The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer: The Women’s Health Study: A Randomized Controlled Trial
Abstract
CONTEXT: Basic research provides plausible mechanisms and observational studies suggest that apparently healthy persons, who self-select for high intakes of vitamin E through diet or supplements, have decreased risks of cardiovascular disease and cancer. Randomized trials do not generally support benefits of vitamin E, but there are few trials of long duration among initially healthy persons. OBJECTIVE: To test whether vitamin E supplementation decreases risks of cardiovascular disease and cancer among healthy women. DESIGN, SETTING, AND PARTICIPANTS: In the Women's Health Study conducted between 1992 and 2004, 39 876 apparently healthy US women aged at least 45 years were randomly assigned to receive vitamin E or placebo and aspirin or placebo, using a 2 x 2 factorial design, and were followed up for an average of 10.1 years. INTERVENTION: Administration of 600 IU of natural-source vitamin E on alternate days. MAIN OUTCOME MEASURES: Primary outcomes were a composite end point of first major cardiovascular event (nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death) and total invasive cancer. RESULTS: During follow-up, there were 482 major cardiovascular events in the vitamin E group and 517 in the placebo group, a nonsignificant 7% risk reduction (relative risk [RR], 0.93; 95% confidence interval [CI], 0.82-1.05; P = .26). There were no significant effects on the incidences of myocardial infarction (RR, 1.01; 95% CI, 0.82-1.23; P = .96) or stroke (RR, 0.98; 95% CI, 0.82-1.17; P = .82), as well as ischemic or hemorrhagic stroke. For cardiovascular death, there was a significant 24% reduction (RR, 0.76; 95% CI, 0.59-0.98; P = .03). There was no significant effect on the incidences of total cancer (1437 cases in the vitamin E group and 1428 in the placebo group; RR, 1.01; 95% CI, 0.94-1.08; P = .87) or breast (RR, 1.00; 95% CI, 0.90-1.12; P = .95), lung (RR, 1.09; 95% CI, 0.83-1.44; P = .52), or colon cancers (RR, 1.00; 95% CI, 0.77-1.31; P = .99). Cancer deaths also did not differ significantly between groups. There was no significant effect of vitamin E on total mortality (636 in the vitamin E group and 615 in the placebo group; RR, 1.04; 95% CI, 0.93-1.16; P = .53). CONCLUSIONS: The data from this large trial indicated that 600 IU of natural-source vitamin E taken every other day provided no overall benefit for major cardiovascular events or cancer, did not affect total mortality, and decreased cardiovascular mortality in healthy women. These data do not support recommending vitamin E supplementation for cardiovascular disease or cancer prevention among healthy women.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Some trials, in fact, have documented potential harm, including an increased risk of lung cancer from beta-carotene supplements in smokers and an increased risk of heart failure 70 and the possibility of increased total mortality 71 from high-dose vitamin E supplements.”
From Diet and Lifestyle Recommendations Revision 2006: A Scientific Statement From the American Heart Association Nutrition Committee (2006) · cites this paper as [71]
In the citing paper
“Evidence of a direct cardiovascular health benefit from consuming soy protein products instead of dairy or other proteins or of isoflavone supplements is minimal.71,72”
From Diet and Lifestyle Recommendations Revision 2006: A Scientific Statement From the American Heart Association Nutrition Committee (2006) · cites this paper as [71]
In the citing paper
“The WHS is a completed randomized trial (1992-2004) testing aspirin and vitamin E for preventing cardiovascular disease and cancer among 39,876 healthy women, ≥45 years, living throughout the US.[32-34]”
From Using accelerometers to measure physical activity in large-scale epidemiological studies: issues and challenges (2014) · cites this paper as [33]
Citations
Cites
Epstein, F. H., Steinberg, D. I., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201407 · Cited by 6,425
(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737
Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?
Halliwell, B. B. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92211-x · Cited by 2,926
Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality
Miller, E. R., Pastor-Barriuso, R., Dalal, D., Riemersma, R. A., Appel, L. J., & Guallar, E. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-1-200501040-00110 · Cited by 2,577
A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380
Vitamin E Consumption and the Risk of Coronary Heart Disease in Men
Rimm, E. B., Stampfer, M. J., Ascherio, A., Giovannucci, E. L., Colditz, G. A., & Willett, W. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282004 · Cited by 2,345
Hennekens, C. H., Buring, J. E., & Mayrent, S. L. (1987) · Medical Entomology and Zoology · Cited by 2,319
Self-citationStephens, N. G., Parsons, A., Brown, M. J., Schofield, P. M., Kelly, F., Cheeseman, K., & Mitchinson, M. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90866-1 · Cited by 2,148
Vitamin E Consumption and the Risk of Coronary Disease in Women
Stampfer, M. J., Hennekens, C. H., Manson, J. E., Colditz, G. A., ROSNER, B. A., & Willett, W. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282003 · Cited by 2,085
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 501–600 of 1,000
Total Magnesium Intake and Colorectal Cancer Incidence in Women
Lin, J., Cook, N. R., Lee, I.-M. M., Manson, J. E., Buring, J. E., & Zhang, S. M. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0454 · Cited by 34
Self-citationPrimary and Secondary Prevention of Coronary Heart Disease
Gaziano, J. M., Ridker, P. M., & Libby, P. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0398-6.00049-4 · Cited by 34
Self-citationHall, K. T., Buring, J. E., Mukamal, K. J., Moorthy, M. V., Wayne, P. M., Kaptchuk, T. J., Battinelli, E. M., Ridker, P. M., Sesso, H. D., Weinstein, S. J., et al. (2018) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djy204 · Cited by 34
Self-citationA Prospective Study of Hemoglobin A1c Concentrations and Risk of Breast Cancer in Women
Lin, J., Ridker, P. M., Rifai, N., Lee, I.-M. M., Manson, J. E., Buring, J. E., & Zhang, S. M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3922 · Cited by 34
Self-citationZhang, J., Ren, X., Nie, Z., You, Y., Zhu, Y., Chen, H., Yu, H., Mo, G. P., Su, L., Peng, Z., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02894-7 · Cited by 33
Protein Oxidation in Metabolic Syndrome
Hopps, E., & Caimi, G. (2013) · Clinical and investigative medicine · doi:10.25011/cim.v36i1.19399 · Cited by 33
Zee, R. Y. L., Ridker, P. M., & Chasman, D. I. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.10.003 · Cited by 32
Self-citationVasomotor Regulation of Coronary Microcirculation by Oxidative Stress: Role of Arginase
Kuo, L., & Hein, T. W. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00237 · Cited by 33
Tuncay, E., Seymen, A., Tanriverdi, E., Yaraş, N., Tandoğan, B., Ulusu, N. N., & Turan, B. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9508-4 · Cited by 33
Levy, N. S., Vardi, M., Blum, S., Miller‐Lotan, R., Afinbinder, Y., Cleary, P. A., Paterson, A. D., Bharaj, B., Snell‐Bergeon, J. K., Rewers, M., et al. (2013) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2013-0018 · Cited by 34
Extrahepatic tissue concentrations of vitamin K are lower in rats fed a high vitamin E diet
Tovar, A., Ameho, C. K., Blumberg, J. B., Peterson, J. W., Smith, D. E., & Booth, S. L. (2006) · Nutrition & Metabolism · doi:10.1186/1743-7075-3-29 · Cited by 33
Prentice, R. L. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.1.308s · Cited by 33
Oxidative Stress Genes, Antioxidants and Coronary Artery Disease in Type 2 Diabetes Mellitus
Tibaut, M., & Petrovi, D. (2016) · Cardiovascular & Hematological Agents in Medicinal Chemistry · doi:10.2174/1871525714666160407143416 · Cited by 34
Immunomodulatory basis of antioxidant therapy and its future prospects: an appraisal
Ajith, Y., Dimri, U., Dixit, S. K., Singh, S. K., Gopalakrishnan, A., Madhesh, E., Rajesh, J. B., & Sangeetha, S. (2017) · Inflammopharmacology · doi:10.1007/s10787-017-0393-5 · Cited by 33
Andreadou, I., Iliodromitis, E. K., Tsovolas, K., Aggeli, I.-K. S., Ζώγα, Α., Gaitanaki, C., PARASKEVAIDIS, I. A., Markantonis, S. L., Beis, I. D., & Kremastinos, D. T. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.06.021 · Cited by 33
Ridker, P. M., Figtree, G. A., Moorthy, M. V., Mora, S., & Buring, J. E. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf658 · Cited by 40
Self-citationVitamin Deficiency After Gastric Bypass Surgery: A Review
Matrana, M. R., & Davis, W. E. (2009) · Southern Medical Journal · doi:10.1097/smj.0b013e3181b62614 · Cited by 32
Cancer Prevention by Different Forms of Tocopherols
Yang, C. S., & Suh, N. (2012) · Topics in current chemistry · doi:10.1007/128_2012_345 · Cited by 32
Fu, J., Zhang, Q., Woods, C. G., Zheng, H., Yang, B., Qu, W., Andersen, M. E., & Pi, J. (2013) · Pharmaceutical Research · doi:10.1007/s11095-013-1013-8 · Cited by 32
Kandaş, N. Ö., Horton, L., Lasano, S. G., & Bosland, M. C. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0152 · Cited by 32
Has vitamin E any shreds of evidence in cisplatin‐induced toxicity
Hakiminia, B., Goudarzi, A., & Moghaddas, A. (2019) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22349 · Cited by 32
El-Hak, H. N. G., ELaraby, E. E., Hassan, A. K., & Abbas, O. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e02645 · Cited by 32
Migraine, headache, and mortality in women: a cohort study
Rohmann, J. L., Rist, P. M., Buring, J. E., & Kurth, T. (2020) · The Journal of Headache and Pain · doi:10.1186/s10194-020-01091-9 · Cited by 32
Self-citationCommon genetic variation within IGFI, IGFII, IGFBP-1, and IGFBP-3 and endometrial cancer risk
McGrath, M., Lee, I.-M. M., Buring, J. E., & Vivo, I. D. (2010) · Gynecologic Oncology · doi:10.1016/j.ygyno.2010.10.012 · Cited by 32
Self-citationSource-specific effects of micronutrients in lung cancer prevention
Roswall, N., Olsen, A., Christensen, J., Dragsted, L. O., Overvad, K., & Tjønneland, A. M. (2009) · Lung Cancer · doi:10.1016/j.lungcan.2009.11.010 · Cited by 31
A Prospective Study of Multivitamin Supplement Use and Risk of Breast Cancer
Ishitani, K., Lin, J., Manson, J. E., Buring, J. E., & Zhang, S. M. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn027 · Cited by 32
Self-citationLifestyle During and After Cancer Treatment
Thomas, R., & Davies, N. (2007) · Clinical Oncology · doi:10.1016/j.clon.2007.06.002 · Cited by 32
Dietary iron and vitamins in association with mortality.
Wang, W., Gao, J., Li, N., Han, S., Wu, L., Zhang, Y., Han, T.-S., Shan, R., Li, Y., Sun, C.-H., et al. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.10.038 · Cited by 22
Migraine and risk of incident diabetes in women: A prospective study
Burch, R. C., Rist, P. M., Winter, A. C., Buring, J. E., Pradhan, A. D., Loder, E., & Kurth, T. (2012) · Cephalalgia · doi:10.1177/0333102412453954 · Cited by 32
Self-citationMultivitamin use and cardiovascular disease in a prospective study of women
Rautiainen, S., Lee, I.-M. M., Rist, P. M., Gaziano, J. M., Manson, J. E., Buring, J. E., & Sesso, H. D. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.088310 · Cited by 33
Self-citationRafieian‐Kopaei, M., & Nasri, H. (2015) · International Journal of Preventive Medicine · doi:10.4103/2008-7802.169077 · Cited by 31
Creatine improves health and survival in mice
Haack, T. B., Bender, A., Beckers, J., Hölter, S., Ruthsatz, T., Weisenhorn, D. M. V., Becker, L., Genius, J., Rujescu, D., Irmler, M., et al. (2007) · Aktuelle Neurologie · doi:10.1055/s-2007-987803 · Cited by 31
Effects of vitamin E on cholesterol levels of hypercholesterolemic patients receiving statins
Leonard, S. W., Joss, J. D., Mustacich, D. J., Blatt, D. H., Lee, Y. S., & Traber, M. G. (2007) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp070041 · Cited by 33
Relation of Renal Function to Risk for Incident Atrial Fibrillation in Women
Sandhu, R. K., Kurth, T., Conen, D., Cook, N. R., Ridker, P. M., & Albert, C. M. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.10.006 · Cited by 31
Self-citationMultivitamin Supplement Use and Risk of Breast Cancer: A Meta-Analysis
Chan, A. L. F., Leung, H. W. C., & Wang, S.-F. (2011) · Annals of Pharmacotherapy · doi:10.1345/aph.1p445 · Cited by 31
Bubb, K. J., Birgisdottir, Å. B., Tang, O., Hansen, T., & Figtree, G. A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.02.012 · Cited by 32
Mixed Tocopherols Inhibit Azoxymethane-Induced Aberrant Crypt Foci in Rats
Newmark, H. L., Huang, M., & Reddy, B. S. (2006) · Nutrition and Cancer · doi:10.1207/s15327914nc5601_11 · Cited by 31
Use of Oral Conjugated Estrogen Alone and Risk of Breast Cancer
Zhang, S. M., Manson, J. E., Rexrode, K. M., Cook, N. R., Buring, J. E., & Lee, I.-M. M. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwk038 · Cited by 31
Self-citationInteraction Between the Haptoglobin Genotype and Vitamin E on Cardiovascular Disease in Diabetes
Hochberg, I., Berinstein, E. M., Milman, U., Shapira, C., & Levy, A. P. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0868-1 · Cited by 30
Risk-reducing medications for primary breast cancer: a network meta-analysis
D, S. M. M., Goodwin, A., & Pasquali, S. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012191.pub2 · Cited by 31
Biomarkers for antioxidant defense and oxidative damage: principles and practical applications.
Aldini, G., Yeum, K., Niki, E., & Russell, R. M. (2010) · Wiley-Blackwell eBooks · Cited by 30
Semeraro, A., Altieri, I., Patriarca, M., & Menditto, A. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.02.063 · Cited by 30
[Antioxidants and diabetes mellitus: review of the evidence].
Cuerda, C., Luengo, L. M., Valero, M. A., Vidal, A., Peláez, R. B., Calvo, F. L., & Martínez, C. (2011) · PubMed · Cited by 31
Awareness, Accuracy, and Predictive Validity of Self-Reported Cholesterol in Women
Huang, P.-Y. A., Buring, J. E., Ridker, P. M., & Glynn, R. J. (2007) · Journal of General Internal Medicine · doi:10.1007/s11606-007-0144-1 · Cited by 30
Self-citationPatient selection and vitamin E treatment in diabetes mellitus
Goldenstein, H., Levy, N. S., Lipener, Y. T., & Levy, A. P. (2013) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.12.187 · Cited by 30
Clinical Practice Guideline for Cardiac Rehabilitation in Korea
Kim, C., Sung, J., Lee, J. H., Kim, W., Lee, G. J., Jee, S., Jung, I., Rah, U. W., Kim, B. O., Choi, K. H., et al. (2019) · Annals of Rehabilitation Medicine · doi:10.5535/arm.2019.43.3.355 · Cited by 29
Yang, H., Xu, M., Lu, F. Y., Zhang, Q., Feng, Y., Yang, C. S., Li, N., & Jia, X. (2018) · Oncogene · doi:10.1038/s41388-018-0246-8 · Cited by 29
Le, N. K., Kesayan, T., Chang, J., & Rose, D. Z. (2020) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2020.104747 · Cited by 29
The Effect of Diet on Cardiovascular Disease and Lipid and Lipoprotein Levels
Feingold, K. R. (2021) · Europe PMC (PubMed Central) · Cited by 30
Micronutrient intake in relation to all-cause mortality in a prospective Danish cohort
Roswall, N., Olsen, A., Christensen, J., Hansen, L., Dragsted, L. O., Overvad, K., & Tjønneland, A. M. (2012) · Food & Nutrition Research · doi:10.3402/fnr.v56i0.5466 · Cited by 29
Vitamin supplement use and risk for breast cancer: the Shanghai Breast Cancer Study
Dorjgochoo, T., Shrubsole, M. J., Shu, X. O., Lu, W., Ruan, Z.-X., Zheng, Y., Cai, H., Dai, Q., Gu, K., Gao, Y., et al. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9772-8 · Cited by 30
Robbins, R. J., Kwik-Uribe, C. L., Hammerstone, J. F., & Schmitz, H. H. (2006) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200606001-00004 · Cited by 30
Primary prevention of coronary heart disease in women
Rees, M., & Stevenson, J. C. (2008) · Menopause international · doi:10.1258/mi.2007.007037 · Cited by 29
Huang, H., He, Y., Cui, X., Goodin, S., Wang, H., Du, Z. Y., Li, D., Zhang, K., Kong, A. T., DiPaola, R. S., et al. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf504058f · Cited by 29
Antioxidant Vitamins in Barley Green Biomass
Belcredi, N. B., Ehrenbergerová, J., Fiedlerová, V., Běláková, S., & Vaculová, K. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf1014389 · Cited by 29
Levy, A. P. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.05.002 · Cited by 29
Bodhini, D., Morton, R. W., Santhakumar, V., Nakabuye, M., Pomares‐Millan, H., Clemmensen, C., Fitzpatrick, S. L., Guasch‐Ferré, M., Pankow, J. S., Ried‐Larsen, M., et al. (2023) · Communications Medicine · doi:10.1038/s43856-023-00363-0 · Cited by 31
ObtainingAntioxidants from Botanic Matrices Applying Novel Extraction Techniques
Moraes, M. N., Zabot, G. L., Prado, J. M., & Meireles, M. A. A. (2013) · Food and public health · doi:10.5923/j.fph.20130304.04 · Cited by 28
Chemoprevention of prostate cancer: an updated view
Klein, E. A., & Thompson, I. M. (2012) · World Journal of Urology · doi:10.1007/s00345-011-0822-9 · Cited by 29
Hosseini, B., Saedisomeolia, A., & Skilton, M. R. (2016) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2016.09.031 · Cited by 28
Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols
Yang, C. S., Lǚ, G., Ju, J., & Li, G. X. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05561.x · Cited by 28
Systematic review on evidence of the effectiveness of cholesterol-lowering drugs
Gupta, A., Guyomard, V., Zaman, M., Rehman, H. U., & Myint, P. K. (2010) · Advances in Therapy · doi:10.1007/s12325-010-0033-6 · Cited by 28
Pharmacological and dietary prevention for colorectal cancer
Nolfo, F., Rametta, S., Marventano, S., Grosso, G., Mistretta, A., Drago, F., Gangi, S., Basile, F., & Biondi, A. (2013) · BMC Surgery · doi:10.1186/1471-2482-13-s2-s16 · Cited by 27
Bahmani, M., Shirzad, H., Shahinfard, N., Sheivandi, L., & Rafieian‐Kopaei, M. (2016) · Journal of Evidence-Based Complementary & Alternative Medicine · doi:10.1177/2156587215625157 · Cited by 28
Whole milk dairy foods and cardiometabolic health: dairy fat and beyond
Pokala, A., Kraft, J., Taormina, V. M., Michalski, M., Vors, C., Torres‐Gonzalez, M., & Bruno, R. S. (2024) · Nutrition Research · doi:10.1016/j.nutres.2024.03.010 · Cited by 33
Fanaroff, A. C., Steffel, J., Alexander, J. H., Lip, G. Y. H., Califf, R. M., & Lópes, R. D. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy236 · Cited by 27
Comprehensive rehabilitation in chronic heart failure.
Gąsiorowski, A., & Dutkiewicz, J. K. (2013) · PubMed · Cited by 27
Association between the intake of α-linolenic acid and the risk of CHD
Vedtofte, M. S., Jakobsen, M. U., Lauritzen, L., O’Reilly, É. J., Virtamo, J. R. K., Knekt, P., Colditz, G. A., Hallmans, G., Buring, J. E., Steffen, L. M., et al. (2014) · British Journal Of Nutrition · doi:10.1017/s000711451400138x · Cited by 27
Self-citationLessons learned from cancer prevention studies with nutrients and non‐nutritive dietary constituents
Yang, C. S., Chen, J. X., Wang, H., & Lim, J. W. E. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500766 · Cited by 27
Albert, M. A., Paré, G., Morris, A. A., Rose, L. M., Buring, J. E., Ridker, P. M., & Zee, R. Y. L. (2009) · American Heart Journal · doi:10.1016/j.ahj.2008.12.012 · Cited by 28
Self-citationBretz, F., & König, F. (2020) · Clinical Trials · doi:10.1177/1740774520941420 · Cited by 25
Schürks, M., Buring, J. E., Ridker, P. M., Chasman, D. I., & Kurth, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022106 · Cited by 26
Self-citationBarriers to preventive therapy for breast and other major cancers and strategies to improve uptake
DeCensi, A. (2015) · ecancermedicalscience · doi:10.3332/ecancer.2015.595 · Cited by 28
Results of Observational Studies: Analysis of Findings from the Nurses’ Health Study
Tai, V., Grey, A. B., & Bolland, M. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110403 · Cited by 28
Novel Pathogenic Insights in the Primary Prevention of Cardiovascular Disease
Claudio Napoli, A., & Cacciatore, F. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2009.01.003 · Cited by 26
Blum, S., Milman, U., Shapira, C., Miller‐Lotan, R., Bennett, L. N., Kostenko, M., Landau, M., Keidar, S., Levy, Y., Khemlin, A., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.159905 · Cited by 26
Tilburt, J. C., Emanuel, E. J., & Miller, F. G. (2008) · Journal of General Internal Medicine · doi:10.1007/s11606-008-0704-z · Cited by 27
Association of dietary vitamin E intake with risk of lung cancer: a dose-response meta-analysis.
Zhu, Y., Bo, Y., Liu, X., & Qiu, C. (2017) · PubMed · doi:10.6133/apjcn.032016.04 · Cited by 26
Vitamin D Status and Cancer Incidence and Mortality: Something New Under the Sun
Schwartz, G. G., & Blot, W. J. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj127 · Cited by 26
Regulation of xenobiotic metabolism, the only signaling function of α‐tocopherol?
Traber, M. G. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900440 · Cited by 25
Gray, J. E., Mao, J. T., Szabo, E. M., Kelley, M. J., Kurie, J. M., & Bepler, G. (2007) · CHEST Journal · doi:10.1378/chest.07-1348 · Cited by 26
Epidemiology of Moderate Alcohol Consumption and Breast Cancer: Association or Causation?
Zakhari, S., & Hoek, J. B. (2018) · Cancers · doi:10.3390/cancers10100349 · Cited by 28
Systems Pharmacogenomics – Gene, Disease, Drug and Placebo Interactions: A Case Study in COMT
Hall, K. T., Loscalzo, J., & Kaptchuk, T. J. (2019) · Pharmacogenomics · doi:10.2217/pgs-2019-0001 · Cited by 27
Torricelli, P., Caraglia, M., Abbruzzese, A., & Beninati, S. (2012) · Amino Acids · doi:10.1007/s00726-012-1278-y · Cited by 25
Oral postmenopausal hormone therapy, C-reactive protein, and cardiovascular outcomes
Kurtz, E. G., Ridker, P. M., Rose, L. M., Cook, N. R., Everett, B. M., Buring, J. E., & Rexrode, K. M. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181e750dd · Cited by 25
Self-citationRandomised aspirin assignment and risk of adult-onset asthma in the Women’s Health Study
Kurth, T., Barr, R. G., Gaziano, J. M., & Buring, J. E. (2008) · Thorax · doi:10.1136/thx.2007.091447 · Cited by 26
Self-citationZee, R. Y. L., Rivera, A., Inostroza‐Nieves, Y., Ridker, P. M., Chasman, D. I., & Romero, J. R. (2018) · International Journal of Genomics · doi:10.1155/2018/2308585 · Cited by 27
Self-citationProspective cohort study of breast implants and the risk of connective-tissue diseases
Lee, I.-M. M., Cook, N. R., Shadick, N. A., Pereira, E., & Buring, J. E. (2010) · International Journal of Epidemiology · doi:10.1093/ije/dyq164 · Cited by 28
Self-citationδ‐Tocopherol inhibits receptor tyrosine kinase‐induced AKT activation in prostate cancer cells
Wang, H., Hong, J., & Yang, C. S. (2015) · Molecular Carcinogenesis · doi:10.1002/mc.22422 · Cited by 24
On oxidative status and cardiovascular risk in women: Keeping pink at heart
Vassalle, C. (2009) · World Journal of Cardiology · doi:10.4330/wjc.v1.i1.26 · Cited by 23
Chemoprevention of colorectal cancer: feasibility in everyday practice?
Herszényi, L., Farinati, F., Miheller, P., & Tulassay, Z. (2008) · European Journal of Cancer Prevention · doi:10.1097/cej.0b013e3282f0c080 · Cited by 24
Impact of Subclinical Hypothyroidism on Cardiometabolic Biomarkers in Women
Harada, P. H. N., Buring, J. E., Cook, N. R., Cobble, M. E., Kulkarni, K. R., & Mora, S. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2016-1085 · Cited by 24
Self-citationVeettil, S. K., Jinatongthai, P., Nathisuwan, S., Teerawattanapong, N., Ching, S. M., Lim, K. G., Saokaew, S., Phisalprapa, P., Reid, C. M., & Chaiyakunapruk, N. (2018) · Clinical Epidemiology · doi:10.2147/clep.s174120 · Cited by 24
Designing of Chitosan Derivatives Nanoparticles with Antiangiogenic Effect for Cancer Therapy
Dragostin, O.-M., Tatia, R., Samal, S. K., Oancea, A., Zamfir, A. S., Dragostin, I., Lisă, E. L., Apetrei, C., & Zamfir, C. L. (2020) · Nanomaterials · doi:10.3390/nano10040698 · Cited by 24
The ongoing quest for ideal myocardial protection. A catalog of the recent English literature.
McGoon, D. C. (1985) · PubMed · Cited by 24
The Two Sides of Vitamin E Supplementation
Ochi, H., & Takeda, S. (2014) · Gerontology · doi:10.1159/000366419 · Cited by 23
Ghezzi, P., & Mooradian, A. D. (2020) · Handbook of experimental pharmacology · doi:10.1007/164_2020_379 · Cited by 25
Djoussé, L., Zhou, G., McClelland, R. L., Ma, N., Zhou, X., Kabagambe, E. K., Talegawkar, S. A., Judd, S. E., Biggs, M. L., Fitzpatrick, A. L., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.03.003 · Cited by 23
Self-citationContribution of Migraine to Cardiovascular Disease Risk Prediction
Rist, P. M., Buring, J. E., Cook, N. R., & Kurth, T. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.03.429 · Cited by 24
Self-citationChang, Y. J., Myung, S., Chung, S. T., Kim, Y., Lee, E., Jeon, Y.-J., Park, C.-H., Seo, H. G., & Huh, B. Y. (2011) · Dermatology · doi:10.1159/000329439 · Cited by 24
Metadata
- Authors
- Lee, I.-M., Cook, N. R., Gaziano, J. M., Gordon, D., Ridker, P. M., Manson, J. E., Hennekens, C. H., & Buring, J. E.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Lee, I-Min
- ORCID
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2005-07-06
- Volume
- 294
- Issue
- 1
- Pages
- 56
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W1995731966
- Cited by
- 1,137
- References
- 57
- Citations by year
- 2026: 18 · 2025: 19 · 2024: 39 · 2023: 29 · 2022: 25 · 2021: 38 · 2020: 45 · 2019: 39 · 2018: 46 · 2017: 34 · 2016: 45 · 2015: 54 · 2014: 66 · 2013: 71 · 2012: 69
- FWCI
- 53.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl043851-10)
- National Heart, Lung, and Blood Institute (HL43851)
- National Cancer Institute (CA-47988, R01CA047988)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Keywords
- vitamin E supplementation, primary prevention, cardiovascular disease, cancer prevention, Women's Health Study, myocardial infarction, stroke, cardiovascular mortality, breast cancer, aspirin, healthy women, cardiovascular events, cardiovascular risk factors, alcohol consumption, physical activity, body mass index, blood pressure
- MeSH terms
- Aged, Aspirin, Cardiovascular Diseases, Double-Blind Method, Drug Interactions, Female, Humans, Middle Aged, Mortality, Neoplasms, Primary Prevention, Risk Factors, Incidence, Dietary Supplements, alpha-Tocopherol
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
