Cited by 783Blood Pressure and Hypertension StudiesSodium Intake and HealthCardiovascular Health and Disease Prevention

The DOI matches its Crossref record, with a small difference in title or year; 32 of the 33 references it cites were found in a registry or an index.

Systolic Blood Pressure Reduction and Risk of Cardiovascular Disease and Mortality: A Systematic Review and Network Meta-analysis

Open access

Bundy, Joshua D., Li, Changwei, Stuchlik, Patrick, Bu, Xiaoqing, Kelly, Tanika N., Mills, Katherine T., He, Hua, Chen, Jing, Whelton, Paul K., He, Jiang·2017·JAMA Cardiology

DOI 10.1001/jamacardio.2017.1421PMC PMC5710614

Open this paper in CoChat — free account Open PDF

Abstract

Importance: Clinical trials have documented that lowering blood pressure reduces cardiovascular disease and premature deaths. However, the optimal target for reduction of systolic blood pressure (SBP) is uncertain. Objective: To assess the association of mean achieved SBP levels with the risk of cardiovascular disease and all-cause mortality in adults with hypertension treated with antihypertensive therapy. Data Sources: MEDLINE and EMBASE were searched from inception to December 15, 2015, supplemented by manual searches of the bibliographies of retrieved articles. Study Selection: Studies included were clinical trials with random allocation to an antihypertensive medication, control, or treatment target. Studies had to have reported a difference in mean achieved SBP of 5 mm Hg or more between comparison groups. Data Extraction and Synthesis: Data were extracted from each study independently and in duplicate by at least 2 investigators according to a standardized protocol. Network meta-analysis was used to obtain pooled randomized results comparing the association of each 5-mm Hg SBP category with clinical outcomes after adjusting for baseline risk. Main Outcomes and Measures: Cardiovascular disease and all-cause mortality. Results: Forty-two trials, including 144 220 patients, met the eligibility criteria. In general, there were linear associations between mean achieved SBP and risk of cardiovascular disease and mortality, with the lowest risk at 120 to 124 mm Hg. Randomized groups with a mean achieved SBP of 120 to 124 mm Hg had a hazard ratio (HR) for major cardiovascular disease of 0.71 (95% CI, 0.60-0.83) compared with randomized groups with a mean achieved SBP of 130 to 134 mm Hg, an HR of 0.58 (95% CI, 0.48-0.72) compared with those with a mean achieved SBP of 140 to 144 mm Hg, an HR of 0.46 (95% CI, 0.34-0.63) compared with those with a mean achieved SBP of 150 to 154 mm Hg, and an HR of 0.36 (95% CI, 0.26-0.51) compared with those with a mean achieved SBP of 160 mm Hg or more. Likewise, randomized groups with a mean achieved SBP of 120 to 124 mm Hg had an HR for all-cause mortality of 0.73 (95% CI, 0.58-0.93) compared with randomized groups with a mean achieved SBP of 130 to 134 mm Hg, an HR of 0.59 (95% CI, 0.45-0.77) compared with those with a mean achieved SBP of 140 to 144 mm Hg, an HR of 0.51 (95% CI, 0.36-0.71) compared with those with a mean achieved SBP of 150 to 154 mm Hg, and an HR of 0.47 (95% CI, 0.32-0.67) compared with those with a mean achieved SBP of 160 mm Hg or more. Conclusions and Relevance: This study suggests that reducing SBP to levels below currently recommended targets significantly reduces the risk of cardiovascular disease and all-cause mortality. These findings support more intensive control of SBP among adults with hypertension.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1001/jamacardio.2017.1421

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
Higgins, J. P. T., Altman, D. G., Gotzsche, P. C., Juni, P., Moher, D., Oxman, A. D., Savovic, J., Schulz, K. F., Weeks, L., Sterne, J. A. C., et al. (2011) · BMJ · doi:10.1136/bmj.d5928 · Cited by 33,817
Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study
Toprak, Ö., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,772
The “Golden Age” of Probiotics: A Systematic Review and Meta-Analysis of Randomized and Observational Studies in Preterm Infants
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,586
Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
Chobanian, A. V., Bakris, G. L., Black, H. R., Cushman, W. C., Green, L. A., Izzo, J. L., Jones, D. W., Materson, B. J., Oparil, S., Wright, J. T., et al. (2003) · Hypertension · doi:10.1161/01.hyp.0000107251.49515.c2 · Cited by 13,271
Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies
(2002) · The Lancet · doi:10.1016/s0140-6736(02)11911-8 · Cited by 10,266
Global burden of hypertension: analysis of worldwide data
Kearney, P. M., Whelton, M., Reynolds, K., Muntner, P., Whelton, P. K., & He, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17741-1 · Cited by 8,698
Self-citation
2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8)
James, P. A., Oparil, S., Carter, B. L., Cushman, W. C., Dennison-Himmelfarb, C., Handler, J., Lackland, D. T., LeFevre, M. L., MacKenzie, T. D., Ogedegbe, O., et al. (2014) · JAMA · doi:10.1001/jama.2013.284427 · Cited by 7,950
Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013
(2015) · The Lancet · doi:10.1016/s0140-6736(14)61682-2 · Cited by 7,439
A Randomized Trial of Intensive versus Standard Blood-Pressure Control
The SPRINT Research Group (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1511939 · Cited by 6,325
Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis
Ettehad, D., Emdin, C. A., Kiran, A., Anderson, S. G., Callender, T., Emberson, J., Chalmers, J., Rodgers, A., & Rahimi, K. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01225-8 · Cited by 3,755

Show all 33 references

Research works printed but not linked: 1

[17]17. Jones DW, Weatherly L, Hall JE. SPRINT: what remains unanswered and where do we go from here? Hypertension. 2016;67(2):261-262.

Sorted by citations

Items 501–600 of 783

Maximizing Cardiovascular Event Reduction by Expanding and Intensifying the Targets
Ziaeian, B., & Fonarow, G. C. (2017) · Circulation · doi:10.1161/circulationaha.117.029844 · Cited by 3
Sprinting Toward the Optimal Blood Pressure Target for Hypertensive Patients
Oparil, S., Cushman, W. C., Johnson, K., Kitzman, D. W., Whelton, P. K., & Wright, J. T. (2018) · Circulation Research · doi:10.1161/circresaha.118.313057 · Cited by 4
Self-citation
A patient-reported questionnaire for evaluating utilization of the National Essential Public Health Service Program in China among older adults with hypertension and diabetes
Liu, L., Liu, M., Yang, L., Chen, X., Liu, Y., & You, L. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1459754 · Cited by 3
Identifying optimal primary prevention interventions for major cardiovascular disease events and all-cause mortality: a systematic review and hierarchical network meta-analysis of RCTs
Uthman, O. A., Court, R. A., Enderby, J., Nduka, C. U., Al-Khudairy, L., Anjorin, S., Mistry, H., Meléndez‐Torres, G. J., Taylor‐Phillips, S., & Clarke, A. (2024) · Health Technology Assessment · doi:10.3310/rldh7432 · Cited by 4
Impact of exercise-based prehabilitation on cardiometabolic health in surgical patients with cancer: a systematic review and meta-analysis
Fernández-Escabías, M., Jurado, J., Carrilho-Candeias, S., Orellana-Jaen, A., Corres, P., Mármol-Pérez, A., Lavie, C. J., Carneiro‐Barrera, A., Nestares, T., & Amaro‐Gahete, F. J. (2025) · Supportive Care in Cancer · doi:10.1007/s00520-025-09940-6 · Cited by 3
“Moreover, the observed BP reductions may decrease the augmented CVD and all-cause mortality risk faced by patients with cancer [94].”
Angiotensin converting enzyme inhibitors and angiotensin receptor blockers impact on the gut microbiome: a systematic review
Wang, E. M., Msdi, A. S., Quach, V. N., Nguyen, S. Q., Quach, E., Jo, J., Eubank, T. A., Garey, K. W., & Rosario, N. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1685424 · Cited by 3
Long-term ozone exposure and risks of diabetes and hypertension: Mediated by inflammatory, lipid and oxidative stress biomarkers in a prospective cohort
Yang, Y., Sun, H., Jiang, Z., Yan, M., Yang, H., Wang, Z., Zhang, H., Yang, X., Hou, F. Y. S., Yu, P., et al. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.140989 · Cited by 3
Evolution in the targets for blood pressure treatment
Whelton, P. K., O’Connell, S. S., & Mills, K. (2025) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000001152 · Cited by 3
Self-citation
Study protocol for a randomized controlled trial to evaluate the effectiveness of an artificial intelligence-based health education accurately linking system based on traditional Chinese medicine body constitution in patients with chronic disease multimorbidity
Liu, Q., Yang, Y., Ys, H., Yang, X., Liu, S., Bao, R., & Wu, Y. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1773974 · Cited by 3
Developing practical recommendations for drug-disease interactions in patients with hypertension
Özokcu, K., Diesveld, M. M. E., Gipmans, S. G. H., Peeters, L. E. J., van den Born, B. H., & Borgsteede, S. D. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1360146 · Cited by 7
Impact of baseline cardiovascular risk on the outcomes of intensive blood pressure intervention: a post hoc analysis of the China rural hypertension control project
Sun, G.-Z., Wang, C., Ye, N., Shi, C., Ouyang, N.-X., Qiao, L., Li, G.-X., Zhang, L., Yu, Y., Li, Z., et al. (2024) · BMC Medicine · doi:10.1186/s12916-024-03494-w · Cited by 3
“Previous studies have showed the benefits from intensive BP management [20, 21].”
Background
Safety vs Efficacy of Lowering Blood Pressure—Reply
Bundy, J. D., Whelton, P. K., & He, J. (2017) · JAMA Cardiology · doi:10.1001/jamacardio.2017.3543 · Cited by 3
Self-citation
What is the most appropriate target SBP in persons with hypertension and diabetes mellitus?
Ahmad, A., & Oparil, S. (2017) · Journal of Hypertension · doi:10.1097/hjh.0000000000001603 · Cited by 3
“[13] recently carried out a meta-analysis of 42 RCTs (30 RCTs including participants with diabetes mellitus; n1⁄4 144220) that analyzed results according to mean achieved SBP to assess the relationship between achieved SBP levels and CVD risk.”
Comparative Study of Metabolite Changes After Antihypertensive Therapy With Calcium Channel Blockers or Angiotensin Type 1 Receptor Blockers
Lü, J., Tian, Y., Gu, J., Qiu, M., Lü, Y., Sun, W. Y., & Kong, X. (2020) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000958 · Cited by 3
Evaluation of Blood Pressure Status and Mortality in Turkey: Findings from Chronic Diseases and Risk Factors Cohort Study
Sözmen, K., Ergör, G., Sakarya, S., Dinç, G., Şahan, C., Ekinci, B., Arikan, A., Sis, S., & Ünal, B. (2023) · Medicina · doi:10.3390/medicina59081366 · Cited by 3
“Due of its significant global burden, HT is regarded as one of the major public health issues [2,3].”
Background
Comparison of the Effects of Self-Administered Moxibustion versus Acupressure on Blood Pressure, Stress, Sleep Quality, and Quality of Life in Hypertensive Patients: A Randomized Parallel Trial
Jung, J., & Kim, J. (2023) · Healthcare · doi:10.3390/healthcare11152182 · Cited by 5
Extract of Chenopodium album lowers blood pressure in rats through endothelium-dependent and -independent vasorelaxation
Javed, A., Khan, S., Salma, U., Ahmad, T., Khan, T., & Shah, A. J. (2023) · Annales Pharmaceutiques Françaises · doi:10.1016/j.pharma.2023.08.003 · Cited by 3
Cumulative Blood Pressure in Early Adulthood and Coronary Artery Calcium and Carotid Intima‐Media Thickness in Middle Age Among Adults With Maintained Blood Pressure of <130/80 mm Hg: A Post Hoc Analysis
Masrouri, S., Afaghi, S., Khalili, D., Shapiro, M. D., & Hadaegh, F. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.123.032091 · Cited by 3
While You Are Sleeping: Marital Ambivalence and Blunted Nocturnal Blood Pressure
Birmingham, W. C., Herr, R. M., Cressman, M., Patel, N., & Hung, M. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21060723 · Cited by 2
“However, research has shown an increased BP trajectory over time associated with poor cardiovascular outcomes, even 25 years later [106].”
Background
Making Sense of Hypertension Guidelines
DeWald, T. A., Granger, B. B., & Bowers, M. (2018) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000000461 · Cited by 3
Profile and Outcome of Medical Emergencies in a Teaching Hospital in the Commercial City of Aba, Southeast Nigeria
Nkpozi, M., Adukwu, B., Onwuchekwa, U., Chikezie, J. A., & Aluka, C. (2020) · Journal of BioMedical Research and Clinical Practice · doi:10.46912/jbrcp.167 · Cited by 3
Is treated hypertension associated with a lower one-year mortality among older residents of long-term care facilities with multimorbidity?
Kańtoch, A., Pac, A., Wizner, B., Wójkowska‐Mach, J., Heczko, P. B., Grodzicki, T. K., & Gryglewska, B. (2021) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.15944 · Cited by 3
Effect of repeat manual blood pressure measurement on blood pressure and stage of hypertension
Rhodehouse, B. C., Fan, J., Chen, W., McNeal, M. J., Durham, C. G., & Erwin, J. P. (2019) · Baylor University Medical Center Proceedings · doi:10.1080/08998280.2019.1626657 · Cited by 3
Effects of Intensive Systolic Blood Pressure Control on All-Cause Hospitalizations
Rocco, M. V., Comeau, M. E., Marion, M. C., Freedman, B. I., Hawfield, A. T., & Langefeld, C. D. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.15868 · Cited by 3
Unilateral adrenalectomy for aldosterone‐producing adenoma in Hong Kong: Outcomes and factors predicting resolution of hypertension
Leung, H., Yuen, W., Lang, B. H., Tan, K. C. B., Fung, B. T., Lau, E., Ng, W. L., Chan, K. W., Chan, B. S., Lau, I. T., et al. (2021) · Surgical Practice · doi:10.1111/1744-1633.12507 · Cited by 3
Is Personalized Antihypertensive Drug Selection Feasible?
Carey, R. M. (2023) · JAMA · doi:10.1001/jama.2023.3704 · Cited by 3
Metabolic Alterations in Acute Cerebral Ischemia.
Poenaru, A. M., Ionescu, M., Albu, C. V., Rogoveanu, I., & Bălşeanu, T. A. (2022) · PubMed Central · doi:10.12865/chsj.48.03.02 · Cited by 2
Association of socioeconomic status with prognosis in hypertensive patients over age 65: a cohort study in the community setting
Martín‐Fernández, J., Alonso‐Safont, T., Gestri-Mora, P. E., Polentinos-Castro, E., Rodríguez-Martínez, G., Bilbao‐González, A., & del Cura-González, I. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-075188 · Cited by 2
Association of psychiatric history with hypertension among adults who present for metabolic and bariatric surgery
Tajeu, G. S., Wu, J., Tewksbury, C. M., Spitzer, J. C., Rubin, D. J., Gadegbeku, C. A., Soans, R. S., Allison, K. C., & Sarwer, D. B. (2024) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2024.10.004 · Cited by 2
Non-debatable issues in defining blood pressure targets for hypertension – Editorial
Egan, B. M., Kjeldsen, S. E., Narkiewicz, K., Kreutz, R. H., Burnier, M., & Mancia, G. (2025) · Blood Pressure · doi:10.1080/08037051.2025.2544721 · Cited by 2
Intensive versus Less-Intensive Blood Pressure Control in Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Clinical Trials
Fallahtafti, P., Semirani-Nezhad, D., Maleki, S., Zafarmandi, S., Dastjerdi, P., Rahmati, S., Roozbehi, K., Shaker, F., Fekri, M., Nanna, M. G., et al. (2025) · American Journal of Nephrology · doi:10.1159/000547812 · Cited by 2
Renal denervation for hypertension: cross-country cost-effectiveness insights from mainland China, Japan, and Thailand
Lian, D., Suo, Y., Gai, R. T., Li, N., Ren, Y., Xiao, D., Zhao, J., Zhang, M., Liu, S., & Chen, Y. (2025) · Health Economics Review · doi:10.1186/s13561-025-00669-w · Cited by 2
“Hypertension emerges as the paramount risk factor for cardiovascular disease (CVD), chronic kidney disease (CKD), and all-cause mortality globally [1–3].”
Genetic impact of central adiposity on systolic blood pressure in females: interaction and mediation by TG/HDL-C, HbA1c, and uric acid across BMI categories
Gumilang, R. A., & Bai, C. (2025) · International Journal of Obesity · doi:10.1038/s41366-025-01917-z · Cited by 2
“Systolic blood pressure (SBP) is a critical determinant of cardiovascular health, with reductions to optimal levels decreasing cardiovascular disease (CVD) events by nearly 60% [1].”
Association of different diet quality scores with cardiovascular disease mortality risk in hypertension treatment group
Zhou, J., Su, Y., He, L., Ding, N., & Zeng, Z. (2025) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2025.2563779 · Cited by 2
Randomised controlled effectiveness study (RCT) of isometric exercise (IE) in adults with stage 1 and 2 hypertension – ISOFITTER study
Rees-Roberts, M., Santer, E., Borthwick, R., Doulton, T. W. R., Swift, P. A., Pellatt‐Higgins, T., Gousia, K., MacInnes, D. L., West, A., Darby, J., et al. (2025) · NIHR Open Research · doi:10.3310/nihropenres.14059.1 · Cited by 2
Role of the Health Belief Model in the Management of Hypertension: A Systematic Review
Islam, M. T., Arafat, S. M., Chowdhury, A. A., Orchi, K., Sultana, S., Bushra, T., Islam, M. R., Fatema, K., Khan, M. M. H., & Haque, M. A. (2025) · Cureus · doi:10.7759/cureus.94139 · Cited by 9
“Controlling hypertension can significantly reduce the risk of cardiovascular events, stroke, renal and retinal complications, and all-cause mortality [2,3].”
The impact of hypertension on hearing loss phenotypes and its causal mediation underlying abnormal BMI: findings from the China national health survey 2023
Huang, H., Fan, Y., Yan, F., Hu, Y., He, H., Liu, Y., Tan, X., Zhu, X., Zhu, Y., Diao, W., et al. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2578727 · Cited by 2
Self-citation
Clinical outcomes of antihypertensive medication use in people with dementia: a systematic review and meta-analysis
Amare, F., Mirkazemi, C., Peterson, G. M., & Bezabhe, W. M. M. (2025) · GeroScience · doi:10.1007/s11357-025-01957-3 · Cited by 2
Optimal dose and effectiveness of different types of physical activity to improve blood pressure in people with type 2 diabetes mellitus: A systematic review and network meta-analysis
Álvarez‐Barbosa, F., Ramos-Munell, J., del Pozo-Cruz, J., Cruz, B. D. P., Ceballos-Sánchez, J. L., & Gallardo‐Gómez, D. (2025) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-025-10005-6 · Cited by 3
Mapping the Dynamic Complexity of Hypertension Management in São Paulo, Brazil
Loo, P. S., Socha, A., Silveira, M., Baxter, Y. C., Avezum, Á., Drager, L. F., Bortolotto, L. A., Boch, J., & Muñoz, D. C. (2026) · International Journal of Public Health · doi:10.3389/ijph.2025.1608895 · Cited by 2
“This is because hypertensive patients, now receiving more care, maintain a stable clinical state for longer periods; hence, a drop in CVD events, disability, and deaths [6, 16, 48, 49].”
The evolving burden of ischemic heart disease in China, 1990-2023: Three decades of trends, risk factors, and future challenges
Li, C., Xu, X., Zhang, Y., Xu, H., Xu, Z., Chang, Q., & Bao, J. (2026) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2026.101413 · Cited by 2
Self-citation
Efficacy and Safety of Combination Therapy With Low Dose of Telmisartan and S-Amlodipine in Patients With Hypertension: A Randomized, Double-Blind, Multicenter, Therapeutic Confirmatory, Phase III Clinical Trial
Lee, S. H., Park, K., Lee, K. H., Cho, Y., Kim, D.-H., Lim, S., Yoon, S. B., Jang, J., Lim, H., Doh, J., et al. (2026) · Clinical Therapeutics · doi:10.1016/j.clinthera.2026.01.001 · Cited by 3
Optimizing Elastic Band Resistance Training for Metabolic Syndrome Components in Older Adults: A Systematic Review, Meta-Analysis, and Meta-Regression of Randomized Controlled Trials
Saez-Berlanga, Á., Gené‐Morales, J., Babiloni-López, C., Jiménez‐Martínez, P., Juesas, Á., & Colado, J. C. (2026) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2026.02.485 · Cited by 2
The prevalence, prevention, and treatment of cardiovascular diseases in Twelve African Countries (2014–2019): An analysis of the World Health Organisation STEPwise approach to chronic disease risk factor surveillance
Ng'ambi, W., Estill, J., Merzouki, F. A., Zyambo, C., Banda, J. C., Beran, D., & Keiser, O. (2026) · PLoS ONE · doi:10.1371/journal.pone.0320276 · Cited by 5
The association between objective and perceived bird diversity and the mental health of minoritized communities living near disused parks in Detroit
Dennison, C. J., Mason, K., Pearson, A. L., & Buxton, R. T. (2026) · Landscape and Urban Planning · doi:10.1016/j.landurbplan.2026.105644 · Cited by 2
Macrophage-Specific SPP1 Contributes to Pressure Overload–Induced Cardiac Dysfunction and Maladaptive Remodeling
Ye, W., Sun, J., Shen, E., Yang, B., Li, L., Long, Y., Shen, J., Liu, W., Xiao, M., Wu, H., et al. (2026) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2026.101623 · Cited by 2
Uncontrolled Hypertension Prevalence, Characteristic Profiles, and Risk of Cardiorenal and Metabolic Outcomes: Insights from the EnligHTN Study
McCormack, T., Ben-Dor, N., Norris, T., Giannoula, A., Coto, E., Rhodes, K. M., Franzén, S., Fernández, C. S., Weil, J., Bech, J. N., et al. (2026) · Advances in Therapy · doi:10.1007/s12325-026-03681-6 · Cited by 2
MODERN OPPORTUNITIES FOR ANTIHYPERTENSION THERAPY: THE PLACE OF AZILSARTAN MEDOXOMIL
Skibitsky, V. V., & Вадимовна, Ф. А. (2017) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2017-12-84-89 · Cited by 2
Individual interventions to improve adherence to pharmaceutical treatment, diet and physical activity among adults with primary hypertension. A systematic review protocol
Parra, D. I., Trapero, I., Rodríguez, J. M. S., Rodríguez-Corredor, L. C., Vargas, J. A. H., López-Romero, L. A., López, F. J. G., Gómez, C. E., Trujillo-Cáceres, S. J., Serrano‐Gallardo, P., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-037920 · Cited by 4
Health care fragmentation and blood pressure control among adults taking antihypertensive medication
Colvin, C. L. (2022) · The American Journal of Managed Care · doi:10.37765/ajmc.2022.88837 · Cited by 2
Hypertension incidence among students at an Islamic boarding school in Malang Regency: A cross sectional study
Tjahjono, C. T., Arthamin, M. Z., Mayangsari, V., Satwikajati, S., Suprayoga, I. M., Hazzy, F., Noverikhe, N., & Prasthiti, N. P. F. B. (2023) · AIP conference proceedings · doi:10.1063/5.0111272 · Cited by 2
Newer alternatives for resistant hypertension: Beyond 2022 paradigms
Laffin, L. J., Briasoulis, Α., & Bakris, G. L. (2023) · Hellenic Journal of Cardiology · doi:10.1016/j.hjc.2023.01.006 · Cited by 2
Risk Assessment of Dyslipidemias, Hyperglycemia, Hyperuricemia, and Hypertension Utilizing Self-Reported Body Silhouettes
Blachman-Braun, R., Talavera, J. O., Pérez‐Rodríguez, M., Roy-García, I. A., Rivas-Ruíz, R., Huitrón-Bravo, G. G., & Salmerón, J. (2023) · Journal of Obesity · doi:10.1155/2023/4991684 · Cited by 2
“Furthermore, it has been shown that a reduction in systolic blood pressure decreases the risk of CVD and all-cause mortality [33].”
Background
Correlation analysis of hypertension, traditional Chinese medicine constitution, and LPL gene polymorphism in the elderly in communities in Shanghai
Tao, Y., Jiang, L., Zhou, C., Lin, Y., Yang, Y., & Wang, Y. (2023) · Technology and Health Care · doi:10.3233/thc-220908 · Cited by 2
“Hypertension is a common chronic disease that can cause severe damage to the heart, brain, kidney, and other target organs [1,2].”
A structured lifestyle intervention combined with mobile health application to reduce chronic disease risk among employees at a university workplace
Lee, C. L. (2022) · International e-Journal of Science Medicine & Education · doi:10.56026/imu.16.1.3 · Cited by 2
“22 An unexpected finding of this present study was the juxtaposed post-intervention improvements in triglyceride and HDL-cholesterol levels, but regression in LDL-cholesterol level.”
Background
Screening for hypertension in adults – the use of tonometric blood pressure monitoring
Hornstrup, B., Rosenbæk, J. B., Hoffmann-Petersen, N., & Bech, J. N. (2023) · Blood Pressure Monitoring · doi:10.1097/mbp.0000000000000679 · Cited by 3
“Arterial hypertension contributes to around half of the cases of ischaemic heart disease and strokes [1,2], and even smaller blood pressure (BP) reductions in hypertensive patients reduce the risk of cardiovascular disease [3].”
Background
Efficacy of Immediate Antihypertensive Treatment in Patients With Acute Ischemic Stroke With Different Blood Pressure Genetic Variants
Zhai, Y., Chen, H., Che, B., Liu, Y., Peng, Y., Chen, J., Xu, T., He, J., Zhang, Y., & Zhong, C. (2024) · Hypertension · doi:10.1161/hypertensionaha.123.21851 · Cited by 3
Self-citation
Evaluation of the Relationship between Sublingual Varices and Hypertension
Jamali, Z., Katebi, K., Alibabaei, H., & Khosroshahi, A. J. (2024) · Frontiers in Dentistry · doi:10.18502/fid.v21i7.14888 · Cited by 2
Baseline knowledge about hypertension and sociodemographic factors related to salt intake behavior among hypertensive individuals in a rural community of Bangladesh: Substudy of a randomized controlled trial
Jahan, Y., Rahman, M. M., & Moriyama, M. (2024) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_130_23 · Cited by 3
“[1] Elevated blood pressure (BP) is a leading preventable cause of global CVD mortality and disease burden.”
Background
Latino–White Disparities in Identification and Control of Elevated Blood Pressure Among Adults With Hypertension
Boston, D., Hwang, J. S., Lucas, J., Marino, M., Larson, Z., Sun, E., Giebultowicz, S., Crookes, D. M., Rodríguez, C. J., & Heintzman, J. D. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.033151 · Cited by 2
Boroxazolidones: Synthesis, In Silico and In Vitro Evaluation as ACE/AChE Dual Inhibitors, and In Vivo Testing of Antihypertensive Activity
Barquet-Nieto, A., Trujillo-Ferrara José, G., Andrade‐Jorge, E., Rodríguez-Rodríguez, J. E., Gallardo‐Ortíz, I. A., & Rafael, V.-M. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673310296240820070142 · Cited by 2
Associations of daily step count with all-cause mortality and cardiovascular mortality in hypertensive US adults: a cohort study from NHANES 2005–2006
Guo, T., Zhou, Y., Yang, G., Zhong, A., Pan, X., Pu, Y., Simons, M., Sheng, L., & Chai, X. (2025) · BMC Public Health · doi:10.1186/s12889-024-21216-y · Cited by 4
The TRAIN Health Awareness Clinical Trial: Baseline Findings and Cardiovascular Risk Management in Aortic Dissection Patients
Bacour, N., Grewal, S., Tirpan, A. U., Theijse, R. T., van Erp, O., Klautz, R. J. M., Sakalihasan, N., Hultgren, R., & Grewal, N. (2024) · Aorta · doi:10.1055/a-2524-4772 · Cited by 2
Drug‐Related Hypertension: A Disproportionality Analysis Leveraging the FDA Adverse Event Reporting System
Zhu, H., Pan, L., Lui, H., & Zhang, J. (2025) · Journal of Clinical Hypertension · doi:10.1111/jch.70029 · Cited by 2
Russian medical society of arterial hypertension experts consensus on standardized clinic (office) blood pressure measurement
Zhernakova, Y., Rogoza, A., Kislyak, O., Blinova, N. V., Bragina, A., & Chazova, I. (2025) · Systemic Hypertension · doi:10.38109/2075-082x-2025-1-5-11
A prediction model for diabetes complications using the Kokuho Database and its application to public health services in Japan
Chiba, S., Itoga, T., Asada, K., & Yabe, D. (2025) · Journal of Diabetes Investigation · doi:10.1111/jdi.70035 · Cited by 2
Noncommunicable disease syndemic among the general population in Iran: a cross-sectional study
Torabi, Z., Farzadfar, F., Rezaei, N., Singer, M. C., Roshani, S., Tajvar, M., & Shakibazadeh, E. (2025) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-025-01615-7 · Cited by 2
Cost-related medication nonadherence in adults with hypertension in the USA: implications for healthcare quality
Reddy, R., Santoyo, K. C., Guerra, D., Lamy, C., Hertelendy, A. J., & Barengo, N. C. (2025) · International Journal for Quality in Health Care · doi:10.1093/intqhc/mzaf039 · Cited by 2
Cardiovascular, Hemodynamic, and Anthropometric Adaptations Induced by Walking Training at FATmax in Obese Males and Females over 45 Years Old
Mille-Hamard, L., Momken, I., Koralsztein, J. P., & Billat, V. L. (2025) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph22050701 · Cited by 2
“HTN and obesity are associated with higher risk of CVD. Lowering systolic blood pressure (SBP) by 10 mmHg can reduce the risk of CVD by 29% [6], illustrating the significant impact of BP management in reducing cardiovascular risk.”
Effectiveness of Xuanshen Yishen Decoction on Intensive Blood Pressure Control: Emulation of a Randomized Target Trial Using Real-World Data
Wang, X., Hu, Y., Huan, J.-M., Liang, S.-B., Xin, L., Jiang, F., Hua, Z., Wang, Z., Kong, L.-H., Wu, Q., et al. (2025) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-025-4007-6 · Cited by 2
Improvements in Blood Pressure Control and the Hypertension Care Continuum Over 2 Years in Urban Haiti Amidst Civil Unrest
Metz, M., Sufra, R., Ogyu, A., Rouzier, V., Sauveur, R. S., Celestin, K., Forestal, G. P. L., Preval, F., Jean, M., Marcelin, S. E., et al. (2025) · Journal of Clinical Hypertension · doi:10.1111/jch.70153 · Cited by 2
Manejo da hipertensão arterial no diabetes
Izar, M. C. D. O., Fonseca, F. A. H., Faludi, A. Á., de Araújo, D. B., & Bertoluci, M. C. (2022) · Conectando Pessoas eBooks · doi:10.29327/557753.2022-16 · Cited by 3
Impacto del control de la tensión arterial sobre la morbimortalidad en pacientes hipertensos mayores de 65 años en el ámbito comunitario
Cascajero, M. Á. A., Alonso‐Safont, T., & Martín‐Fernández, J. (2023) · Revista Clínica de Medicina de Familia · doi:10.55783/rcmf.160104 · Cited by 2
How low can you go? Achieved blood pressure and cardiovascular outcomes
Wyatt, C. M., & Cheung, A. K. (2017) · Kidney International · doi:10.1016/j.kint.2017.07.002 · Cited by 2
Lowering the systolic blood pressure target in hypertensive patients: current controversies and future outlook
Narita, K., Hoshide, S., & Kario, K. (2018) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2018.1538784 · Cited by 2
Neue europäische Empfehlungen zum Blutdruckmanagement im Alter
Hoffmann, U., & Thrun, J.-M. (2018) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/a-0622-9131 · Cited by 2
Should blood pressure ≥130/80 mm Hg be considered as a cardiovascular disease?
Tadic, M. V., & Cuspidi, C. (2019) · Journal of Clinical Hypertension · doi:10.1111/jch.13607 · Cited by 2
NICE guideline: the diagnosis and management of hypertension
Corr, L. (2019) · Trends in Urology & Men s Health · doi:10.1002/tre.719 · Cited by 2
Risk assessment for health insurance using equation modeling and machine learning
Singh, A., & Ramkumar, K. R. (2021) · International Journal of Knowledge-based and Intelligent Engineering Systems · doi:10.3233/kes-210065 · Cited by 2
The US Surgeon General’s Call-to-Action to Control Hypertension: Introduction to an American Journal of Hypertension Compendium
Muntner, P. (2021) · American Journal of Hypertension · doi:10.1093/ajh/hpab188 · Cited by 2
Blood Pressure Screening in Faith Communities
Sailors, R., Saint, D., & Ayer, N. (2022) · Journal of Christian Nursing · doi:10.1097/cnj.0000000000000982 · Cited by 2
Bayesian fractional polynomial approach to quantile regression and variable selection with application in the analysis of blood pressure among US adults
Soomro, S., & Yu, K. (2024) · Journal of Applied Statistics · doi:10.1080/02664763.2024.2359526 · Cited by 2
The association of conventionally medicated systolic and diastolic blood pressure level and mortality from cardiovascular disease: is the lower the better in high stroke population?
Sakaniwa, R., Tromp, J., Shirai, K., Yamagishi, K., Tamakoshi, A., & Iso, H. (2020) · Clinical Research in Cardiology · doi:10.1007/s00392-019-01587-8 · Cited by 2
Perfil de gestantes de alto risco acompanhadas em uma Unidade Básica de Saúde
Gomes, A. T., Viana, V. M. O., Soares, T. D. C., Viana, V. M. O., Moura, P. R. D. S. E. S., Lemos, M. H. D. S., Vilarinho, M. D. F. S. B., & Rocha, G. D. C. (2021) · Research Society and Development · doi:10.33448/rsd-v10i11.19038 · Cited by 2
Hypertension and cardiovascular disease: Is a treatment strategy focused on high risk sufficient?
Jones, D. W. (2018) · Journal of Clinical Hypertension · doi:10.1111/jch.13324 · Cited by 2
Early Decline in Kidney Function With Intensive Systolic Blood Pressure Lowering
Beddhu, S., & Whelton, P. K. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14784 · Cited by 2
Self-citation
Network meta-analyses in hypertension
Thomopoulos, C., & Mancia, G. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002622 · Cited by 2
Selection of invalid instruments can improve estimation in Mendelian randomizationPreprint
Patel, A. R., DiTraglia, F. J., Zuber, V., & Burgess, S. (2021) · arXiv (Cornell University) · Cited by 2
It Is Time to Reconsider the Blood Pressure Targets in Patients With Type 2 Diabetes?
Verdecchia, P., Reboldi, G., & Angeli, F. (2023) · Hypertension · doi:10.1161/hypertensionaha.123.21461 · Cited by 2
Trends of Hypertension Stages among Iranian Adults from 2005 to 2025 using WHO STEPS studies: A Comparison among 2017 ACC/AHA, JNC7, and 2020 ISH GuidelinesPreprint
Golestani, A., Sheidaei, A., Khosravi, S., Ostovar, A., Heshmat, R., & Shafiee, G. (2024) · Research Square · doi:10.21203/rs.3.rs-3966386/v1 · Cited by 2
Effect of daily physical activity on ambulatory blood pressure in pregnant women with chronic hypertension: A prospective cohort study protocol
Lv, Y., Hu, R., Liang, Y., Zhou, Y., Lian, Y., & He, T. (2024) · PLoS ONE · doi:10.1371/journal.pone.0296023 · Cited by 2
Impact of Telemedicine on the Clinical Outcomes among Elderly Patients: A Systematic Review
Hossain, M. A. (2024) · Archives of Pharmacy Practice · doi:10.51847/2tavelw0xj · Cited by 1
Association between Dietary Vitamin E Intake and the Risk of Hypertension in US Adults
Liu, C., & Liang, D. (2024) · Current Vascular Pharmacology · doi:10.2174/0115701611297956240425115501 · Cited by 1
Validation of a novel multi-exercise approach to isometric resistance training in normotensive adults
Wright, B., Jones, P., Antrobus, M., & Baross, A. (2025) · European Journal of Applied Physiology · doi:10.1007/s00421-025-05785-3 · Cited by 1
“…with ischemic heart disease, cerebrovascular disease, and chronic kidney disease attributed to increased systolic blood pressure (sBP, ≥ 140 mmHg) (Bundy et al. 2017; Mills et al. 2020; Webb and Werring 2022), efficacious prevention, treatment, and management approaches are needed to address…”
Real-world effectiveness and safety of oral azvudine versus Paxlovid in patients with COVID-19 and pre-existing hypertension: a multicentre, retrospective, cohort study in Henan Province, China
Wang, F., Jia, B., Li, G., Jin, X., Yang, M., Li, G., Zhang, S., Qian, G., Luo, H., Cheng, M. H., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-090230 · Cited by 1
Differential associations between education and blood pressure by gender and race
Pacca, L., Irish, A. M., Duarte, C., Riley, A. R., Pletcher, M. J., Bailey, Z., & Vable, A. M. (2025) · BMC Public Health · doi:10.1186/s12889-025-23409-5 · Cited by 4
Blue space and health/well-being: An overview of six meta-analyses and their evidence certainty (PRIOR item 1)
Han, K.-T., & Zhang, X.-L. (2025) · Water Research · doi:10.1016/j.watres.2025.124530 · Cited by 2
Resistant Blood Pressure: New Frontiers in Interventional Hypertension Therapy
Taylor, J., Uche, C., Rowe, V., Hattab, A., Draffen, A., Groo, V. L., & Shroff, A. R. (2025) · Cardiology and Therapy · doi:10.1007/s40119-025-00434-4 · Cited by 1
“…therapy lowered the risk of the primary composite outcome (myocardial infarction, stroke, heart failure, or cardiovascular death) by 25%, all-cause mortality by 27%, heart failure by 38%, cardiovascular death by 43%, and the combined endpoint of the primary outcome or death by 22% [41].”
Impact of intensive versus standard blood pressure control on cardiovascular events in hypertensive patients: a meta-analysis of randomized controlled trials
Prizão, V. M., de Morais, B. C., de Souza, M. M., Mendes, B. X., Defante, M. L. R., Cavalcante, D. N., & Okawa, R. T. P. (2025) · Journal of Hypertension · doi:10.1097/hjh.0000000000004195 · Cited by 2
Remnant Cholesterol is Associated with Blood Pressure Control in US Adults with Hypertension: NHANES 2007–2018 Analysis
Feng, S., Zou, S., Tang, M., Tian, R., & Xu, Y. (2025) · Vascular Health and Risk Management · doi:10.2147/vhrm.s553282 · Cited by 1

Authors: Bundy, J. D., Li, C., Stuchlik, P., Bu, X., Kelly, T. N., Mills, K. T., He, H., Chen, J., Whelton, P. K., & He, J.
Affiliations: Tulane University (US)
Corresponding author: He, Jiang
ORCID: Bundy, Joshua D.
Li, Changwei
Bu, Xiaoqing
Kelly, Tanika N.
Mills, Katherine T.
He, Hua
Chen, Jing
Whelton, Paul K.
He, Jiang
Venue: JAMA Cardiology
Publisher: American Medical Association (AMA)
Published: 2017-07-01
Volume: 2
Issue: 7
Pages: 775
ISSN: 2380-6583 (ISSN-L)
DOI: 10.1001/jamacardio.2017.1421
PMC: PMC5710614
OpenAlex: W2618382346
Cited by: 783
References: 33
Citations by year: 2026: 59 · 2025: 102 · 2024: 96 · 2023: 99 · 2022: 65 · 2021: 95 · 2020: 80 · 2019: 78 · 2018: 73 · 2017: 35
FWCI: 56.22
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: JAMA Cardiology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (P20GM109036)
Fogarty International Center (D43TW009107)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: systolic blood pressure, blood pressure targets, hypertension, antihypertensive therapy, cardiovascular disease, all-cause mortality, blood pressure reduction, linear dose-response relationship, cardiovascular risk reduction, cardiovascular disease prevention, cardiovascular disease prevention and treatment
MeSH terms: Antihypertensive Agents, Blood Pressure, Cardiovascular Diseases, Humans, Hypertension, Mortality, Patient Care Planning, Systole

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Systolic Blood Pressure Reduction and Risk of Cardiovascular Disease and Mortality: A Systematic Review and Network Meta-analysis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks