The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
An Outbreak of Fusarium Keratitis Associated With Contact Lens Wear in Singapore
Abstract
CONTEXT: Fungal keratitis is a potentially blinding condition that is rarely seen with contact lens wear. OBJECTIVE: To describe a nationwide outbreak of fungal keratitis caused by Fusarium species among contact lens wearers in Singapore. DESIGN, SETTING, AND PATIENTS: Nationwide, hospital-based case series. All cases of fungal keratitis among contact lens wearers in all ophthalmology departments in Singapore were reviewed along with the charts of all contact lens wearers with culture-proven fungal keratitis from March 2005 through May 2006. A standardized telephone interview was conducted to obtain additional clinical information. MAIN OUTCOME MEASURE: Diagnosis of Fusarium keratitis associated with contact lens wear. RESULTS: During the study period, 66 patients (68 affected eyes) were diagnosed with Fusarium keratitis associated with contact lens wear; the estimated annual national incidence is 2.35 cases per 10,000 contact lens wearers (95% confidence interval, 0.62-7.22). Patients ranged in age from 13 to 44 years (mean [SD], 27.1 [8.4] years), of which 32 (48.5%) were men. The vast majority (65 patients; 98.5%) wore soft, disposable contact lenses; 62 patients (93.9%) reported using 1 brand of contact lens cleaning solution (ReNu, Bausch & Lomb, Rochester, NY), including 42 patients (63.6%) who recalled using ReNu with MoistureLoc. Most patients (81.8%) reported poor contact lens hygiene practices, including overnight use of daily wear contact lenses (19.7%), and use of contact lenses past the replacement date (43.9%). The final best-corrected visual acuity ranged from 20/20 to 20/80. Five patients (5 eyes; 7.4%) required emergency therapeutic or tectonic corneal transplantation. CONCLUSIONS: A new and evolving epidemic of Fusarium keratitis associated with contact lens wear was found in Singapore. Physicians and eye care practitioners worldwide need to be aware of the likelihood of similar outbreaks emerging among contact lens wearers.
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Cites
Epidemiology: Beyond the Basics
Szklo, M., & Nieto, F. J. (1999) · Cited by 1,441
Epidemiology: Beyond the Basics
Szklo, M. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.8.821 · Cited by 1,310
Taxonomy, biology, and clinical aspects of Fusarium species
Nelson, P. E., Dignani, M. C., & Anaissie, E. J. (1994) · Clinical Microbiology Reviews · doi:10.1128/cmr.7.4.479 · Cited by 704
Epidemiology and aetiological diagnosis of corneal ulceration in Madurai, south India
Srinivasan, M., Gonzales, C. A., George, C., Cevallos, V., Mascarenhas, J. M., Asokan, B., Wilkins, J., Smolin, G., & Whitcher, J. P. (1997) · British Journal of Ophthalmology · doi:10.1136/bjo.81.11.965 · Cited by 661
Incidence of contact-lens-associated microbial keratitis and its related morbidity
Cheng, K. H., Leung, S. L., Hoekman, H. W., Beekhuis, W. H., Mulder, P. G., Geerards, A. J., & Kijlstra, A. (1999) · The Lancet · doi:10.1016/s0140-6736(98)09385-4 · Cited by 611
Schein, O. D., Glynn, R. J., Poggio, E. C., Seddon, J. M., Kenyon, K. R., & The Microbial Keratitis Study Group (1989) · New England Journal of Medicine · doi:10.1056/nejm198909213211201 · Cited by 523
Spectrum of Microbial Keratitis in South Florida
Liesegang, T. J., & Forster, R. K. (1980) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)75075-5 · Cited by 522
Current Perspectives on Ophthalmic Mycoses
Thomas, P. A. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.4.730-797.2003 · Cited by 461
Contact lenses and other risk factors in microbial keratitis
Dart, J. K. G., Stapleton, F., Minassian, D., & Dart, J. K. G. (1991) · The Lancet · doi:10.1016/0140-6736(91)91231-i · Cited by 425
The Changing Spectrum of Fungal Keratitis in South Florida
Rosa, R. H., Miller, D., & Alfonso, E. C. (1994) · Ophthalmology · doi:10.1016/s0161-6420(94)31225-5 · Cited by 371
Cited by
Multistate Outbreak of Fusarium Keratitis Associated With Use of a Contact Lens Solution
Chang, D. C., Grant, G. B., O’Donnell, K., Wannemuehler, K. A., Noble-Wang, J., Rao, C. Y., Jacobson, L. M., Crowell, C. S., Sneed, R. S., Lewis, F. M. T., et al. (2006) · JAMA · doi:10.1001/jama.296.8.953 · Cited by 600
Report on Testing From an Investigation of Fusarium Keratitis in Contact Lens Wearers
Levy, B., Heiler, D., & Norton, S. (2006) · Eye & Contact Lens: Science & Clinical Practice · doi:10.1097/01.icl.0000245556.46738.14 · Cited by 92
Fungal keratitis in the Republic of Ireland
Farrell, S., McElnea, E., Moran, S., Knowles, S., & Murphy, C. C. (2017) · Eye · doi:10.1038/eye.2017.82 · Cited by 28
Metadata
- Authors
- Khor, W.-B., Aung, T., Saw, S.-M., Wong, T.-Y., Tambyah, P. A., Tan, A.-L., Beuerman, R., Lim, L., Chan, W.-K., Heng, W.-J., Lim, J., Loh, R. S. K., Lee, S.-B., & Tan, D. T. H.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2006-06-28
- Volume
- 295
- Issue
- 24
- Pages
- 2867
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2103617967
- Cited by
- 255
- References
- 27
- FWCI
- 20.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Khor, W.-B., Aung, T., Saw, S.-M., Wong, T.-Y., Tambyah, P. A., Tan, A.-L., Beuerman, R., Lim, L., Chan, W.-K., Heng, W.-J., Lim, J., Loh, R. S. K., Lee, S.-B., & Tan, D. T. H. (2006). An Outbreak of Fusarium Keratitis Associated With Contact Lens Wear in Singapore. JAMA. https://doi.org/10.1001/jama.295.24.2867
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