CoChat
Sign Up
Cited by 651Child and Adolescent Psychosocial and Emotional DevelopmentMaternal Mental Health During Pregnancy and PostpartumFamily Support in Illness

The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.

Remissions in Maternal Depression and Child Psychopathology: A STAR*D-Child Report

Weissman, Myrna M., Pilowsky, Daniel J., Wickramaratne, Priya J., Talati, Ardesheer, Wisniewski, Stephen R., Fava, Maurizio, Hughes, Carroll W., Garber, Judy, Malloy, Erin, King, Cheryl A., Cerda, Gabrielle, Sood, A. Bela, Alpert, Jonathan E., Trivedi, Madhukar H., Rush, A. John, STAR*D-Child Team, for the·2006·JAMA
DOI 10.1001/jama.295.12.1389
Open this paper in CoChat — free account

Abstract

CONTEXT: Children of depressed parents have high rates of anxiety, disruptive, and depressive disorders that begin early, often continue into adulthood, and are impairing. OBJECTIVE: To determine whether effective treatment with medication of women with major depression is associated with reduction of symptoms and diagnoses in their children. DESIGN: Assessments of children whose depressed mothers were being treated with medication as part of the multicenter Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial conducted (between December 16, 2001 and April 24, 2004) in broadly representative primary and psychiatric outpatient practices. Children were assessed by a team of evaluators not involved in maternal treatment and unaware of maternal outcomes. Study is ongoing with cases followed at 3-month intervals. SETTING AND PATIENTS: One hundred fifty-one mother-child pairs in 8 primary care and 11 psychiatric outpatient clinics across 7 regional centers in the United States. Children were aged 7 to 17 years. MAIN OUTCOME MEASURES: Child diagnoses based on the Kiddie Schedule for Affective Disorders and Schizophrenia; child symptoms based on the Child Behavior Checklist; child functioning based on the Child Global Assessment Scale in mothers whose depression with treatment remitted with a score of 7 or lower or whose depression did not remit with a score higher than 7 on the Hamilton Rating Scale for Depression. RESULTS: Remission of maternal depression after 3 months of medication treatment was significantly associated with reductions in the children's diagnoses and symptoms. There was an overall 11% decrease in rates of diagnoses in children of mothers whose depression remitted compared with an approximate 8% increase in rates of diagnoses in children of mothers whose depression did not. This rate difference remained statistically significant after controlling for the child's age and sex, and possible confounding factors (P = .01). Of the children with a diagnosis at baseline, remission was reported in 33% of those whose mothers' depression remitted compared with only a 12% remission rate among children of mothers whose depression did not remit. All children of mothers whose depression remitted after treatment and who themselves had no baseline diagnosis for depression remained free of psychiatric diagnoses at 3 months, whereas 17% of the children whose mothers remained depressed acquired a diagnosis. Findings were similar using child symptoms as an outcome. Greater level of maternal response was associated with fewer current diagnoses and symptoms in the children, and a maternal response of at least 50% was required to detect an improvement in the child. CONCLUSIONS: Remission of maternal depression has a positive effect on both mothers and their children, whereas mothers who remain depressed may increase the rates of their children's disorders. These findings support the importance of vigorous treatment for depressed mothers in primary care or psychiatric clinics and suggest the utility of evaluating the children, especially children whose mothers continue to be depressed.

Overview

Integrity signals

Registry

Crossref · 10.1001/jama.295.12.1389

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 43 references

Cited by

Sorted by citations

Items 501–600 of 651

Related

See all

Metadata

Authors
Weissman, M. M., Pilowsky, D. J., Wickramaratne, P. J., Talati, A., Wisniewski, S. R., Fava, M., Hughes, C. W., Garber, J., Malloy, E., King, C. A., Cerda, G., Sood, A. B., Alpert, J. E., Trivedi, M. H., Rush, A. J., & STAR*D-Child Team, F. T.
Affiliations
New York State Psychiatric Institute (US)
Corresponding author
Weissman, Myrna M.
ORCID
Venue
JAMA
Publisher
American Medical Association (AMA)
Published
2006-03-22
Volume
295
Issue
12
Pages
1389
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.295.12.1389
OpenAlex
W1499200300
Cited by
9
References
43
Citations by year
2023: 1 · 2021: 1 · 2016: 1 · 2015: 2 · 2014: 1
FWCI
0.36
Type
journal article
Language
en
Open access
closed
Locations
JAMA (publishedVersion)
Funders
National Institute of Mental Health (R01MH063852, N01‐MH‐90003, K02MH066249)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Social Sciences › Psychology › Clinical Psychology › Family Support in Illness
Keywords
maternal depression, depression remission, child psychopathology, intergenerational transmission of depression, antidepressants, STAR*D trial, childhood anxiety disorders, disruptive behavior disorders, child functioning

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review