Cited by 1,121Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsCardiac pacing and defibrillation studies

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Radiofrequency Ablation vs Antiarrhythmic Drugs as First-line Treatment of Symptomatic Atrial Fibrillation: A Randomized Trial

Wazni, Oussama M., Marrouche, Nassir F., Martin, David O., Verma, Atul, Bhargava, Mandeep, Saliba, Walid, Bash, Dianna, Schweikert, Robert, Brachmann, Johannes, Gunther, Jens, Gutleben, Klaus, Pisano, Ennio, Potenza, Dominico, Fanelli, Raffaele, Raviele, Antonio, Themistoclakis, Sakis, Rossillo, Antonio, Bonso, Aldo, Natale, Andrea·2005·JAMA

DOI 10.1001/jama.293.21.2634

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Abstract

CONTEXT: Treatment with antiarrhythmic drugs and anticoagulation is considered first-line therapy in patients with symptomatic atrial fibrillation (AF). Pulmonary vein isolation (PVI) with radiofrequency ablation may cure AF, obviating the need for antiarrhythmic drugs and anticoagulation. OBJECTIVE: To determine whether PVI is feasible as first-line therapy for treating patients with symptomatic AF. DESIGN, SETTING, AND PARTICIPANTS: A multicenter prospective randomized study conducted from December 31, 2001, to July 1, 2002, of 70 patients aged 18 to 75 years who experienced monthly symptomatic AF episodes for at least 3 months and had not been treated with antiarrhythmic drugs. INTERVENTION: Patients were randomized to receive either PVI using radiofrequency ablation (n=33) or antiarrhythmic drug treatment (n=37), with a 1-year follow-up. MAIN OUTCOME MEASURES: Recurrence of AF, hospitalization, and quality of life assessment. RESULTS: Two patients in the antiarrhythmic drug treatment group and 1 patient in the PVI group were lost to follow-up. At the end of 1-year follow-up, 22 (63%) of 35 patients who received antiarrhythmic drugs had at least 1 recurrence of symptomatic AF compared with 4 (13%) of 32 patients who received PVI (P<.001). Hospitalization during 1-year follow-up occurred in 19 (54%) of 35 patients in the antiarrhythmic drug group compared with 3 (9%) of 32 in the PVI group (P<.001). In the antiarrhythmic drug group, the mean (SD) number of AF episodes decreased from 12 (7) to 6 (4), after initiating therapy (P = .01). At 6-month follow-up, the improvement in quality of life of patients in the PVI group was significantly better than the improvement in the antiarrhythmic drug group in 5 subclasses of the Short-Form 36 health survey. There were no thromboembolic events in either group. Asymptomatic mild or moderate pulmonary vein stenosis was documented in 2 (6%) of 32 patients in the PVI group. CONCLUSION: Pulmonary vein isolation appears to be a feasible first-line approach for treating patients with symptomatic AF. Larger studies are needed to confirm its safety and efficacy.

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Untitled work
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Method
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“Atrial fibrosis is also a major determinant for the success of rhythm control strategies in AF, including catheter ablation, one of the most efficacious methods of treating patients with AF [8].”
Background
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Background
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“(1) The average MCL post-PV isolation was 135 ± 24 ms with approximately 45 ± 17% of the LA surface area consisting of areas of CFAE (i.”
Background
Defining endpoints in clinical trials on atrial fibrillation
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“Based on the results of clinical studies evaluating different PVI techniques, several conclusions can be drawn: (1) empirical isolation of all PVs is necessary to eliminate the majority of AF triggers and improve arrhythmia-free survival; (2) PVI should be verified with a circular mapping catheter; (3) a wide antral P…”
Uremic Toxins and Atrial Fibrillation: Mechanisms and Therapeutic Implications
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Abutting Left Atrial Appendage and Left Superior Pulmonary Vein Predicts Recurrence of Atrial Fibrillation After Point-by-Point Pulmonary Vein Isolation
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“Catheter ablation for the treatment of symptomatic atrial fibrillation (AF) has gained increasing acceptance as effective therapy [1, 2], with improvement in quality of life when compared to pharmacologic rhythm management [3, 4].”
Background
Gender differences in symptoms and functional status in patients with atrial fibrillation undergoing catheter ablation
Bazemore, T. C., Bolger, L. E., Sears, S. F., Sadaf, M. I., & Gehi, A. K. (2018) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.13577 · Cited by 19
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Site Localization and Characterization of Pain During Radiofrequency Ablation of the Pulmonary Veins
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“Ganglionated plexi were abundant in both atria and were identified on (1) the superior surface of the right atrium, (2) the superior surface of the left atrium, (3) the posterior surface of the right atrium, (4) the posterior medial surface of the left atrium, and (5) the inferior and lateral aspects of the posterior…”
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Influential
Atrial Fibrillation: Goals of Therapy and Management Strategies to Achieve the Goals
Padanilam, B. J., & Prystowsky, E. N. (2008) · Cardiology Clinics · doi:10.1016/j.ccl.2008.09.006 · Cited by 19
Catheter ablation for the treatment of atrial fibrillation is associated with a reduction in health care resource utilization
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The Impact of Left Atrial Surface Area and the Second Generation Cryoballoon on Clinical Outcome of Atrial Fibrillation Cryoablation
Greiß, H., Berkowitsch, A., Wójcik, M., Zaltsberg, S., Pajitnev, D., Deubner, N., Akkaya, E., Güttler, N., Hamm, C. W., Neumann, T., et al. (2015) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12637 · Cited by 19
“Exclusion criteria were defined as the following: (1) advanced structural heart disease, including moderate-tosevere valvular stenosis or insufficiency; (2) previous myocardial infarction; (3) congenital heart disease; (4) left ventricular ejection fraction <50%; (5) coronary artery bypass graft surgery within 3 month…”
Background
Curative ablation for atrial fibrillation: A systematic review
Gjesdal, K., Vist, G. E., Einar Bugge, B., Rossvoll, O., Johansen, M., Norderhaug, I. N., & Ohm, O. (2008) · Scandinavian Cardiovascular Journal · doi:10.1080/14017430701798838 · Cited by 19
“(7) studied 70 patients, 67 with paroxysmal and three with persistent AF.”
Background
Effect of Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Patients Following Ablation of Atrial Fibrillation
Park, J. H., Oh, Y., Kim, J., Chung, W., Oh, S., Lee, D., Choi, Y., Shin, W., Park, C., Youn, H., et al. (2009) · Korean Circulation Journal · doi:10.4070/kcj.2009.39.5.185 · Cited by 19
Population-Based Evaluation of Major Adverse Events After Catheter Ablation for Atrial Fibrillation
Samuel, M., Almohammadi, M., Tsadok, M. A., Joza, J. E., Jackevicius, C. A., Koh, M., Behlouli, H., Verma, A., Pilote, L., & Essebag, V. (2017) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2017.04.010 · Cited by 19
“As improvements in CA technology and operator experience broaden patient selection criteria for the procedure (1), the assessment of periprocedural AEs at the population level over time is essential.”
Background
Rhythm versus rate control for atrial fibrillation in heart failure with preserved ejection fraction
Al‐Sadawi, M., Aleem, S., Aslam, F., Jacobs, R., Stevens, G., Almasry, I. O., Singh, A., Fan, R., & Rashba, E. J. (2022) · Heart Rhythm O2 · doi:10.1016/j.hroo.2022.06.009 · Cited by 18
Evolving Role of Catheter Ablation for Atrial Fibrillation: Early and Effective Rhythm Control
Chen, S., Yin, Y., Ling, Z., Meyer, C. G., Pürerfellner, H., Martinek, M., Kiuchi, M. G., Futyma, P., Zhu, L., Schratter, A., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11226871 · Cited by 18
Fluoroless catheter ablation of atrial fibrillation: a step-by-step workflow
Enriquez, A. A., Velasco, A., Díaz, J. C., Sadek, M. M., Osorio, J., Zei, P. C., & Romero, J. E. (2023) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-023-01469-0 · Cited by 18
Ablation as First-line Therapy for Atrial Fibrillation
Andrade, J. G. (2023) · European Cardiology Review · doi:10.15420/ecr.2023.04 · Cited by 20
Safety and acute efficacy of catheter ablation for atrial fibrillation with pulsed field ablation vs thermal energy ablation: A meta-analysis of single proportions
Aldaas, O. M., Malladi, C., Aldaas, A. M., Han, F. T., Hoffmayer, K. S., Krummen, D. E., Ho, G., Raissi, F., Birgersdotter-Green, U. M., Feld, G. K., et al. (2023) · Heart Rhythm O2 · doi:10.1016/j.hroo.2023.09.003 · Cited by 18
Feasibility and efficacy of minimally invasive stand-alone surgical ablation of atrial fibrillation. A single-center experience
Santini, M., Loiaconi, V., Tocco, M. P., Mele, F., & Pandozi, C. (2012) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-011-9650-5 · Cited by 18
“In recent years, transvenous pulmonary vein isolation has become the first choice for patients with highly symptomatic atrial fibrillation refractory to antiarrhythmic drugs [3].”
Background
Catheter Ablation Is Established as a Treatment Option for Atrial Fibrillation - Is Catheter Ablation Established as a Treatment Option of Atrial Fibrillation? (Pro) -
Takahashi, A. (2010) · Circulation Journal · doi:10.1253/circj.cj-10-0693 · Cited by 18
Gender and AF: Differences and Disparities
Pothineni, N. V. K., & Vallurupalli, S. (2018) · US Cardiology Review · doi:10.15420/usc.2017:39:1 · Cited by 22
“Wazni et al.23 RAAFT 2005 33 Not reported Oral et al.24 - 2006 77 10 (12.9”
BackgroundInfluential
Atrial Fibrillation in Heart Failure Patients with Preserved or Reduced Ejection Fraction. Prognostic significance of Rhythm control strategy with Catheter Ablation
Vecchio, N. (2019) · Journal of Atrial Fibrillation · doi:10.4022/jafib.2128 · Cited by 18
“The superiority of CA over antiarrhythmic treatment in patients with symptomatic AF has been already demonstrated[22-25].”
Background
Incidence and risk factors of post-operative cognitive decline after ablation for atrial fibrillation
Zhang, J., Xia, S., Du, X., Jiang, C., Lai, Y., Wang, Y., Jia, Z., He, L., Tang, R., Dong, J., et al. (2021) · BMC Cardiovascular Disorders · doi:10.1186/s12872-021-02139-7 · Cited by 19
Silent Cerebral Thromboembolism with Left Atrial Ablation: A Lurking Danger
Asirvatham, S. J., & Friedman, P. A. (2006) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2005.00337.x · Cited by 18
Lesion-forming technologies for catheter ablation of atrial fibrillation
Cesario, D. A., Mahajan, A., & Shivkumar, K. (2006) · Heart Rhythm · doi:10.1016/j.hrthm.2006.12.025 · Cited by 18
Cost-effectiveness of catheter ablation for atrial fibrillation
Khaykin, Y. (2006) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e32801129d7 · Cited by 19
Impact of centre volume on atrial fibrillation ablation outcomes in Europe: a report from the ESC EHRA EORP Atrial Fibrillation Ablation Long-Term (AFA LT) Registry
Vassilikos, V. P., Pagourelias, E. D., Laroche, C., Blomström‐Lundqvist, C., Kautzner, J., Maggioni, A. P., Tavazzi, L., Dagres, N., Brugada, J., Stuehlinger, M., et al. (2020) · EP Europace · doi:10.1093/europace/euaa236 · Cited by 19
What clinical trials of ablation for atrial fibrillation tell us – and what they do not
Amuthan, R., & Curtis, A. B. (2021) · Heart Rhythm O2 · doi:10.1016/j.hroo.2021.02.001 · Cited by 17
Reflections on the usefulness of today’s atrial fibrillation ablation procedure endpoints and patient-reported outcomes
Blomström‐Lundqvist, C., & Wettervik, V. S. (2021) · EP Europace · doi:10.1093/europace/euab318 · Cited by 17
REVIEW: New Approaches to Atrial Fibrillation Management: Treat the Patient, not the ECG
Pintér, A., & Dorian, P. (2010) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2010.00135.x · Cited by 17
Catheter ablation of atrial fibrillation: randomized controlled trials and registries, a look back and the view forward
Santangeli, P., Biase, L. D., Pelargonio, G., Russo, A. D., Casella, M., Sánchez, J., Horton, R., Gallinghouse, G. J., & Natale, A. (2011) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-011-9562-4 · Cited by 17
“Antiarrhythmic Drugs as First-Line Treatment of Symptomatic Atrial Fibrillation trial, 70 patients with monthly symptomatic episodes of AF for at least 3 months (96% paroxysmal AF) were randomly assigned to PVAI or antiarrhythmic drug therapy [7].”
BackgroundMethodResultInfluential
Effectiveness of esophagus detection by three-dimensional electroanatomical mapping to avoid esophageal injury during ablation of atrial fibrillation
Maenosono, R., Oketani, N., Ishida, S., Iriki, Y., Ichiki, H., Okui, H., Ninomiya, Y., Hamasaki, S., Namino, F., Matsushita, M., et al. (2012) · Journal of Cardiology · doi:10.1016/j.jjcc.2012.02.009 · Cited by 18
In-Hospital Management of Atrial Fibrillation: The CHADS2 Score Predicts Increased Cost
Kotowycz, M. A., Filion, K. B., Joza, J. E., Dube, D., Reynolds, M. R., Pilote, L., Eisenberg, M. J., & Essebag, V. (2011) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2011.01.002 · Cited by 17
“There is also growing evidence that catheter ablation therapy may be superior to antiarrhythmic medication in controlling AF,(9-13) and some data suggest that ablation may reduce hospitalizations and may be reasonably cost effective when compared with medical therapy.(14-16) Given that hospitalizations play such an im…”
Background
Cardiac Autoantibody Levels Predict Recurrence Following Cryoballoon‐Based Pulmonary Vein Isolation in Paroxysmal Atrial Fibrillation Patients
Yalçın, M. U., Gürses, K. M., Koçyiğit, D., Kesikli, S. A., Dural, M., Evranos, B., Yorgun, H., ŞAHINER, L., Kaya, E. B., Oto, M. A., et al. (2015) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12665 · Cited by 17
Atrial Fibrillation in the Elderly: A Review
Hakim, F. A., & Shen, W.-K. (2014) · Future Cardiology · doi:10.2217/fca.14.32 · Cited by 19
Catheter ablation for treatment of atrial fibrillation in patients with heart failure with reduced ejection fraction: A systematic review and meta‐analysis
Agasthi, P., Lee, J. Z., Amin, M., Al‐Saffar, F., Goel, V., Tseng, A. S., Almader‐Douglas, D., Killu, A. M., Deshmukh, A. J., Munoz, F. D., et al. (2019) · Journal of Arrhythmia · doi:10.1002/joa3.12146 · Cited by 16
RAAFT-2: Radiofrequency ablation vs antiarrhythmic drugs as first-line treatment of paroxysmal atrial fibrillation
Kaba, R. A., Cannie, D. E., & Ahmed, O. (2014) · Global Cardiology Science and Practice · doi:10.5339/gcsp.2014.26 · Cited by 17
Kommentar zu „ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial fibrillation – executive summary“
Lewalter, T., Tebbenjohanns, J., Wichter, T., Antz, M., Geller, J. C., Seidl, K., Gulba, D. C., Röhrig, F., & Willems, S. (2008) · Der Kardiologe · doi:10.1007/s12181-008-0080-2 · Cited by 16
Advances in management
Dalzell, J. R., Petrie, M. C., & Gardner, R. S. (2010) · BMJ · doi:10.1136/bmj.c4280 · Cited by 17
Acute safety outcomes in younger and older patients with atrial fibrillation treated with catheter ablation
Hao, S. C., Hunter, T. D., Gunnarsson, C., March, J. L., White, S., Ladapo, J. A., & Reynolds, M. R. (2012) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-012-9690-5 · Cited by 16
Risk Factors for Ischemic Stroke in Atrial Fibrillation Patients Undergoing Radiofrequency Catheter Ablation
Kim, Y. G., Shim, J., Oh, S., Lee, K., Choi, J., & Kim, Y. (2019) · Scientific Reports · doi:10.1038/s41598-019-43566-z · Cited by 16
Adverse Clinical Events during Long-Term Follow-Up After Catheter Ablation of Atrial Fibrillation
Arai, M., Okumura, Y., Nagashima, K., Watanabe, I., Watanabe, R., Wakamatsu, Y., Otsuka, N., Yagyu, S., Kurokawa, S., Ohkubo, K., et al. (2019) · International Heart Journal · doi:10.1536/ihj.18-517 · Cited by 16
Actualización detallada de las guías de la ESC para el manejo de la fibrilación auricular de 2012
Camm, A. J., Lip, G. Y. H., Caterina, R. D., Savelieva, I., Atar, D., Hohnloser, S. H., Hindricks, G., Kirchhof, P. F., Bax, J. J., Baumgartner, H., et al. (2012) · Revista Española de Cardiología · doi:10.1016/j.recesp.2012.11.001 · Cited by 16
Catheter ablation of atrial fibrillation in patients with severely impaired left ventricular systolic function
Kato, K., Ejima, K., Fukushima, N., Ishizawa, M., Wakisaka, O., Henmi, R., Yoshida, K., Nuki, T., Arai, K., Yashiro, B., et al. (2015) · Heart and Vessels · doi:10.1007/s00380-015-0635-7 · Cited by 16
“The RAAFT study reported that catheter ablation as a first-line therapy for symptomatic AF was associated with less AF recurrence, an improved quality of life, and lower hospitalization rate in normal LVEF patients [16].”
Background
Experience of atrial fibrillation ablation in a new cardiac centre using three-dimensional mapping and multielectrode duty-cycled radiofrequency ablation
Choo, W. K., Farwell, D. J., & Harris, S. J. (2011) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2011.05.003 · Cited by 16
Catheter Ablation for “Lone” Atrial Fibrillation: Efficacy and Predictors of Recurrence
Buiatti, A., Kaess, B. M., Reents, T., Semmler, V., TELISHVESKA, M., Bourier, F. J., Kornmayer, M., Kottmaier, M., Hessling, G., & Deisenhofer, I. (2016) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12936 · Cited by 16
Catheter ablation of atrial fibrillation
Santangeli, P., Biase, L. D., BURKHARDT, D. J., Horton, R., Sánchez, J., Bai, R., Pump, A., Perez, M. V., Wang, P. J., Natale, A., et al. (2011) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0b013e32834f2371 · Cited by 16
Atrial Fibrillation and Deterioration in Cognitive Function
Chinta, V., Askandar, S., Nanda, A. S., Sharma, A., Abader, P., Kabra, R., & Khouzam, R. N. (2018) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2018.07.001 · Cited by 16
Developing the Safety of Atrial Fibrillation Ablation Registry Initiative (SAFARI) as a collaborative pan-stakeholder critical path registry model: A Cardiac Safety Research Consortium “Incubator” Think Tank
Al‐Khatib, S. M., Calkins, H. G., Eloff, B. C., Kowey, P. R., Hammill, S. C., Ellenbogen, K. A., Marinac‐Dabic, D., Waldo, A. L., Brindis, R. G., Wilbur, D. J., et al. (2010) · American Heart Journal · doi:10.1016/j.ahj.2010.06.044 · Cited by 16
Cost-effectiveness of atrial fibrillation catheter ablation
Andrikopoulos, G. K., Tzeis, S. E., Maniadakis, N., Mavrakis, H. E., & Vardas, P. E. (2008) · EP Europace · doi:10.1093/europace/eun342 · Cited by 16
Differences in Quality of Life Between Atrial Fibrillation Patients with Low Stroke Risk Treated With and Without Catheter Ablation
Bai, Y., Bai, R., Wu, J., Zhang, T., Liu, N., Shi, X., Liu, X., Liu, X., Du, X., Dong, J., et al. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.002130 · Cited by 17
A 1 Per 1,000 Mortality Rate After Catheter Ablation of Atrial Fibrillation
Belhassen, B. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.02.024 · Cited by 16
Cost comparison of radiofrequency catheter ablation versus cryoablation for atrial fibrillation in hospitals using both technologies
Hunter, T. D., Palli, S. R., & Rizzo, J. A. (2016) · Journal of Medical Economics · doi:10.1080/13696998.2016.1187153 · Cited by 16
Role of Intracardiac echocardiography in Atrial Fibrillation Ablation.
Russo, A. D., Russo, E., Fassini, G., Casella, M., Innocenti, E., Zucchetti, M., Cefalu, C., Solimene, F., Mottola, G., Colombo, D., et al. (2013) · Europe PMC (PubMed Central) · doi:10.4022/jafib.786 · Cited by 16
“ICE has proved to be helpful in the setting of electrophysiological (EP) procedures and in particular for AF catheter-based ablation allowing: (1) a correct identification of the endocardial structures (assessment of pulmonary veins anatomy, ostium size, and normal blood flow via 2-D anatomical imaging and Doppler mea…”
Bayesian network meta‐analysis comparing cryoablation, radiofrequency ablation, and antiarrhythmic drugs as initial therapies for atrial fibrillation
Elsayed, M., Abdelfattah, O., Sayed, A., Prasad, R. M., Barakat, A. F., Elgendy, I. Y., Andrade, J. G., Bunch, T. J., Thosani, A. J., Saliba, W. I., et al. (2021) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15308 · Cited by 15
“Our network meta‐analysis aimed to compare cryoablation versus RFA versus AAD as first‐choice therapies in the treatment of AF.”
BackgroundInfluential
Contact‐Force Recovery Can Predict Cardiac Perforation during Radiofrequency Ablation
Nazeri, A., Ganapathy, A. V., Massumi, A., Massumi, M., Constantine, G., RAZ, S., & Razavi, M. (2014) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12409 · Cited by 15

Authors: Wazni, O. M., Marrouche, N. F., Martin, D. O., Verma, A., Bhargava, M., Saliba, W., Bash, D., Schweikert, R., Brachmann, J., Gunther, J., Gutleben, K., Pisano, E., Potenza, D., Fanelli, R., Raviele, A., Themistoclakis, S., Rossillo, A., Bonso, A., & Natale, A.
Affiliations: Cleveland Clinic (US)
Corresponding author: Natale, Andrea
ORCID: Wazni, Oussama M.
Marrouche, Nassir F.
Martin, David O.
Verma, Atul
Bhargava, Mandeep
Saliba, Walid
Brachmann, Johannes
Raviele, Antonio
Themistoclakis, Sakis
Rossillo, Antonio
Natale, Andrea
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2005-06-01
Volume: 293
Issue: 21
Pages: 2634
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.293.21.2634
OpenAlex: W2154269490
Cited by: 1,121
References: 39
Citations by year: 2026: 18 · 2025: 31 · 2024: 38 · 2023: 29 · 2022: 61 · 2021: 52 · 2020: 45 · 2019: 36 · 2018: 53 · 2017: 40 · 2016: 44 · 2015: 52 · 2014: 69 · 2013: 75 · 2012: 78
FWCI: 43.53
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Keywords: atrial fibrillation, radiofrequency ablation, pulmonary vein isolation, antiarrhythmic drugs, first-line therapy, atrial fibrillation recurrence, hospitalization, quality of life, pulmonary vein stenosis, anticoagulation, thromboembolic events, Short Form 36 Health Survey, randomized trial comparison, cost-effectiveness, patient satisfaction
MeSH terms: Anti-Arrhythmia Agents, Atrial Fibrillation, Humans, Middle Aged, Pilot Projects, Prospective Studies, Pulmonary Veins, Quality of Life, Survival Analysis, Treatment Outcome, Catheter Ablation

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Radiofrequency Ablation vs Antiarrhythmic Drugs as First-line Treatment of Symptomatic Atrial Fibrillation: A Randomized Trial

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