Fibrillation and Flutter Following Pulmonary Vein Ablation
Leong‐Sit, P., Robinson, M., Zado, E. S., Callans, D. J., Garcia, F. C., Lin, D., Dixit, S., Bala, R., Riley, M. P., Hutchinson, M. D., et al. (2013) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12088 · Cited by 49
Virtual ablation for atrial fibrillation in personalized in-silico three-dimensional left atrial modeling: Comparison with clinical catheter ablation
Hwang, M., Kwon, S.-S., Wi, J. H., Park, M., Lee, H., Park, J. S., Lee, Y.-S., Shim, E. B., & Pak, H. (2014) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2014.09.006 · Cited by 47
“, 2010) with a better rhythm control efficacy as compared to anti-arrhythmic drugs (Wazni et al., 2005).”
Background
Left Atrial Diverticula in Patients Referred for Radiofrequency Ablation of Atrial Fibrillation
Peng, L., Yu, J., Yang, Z., Wu, D., Xu, J.-J., Chu, Z., Li, X., Chen, D., Luo, Y., Shao, H., et al. (2012) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.111.965665 · Cited by 47
“Main Findings The main findings of this study were that (1) LAD were common entities, with a prevalence of 36.”
Healthcare Utilization and Expenditures in Patients with Atrial Fibrillation Treated with Catheter Ablation
Ladapo, J. A., David, G., Gunnarsson, C., Hao, S. C., White, S., March, J. L., & Reynolds, M. R. (2011) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2011.02130.x · Cited by 47
Catheter ablation versus medical therapy for patients with persistent atrial fibrillation: a systematic review and meta-analysis of evidence from randomized controlled trials
Chen, C., Zhou, X., Zhu, M., Chen, S., Chen, J., Cai, H., Dai, J. M., Xu, X., & Mao, W. (2018) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-018-0349-8 · Cited by 47
“Third, it is unfortunate that persistent AF subgroups are often not published for mixed persistent/paroxysmal trials [27, 28], so these data were not be included in this meta-analysis.”
Background
Understanding Atrial Fibrillation: The Signal Processing Contribution, Part II
Mainardi, L., Sörnmo, L., & Cerutti, S. (2008) · Synthesis lectures on biomedical engineering · doi:10.2200/s00153ed1v01y200809bme025 · Cited by 47
Catheter ablation for atrial fibrillation: results from the first European Snapshot Survey on Procedural Routines for Atrial Fibrillation Ablation (ESS-PRAFA) Part II
Chen, J., Dagres, N., Hocini, M., Fauchier, L., Bongiorni, M. G., Defaye, P., Hernández‐Madrid, A., Estner, H., Sciaraffia, E., & Blomström‐Lundqvist, C. (2015) · EP Europace · doi:10.1093/europace/euv315 · Cited by 46
Patient selection, peri-procedural management, and ablation techniques for catheter ablation of atrial fibrillation: an EHRA survey
Iliodromitis, K. E., Lenarczyk, R., Scherr, D., Conte, G., Farkowski, M. M., Marín, F. R., García‐Seara, J., Simovic, S. M., & Potpara, T. (2022) · EP Europace · doi:10.1093/europace/euac236 · Cited by 46
Integration of Three‐Dimensional Left Atrial Magnetic Resonance Images into a Real‐Time Electroanatomic Mapping System: Validation of a Registration Method
Bertaglia, E., BRANDOLINO, G., Zoppo, F., Zerbo, F., & Pascotto, P. (2008) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2008.00986.x · Cited by 45
Risk of Stroke or Transient Ischemic Attack After Atrial Fibrillation Ablation with Oral Anticoagulant Use Guided by ECG Monitoring and Pulse Assessment
Riley, M. P., Zado, E. S., Hutchinson, M. D., Lin, D., Bala, R., Garcia, F. C., Callans, D. J., Cooper, J. M., Verdino, R. J., Dixit, S., et al. (2014) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12387 · Cited by 44
The Short and Long-Term Efficacy of Pulmonary Vein Isolation as a Sole Treatment Strategy for Paroxysmal Atrial Fibrillation: A Systematic Review and Meta-Analysis
Kis, Z., Muka, T., Franco, O. H., Bramer, W. M., de Vries, L. J., Kardos, A., & Szili‐Törok, T. (2017) · Current Cardiology Reviews · doi:10.2174/1573403x13666170117125124 · Cited by 45
Atrial fibrillation reduction by renal sympathetic denervation: 12 months’ results of the AFFORD study
Feyz, L., Theuns, D. A. M. J., Bhagwandien, R. E., Strachinaru, M., Kardys, I., Mieghem, N. M. V., & Daemen, J. (2018) · Clinical Research in Cardiology · doi:10.1007/s00392-018-1391-3 · Cited by 47
Hybrid solid-state SPECT/CT left atrial innervation imaging for identification of left atrial ganglionated plexi: Technique and validation in patients with atrial fibrillation
Stirrup, J., Gregg, S., Baavour, R., Roth, N., Breault, C., Agostini, D., Ernst, S., & Underwood, S. R. (2019) · Journal of Nuclear Cardiology · doi:10.1007/s12350-018-01535-5 · Cited by 45
Atrial Fibrillation in Congestive Heart Failure
Seiler, J., & Stevenson, W. G. (2009) · Cardiology in Review · doi:10.1097/crd.0b013e3181c21cff · Cited by 44
“Two small randomized trials of 70 and 112 patients found that catheter ablation of AF was superior to treatment with antiarrhythmic drugs in the maintenance of sinus rhythm, improvement of exercise capacity and quality of life.(117,118) However, these high success rates reported from patients with predominantly no or…”
Background
Catheter ablation vs. antiarrhythmic drugs as ‘first-line’ initial therapy for atrial fibrillation: a pooled analysis of randomized data
Chen, S., Pürerfellner, H., Ouyang, F. O., Kiuchi, M. G., Meyer, C. G., Martinek, M., Futyma, P., Zhu, L., Schratter, A., Wang, J., et al. (2021) · EP Europace · doi:10.1093/europace/euab185 · Cited by 45
Accuracy of integration of multislice computed tomography imaging into three-dimensional electroanatomic mapping for real-time guided radiofrequency ablation of left atrial fibrillation—Influence of heart rhythm and radiofrequency lesions
Martinek, M., Nesser, H., Aichinger, J., Boehm, G., & Pürerfellner, H. (2007) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-006-9067-8 · Cited by 44
“With radiofrequency ablation finding its way to probably become a first-line therapy in AF at least for selected patients, ablation strategies have to meet a few crucial points [18].”
Background
Characteristics of Patients Undergoing Atrial Fibrillation Ablation: Trends Over a Seven‐Year Period 1999–2005
Gerstenfeld, E. P., Callans, D. J., Dixit, S., Lin, D., Cooper, J. M., Russo, A. M., Verdino, R. J., Weiner, M., Zado, E. S., & Marchlinski, F. E. (2006) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2006.00662.x · Cited by 44
JCS / JHRS 2020 Guideline on Pharmacotherapy of Cardiac Arrhythmias
Ono, K., Iwasaki, Y., Akao, M., Ikeda, T., Ishii, K., Inden, Y., Kusano, K., Kobayashi, Y., Koretsune, Y., Sasano, T., et al. (2022) · Journal of Arrhythmia · doi:10.1002/joa3.12714 · Cited by 41
How many atrial fibrillation ablation candidates have an underlying supraventricular tachycardia previously unknown? Efficacy of isolated triggering arrhythmia ablation
Sciarra, L., Rebecchi, M., Ruvo, E. D., Luca, L. D., Zuccaro, L. M., Fagagnini, A., Corò, L., Allocca, G., Lioy, E., Delise, P., et al. (2010) · EP Europace · doi:10.1093/europace/euq327 · Cited by 42
New Technologies in Atrial Fibrillation Ablation
Burkhardt, J. D., & Natale, A. (2009) · Circulation · doi:10.1161/circulationaha.109.858233 · Cited by 43
Radiofrequency Catheter Ablation Improves the Quality of Life Measured with a Short Form-36 Questionnaire in Atrial Fibrillation Patients: A Systematic Review and Meta-Analysis
Kim, Y. G., Shim, J., Choi, J., & Kim, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163755 · Cited by 43
The burden of proof: The current state of atrial fibrillation prevention and treatment trials
Zakeri, R., Wagoner, D. R. V., Calkins, H. G., Wong, T., Ross, H., Heist, E. K., Meyer, T. E., Kowey, P. R., Mentz, R. J., Cleland, J. G. F., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.01.032 · Cited by 42
Five‐Year Change in the Renal Function After Catheter Ablation of Atrial Fibrillation
Park, J., Yang, P., Bae, H., Yang, S., Yu, H. T., Kim, T., Uhm, J., Joung, B., Lee, M., & Pak, H. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.013204 · Cited by 43
Catheter Ablation Improves Mortality and Other Outcomes in Real‐World Patients With Atrial Fibrillation
Yang, P., Sung, J., Jang, E., Yu, H. T., Kim, T., Uhm, J., Kim, J., Pak, H., Lee, M., & Joung, B. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.015740 · Cited by 43
Quality of Life and Health Care Utilization in the CIRCA-DOSE Study
Andrade, J. G., Macle, L., Verma, A., Deyell, M. W., Champagne, J., Dubuc, M., Leong‐Sit, P., NOVAK, P. G., Roux, J.-F., Sapp, J. L., et al. (2020) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2020.04.017 · Cited by 43
Isolating the pulmonary veins as first-line therapy in patients with lone paroxysmal atrial fibrillation using the Cryoballoon
Namdar, M., Chierchia, G., Westra, S. W., Sorgente, A., Meir, M. L., Bayrak, F., Rao, J. Y., Ricciardi, D., de Asmundis, C., Sarkozy, A., et al. (2011) · EP Europace · doi:10.1093/europace/eur299 · Cited by 42
“Recently gathered evidence, including the STOP-AF trial, where patients were treated by CBA, adds substantially to hitherto available analyses.(25,34) Our favourable results as compared to the STOP-AF study, however, might be due to the highly experienced operators, the single-centre nature of the study and the younge…”
The role of myocardial innervation imaging in different clinical scenarios: an expert document of the European Association of Cardiovascular Imaging and Cardiovascular Committee of the European Association of Nuclear Medicine
Gimelli, A., Liga, R., Agostini, D., Bengel, F. M., Ernst, S., Hyafil, F., Saraste, A., Scholte, A. J. H. A., Verberne, H. J., Verschure, D. O., et al. (2021) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jeab007 · Cited by 42
“(PVI) represents the cornerstone technique for treating patients with AF resistant to standard pharmacological therapies.(48) However, the success rate of the first AF ablation remains only 60% at 1 year.”
Method
Quality of life in older people with atrial fibrillation
Lane, D. A., & Lip, G. Y. H. (2008) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-008-9318-y · Cited by 42
“Direct comparison of ‘traditional’ rhythm control (with anti-arrhythmic drugs) and these ‘newer’ rhythm-control interventions has demonstrated significant improvement in QoL in patients undergoing radiofrequency ablation of the pulmonary vein [22, 23] compared to those receiving antiarrhythmic pharmacological therapy.”
Result
Improvement in Quality of Life After Catheter Ablation for Paroxysmal Versus Long‐standing Persistent Atrial Fibrillation: A Prospective Study With 3‐Year Follow‐up
Bulková, V., Fiala, M., Havránek, Š., Šimek, J., Škňouřil, L., Januška, J., Špinar, J., & Wichterle, D. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.000881 · Cited by 42
Registro Español de Ablación con Catéter. IV Informe Oficial de la Sección de Electrofisiología y Arritmias de la Sociedad Española de Cardiología (2004)
López, M. Á., Font, E. R., & Alberola, A. G. (2005) · Revista Española de Cardiología · doi:10.1016/s0300-8932(05)74075-6 · Cited by 42
Clinical Outcome of Electrophysiologically Guided Ablation for Nonparoxysmal Atrial Fibrillation Using a Novel Real-Time 3-Dimensional Mapping Technique
Pappone, C., Ciconte, G., Vicedomini, G., Mangual, J. O., Li, W., Conti, M. A., Giannelli, L., Lipartiti, F., McSpadden, L. C., Ryu, K., et al. (2018) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.117.005904 · Cited by 42
Immediate and medium-term outcomes of cryoballoon-based pulmonary vein isolation in patients with paroxysmal and persistent atrial fibrillation: single-centre experience
Aytemir, K., Oto, A., Canpolat, U., Sunman, H., Yorgun, H., ŞAHINER, L., & Kaya, E. B. (2013) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-013-9834-2 · Cited by 41
Catheter ablation for paroxysmal and persistent atrial fibrillation
Chen, H. S., Wen, J., Wu, S., & Liu, J. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007101.pub2 · Cited by 42
CAABL-AF (California Study of Ablation for Atrial Fibrillation)
Srivatsa, U. N., Danielsen, B. H., Amsterdam, E. A., Pezeshkian, N. G., Yang, Y., Nordsieck, E. J., Fan, D., Chiamvimonvat, N., & White, R. H. R. (2018) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.117.005739 · Cited by 42
Near-infrared spectroscopy integrated catheter for characterization of myocardial tissues: preliminary demonstrations to radiofrequency ablation therapy for atrial fibrillation
Singh‐Moon, R. P., Marboe, C. C., & Hendon, C. P. (2015) · Biomedical Optics Express · doi:10.1364/boe.6.002494 · Cited by 41
Efficacy of Cryoballoon Pulmonary Vein Isolation in Patients With Persistent Atrial Fibrillation
Guhl, E., Siddoway, D., ADELSTEIN, E. C., Voigt, A., Saba, S., & Jain, S. K. (2016) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12924 · Cited by 39
A computational comparison of radiofrequency and pulsed field ablation in terms of lesion morphology in the cardiac chamber
Gómez-Barea, M., García-Sánchez, T., & Ivorra, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-20212-9 · Cited by 40
“Enthalpy is related to temperature by the following expression48,49: (1) ∇ · (σ∇�) = 0”
Symptomatic and Asymptomatic Atrial Fibrillation after Pulmonary Vein Ablation and the Impact on Quality of Life
Pontoppidan, J., Nielsen, J. C., Poulsen, S. H., & HANSEN, P. S. (2009) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2009.02357.x · Cited by 40
Effect of Eplerenone on Maintenance of Sinus Rhythm After Catheter Ablation in Patients With Long-Standing Persistent Atrial Fibrillation
Ito, Y., Yamasaki, H., Naruse, Y., Yoshida, K., Kaneshiro, T., Murakoshi, N., Igarashi, M., Kuroki, K., Machino, T., Xu, D., et al. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.12.020 · Cited by 40
Catheter ablation for atrial fibrillation: Should it be first-line therapy?
Wharton, J. M. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.01.017 · Cited by 40
Smartphone ECG Monitoring System Helps Lower Emergency Room and Clinic Visits in Post–Atrial Fibrillation Ablation Patients
Aljuaid, M., Marashly, Q., Danaf, J. A., Tawhari, I. H., Barakat, M. M., Barakat, R., Zobell, B., Cho, W., Chelu, M. G., & Marrouche, N. F. (2020) · Clinical Medicine Insights Cardiology · doi:10.1177/1179546820901508 · Cited by 40

Authors: Wazni, O. M., Marrouche, N. F., Martin, D. O., Verma, A., Bhargava, M., Saliba, W., Bash, D., Schweikert, R., Brachmann, J., Gunther, J., Gutleben, K., Pisano, E., Potenza, D., Fanelli, R., Raviele, A., Themistoclakis, S., Rossillo, A., Bonso, A., & Natale, A.
Affiliations: Cleveland Clinic (US)
Corresponding author: Natale, Andrea
ORCID: Wazni, Oussama M.
Marrouche, Nassir F.
Martin, David O.
Verma, Atul
Bhargava, Mandeep
Saliba, Walid
Brachmann, Johannes
Raviele, Antonio
Themistoclakis, Sakis
Rossillo, Antonio
Natale, Andrea
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2005-06-01
Volume: 293
Issue: 21
Pages: 2634
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.293.21.2634
OpenAlex: W2154269490
Cited by: 1,121
References: 39
Citations by year: 2026: 18 · 2025: 31 · 2024: 38 · 2023: 29 · 2022: 61 · 2021: 52 · 2020: 45 · 2019: 36 · 2018: 53 · 2017: 40 · 2016: 44 · 2015: 52 · 2014: 69 · 2013: 75 · 2012: 78
FWCI: 43.53
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Keywords: atrial fibrillation, radiofrequency ablation, pulmonary vein isolation, antiarrhythmic drugs, first-line therapy, atrial fibrillation recurrence, hospitalization, quality of life, pulmonary vein stenosis, anticoagulation, thromboembolic events, Short Form 36 Health Survey, randomized trial comparison, cost-effectiveness, patient satisfaction
MeSH terms: Anti-Arrhythmia Agents, Atrial Fibrillation, Humans, Middle Aged, Pilot Projects, Prospective Studies, Pulmonary Veins, Quality of Life, Survival Analysis, Treatment Outcome, Catheter Ablation

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Radiofrequency Ablation vs Antiarrhythmic Drugs as First-line Treatment of Symptomatic Atrial Fibrillation: A Randomized Trial

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