The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Radiofrequency Ablation vs Antiarrhythmic Drugs as First-line Treatment of Symptomatic Atrial Fibrillation: A Randomized Trial
Abstract
CONTEXT: Treatment with antiarrhythmic drugs and anticoagulation is considered first-line therapy in patients with symptomatic atrial fibrillation (AF). Pulmonary vein isolation (PVI) with radiofrequency ablation may cure AF, obviating the need for antiarrhythmic drugs and anticoagulation. OBJECTIVE: To determine whether PVI is feasible as first-line therapy for treating patients with symptomatic AF. DESIGN, SETTING, AND PARTICIPANTS: A multicenter prospective randomized study conducted from December 31, 2001, to July 1, 2002, of 70 patients aged 18 to 75 years who experienced monthly symptomatic AF episodes for at least 3 months and had not been treated with antiarrhythmic drugs. INTERVENTION: Patients were randomized to receive either PVI using radiofrequency ablation (n=33) or antiarrhythmic drug treatment (n=37), with a 1-year follow-up. MAIN OUTCOME MEASURES: Recurrence of AF, hospitalization, and quality of life assessment. RESULTS: Two patients in the antiarrhythmic drug treatment group and 1 patient in the PVI group were lost to follow-up. At the end of 1-year follow-up, 22 (63%) of 35 patients who received antiarrhythmic drugs had at least 1 recurrence of symptomatic AF compared with 4 (13%) of 32 patients who received PVI (P<.001). Hospitalization during 1-year follow-up occurred in 19 (54%) of 35 patients in the antiarrhythmic drug group compared with 3 (9%) of 32 in the PVI group (P<.001). In the antiarrhythmic drug group, the mean (SD) number of AF episodes decreased from 12 (7) to 6 (4), after initiating therapy (P = .01). At 6-month follow-up, the improvement in quality of life of patients in the PVI group was significantly better than the improvement in the antiarrhythmic drug group in 5 subclasses of the Short-Form 36 health survey. There were no thromboembolic events in either group. Asymptomatic mild or moderate pulmonary vein stenosis was documented in 2 (6%) of 32 patients in the PVI group. CONCLUSION: Pulmonary vein isolation appears to be a feasible first-line approach for treating patients with symptomatic AF. Larger studies are needed to confirm its safety and efficacy.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Fewer data are available reporting the effectiveness and safety of catheter ablation in patients with persistent or long-standing persistent AF, but all point to lower recurrence rates after catheter ablation compared to antiarrhythmic drug therapy with or without cardioversion.185,717,[723][724][725][726]1039”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [723]
In the citing paper
“Fewer data are available reporting the effectiveness and safety of catheter ablation in patients with persistent or long-standing persistent AF, but all point to lower recurrence rates after catheter ablation compared to antiarrhythmic drug therapy with or without cardioversion.185,717,[723][724][725][726]1039”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [723]
Citations
Cites
(1992) · PubMed · Cited by 33,716
Go, A. S., Hylek, E. M., Phillips, K. A., Chang, Y., Henault, L. E., Selby, J. V., & Singer, D. E. (2001) · JAMA · doi:10.1001/jama.285.18.2370 · Cited by 6,205
A comparison of rate control and rhythm control in patients with atrial fibrillation
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa021328 · Cited by 4,405
Atrial Fibrillation Begets Atrial Fibrillation
WIJFFELS, M. C. E. F., Kirchhof, C. J. H. J., Dorland, R., & Allessie, M. A. (1995) · Circulation · doi:10.1161/01.cir.92.7.1954 · Cited by 3,500
Cappato, R., Calkins, H., Chen, S.-A., Davies, W., Iesaka, Y., Kalman, J., Kim, Y.-H., Klein, G., Natale, A., Packer, D., et al. (2010) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.109.859116 · Cited by 2,852
Gelder, I. C. V., Hagens, V. E., Bosker, H. A., Kingma, J. H., Otto Kamp, B., Kingma, T., Said, S. A., Darmanata, J. I., Timmermans, A. J. M., Tijssen, J. G. P., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021375 · Cited by 2,355
ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation: executive summary
Fuster, V., Rydén, L., ASINGER, R. W., Cannom, D. S., Crijns, H. J. G. M., Frye, R. L., Halperin, J. L., Kay, G. N., Klein, W. W., Lévy, S., et al. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01587-x · Cited by 1,362
Cappato, R., Calkins, H. G., Chen, S., Davies, W. D., Iesaka, Y., Kalman, J. M., Kim, Y.-H., Klein, G. J., Packer, D. L., & Skanes, A. C. (2005) · Circulation · doi:10.1161/01.cir.0000157153.30978.67 · Cited by 1,303
The AFFIRM Investigators (2004) · Circulation · doi:10.1161/01.cir.0000121736.16643.11 · Cited by 1,202
Pulmonary Vein Isolation for Paroxysmal and Persistent Atrial Fibrillation
Oral, H., Knight, B. P., Tada, H., Özaydın, M., Chugh, A., Hassan, S. A., Scharf, C., Lai, S. W. K., Greenstein, R., Pelosi, F., et al. (2002) · Circulation · doi:10.1161/hc0902.104712 · Cited by 1,112
Cited by
Sorted by citations
Items 301–400 of 1,000
Verma, A., Minor, S., Kılıçaslan, F., Patel, D., Hao, S. C., Beheiry, S., Lakkireddy, D., Elayi, S. C., Cummings, J. E., Martin, D. O., et al. (2007) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2007.00789.x · Cited by 40
“4 Therefore, we sought to (1) assess the incidence of atrial arrhythmia recurrences post-AF ablation as detected by a permanent pacemaker (PPM) and (2) determine if there is a correlation between these PPM-detected recurrences and symptom-based recurrence.”
MANSOUR, M. C., Forleo, G. B., Pappalardo, A., Heist, E. K., Avella, A., Laurenzi, F., Girolamo, P. D., Bencardino, G., Russo, A. D., Mantica, M., et al. (2008) · Heart Rhythm · doi:10.1016/j.hrthm.2008.08.024 · Cited by 40
Catheter ablation for atrial fibrillation: indications and future perspective
Natale, A., Mohanty, S., Sanders, P., Anter, E., Shah, A. J., Al-Mohani, G., & Haı̈ssaguerre, M. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae618 · Cited by 44
Should We Perform Catheter Ablation for Asymptomatic Atrial Fibrillation?
Kalman, J. M., Sanders, P., Rosso, R., & Calkins, H. G. (2017) · Circulation · doi:10.1161/circulationaha.116.024926 · Cited by 42
Influence of atrial fibrillation type on outcomes of ablation vs. drug therapy: results from CABANA
Monahan, K. H., Bunch, T. J., Mark, D. B., Poole, J. E., Bahnson, T. D., Al‐Khalidi, H. R., Silverstein, A. P., Daniels, M. R., Lee, K. L., Packer, D. L., et al. (2022) · EP Europace · doi:10.1093/europace/euac055 · Cited by 39
Jøns, C., HANSEN, P. S., Johannessen, A. C., Hindricks, G., Raatikainen, P. M. J., Kongstad, O., Walfridsson, H., Pehrson, S. M., Almroth, H., Hartikainen, J. E. K., et al. (2009) · EP Europace · doi:10.1093/europace/eup122 · Cited by 39
Atrial-selective sodium channel block for the treatment of atrial fibrillation
Burashnikov, A., & Antzelevitch, C. N. (2009) · Expert Opinion on Emerging Drugs · doi:10.1517/14728210902997939 · Cited by 39
“A number of recent randomized, prospective and multi-center studies have provided compelling evidence that catheter ablation strategy, primarily targeting pulmonary vein regions of the left atrium, is more effective than AADs in the long-term maintenance of sinus rhythm in symptomatic and relatively young patients wit…”
BackgroundReynolds, M. R., Morais, E., & ZIMETBAUM, P. J. (2010) · American Heart Journal · doi:10.1016/j.ahj.2010.06.034 · Cited by 38
Catheter Ablation for Atrial Fibrillation
Thomas, S. P., & Sanders, P. (2012) · Heart Lung and Circulation · doi:10.1016/j.hlc.2012.03.122 · Cited by 38
Kawaji, T., Shizuta, S., Morimoto, T., Aizawa, T., Yamagami, S., Yoshizawa, T., Ota, C., Onishi, N., Sasaki, Y., Yahata, M., et al. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.09.023 · Cited by 38
C-reactive protein for prediction of atrial fibrillation recurrence after catheter ablation
Meyre, P. B., Sticherling, C., Spies, F., Aeschbacher, S., Blum, S., Voellmin, G., Madaffari, A., Conen, D., Osswald, S., Kühne, M., et al. (2020) · BMC Cardiovascular Disorders · doi:10.1186/s12872-020-01711-x · Cited by 38
Fan, J., Cao, H., Su, L., Ling, Z., Liu, Z., Lan, X., Xu, Y., Chen, W., & Yin, Y. (2011) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-011-9606-9 · Cited by 38
Zhang, X.-D., Gu, J., Jiang, W.-F., Zhao, L., Zhou, L., Wang, Y.-L., Liu, Y.-G., & Liu, X. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu017 · Cited by 37
“–7 Wazni et al.(3) first demonstrated thatCAshould be considered as the first-line treatment for symptomatic paroxysmal AF.”
BackgroundResultInfluentialRaatikainen, M. J. P., Hakalahti, A., Uusimaa, P., Nielsen, J. C., Johannessen, A. C., Hindricks, G., Walfridsson, H., Pehrson, S. M., Englund, A., Hartikainen, J. E. K., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.06.160 · Cited by 35
Budoff, M. J., Shittu, A., Hacıoğlu, Y., Gang, E. S., Li, D., Bhatia, H. S., Alvergue, J., & Karlsberg, R. P. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.09.037 · Cited by 36
Forleo, G. B., Martino, G. D., Mantica, M., Carreras, G., Parisi, Q., Zingarini, G., Panigada, S., Romano, E., Russo, A. D., Biase, L. D., et al. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.06.132 · Cited by 36
“This could be in part related to the patients' desire to avoid anticoagulation or because in some cases AF ablation is performed as a first-line therapy [5] or to arrest the progression of heart failure.”
Lakkireddy, D., Nadzam, G. R., Verma, A., Prasad, S. K., Ryschon, K. L., Biase, L. D., Khan, M., BURKHARDT, D. J., Schweikert, R. A., & Natale, A. (2008) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-008-9316-0 · Cited by 35
MANSOUR, M. C., Forleo, G. B., Pappalardo, A., Barrett, C. D., Heist, E. K., Avella, A., Bencardino, G., Russo, A. D., Casella, M., Ruskin, J. N., et al. (2009) · Heart Rhythm · doi:10.1016/j.hrthm.2009.12.012 · Cited by 35
Rogers, P. A., Bernard, M. L., Madias, C. A., Thihalolipavan, S., Estes, N. A. M., & Morin, D. P. (2017) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2017.06.001 · Cited by 36
SCHRON, E. B., Friedmann, E., & Thomas, S. A. (2013) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12266 · Cited by 37
Pharmacological and Electrical Conversion of Atrial Fibrillation to Sinus Rhythm Is Worth the Effort
Anter, E., & Callans, D. J. (2009) · Circulation · doi:10.1161/circulationaha.108.824847 · Cited by 34
Catheter ablation of atrial fibrillation as first-line therapy--a single-centre experience
Tanner, H., Makowski, K., Roten, L., Seiler, J., Schwick, N. G., Muller, C., Fuhrer, J., & Delacrétaz, E. (2011) · EP Europace · doi:10.1093/europace/eur065 · Cited by 34
“Repeat ablation, n (%) 15 (21) 138 (38) 0.”
Donal, E., Ollivier, R., Veillard, D., Hamonic, S., Pavin, D., Daubert, C., & Mabo, P. (2010) · European Journal of Echocardiography · doi:10.1093/ejechocard/jeq074 · Cited by 34
Virk, S. A., Bennett, R. G., Chow, C. K., Sanders, P., Kalman, J. M., Thomas, S. P., & Kumar, S. (2018) · Heart Lung and Circulation · doi:10.1016/j.hlc.2018.10.022 · Cited by 36
Andrade, J. G., Champagne, J., Deyell, M. W., Essebag, V., Lauck, S., Morillo, C. A., Sapp, J. L., Skanes, A. C., Theoret-Patrick, P., Wells, G. A., et al. (2018) · American Heart Journal · doi:10.1016/j.ahj.2018.05.020 · Cited by 34
Prevention of stroke in patients with atrial fibrillation: current strategies and future directions
Hohnloser, S. H., Duray, G. Z., Baber, U., & Halperin, J. L. (2008) · European Heart Journal Supplements · doi:10.1093/eurheartj/sun029 · Cited by 34
Atrial Fibrillation Ablation and Reduction of Stroke Events
Barra, S., Narayanan, K., Bovéda, S., Primo, J. J., Gonçalves, H., Baran, J. M., Agarwal, S., Marijon, É., & Providencia, R. A. (2019) · Stroke · doi:10.1161/strokeaha.119.026890 · Cited by 33
Antiarrhythmic Drug Therapy for Rhythm Control in Atrial Fibrillation
Waks, J. W., & ZIMETBAUM, P. J. (2016) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248416651722 · Cited by 34
Arrhythmogenic Substrates for Atrial Fibrillation in Obesity
Lubbers, E. R., Price, M. V., & Mohler, P. J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01482 · Cited by 36
Saglietto, A., Gaïta, F., Ponti, R. D., Ferrari, G. M. D., & Anselmino, M. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.664647 · Cited by 33
Razzack, A. A., Lak, H. M., Pothuru, S., Rahman, S., Hassan, S. A., Hussain, N., Najeeb, H., Reddy, K. T., Syeda, H., Yasmin, F., et al. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2303112 · Cited by 33
“Five studies [23–27] included patients with paroxysmal AF and one study involved 35 patients with paroxysmal AF and two patients with persistent AF [22].”
InfluentialTurco, P., Simone, A. D., Rocca, V. L., Iuliano, A., Capuano, V., Astarita, C., Napoli, T. D., Messina, V., Baldi, S., & Stabile, G. (2007) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2007.00618.x · Cited by 33
“The main exclusion criteria were: (1) age <18 or >75 years; (2) permanent AF (AF was the only recorded rhythm in the last 12 months); (3) AF secondary to a transient or correctable abnormality; (4) persistence of AF episodes triggered by another atrial tachyarrhythmia (i.”
BackgroundIs pulmonary vein isolation still the cornerstone in atrial fibrillation ablation?
Bunch, T. J., & Cutler, M. J. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2072-1439.2014.12.46 · Cited by 33
“For example, multiple clinical trials report arrhythmia free survival of 50-75% at 1-year post ablation in contrast to only 10-30% with antiarrhythmic drugs (1-6).”
BackgroundCatheter Ablation Therapy for Supraventricular Arrhythmias
Marine, J. E. (2007) · JAMA · doi:10.1001/jama.298.23.2768 · Cited by 32
Fang, Y., Hu, F., Ren, W., Xiang, L., Wang, T., Zhu, C., He, R., Dong, X., Liu, C. X., Ding, H., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123087 · Cited by 34
Avoiding permanent atrial fibrillation: treatment approaches to prevent disease progression
Curtis, A. B., & Shukla (2013) · Vascular Health and Risk Management · doi:10.2147/vhrm.s49334 · Cited by 34
Latchamsetty, R., & Morady, F. (2017) · Annual Review of Medicine · doi:10.1146/annurev-med-041316-090015 · Cited by 32
Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation
Andrade, J. G., Turgeon, R. D., Macle, L., & Deyell, M. W. (2022) · European Cardiology Review · doi:10.15420/ecr.2021.38 · Cited by 33
Racial Disparities in the Use of Catheter Ablation for Atrial Fibrillation and Flutter
Tamariz, L. J., Rodríguez, A., Palacio, A., Li, H., & Myerburg, R. J. (2014) · Clinical Cardiology · doi:10.1002/clc.22330 · Cited by 31
Prior antiarrhythmic drug use and the outcome of atrial fibrillation ablation
Winkle, R. A., Mead, R. H., Engel, G., Kong, M. H., & Patrawala, R. A. (2012) · EP Europace · doi:10.1093/europace/eur370 · Cited by 32
“37% with drugs).(8) The Catheter Ablation vs.”
How to select patients for atrial fibrillation ablation
Oral, H., & Morady, F. (2006) · Heart Rhythm · doi:10.1016/j.hrthm.2006.01.016 · Cited by 32
Continuation of Amiodarone Therapy Despite Type II Amiodarone-Induced Thyrotoxicosis
Uzan, L., Guignat, L., Meune, C., Mouly, S., Weber, S., Bertagna, X., Bertherat, J., Thomopoulos, P., & Duboc, D. (2006) · Drug Safety · doi:10.2165/00002018-200629030-00006 · Cited by 31
Catheter ablation of atrial fibrillation—patient satisfaction from a single-center UK experience
Ezzat, V., Chew, A., McCready, J. W., Lambiase, P. D., CHOW, A. W. C., LOWE, M. D., Rowland, E., & Segal, O. R. (2012) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-012-9763-5 · Cited by 31
“Current evidence supports the use of percutaneous radiofrequency catheter ablation (RFA) for AF in appropriately selected patients [3–7], although approaches vary between centers.”
BackgroundStabile, G., Bertaglia, E., Pappone, A., Themistoclakis, S., Tondo, C., Calzolari, V., Bottoni, N., Arena, G., Rebellato, L., Greco, M. D., et al. (2014) · EP Europace · doi:10.1093/europace/euu002 · Cited by 31
“The demonstration of superiority of CA over antiarrhythmic therapy in the management of several settings of AF patients (3-5) has greatly increased the procedure recommendation in t he last decade (19,20).”
BackgroundInfluentialNovel Perspectives on Arrhythmia-Induced Cardiomyopathy
Rocca, D. G. D., Santini, L., Forleo, G. B., Sanniti, A., Prete, A. D., Lavalle, C., Biase, L. D., Natale, A., & Romeo, F. (2014) · Cardiology in Review · doi:10.1097/crd.0000000000000040 · Cited by 31
Yoshimura, A., Iriki, Y., Ichiki, H., Oketani, N., Okui, H., Maenosono, R., Namino, F., Miyata, M., & Ohishi, M. (2016) · Journal of Cardiology · doi:10.1016/j.jjcc.2016.03.014 · Cited by 32
Andrade, J. G., Deyell, M. W., Badra‐Verdu, M., Champagne, J., Dubuc, M., Leong‐Sit, P., Macle, L., NOVAK, P. G., Roux, J.-F., Sapp, J. L., et al. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-017970 · Cited by 31
Safety of Same Day Discharge after Atrial Fibrillation Ablation
Lakkireddy, D. (2020) · Journal of Atrial Fibrillation · doi:10.4022/jafib.2150 · Cited by 30
McBride, S., Avazzadeh, S., Wheatley, A. M., O’Brien, B., Coffey, K., Elahi, A., O’Halloran, M., & Quinlan, L. R. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10122657 · Cited by 31
Simon, J., Mahdiui, M. E., Smit, J. M., Száraz, L., van Rosendael, A. R., Herczeg, S., Zsarnóczay, E., Nagy, A. I., Kolossváry, M., Szilveszter, B., et al. (2021) · Clinical Cardiology · doi:10.1002/clc.23748 · Cited by 31
Pimentel, R., Rahai, N., Maccioni, S., & Khanna, R. (2022) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15599 · Cited by 31
Catheter and surgical ablation of atrial fibrillation
Earley, M. J., & SCHILLING, R. J. (2006) · Heart · doi:10.1136/hrt.2005.067389 · Cited by 32
“For many patients with a previously untreatable heart rhythm, ablation has dramatically improved their symptoms by restoring and maintaining sinus rhythm. The rapid development of these treatments has made this an exciting time to be involved in cardiac electrophysiology. Despite this we cannot be sure that catheter o…”
BackgroundIntracardiac Echocardiography during Catheter-Based Ablation of Atrial Fibrillation
Biermann, J., Bode, C., & Asbach, S. (2012) · Cardiology Research and Practice · doi:10.1155/2012/921746 · Cited by 30
Sullivan, S. D., Orme, M. E., Morais, E., & Mitchell, S. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.03.070 · Cited by 29
Catheter Ablation of Atrial Fibrillation in Heart Failure
Kirubakaran, S., & O'Neill, M. D. (2013) · Heart Failure Clinics · doi:10.1016/j.hfc.2013.07.006 · Cited by 30
Gürses, K. M., Yalçın, M. U., Koçyiğit, D., Kesikli, S. A., Canpolat, U., Yorgun, H., ŞAHINER, L., Kaya, E., Hazırolan, T., Ozer, N., et al. (2014) · EP Europace · doi:10.1093/europace/euu228 · Cited by 29
“Atrial fibrosis is an important part of remodelling process in patients with AF.”
BackgroundInfluentialDickow, J., Kany, S., Cardoso, V. R., Ellinor, P. T., Gkoutos, G. V., Houten, H. K. V., Kirchhof, P. F., Metzner, A., Noseworthy, P. A., Yao, X., et al. (2023) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.122.011585 · Cited by 29
Calvo, N., Nadal, M., Berruezo, A., Andreu, D., Arbelo, E., Tolosana, J. M., Guasch, E., Matiello, M., Matas, M., Alsina, X., et al. (2011) · Revista Española de Cardiología · doi:10.1016/j.recesp.2011.08.015 · Cited by 29
“Estenosis VP asintomática 2 (0,3) 2 (0,5) 0 0,511 Totales 61 (8,4) 48 (11,4) 13 (4,2) 0,002”
Pulsed Field Ablation of Atrial Fibrillation: A Comprehensive Review
Matos, C. D., Hoyos, C., Miranda‐Arboleda, A. F., Díaz, J. C., Hincapie, D., Patiño, C., Hernadez, R. H., Zei, P. C., Romero, J. E., & Osorio, J. (2023) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2411337 · Cited by 29
“RFA has been proven superior to AADs in several randomized control trials (RCT) [12–14].”
BackgroundAl‐Khatib, S. M., Calkins, H. G., Eloff, B. C., Packer, D. L., Ellenbogen, K. A., Hammill, S. C., Natale, A., Page, R. L., Prystowsky, E. N., Jackman, W. M., et al. (2009) · American Heart Journal · doi:10.1016/j.ahj.2009.10.018 · Cited by 28
Radiofrequency Catheter Ablation For Atrial Fibrillation: Approaches And Outcomes
Kalla, M., Sanders, P., Kalman, J. M., & Lee, G. (2017) · Heart Lung and Circulation · doi:10.1016/j.hlc.2017.05.125 · Cited by 29
Measuring health-related quality of life in drug clinical trials: is it given due importance?
Miguel, R. S., López-González, A. M., Sánchez, E., Mar, J., & Hita, J. M. C. (2007) · Pharmacy World & Science · doi:10.1007/s11096-007-9152-9 · Cited by 28
Hunter, R. J., & SCHILLING, R. J. (2010) · Heart · doi:10.1136/hrt.2010.194613 · Cited by 28
Wasmer, K., BREITHARDT, G. E., & Eckardt, L. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu113 · Cited by 29
Constrained Registration for Motion Compensation in Atrial Fibrillation Ablation Procedures
Brost, A., Wimmer, A., Liao, R. J., Bourier, F. J., Koch, M., Strobel, N. K., Kurzidim, K. W., & Joachim Hornegger, A. (2011) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2011.2181184 · Cited by 27
Multimorbidity in Older Adults with Atrial Fibrillation
Chen, M. A. (2016) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2016.01.001 · Cited by 27
“Both showed higher rates of freedom from atrial fibrillation in the ablation arm at the end of follow-up (1 year and 2 years).(9,10) Based on these findings, current guidelines suggest considering catheter ablation as first-line therapy in selected patients before a trial of antiarrhythmic drug treatment when a rhythm…”
BackgroundRocca, D. G. D., Mohanty, S., Mohanty, P. K., Trivedi, C. G., Gianni, C., Al‐Ahmad, A., Burkhardt, J. D., Gallinghouse, G. J., Hranitzky, P. M., Sánchez, J., et al. (2018) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13721 · Cited by 27
“Pulmonary vein antrum isolation (PVAI) represents a major therapeutic cornerstone in the management of patients with paroxysmal atrial fibrillation (AF).(1,2) After the pivotal study by Haïssaguerre et al(3) reporting pulmonary vein (PV) triggers initiating paroxysms of AF, PV isolation, and, subsequently, PVAI became…”
BackgroundHindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J. J., Blomström‐Lundqvist, C., Boriani, G., Castellà, M., Dan, G., Dilaveris, P., et al. (2021) · Revista Española de Cardiología · doi:10.1016/j.recesp.2020.10.022 · Cited by 34
Catheter ablation of atrial fibrillation in the elderly.
Lioni, L., Letsas, Κ. P., Efremidis, M., Vlachos, K. G., Γιαννόπουλος, Γ., Kareliotis, V., Deftereos, S. G., & Sideris, A. (2014) · Europe PMC (PubMed Central) · doi:10.11909/j.issn.1671-5411.2014.04.003 · Cited by 27
Benefits of early rhythm control of atrial fibrillation
Eckardt, L., Wolfes, J., & Frommeyer, G. (2023) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2023.04.001 · Cited by 27
Maagh, P., Butz, T., Wickenbrock, I., Prull, M. W., Plehn, G., Trappe, H., & Meißner, A. (2010) · Clinical Research in Cardiology · doi:10.1007/s00392-010-0227-6 · Cited by 26
“Pulmonary vein isolation is increasingly being used to treat AF in patients early [27–30], and in patients with heart failure [31].”
BackgroundJohansson, B., Houltz, B., Berglin, E., Brandrup‐Wognsen, G., Karlsson, T., & Edvardsson, N. G. (2008) · EP Europace · doi:10.1093/europace/eun066 · Cited by 26
“54 I 16 (41) 18 (46) II 11 (28) 12 (31) IIIa 9 (23) 6 (15) IIIb 2 (5) 3 (8) IV 1 (3) 0 (0) Higgins score (0/2) 2.”
Impact of Atrial Fibrillation Ablation on Recurrent Hospitalization
Guo, J., Nayak, H. M., Besser, S. A., Beaser, A. D., Aziz, Z. A., Broman, M., Özcan, C., Tung, R. H., & Upadhyay, G. A. (2018) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2018.10.015 · Cited by 26
Dagres, N., Varounis, C., Flevari, P. G., Piorkowski, C., Bode, K., Rallidis, L. S., Tsougos, E., Leftheriotis, D. I., Sommer, P., Hindricks, G., et al. (2009) · American Heart Journal · doi:10.1016/j.ahj.2009.05.012 · Cited by 26
Ablation of Atrial Fibrillation
Riley, M. J., & Marrouche, N. F. (2006) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2006.01.002 · Cited by 26
Kaypaklı, O., Koca, H., Şahin, D. Y., Okar, S., Karataş, F., & Koç, M. (2017) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2017.09.016 · Cited by 25
Ravi, V., Poudyal, A., Li, L., Larsen, T. R., Wasserlauf, J., Trohman, R. G., Krishnan, K., Sharma, P. S., & Huang, H. D. (2021) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15330 · Cited by 25
Kochhäuser, S., Joza, J. E., Essebag, V., Proietti, R., Koehler, J. L., Tsang, B., Wulffhart, Z. A., Pantano, A. A., Khaykin, Y., Ziegler, P., et al. (2015) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12772 · Cited by 25
Catheter and Surgical Ablation for Atrial Fibrillation
Montané, B., Zhang, S., Wolfe, J. D., Prime, S., Luo, C., Cooper, D. H., Doering, M. M., Blomström‐Lundqvist, C., Nashef, S. A. M., Osmancik, P. P., et al. (2025) · Annals of Internal Medicine · doi:10.7326/annals-25-00253 · Cited by 24
Iriki, Y., Ishida, S., Oketani, N., Ichiki, H., Okui, H., Ninomiya, Y., Maenosono, R., 松下, 毅., Miyata, M., Hamasaki, S., et al. (2011) · Journal of Cardiology · doi:10.1016/j.jjcc.2011.07.006 · Cited by 24
“Catheter ablation is an effective approach for the management of patients with atrial fibrillation (AF) [1—7].”
BackgroundBrabandt, H. V., Neyt, M., & Devos, C. (2013) · EP Europace · doi:10.1093/europace/eut004 · Cited by 24
“When looking at the larger studies of patients with paroxysmal AF, recurrence rates vary from 22 to 53% within 5 years after a single ablation, off-AAD.”
BackgroundInfluentialScreening and management of atrial fibrillation in primary care
Ponamgi, S., Siontis, K. C., Rushlow, D. R., Graff‐Radford, J., Montori, V. M., & Noseworthy, P. A. (2021) · BMJ · doi:10.1136/bmj.n379 · Cited by 27
“Although dedicated ablation trials such as RAAFT-1, RAAFT-2, and MANTRA-PAF have not, to date, shown such benefits with ablation alone, 157-159 they showed significant improvement in quality of life and reduction in recurrence of symptomatic atrial fibrillation and associated hospital admissions,…”
MethodKheiri, B., Simpson, T. F., Przybylowicz, R., Merrill, M. E., Alhamoud, H., Osman, M., Dalouk, K. A., Stecker, E. C., Henrikson, C. A., & Nazer, B. (2021) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.120.009692 · Cited by 25
Paul‐Nordin, A., Drca, N., Insulander, P., Bastani, H., Bourke, T., Braunschweig, F., Kennebäck, G., von Olshausen, G., Sadigh, B., Saluveer, O., et al. (2021) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15243 · Cited by 25
Bunch, T. J., & Gersh, B. J. (2010) · Journal of General Internal Medicine · doi:10.1007/s11606-010-1574-8 · Cited by 24
“001).(58) Pulmonary vein isolation compared to nodal ablation with biventricular pacing in patients with symptomatic, drug-resistant AF and heart failure, was associated with longer 6-minute walk times and mean ejection fraction at 6 months.”
BackgroundAblation Versus Drugs: What Is the Best First-Line Therapy for Paroxysmal Atrial Fibrillation?
Santangeli, P., Biase, L. D., & Natale, A. (2014) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.113.000629 · Cited by 24
“After the encouraging results of the RAAFT, 2 larger multicenter randomized trials on CA as a first-line therapy for AF have been reported.19,20 The Medical ANtiarrhythmic Treatment or Radiofrequency Ablation in Paroxysmal Atrial Fibrillation (MANTRA-PAF) trial compared CA versus AAD therapy for the firstline therapy…”
BackgroundMethodInfluentialAssasi, N., Blackhouse, G., Xie, F. X., Gaebel, K., Robertson, D., Hopkins, R. B., Healey, J. S., Roy, D., & Goeree, R. A. (2012) · Europe PMC (PubMed Central) · Cited by 24
Driessen, A. H. G., Berger, W. R., Bierhuizen, M. F. A., Piersma, F. R., van den Berg, N. W. E., Neefs, J., Krul, S. P. J., van Boven, W. J., & de Groot, J. R. (2017) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2017.09.093 · Cited by 24
Sex Differences In Outcomes Of Ablation Of Atrial Fibrillation.
Beck, H., & Curtis, A. B. (2014) · PubMed Central · doi:10.4022/jafib.1024 · Cited by 24
Stavrakis, S., Madden, G. W., Stoner, J. A., & Sivaram, C. A. (2010) · Echocardiography · doi:10.1111/j.1540-8175.2010.01250.x · Cited by 24
Rossillo, A., Bonso, A., Themistoclakis, S., Riccio, G., Madalosso, M., Corrado, A., Piccoli, B. D., & Raviele, A. (2008) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0b013e32801462d4 · Cited by 24
Atrial fibrillation: Catheter ablation
Chugh, A., & Morady, F. (2006) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-006-9018-4 · Cited by 24
“However, a recent study noted good results and low risk of complications in patients undergoing catheter ablation of AF as first-line treatment [25].”
ResultCatheter ablation of atrial fibrillation in the elderly: where do we stand?
Traub, D. M., Daubert, J. P., McNitt, S. A., Zaręba, W., & HALL, B. W. (2009) · PubMed · Cited by 23
Wasmer, K., Dechering, D. G., Köbe, J., Mönnig, G., Pott, C., Frommeyer, G., Lange, P. S., Kochhäuser, S., & Eckardt, L. (2016) · Clinical Research in Cardiology · doi:10.1007/s00392-016-0980-2 · Cited by 23
“End point for AF ablation is the electrical isolation of the pulmonary veins which has been shown to have a high success rate in pAF [2–4].”
BackgroundWang, Q., Zhuo, C., Shang, Y., Zhao, J., Chen, N., Lv, N., Huang, Y., Zheng, L., Lai, J., Han, J., et al. (2019) · Circulation Journal · doi:10.1253/circj.cj-19-0167 · Cited by 23
Dada, R. S., Hayanga, J. W. A., Woods, K. E., SCHWARTZMAN, D. S., Thibault, D. P., Ellison, M. B., Schmidt, S. B., Siddoway, D., Badhwar, V., & Hayanga, H. K. (2021) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2020.12.046 · Cited by 23
Charitakis, E., Metelli, S., Karlsson, L., Antoniadis, A. P., Rizas, K. D., Liuba, I., Almroth, H., Jönsson, A. H., Schwieler, J. H., Tsartsalis, D., et al. (2022) · BMC Medicine · doi:10.1186/s12916-022-02385-2 · Cited by 23
Radio‐frequency ablation for the treatment of Morton's neuroma
Genon, M. P., Chin, T., Bedi, H. S., & Blackney, M. C. (2010) · ANZ Journal of Surgery · doi:10.1111/j.1445-2197.2010.05401.x · Cited by 23
Catheter Ablation of Atrial Fibrillation
Latchamsetty, R., & Morady, F. (2016) · Heart Failure Clinics · doi:10.1016/j.hfc.2015.08.018 · Cited by 23
Akkaya, E., Berkowitsch, A., Zaltsberg, S., Greiß, H., Hamm, C. W., Sperzel, J., Neumann, T., & Kuniss, M. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.11.011 · Cited by 23
Metadata
- Authors
- Wazni, O. M., Marrouche, N. F., Martin, D. O., Verma, A., Bhargava, M., Saliba, W., Bash, D., Schweikert, R., Brachmann, J., Gunther, J., Gutleben, K., Pisano, E., Potenza, D., Fanelli, R., Raviele, A., Themistoclakis, S., Rossillo, A., Bonso, A., & Natale, A.
- Affiliations
- Cleveland Clinic (US)
- Corresponding author
- Natale, Andrea
- ORCID
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2005-06-01
- Volume
- 293
- Issue
- 21
- Pages
- 2634
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2154269490
- Cited by
- 1,121
- References
- 39
- Citations by year
- 2026: 18 · 2025: 31 · 2024: 38 · 2023: 29 · 2022: 61 · 2021: 52 · 2020: 45 · 2019: 36 · 2018: 53 · 2017: 40 · 2016: 44 · 2015: 52 · 2014: 69 · 2013: 75 · 2012: 78
- FWCI
- 43.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- atrial fibrillation, radiofrequency ablation, pulmonary vein isolation, antiarrhythmic drugs, first-line therapy, atrial fibrillation recurrence, hospitalization, quality of life, pulmonary vein stenosis, anticoagulation, thromboembolic events, Short Form 36 Health Survey, randomized trial comparison, cost-effectiveness, patient satisfaction
- MeSH terms
- Anti-Arrhythmia Agents, Atrial Fibrillation, Humans, Middle Aged, Pilot Projects, Prospective Studies, Pulmonary Veins, Quality of Life, Survival Analysis, Treatment Outcome, Catheter Ablation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
